| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
A fluorescent complex between ethidium bromide and nucleic acids. Physical-chemical characterization.
|
J Mol Biol
|
1967
|
10.36
|
|
2
|
A new fluorometric method for RNA and DNA determination.
|
Anal Biochem
|
1966
|
6.74
|
|
3
|
cis elements and trans-acting factors involved in dimer formation of murine leukemia virus RNA.
|
J Virol
|
1990
|
3.40
|
|
4
|
Electrochemotherapy potentiation of antitumour effect of bleomycin by local electric pulses.
|
Eur J Cancer
|
1991
|
2.79
|
|
5
|
Characterization of a new class of circular DNA molecules in yeast.
|
Biochem Biophys Res Commun
|
1971
|
2.33
|
|
6
|
alpha-DNA II. Synthesis of unnatural alpha-anomeric oligodeoxyribonucleotides containing the four usual bases and study of their substrate activities for nucleases.
|
Nucleic Acids Res
|
1987
|
2.06
|
|
7
|
Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs.
|
Biochem Pharmacol
|
1988
|
1.91
|
|
8
|
Control of UV induction of recA protein.
|
Proc Natl Acad Sci U S A
|
1983
|
1.68
|
|
9
|
An analytical study of the dimerization of in vitro generated RNA of Moloney murine leukemia virus MoMuLV.
|
Nucleic Acids Res
|
1990
|
1.62
|
|
10
|
Introduction of definite amounts of nonpermeant molecules into living cells after electropermeabilization: direct access to the cytosol.
|
Exp Cell Res
|
1988
|
1.57
|
|
11
|
alpha-DNA. VI: Comparative study of alpha- and beta-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition.
|
Nucleic Acids Res
|
1987
|
1.53
|
|
12
|
[Electrochemotherapy, a new antitumor treatment: first clinical trial].
|
C R Acad Sci III
|
1991
|
1.52
|
|
13
|
Preparation and properties of nuclear and satellite deoxyribonucleic acid of Trypanosoma cruzi.
|
J Mol Biol
|
1967
|
1.31
|
|
14
|
Electrochemotherapy of spontaneous mammary tumours in mice.
|
Eur J Cancer
|
1991
|
1.26
|
|
15
|
The use of ethidium bromide-circular DNA complexes for the fluorometric analysis of breakage and joining of DNA.
|
J Mol Biol
|
1971
|
1.23
|
|
16
|
Smoking cessation rates 4 years after treatment by nicotine gum and acupuncture.
|
Prev Med
|
1997
|
1.22
|
|
17
|
Purification and characterization of recA protein from salmonella typhimurium.
|
J Biol Chem
|
1983
|
1.20
|
|
18
|
A new antitumoral agent: 9-hydroxyellipticine. Possibility of a rational design of anticancerous drugs in the series of DNA intercalating drugs.
|
Proc Natl Acad Sci U S A
|
1974
|
1.18
|
|
19
|
[Interaction of ethidium hydrobromate (EH) with polyribonucleotides. Applications to the study of hybridization reactions].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1965
|
1.15
|
|
20
|
Initial degradation of deoxyribonucleic acid after injection in mammals.
|
Cancer Res
|
1965
|
1.06
|
|
21
|
Comparative activity of alpha- and beta-anomeric oligonucleotides on rabbit beta globin synthesis: inhibitory effect of cap targeted alpha-oligonucleotides.
|
Biochem Biophys Res Commun
|
1989
|
1.05
|
|
22
|
A protein inhibitor of acid deoxyribonucleases.
|
Proc Natl Acad Sci U S A
|
1969
|
1.03
|
|
23
|
VanA-type enterococci from humans, animals, and food: species distribution, population structure, Tn1546 typing and location, and virulence determinants.
|
Appl Environ Microbiol
|
2007
|
1.03
|
|
24
|
[Fractionation and characterization of desoxyribonucleic acid (DNA) of trypanosomes (Trypanosoma equiperdum)].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1966
|
1.00
|
|
25
|
Alpha-DNA VIII: thermodynamic parameters of complexes formed between the oligo-alpha-deoxynucleotides: alpha-d(GGAAGG) and alpha-d(CCTTCC) and their complementary oligo-beta-deoxynucleotides: beta-d(CCTTCC) and beta-d(GGAAGG) are different.
