Analysis of cDNA clones specific for human T cells and the alpha and beta chains of the T-cell receptor heterodimer from a human T-cell line.

PubWeight™: 3.41‹?› | Rank: Top 1%

🔗 View Article (PMC 397789)

Published in Proc Natl Acad Sci U S A on May 01, 1985

Authors

Y Yanagi, A Chan, B Chin, M Minden, T W Mak

Articles citing this

Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. Proc Natl Acad Sci U S A (1985) 3.29

Expression of T3 in association with a molecule distinct from the T-cell antigen receptor heterodimer. Proc Natl Acad Sci U S A (1986) 2.73

Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nat Biotechnol (2014) 2.10

Human natural killer cells isolated from peripheral blood do not rearrange T cell antigen receptor beta chain genes. J Exp Med (1986) 2.01

Antigen recognition by human T cell receptor gamma-positive lymphocytes. Specific lysis of allogeneic cells after activation in mixed lymphocyte culture. J Exp Med (1988) 1.84

Sequences and repertoire of human T cell receptor alpha chain variable region genes in mature T lymphocytes. J Exp Med (1986) 1.75

Diversity and structure of human T-cell receptor alpha-chain variable region genes. Proc Natl Acad Sci U S A (1987) 1.69

Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia. Proc Natl Acad Sci U S A (1986) 1.66

Rearrangement and expression of the alpha, beta, and gamma chain T cell receptor genes in human thymic leukemia cells and functional T cells. J Exp Med (1986) 1.62

Sequences and diversity of human T cell receptor beta chain variable region genes. J Exp Med (1986) 1.62

Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus. Proc Natl Acad Sci U S A (1988) 1.53

Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. Proc Natl Acad Sci U S A (1986) 1.44

Genomic organization of the human T-cell antigen-receptor alpha/delta locus. Proc Natl Acad Sci U S A (1988) 1.41

Characterization of CD3+, CD4-, CD8- clones expressing the putative T cell receptor gamma gene product. Analysis of the activation pathways leading to interleukin 2 production and triggering of the lytic machinery. J Exp Med (1987) 1.37

Restricted heterogeneity of T lymphocytes in combined immunodeficiency with hypereosinophilia (Omenn's syndrome). J Clin Invest (1991) 1.36

Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies. Proc Natl Acad Sci U S A (1992) 1.31

Diversity and structure of human T cell receptor delta chain genes in peripheral blood gamma/delta-bearing T lymphocytes. J Exp Med (1989) 1.22

Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus. Proc Natl Acad Sci U S A (1988) 1.13

Expression of T cell receptor genes in human B cells. J Exp Med (1986) 1.10

Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development. J Exp Med (1996) 1.09

T-cell receptor and immunoglobulin genes are rearranged together in Abelson virus-transformed pre-B and pre-T cells. Mol Cell Biol (1987) 1.07

Comparison of T cell receptor alpha, beta, and gamma gene rearrangement and expression in T cell acute lymphoblastic leukemia. J Clin Invest (1988) 1.04

Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3' side of MYC. Proc Natl Acad Sci U S A (1986) 1.01

Structural and functional properties of ribosomal protein L7 from humans and rodents. Nucleic Acids Res (1993) 1.00

Increased radiosensitivity of granulocyte macrophage colony-forming units and skin fibroblasts in human autosomal recessive severe combined immunodeficiency. J Clin Invest (1993) 1.00

Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. Proc Natl Acad Sci U S A (1986) 0.99

Involvement of the interleukin 2 pathway in the rearrangement and expression of both alpha/beta and gamma/delta T cell receptor genes in human T cell precursors. J Exp Med (1988) 0.99

The cDNA and protein sequences of human lactate dehydrogenase B. Biochem J (1987) 0.98

The lysine residue in the membrane-spanning domain of the beta chain is necessary for cell surface expression of the T cell antigen receptor. J Exp Med (1988) 0.98

Abelson virus transformation of an interleukin 2-dependent antigen-specific T-cell line. Mol Cell Biol (1987) 0.96

In vitro expansion of CD3/TCR- human thymocyte populations that selectively lack CD3 delta gene expression: a phenotypic and functional analysis. J Exp Med (1990) 0.96

Restriction fragment length polymorphism of the gene encoding the alpha chain of the human T cell receptor. J Exp Med (1985) 0.96

Detection and mapping of polymorphic KpnI alleles in the human T-cell receptor constant beta-2 locus. Immunology (1989) 0.95

