Published in J Biol Chem on October 10, 1973
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci U S A (1990) 2.22
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase. Mol Aspects Med (2008) 1.92
Mechanism of translational control by hemin in reticulocyte lysates. Proc Natl Acad Sci U S A (1977) 1.36
Selective inhibition of gamma-glutamyl-cycle enzymes by substrate analogs. Proc Natl Acad Sci U S A (1977) 1.26
On the active site thiol of gamma-glutamylcysteine synthetase: relationships to catalysis, inhibition, and regulation. Proc Natl Acad Sci U S A (1988) 1.24
Tor1/2 regulation of retrograde gene expression in Saccharomyces cerevisiae derives indirectly as a consequence of alterations in ammonia metabolism. J Biol Chem (2003) 1.11
Radioprotection of human lymphoid cells by exogenously supplied glutathione is mediated by gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1983) 1.07
Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides functional insights. Proc Natl Acad Sci U S A (2005) 0.97
Inhibition of the glutamate transporter and glial enzymes in rat striatum by the gliotoxin, alpha aminoadipate. Br J Pharmacol (1994) 0.92
Hyperammonaemia does not impair brain function in the absence of net glutamine synthesis. Biochem J (1991) 0.84
Ultrastructural study of methionine sulfoximine-induced Alzheimer type II astrocytosis. Am J Pathol (1977) 0.78
Inhibition of human glutamine synthetase by L-methionine-S,R-sulfoximine-relevance to the treatment of neurological diseases. Metab Brain Dis (2013) 0.75
Glutathione. Annu Rev Biochem (1983) 15.18
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem (1979) 7.16
Calmodulin. Annu Rev Biochem (1980) 4.22
Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization. Annu Rev Biochem (1976) 3.84
Selective modification of glutathione metabolism. Science (1983) 3.64
On the enzymology of amino acid transport. Science (1973) 3.24
Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem (1975) 3.23
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci U S A (1992) 3.22
Interaction of gamma-glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione. J Biol Chem (1974) 3.18
The gamma-glutamyl cycle: a possible transport system for amino acids. Proc Natl Acad Sci U S A (1970) 3.13
Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine. Biochemistry (1969) 3.10
Cytologically integrated physical restriction fragment length polymorphism maps for the barley genome based on translocation breakpoints. Genetics (2000) 3.05
Glutathione: interorgan translocation, turnover, and metabolism. Proc Natl Acad Sci U S A (1979) 2.71
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev (1990) 2.46
CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway. J Virol (1998) 2.38
Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci U S A (1985) 2.37
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci U S A (1990) 2.22
Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase. Proc Natl Acad Sci U S A (1979) 2.20
Evidence that pituitary cation-sensitive neutral endopeptidase is a multicatalytic protease complex. J Neurochem (1983) 2.18
Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem (1993) 2.13
An efficient screen for reproductive pathways using mature seeds of monocots and dicots. Plant J (2000) 2.11
Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1978) 2.03
gamma-Glutamyl transpeptidase: catalytic, structural and functional aspects. Mol Cell Biochem (1981) 1.98
Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase. J Biol Chem (1979) 1.91
The specificity of glutamine synthetase and its relationship to substrate conformation at the active site. Adv Enzymol Relat Areas Mol Biol (1968) 1.91
Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle. Proc Natl Acad Sci U S A (1971) 1.90
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain. Biochemistry (1969) 1.89
Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione. Arch Biochem Biophys (1985) 1.82
Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase. Biochemistry (1969) 1.82
gamma-Glutamyl transpeptidase, a lymphoid cell-surface marker: relationship to blastogenesis, differentiation, and neoplasia. Proc Natl Acad Sci U S A (1976) 1.78
Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation. Proc Natl Acad Sci U S A (1981) 1.77
Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes. Proc Natl Acad Sci U S A (1978) 1.77
Studies on glutamine synthetase from Escherichia coli. Formation of pyrrolidone carboxylate and inhibition by methionine sulfoximine. J Biol Chem (1973) 1.76
Histone H4 acetylation of euchromatin and heterochromatin is cell cycle dependent and correlated with replication rather than with transcription. Plant Cell (2000) 1.75
A soluble metalloendopeptidase from rat brain. Purification of the enzyme and determination of specificity with synthetic and natural peptides. Eur J Biochem (1983) 1.74
Cation-sensitive neutral endopeptidase: isolation and specificity of the bovine pituitary enzyme. J Neurochem (1980) 1.74
Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex. Biochemistry (1992) 1.74
Phosphorylation of methionine sulfoximine by glutamine synthetase. Proc Natl Acad Sci U S A (1968) 1.72
gamma-Glutamyl transpeptidase from kidney. Methods Enzymol (1985) 1.69
Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester. Proc Natl Acad Sci U S A (1989) 1.66
Association of Enzymatic Activity with Submicroscopic Particles. Science (1952) 1.65
Gamma-glutamyl transpeptidase. Methods Enzymol (1981) 1.63
Control of Escherichia coli carbamyl phosphate synthetase by purine and pyrimidine nucleotides. Biochemistry (1966) 1.58
-Glutamyl cyclotransferase. Distribution, isozymic forms, and specificity. J Biol Chem (1973) 1.56
Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids. Proc Natl Acad Sci U S A (1982) 1.52
Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem (1993) 1.52
Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria). Proc Natl Acad Sci U S A (1974) 1.51
D-and L-stereoisomers of allylglycine: convulsive action and inhibition of brain L-glutamate decarboxylase. J Neurochem (1977) 1.51
Glutathione biosynthesis; gamma-glutamylcysteine synthetase from rat kidney. Methods Enzymol (1985) 1.50
Identity of maleate-stimulated glutaminase with gamma-glutamyl transpeptidase in rat kidney. J Biol Chem (1975) 1.50
Asparagine synthetase activity of mouse leukemias. Science (1968) 1.49
Membrane bound pituitary metalloendopeptidase: apparent identity to enkephalinase. Biochem Biophys Res Commun (1981) 1.47
Tripeptide (glutathione) synthetase. Purification, properties, and mechanism of action. Biochemistry (1967) 1.46
Affinity labeling of gamma-glutamyl transpeptidase and location of the gamma-glutamyl binding site on the light subunit. Proc Natl Acad Sci U S A (1977) 1.45
Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis. Proc Natl Acad Sci U S A (1983) 1.45
Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition. J Biol Chem (1972) 1.45
Glutathione, a first line of defense against cadmium toxicity. FASEB J (1987) 1.44
Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits. J Biol Chem (1984) 1.44
Glutathione deficiency leads to mitochondrial damage in brain. Proc Natl Acad Sci U S A (1991) 1.43
Enzymes of the gamma-glutamyl cycle in the ciliary body and lens. Proc Natl Acad Sci U S A (1973) 1.43
Glutathione is required for intestinal function. Proc Natl Acad Sci U S A (1990) 1.43
Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress. Proc Natl Acad Sci U S A (1991) 1.43
The gamma-glutamyl cycle. Diseases associated with specific enzyme deficiencies. Ann Intern Med (1974) 1.43
Translocation of glutathione from lymphoid cells that have markedly different gamma-glutamyl transpeptidase activities. Proc Natl Acad Sci U S A (1979) 1.43
Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl Acad Sci U S A (1991) 1.40
Resolution of the light-harvesting chlorophyll a/b-protein of vicia faba chloroplasts into two different chlorophyll-protein complexes. Biochim Biophys Acta (1979) 1.38
Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1979) 1.38
Soluble metalloendopeptidase from rat brain: action on enkephalin-containing peptides and other bioactive peptides. Endocrinology (1985) 1.38
Accumulation of 5-oxoproline in mouse tissues after inhibition of 5-oxoprolinase and administration of amino acids: evidence for function of the gamma-glutamyl cycle. Proc Natl Acad Sci U S A (1974) 1.37
Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage. Proc Natl Acad Sci U S A (1989) 1.37
Purification and specificity of a membrane-bound metalloendopeptidase from bovine pituitaries. Biochemistry (1981) 1.37
Stimulation of the hydrolytic activity and decrease of the transpeptidase activity of gamma-glutamyl transpeptidase by maleate; identity of a rat kidney maleate-stimulated glutaminase and gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1974) 1.37
Regulation of rat liver glutamine synthetase: activation by alpha-ketoglutarate and inhibition by glycine, alanine, and carbamyl phosphate. Proc Natl Acad Sci U S A (1971) 1.37
Hydrolysis and transfer reactions catalyzed by gamma-glutamyl transpeptidase; evidence for separate substrate sites and for high affinity of L-cystine. Biochem Biophys Res Commun (1976) 1.36
Glutamine-binding subunit of glutamate synthase and partial reactions catalyzed by this glutamine amidotransferase. Proc Natl Acad Sci U S A (1974) 1.36
Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid. Proc Natl Acad Sci U S A (1973) 1.36
Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate. J Biol Chem (1972) 1.36
Reversible dissociation of carbamyl phosphate synthetase into a regulated synthesis subunit and a subunit required for glutamine utilization. Proc Natl Acad Sci U S A (1971) 1.35
Molecular cloning and primary structure of rat testes metalloendopeptidase EC 3.4.24.15. Biochemistry (1990) 1.35
Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc Natl Acad Sci U S A (1984) 1.35
Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney. Proc Natl Acad Sci U S A (1983) 1.35
The -glutamyl cycle in the choroid plexus: its possible function in amino acid transport. Proc Natl Acad Sci U S A (1973) 1.35
Inhibition of gamma-glutamylcysteine synthetase by cystamine: an approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria). Biochem Biophys Res Commun (1977) 1.34
Evidence for an activated form of carbon dioxide in the reaction catalyzed by Escherichia coli carbamyl phosphate synthetase. Biochemistry (1965) 1.33
Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor. Cancer Res (1998) 1.33
Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency. Proc Natl Acad Sci U S A (1980) 1.33
Glutathione turnover in the kidney; considerations relating to the gamma-glutamyl cycle and the transport of amino acids. Proc Natl Acad Sci U S A (1974) 1.33
High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Proc Natl Acad Sci U S A (1990) 1.32
Reversible dissociation of the monomer of glutamine-dependent carbamyl phosphate synthetase into catalytically active heavy and light subunits. J Biol Chem (1974) 1.32
Plasma membrane proteins of Dictyostelium: the spore coat proteins. Dev Biol (1979) 1.31
gamma-Glutamyl dopa: a kidney-specific dopamine precursor. J Pharmacol Exp Ther (1978) 1.30
Identification of L-methionine-S-sulfoximine as the convulsant isomer of methionine sulfoximine. Proc Natl Acad Sci U S A (1970) 1.30
Binding of adenosine triphosphate and adenosine diphosphate by glutamine synthetase. Biochemistry (1966) 1.30