|
Nucleic Acids Res
|
1989
|
0.96
|
|
26
|
Alpha-DNA. IV: Alpha-anomeric and beta-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. Synthesis, physicochemical properties and poly (rA) binding.
|
Nucleic Acids Res
|
1987
|
0.96
|
|
27
|
Antitumor activity, pharmacology, and toxicity of ellipticines, ellipticinium, and 9-hydroxy derivatives: preliminary clinical trials of 2-methyl-9-hydroxy ellipticinium (NSC 264-137).
|
Recent Results Cancer Res
|
1980
|
0.94
|
|
28
|
Potential antitumor agents: synthesis and biological properties of aliphatic amino acid 9-hydroxyellipticinium derivatives.
|
J Med Chem
|
1984
|
0.93
|
|
29
|
Sequence requirements for mammalian topoisomerase II mediated DNA cleavage stimulated by an ellipticine derivative.
|
Nucleic Acids Res
|
1991
|
0.92
|
|
30
|
Circulating tumour cells: insights into tumour heterogeneity.
|
J Intern Med
|
2013
|
0.91
|
|
31
|
Ellipticine and derivatives induce breakage of L1210 cells DNA in vitro.
|
Biochem Pharmacol
|
1979
|
0.91
|
|
32
|
An immunoradiometric quantitative assay of Escherichia coli recA protein.
|
Biochimie
|
1982
|
0.91
|
|
33
|
Relative efficiencies of a series of square-planar plantinum(II) compounds on Salmonella mutagenesis.
|
Mutat Res
|
1977
|
0.90
|
|
34
|
Lack of single-strand DNA-binding protein amplification under conditions of SOS induction in E. coli.
|
Mol Gen Genet
|
1983
|
0.90
|
|
35
|
Voltage-dependent introduction of a d[alpha]octothymidylate into electropermeabilized cells.
|
Biochem Biophys Res Commun
|
1989
|
0.88
|
|
36
|
Circular oligomers in mitochondrial DNA of human and beef nonmalignant thyroid glands.
|
Proc Natl Acad Sci U S A
|
1972
|
0.88
|
|
37
|
Synthesis, thermal stability and reactivity towards 9-aminoellipticine of double-stranded oligonucleotides containing a true abasic site.
|
Nucleic Acids Res
|
1989
|
0.87
|
|
38
|
[N-Methyl-9 hydroxy-ellipticine (NSC 264-137) in the treatment of malignant metastases. Preliminary results (author's transl)].
|
Nouv Presse Med
|
1981
|
0.87
|
|
39
|
Alpha-anomeric DNA: beta-RNA hybrids as new synthetic inhibitors of Escherichia coli RNase H, Drosophila embryo RNase H and M-MLV reverse transcriptase.
|
Gene
|
1988
|
0.87
|
|
40
|
[Kinetic study of the replicative forms of DNA in animal cells].
|
Biochim Biophys Acta
|
1967
|
0.87
|
|
41
|
A new DNA intercalating drug: Methoxy-9-ellipticine.
|
FEBS Lett
|
1971
|
0.86
|
|
42
|
Frameshift lesions induced by oxazolopyridocarbazoles are recognized by the mismatch repair system in Escherichia coli.
|
Mutat Res
|
1988
|
0.85
|
|
43
|
A yeast mitochondrial deoxyribonuclease stimulated by ethidium bromide.
|
Biochem Biophys Res Commun
|
1972
|
0.85
|
|
44
|
[Isolation and fractionation of yeast deoxyribonucleic acid (DNA)].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1966
|
0.85
|
|
45
|
Bioactivation of the antitumor drugs 9-hydroxyellipticine and derivatives by a peroxidase-hydrogen peroxide system.