An altered repertoire of T cell receptor V gene expression by rheumatoid synovial fluid T lymphocytes. Clin Exp Immunol (1992) 0.94

Regions of the T cell receptor alpha and beta chains that are responsible for interactions with CD3. J Exp Med (1991) 0.94

The T-cell receptor gamma chain-CD3 complex: implication in the cytotoxic activity of a CD3+ CD4- CD8- human natural killer clone. Proc Natl Acad Sci U S A (1987) 0.93

Genetic study of a new X-linked recessive immunodeficiency syndrome. J Clin Invest (1992) 0.92

T cell receptor alpha-, beta-, and gamma-genes in T cell and pre-B cell acute lymphoblastic leukemia. J Clin Invest (1987) 0.92

Identification of a late stage of small noncycling pTalpha- pre-T cells as immediate precursors of T cell receptor alpha/beta+ thymocytes. J Exp Med (1998) 0.92

Molecular heterogeneity of gamma delta T-cell antigen receptors expressed by CD4- CD8- T-cell clones from normal donors: both disulfide- and non-disulfide-linked receptors are delta TCS1+. Proc Natl Acad Sci U S A (1989) 0.91

T-cell clones and T-cell receptors. Microbiol Rev (1986) 0.90

Identification of clonally expanded T cells in rheumatoid arthritis using a sequence enrichment nuclease assay. J Clin Invest (1996) 0.90

A specific defect in CD3 gamma-chain gene transcription results in loss of T-cell receptor/CD3 expression late after human immunodeficiency virus infection of a CD4+ T-cell line. Proc Natl Acad Sci U S A (1990) 0.90

Putative prethymic T cell precursors within the early human embryonic liver: a molecular and functional analysis. J Exp Med (1993) 0.89

Thyroglobulin antibodies in Graves' disease are associated with T-cell receptor beta chain and major histocompatibility complex loci. Clin Exp Immunol (1989) 0.85

Genetic recombination within the human T-cell receptor alpha-chain gene complex. Proc Natl Acad Sci U S A (1987) 0.83

Epstein-Barr virus-transformed pro-B cells are prone to illegitimate recombination between the switch region of the mu chain gene and other chromosomes. Proc Natl Acad Sci U S A (1989) 0.83

Malignant histiocytosis. A phenotypic and genotypic investigation. Am J Pathol (1990) 0.80

Acute leukemia expressing the gamma gene product of the putative second T cell receptor. J Clin Invest (1987) 0.79

Surface expression of only gamma delta and/or alpha beta T cell receptor heterodimers by cells with four (alpha, beta, gamma, delta) functional receptor chains. J Exp Med (1988) 0.79

A new approach to understanding T cell development: the isolation and characterization of immature CD4-, CD8-, CD3- T cell cDNAs by subtraction cloning. Mol Biol Cell (1992) 0.78

High levels of heterodisperse RNAs accumulate in T cells infected with human immunodeficiency virus and in normal thymocytes. Proc Natl Acad Sci U S A (1988) 0.78

Human immunodeficiency virus type 2 produces a defect in CD3-gamma gene transcripts similar to that observed for human immunodeficiency virus type 1. J Virol (1999) 0.77

A comprehensive list of cloned human DNA sequences. Nucleic Acids Res (1987) 0.75

Six RFLPs for human T cell receptor alpha (TCRA) on chromosome 14. Nucleic Acids Res (1989) 0.75

Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. J Clin Invest (2015) 0.75

Articles cited by this

DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54

Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08

Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A (1980) 109.70

The differentiation and function of human T lymphocytes. Cell (1980) 11.88

Analysis of repeating DNA sequences by reassociation. Methods Enzymol (1974) 10.63

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature (1984) 10.02

Sequence relationships between putative T-cell receptor polypeptides and immunoglobulins. Nature (1984) 6.08

Requirement for the coexpression of T3 and the T cell antigen receptor on a malignant human T cell line. J Exp Med (1984) 5.26

Complete primary structure of a heterodimeric T-cell receptor deduced from cDNA sequences. Nature (1984) 5.19

Characterization of EBV-genome negative "null" and "T" cell lines derived from children with acute lymphoblastic leukemia and leukemic transformed non-Hodgkin lymphoma. Int J Cancer (1977) 4.53

Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell (1984) 4.34

Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytes. Nature (1981) 4.26

Somatic recombination in a murine T-cell receptor gene. Nature (1984) 4.21

Sequence and expression of transcripts of the human T-cell receptor beta-chain genes. Nature (1985) 3.53

