Published in Virology on July 30, 1985
Six distinct nuclear factors interact with the 75-base-pair repeat of the Moloney murine leukemia virus enhancer. Mol Cell Biol (1987) 4.02
Alignment of U3 region sequences of mammalian type C viruses: identification of highly conserved motifs and implications for enhancer design. J Virol (1990) 2.34
Binding of SL3-3 enhancer factor 1 transcriptional activators to viral and chromosomal enhancer sequences. J Virol (1991) 1.78
A transcriptional enhancer with specificity for erythroid cells is located in the long terminal repeat of the Friend murine leukemia virus. EMBO J (1986) 1.75
Point mutations in the Moloney murine leukemia virus enhancer identify a lymphoid-specific viral core motif and 1,3-phorbol myristate acetate-inducible element. J Virol (1990) 1.74
An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: analysis of the beta-globin locus control region. Proc Natl Acad Sci U S A (1993) 1.60
Substitution of leucine for isoleucine in a sequence highly conserved among retroviral envelope surface glycoproteins attenuates the lytic effect of the Friend murine leukemia virus. Proc Natl Acad Sci U S A (1991) 1.40
Sequences in the U5-gag-pol region influence early and late pathogenic effects of Friend and Moloney murine leukemia viruses. J Virol (1990) 1.34
Nuclear factors that bind to the enhancer region of nondefective Friend murine leukemia virus. J Virol (1989) 1.23
Structural diversity and nuclear protein binding sites in the long terminal repeats of feline leukemia virus. J Virol (1990) 1.17
Tissue tropism of a leukemogenic murine retrovirus is determined by sequences outside of the long terminal repeats. Proc Natl Acad Sci U S A (1986) 1.00
Transcriptional activation of cKi-ras proto-oncogene resulting from retroviral promoter insertion. Nucleic Acids Res (1989) 0.95
A set of viral DNA decamers enriched in transcription control signals. Nucleic Acids Res (1991) 0.94
JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2. Proc Natl Acad Sci U S A (1993) 0.83
Recombinant origins of pathogenic and nonpathogenic mouse gammaretroviruses of polytropic host range. J Virol (2017) 0.75
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98
Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med (2000) 13.13
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32
Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity (1995) 10.65
A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature (1984) 10.02
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell (1993) 9.84
BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33
DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93
Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38
Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity (1997) 6.15
Duplication of CaMV 35S Promoter Sequences Creates a Strong Enhancer for Plant Genes. Science (1987) 6.00
Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell (1998) 5.92
Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science (2000) 5.84
Regulation of PTEN transcription by p53. Mol Cell (2001) 5.44
Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell (1998) 5.32
FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science (1998) 5.29
The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07
Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell (1986) 4.68
T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62
Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev (2000) 4.51
Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol (2004) 4.46
Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34
Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell (1984) 4.34
Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun (1995) 4.33
Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23
T-cell co-stimulation through B7RP-1 and ICOS. Nature (1999) 4.20
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell (1991) 4.05
ICOS is essential for effective T-helper-cell responses. Nature (2001) 4.01
Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 3.80
Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell (1994) 3.56
Sequence and expression of transcripts of the human T-cell receptor beta-chain genes. Nature (1985) 3.53
The TIGR Gene Indices: clustering and assembling EST and known genes and integration with eukaryotic genomes. Nucleic Acids Res (2005) 3.53
Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45
Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron (2001) 3.42
Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line. Proc Natl Acad Sci U S A (1985) 3.41
The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41
Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30
Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. Proc Natl Acad Sci U S A (1985) 3.29
Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity (2000) 3.29
Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci U S A (2008) 3.27
High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res (2000) 3.24
Universals and cultural differences in the judgments of facial expressions of emotion. J Pers Soc Psychol (1987) 3.22
The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18
Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13
Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain. Nature (1985) 3.08
Genes of the T-cell antigen receptor in normal and malignant T cells. Annu Rev Immunol (1987) 3.01
Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (1999) 2.96
Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med (1997) 2.91
Human T-cell receptor variable gene segment families. Immunogenetics (1995) 2.86
Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science (1994) 2.86
Two distinct pathways leading to nuclear apoptosis. J Exp Med (2000) 2.84
Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature (1985) 2.84
An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (1995) 2.79
Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J Immunol (1999) 2.77
Improved optical equipment for immunofluorescence studes. J Clin Pathol (1967) 2.77
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72
CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood (1997) 2.71
Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science (1992) 2.60
Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort. Neurology (2012) 2.60
A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene (1993) 2.59
Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J (1998) 2.56
Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science (1996) 2.56
Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol (1999) 2.55
Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol (1992) 2.53
Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem (2001) 2.50
Characterization of reticuloendotheliosis virus strain T DNA and isolation of a novel variant of reticuloendotheliosis virus strain T by molecular cloning. J Virol (1981) 2.49
WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity (2001) 2.49
Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature (1997) 2.46
Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science (2013) 2.38
Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res (1995) 2.33
Sequences and repertoire of the human T cell receptor alpha and beta chain variable region genes in thymocytes. Eur J Immunol (1987) 2.32
The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol (Phila) (2014) 2.31
Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science (1994) 2.28
Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat Genet (1997) 2.28
Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity (1997) 2.25
Mouse T-cell receptor variable gene segment families. Immunogenetics (1995) 2.24
Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J Exp Med (1991) 2.24
Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein. Proc Natl Acad Sci U S A (1983) 2.23
Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based flow cytometry: allergics vs. non-allergics. J Immunol Methods (2001) 2.22
T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. J Exp Med (1986) 2.20
Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev (1997) 2.20
EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism. Clin Exp Metastasis (1996) 2.16
LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med (1996) 2.14
Relationship between Arp2/3 complex and the barbed ends of actin filaments at the leading edge of carcinoma cells after epidermal growth factor stimulation. J Cell Biol (1999) 2.14
The Friend virus genome: evidence for the stable association of MuLV sequences and sequences involved in erythroleukemic transformation. Cell (1977) 2.12