|
J Med Chem
|
1981
|
0.85
|
|
46
|
[Purification and properties of a snail (Helix pomatia L.) hepato-pancreas acid desoxyribonuclease].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1966
|
0.85
|
|
47
|
Efficient breakage of DNA apurinic sites by the indoleamine related 9-amino-ellipticine.
|
Chem Biol Interact
|
1986
|
0.84
|
|
48
|
[Mitochondrial DNA of malignant cells].
|
Bull Cancer
|
1971
|
0.84
|
|
49
|
Different levels of induction of RecA protein in E. coli (PQ 10) after treatment with two related carcinogens.
|
Nucleic Acids Res
|
1983
|
0.84
|
|
50
|
A randomised 2 x 2 factorial design to evaluate different smoking cessation methods.
|
Rev Epidemiol Sante Publique
|
1992
|
0.84
|
|
51
|
Stimulation of topoisomerase II-mediated DNA cleavage by ellipticine derivatives: structure-activity relationship.
|
Mol Pharmacol
|
1992
|
0.84
|
|
52
|
Interactions between ellipticine and some derivatives and phospholipids in model membranes.
|
FEBS Lett
|
1979
|
0.84
|
|
53
|
Quantification by fluorescence of apurinic sites in DNA.
|
Biochem Biophys Res Commun
|
1987
|
0.83
|
|
54
|
Measurement of recA protein induction in Salmonella typhimurium: a possible biochemical test for the detection of DNA damaging agents.
|
Biochimie
|
1983
|
0.83
|
|
55
|
alpha-DNA X: alpha and beta tetrathymidilates covalently linked to oxazolopyridocarbazolium (OPC): comparative stabilization of oligo beta-[dT]:oligo beta-[dA] and oligo alpha-[dT]:oligo beta-[dA] duplexes by the intercalating agent.
|
Nucleic Acids Res
|
1989
|
0.82
|
|
56
|
Lipid peroxidation in liver: hydroxy dimethyl carbazole a new potent inhibitor.
|
Biochem Biophys Res Commun
|
1980
|
0.82
|
|
57
|
[A new antitumor compound: hydroxy-9 ellipticin. Effect on mouse L 1210 leukemia].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1973
|
0.82
|
|
58
|
Inhibition of Moloney murine leukemia virus reverse transcriptase by alpha-anomeric oligonucleotides.
|
Biochem Biophys Res Commun
|
1989
|
0.82
|
|
59
|
Does cruciform DNA provide a recognition signal for DNA-topoisomerase II?
|
Biochimie
|
1992
|
0.81
|
|
60
|
Oxaliplatin, 5-fluorouracil/leucovorin and epirubicin as first-line treatment in advanced gastric carcinoma: a phase II study.
|
Br J Cancer
|
2007
|
0.81
|
|
61
|
Mitochondrial and nuclear mutagenicity of ellipticine and derivatives in the yeast Saccharomyces cerevisiae.
|
Biochem Pharmacol
|
1982
|
0.80
|
|
62
|
[Studies on the toxicity of 9-hydroxyellipticine].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1974
|
0.80
|
|
63
|
[Studies on the interaction of a diamine steroid, irehdiamine A, with desoxyribonucleic acid].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1968
|
0.80
|
|
64
|
Mechanism of deoxyribonucleic acid degradation by an acid deoxyribonuclease from the snail Helix aspersa Müll.
|
Biochemistry
|
1972
|
0.80
|
|
65
|
[Potentiation of the antitumoral effect of electrochemotherapy by immunotherapy with allogeneic cells producing interleukin 2].
|
C R Acad Sci III
|
1992
|
0.80
|
|
66
|
Mutagenicity and cytotoxicity of five antitumor ellipticines in mammalian cells and their structure-activity relationships in Salmonella.
|
Cancer Res
|
1983
|
0.80
|
|
67
|
Yeast mitochondrial deoxyribonuclease stimulated by ethidium bromide. 1. Purification and properties.
|
Biochemistry
|
1979
|
0.80
|
|
68
|
A new extraction procedure of autonomous DNA from eucaryotic cells, where DNA could be bound to proteins.