The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41

The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans. Cell (1984) 3.34

A third type of murine T-cell receptor gene. Nature (1984) 3.24

The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18

The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors. Cell (1983) 3.07

Primary structure of human T-cell receptor alpha-chain. Nature (1985) 2.93

The mouse T cell receptor: comparison of MHC-restricted receptors on two T cell hybridomas. Cell (1983) 2.58

Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein. Proc Natl Acad Sci U S A (1983) 2.23

Somatic variants of murine immunoglobulin lambda light chains. Nature (1982) 2.15

The mouse T cell receptor: structural heterogeneity of molecules of normal T cells defined by xenoantiserum. Cell (1983) 2.04

Rearrangements of T-cell receptor gene YT35 in human DNA from thymic leukaemia T-cell lines and functional T-cell clones. Nature (1984) 1.96

Identification of a diversity segment of human T-cell receptor beta-chain, and comparison with the analogous murine element. Nature (1984) 1.92

Purification and NH2-terminal amino acid sequencing of the beta subunit of a human T-cell antigen receptor. Proc Natl Acad Sci U S A (1984) 1.41

Homology of Ti alpha-subunit of a T-cell antigen-MHC receptor with immunoglobulin. Nature (1984) 1.09

Genes encoding the human T cell antigen receptor. Immunol Rev (1984) 1.06

Articles by these authors

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 21.59

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 16.19

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell (1998) 13.98

Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med (2000) 13.13

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature (1999) 12.32

Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity (1995) 10.65

A human T cell-specific cDNA clone encodes a protein having extensive homology to immunoglobulin chains. Nature (1984) 10.02

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection. Cell (1993) 9.84

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Mol Cell (2001) 9.33

DNA damage-induced activation of p53 by the checkpoint kinase Chk2. Science (2000) 7.85

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev (1999) 6.93

Differential T cell costimulatory requirements in CD28-deficient mice. Science (1993) 6.93

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol (1998) 6.38

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice. Immunity (1997) 6.15

SLAM (CDw150) is a cellular receptor for measles virus. Nature (2000) 6.07

Duplication of CaMV 35S Promoter Sequences Creates a Strong Enhancer for Plant Genes. Science (1987) 6.00

Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell (1998) 5.92

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science (2000) 5.84

Regulation of PTEN transcription by p53. Mol Cell (2001) 5.44

Apaf1 is required for mitochondrial pathways of apoptosis and brain development. Cell (1998) 5.32

FADD: essential for embryo development and signaling from some, but not all, inducers of apoptosis. Science (1998) 5.29

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Cell (1996) 5.10

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death. Nature (2001) 5.07

Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell (1986) 4.68

T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity (2001) 4.62

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice. Genes Dev (2000) 4.51

Abbreviated course of radiation therapy in older patients with glioblastoma multiforme: a prospective randomized clinical trial. J Clin Oncol (2004) 4.46

Enhanced establishment of a virus carrier state in adult CD4+ T-cell-deficient mice. J Virol (1994) 4.34

Mouse T cell antigen receptor: structure and organization of constant and joining gene segments encoding the beta polypeptide. Cell (1984) 4.34

Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun (1995) 4.33

Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science (1997) 4.23

T-cell co-stimulation through B7RP-1 and ICOS. Nature (1999) 4.20

Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18

CD8 is needed for development of cytotoxic T cells but not helper T cells. Cell (1991) 4.05

ICOS is essential for effective T-helper-cell responses. Nature (2001) 4.01

Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev (1998) 3.92

Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure. Cell (2001) 3.80

Cellular commitment to oncogene-induced transformation or apoptosis is dependent on the transcription factor IRF-1. Cell (1994) 3.56

Sequence and expression of transcripts of the human T-cell receptor beta-chain genes. Nature (1985) 3.53

The TIGR Gene Indices: clustering and assembling EST and known genes and integration with eukaryotic genomes. Nucleic Acids Res (2005) 3.53

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet (2001) 3.45

Direct neural fate specification from embryonic stem cells: a primitive mammalian neural stem cell stage acquired through a default mechanism. Neuron (2001) 3.42

The human T cell antigen receptor is encoded by variable, diversity, and joining gene segments that rearrange to generate a complete V gene. Cell (1984) 3.41

Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development (1995) 3.30

Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor beta chain. Proc Natl Acad Sci U S A (1985) 3.29

Requirement for Casper (c-FLIP) in regulation of death receptor-induced apoptosis and embryonic development. Immunity (2000) 3.29

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation. Proc Natl Acad Sci U S A (2008) 3.27

Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor. J Virol (2001) 3.27

High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res (2000) 3.24

Universals and cultural differences in the judgments of facial expressions of emotion. J Pers Soc Psychol (1987) 3.22

The structure, rearrangement and expression of D beta gene segments of the murine T-cell antigen receptor. Nature (1984) 3.18

Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13

Organization and sequences of the variable, joining and constant region genes of the human T-cell receptor alpha-chain. Nature (1985) 3.08

Genes of the T-cell antigen receptor in normal and malignant T cells. Annu Rev Immunol (1987) 3.01

Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science (1999) 2.96

Molecular mechanisms of accommodation in Escherichia coli to toxic levels of Cd2+. J Bacteriol (1975) 2.95

Abnormal development of intestinal intraepithelial lymphocytes and peripheral natural killer cells in mice lacking the IL-2 receptor beta chain. J Exp Med (1997) 2.91

Human T-cell receptor variable gene segment families. Immunogenetics (1995) 2.86

Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science (1994) 2.86

Reconstitution of an active surface T3/T-cell antigen receptor by DNA transfer. Nature (1985) 2.84

Two distinct pathways leading to nuclear apoptosis. J Exp Med (2000) 2.84

An IRF-1-dependent pathway of DNA damage-induced apoptosis in mitogen-activated T lymphocytes. Nature (1995) 2.79

Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous. J Immunol (1999) 2.77

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes Dev (1998) 2.72

CD44 regulates hematopoietic progenitor distribution, granuloma formation, and tumorigenicity. Blood (1997) 2.71

MOMs (multiples of the median) and DADs (discriminant aneuploidy detection): improved specificity and cost-effectiveness of biochemical screening for aneuploidy with DADs. Am J Obstet Gynecol (1995) 2.67

Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia. Science (1991) 2.64

Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Science (1992) 2.60

Anti-JC virus antibodies in a large German natalizumab-treated multiple sclerosis cohort. Neurology (2012) 2.60

A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene (1993) 2.59

Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J (1998) 2.56

Regulation of T cell receptor signaling by tyrosine phosphatase SYP association with CTLA-4. Science (1996) 2.56

Genetic evidence for functional redundancy of Platelet/Endothelial cell adhesion molecule-1 (PECAM-1): CD31-deficient mice reveal PECAM-1-dependent and PECAM-1-independent functions. J Immunol (1999) 2.55

Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol (1992) 2.53

Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death. J Biol Chem (2001) 2.50

Characterization of reticuloendotheliosis virus strain T DNA and isolation of a novel variant of reticuloendotheliosis virus strain T by molecular cloning. J Virol (1981) 2.49

WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity (2001) 2.49

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J (2000) 2.48

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature (1997) 2.46

Nuclear PTEN controls DNA repair and sensitivity to genotoxic stress. Science (2013) 2.38

Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE). Nucleic Acids Res (1995) 2.33

Sequences and repertoire of the human T cell receptor alpha and beta chain variable region genes in thymocytes. Eur J Immunol (1987) 2.32

The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model. Clin Toxicol (Phila) (2014) 2.31

Morbilliviruses use signaling lymphocyte activation molecules (CD150) as cellular receptors. J Virol (2001) 2.29

Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science (1994) 2.28

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Nat Genet (1997) 2.28

Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation. Immunity (1997) 2.25

Mouse T-cell receptor variable gene segment families. Immunogenetics (1995) 2.24

Immune response against lymphocytic choriomeningitis virus infection in mice without CD8 expression. J Exp Med (1991) 2.24

Complete nucleotide sequence of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein. Proc Natl Acad Sci U S A (1983) 2.23

Simultaneous measurement of six cytokines in a single sample of human tears using microparticle-based flow cytometry: allergics vs. non-allergics. J Immunol Methods (2001) 2.22

T cell-specific gamma genes in C57BL/10 mice. Sequence and expression of new constant and variable region genes. J Exp Med (1986) 2.20

Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev (1997) 2.20

EGF stimulates lamellipod extension in metastatic mammary adenocarcinoma cells by an actin-dependent mechanism. Clin Exp Metastasis (1996) 2.16

LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J Exp Med (1996) 2.14