|
Nucleic Acids Res
|
1990
|
0.79
|
|
69
|
Relationship between cytostatic activity of oxazolopyridocarbazoles and accessibility of DNA intercalation sites in living bacteria.
|
Biochemistry
|
1986
|
0.79
|
|
70
|
A new series of ellipticine derivatives (1-(alkylamino)-9-methoxyellipticine). Synthesis, DNA binding, and biological properties.
|
J Med Chem
|
1988
|
0.79
|
|
71
|
Uptake, cytofluorescence, and cytotoxicity of oxazolopyridocarbazoles (amino acid-ellipticine conjugates) in murine sarcoma cells.
|
Cancer Res
|
1986
|
0.79
|
|
72
|
Ellipticines as potent inhibitors of aryl hydrocarbon hydroxylase: their binding to microsomal cytochromes P450 and protective effect against benzo(a)pyrene mutagenicity.
|
Biochem Pharmacol
|
1978
|
0.79
|
|
73
|
Preliminary trial of 9-hydroxy-2-methyl ellipticinium (NSC 264--137) in advanced human cancers.
|
Eur J Cancer
|
1978
|
0.79
|
|
74
|
Structural changes of polyriboinosinic acid induced by a steroidal diamine, irehdiamine A.
|
Biochem Biophys Res Commun
|
1967
|
0.79
|
|
75
|
Cardiovascular activity of 9-hydroxy-ellipticine.
|
Pharmacology
|
1976
|
0.78
|
|
76
|
omicron-Quinone formation in the biochemical oxidation of the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.
|
J Med Chem
|
1983
|
0.78
|
|
77
|
Histochemical evidence of altered development of cholinergic fibers in the rat dentate gyrus following lesions. II. Effects of partial entorhinal and simultaneous multiple lesions.
|
J Comp Neurol
|
1977
|
0.78
|
|
78
|
Some antitumor derivatives of ellipticine deprived of mutagenic properties.
|
Chem Biol Interact
|
1978
|
0.78
|
|
79
|
Physicochemical and pharmacological properties of the antitumor ellipticine derivative 2-(diethylamino-2-ethyl)9-hydroxy ellipticinium-chloride, HCl.
|
Cancer Res
|
1987
|
0.78
|
|
80
|
The G.C base-pair preference of 2-N-methyl 9-hydroxyellipticinium.
|
Eur J Biochem
|
1989
|
0.78
|
|
81
|
Peroxidase-catalyzed covalent binding of the antitumor drug N2-methyl-9-hydroxyellipticinium to DNA in vitro.
|
Biochemistry
|
1986
|
0.78
|
|
82
|
A revised structure of the antitumor drug elliptinium--amino(acid) adducts.
|
Biochem Biophys Res Commun
|
1985
|
0.78
|
|
83
|
Lactobacillus rhamnosus GG inhibits invasion of cultured human respiratory cells by prtF1-positive macrolide-resistant group A streptococci.
|
Lett Appl Microbiol
|
2009
|
0.78
|
|
84
|
Pattern of recognition of DNA by mammalian DNA topoisomerase II.
|
Biochem Biophys Res Commun
|
1988
|
0.78
|
|
85
|
Purification and properties of an acid deoxyribonuclease from the snail Helix aspersa Müll.
|
Biochemistry
|
1972
|
0.78
|
|
86
|
Bis(pyrrolecarboxamide) linked to intercalating chromophore oxazolopyridocarbazole (OPC): selective binding to DNA and polynucleotides.
|
Biochemistry
|
1991
|
0.78
|
|
87
|
[Hydroxy 9-methyl 2-ellipticinium acetate (NSC 264-137). Toxicologic study and therapeutic effect in 100 cancers (author's transl)].
|
Nouv Presse Med
|
1979
|
0.78
|
|
88
|
A phase I trial with recombinant interferon gamma (Roussel UCLAF) in advanced cancer patients.
|
Cancer Immunol Immunother
|
1990
|
0.77
|
|
89
|
Binding of ellipticine base and ellipticinium cation to calf-thymus DNA. A thermodynamic and kinetic study.
|
Eur J Biochem
|
1988
|
0.77
|
|
90
|
Stacking and edge-to-edge associations of antitumoral ellipticine derivatives are controlled in solution by interactions involving their nitrogen sites.
|
Biopolymers
|
1988
|
0.77
|
|
91
|
Mechanism of cleavage of apurinic sites by 9-aminoellipticine.
|
J Biol Chem
|
1989
|
0.77
|
|
92
|
Comparative cytotoxic and antitumoral effects of ellipticine derivatives on mouse L 1210 leukemia.
|
Chem Biol Interact
|
1979
|
0.77
|
|
93
|
[Study of displacement reactions between polyribonucleotides by use of ethidium hydrobromate (ETB). Demonstration of displacement of the poly (A-2 I) by poly U].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1965
|
0.77
|
|
94
|
A carboline derivative as a novel mammalian DNA topoisomerase II targeting agent.
|
Biochem Pharmacol
|
1992
|
0.76
|
|
95
|
Fasciola hepatica L. homogenate proteolytic activity: action against different substrates.
|
Arch Vet Ital
|
1969
|
0.76
|
|
96
|
Long-term survival in metastatic melanoma patients treated with sequential biochemotherapy: report of a Phase II study.
|
Cancer Invest
|
2006
|
0.76
|
|
97
|
Regioselective arylation of ribose in adenosine and guanosine with the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.
|
Proc Natl Acad Sci U S A
|
1984
|
0.75
|
|
98
|
Peroxidase-catalysed covalent binding of the antitumor drug 2N-methyl-9-hydroxy-ellipticine to proteins.
|
Biochem Pharmacol
|
1983
|
0.75
|
|
99
|
Antitumor activity of 9-hydroxyellipticine (NSC 210717) ON L1210 mouse leukemia and the effect of route of injection.
|
Cancer Res
|
1976
|
0.75
|
|
100
|
Frameshift mutagenesis in Salmonella typhimurium by reversible DNA intercalators: effect of a UVR B mutation.
|
Biochem Biophys Res Commun
|
1986
|
0.75
|
|
101
|
Evidence for electrophilic properties of N2-methyl-9-hydroxy ellipticinium acetate (Celiptium) from human biliary metabolites.
|
Cancer Chemother Pharmacol
|
1985
|
0.75
|
|
102
|
Effects of 9-hydroxyellipticine on growth and macromolecular synthesis in Escherichia coli.
|
FEBS Lett
|
1976
|
0.75
|
|
103
|
Autoxidation of the antitumor drug 9-hydroxyellipticine and its derivatives.
|
J Med Chem
|
1983
|
0.75
|
|
104
|
Selective binding of elliptinium acetate onto the 3'-terminal ribose of diribonucleosides monophosphates.
|
Biochem Biophys Res Commun
|
1985
|
0.75
|
|
105
|
[2 new antineoplastic derivatives: 9-hydroxy-2-methyl-ellipticinium (acetate) and 9-hydroxy-2,6-dimethyl-ellipticinium (chloride). Effect on mouse L 1210 leukemia].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1975
|
0.75
|
|
106
|
Yeast mitochondrial deoxyribonuclease stimulated by ethidium bromide. 2. Mechanism of enzyme activation.
|
Biochemistry
|
1979
|
0.75
|
|
107
|
Rearrangement of mitochondrial DNA molecules during the differentiation of mitochondria in yeast. II. - Labelling studies of the precursor product relationship.
|
Biochimie
|
1975
|
0.75
|
|
108
|
[Evaluation of cerebral blood flow in severe brain injuries by SVO2 measurement in the internal jugular vein].
|
Agressologie
|
1991
|
0.75
|
|
109
|
A spectrofluorometric method for the study of transcription of single-stranded DNA by RNA polymerase.
|
Biochim Biophys Acta
|
1966
|
0.75
|
|
110
|
Isolation and characterization of the glutathione-elliptinium conjugate in human urine.
|
Anticancer Res
|
1987
|
0.75
|
|
111
|
Further observations on the liver fluke (Fasciola hepatica, L.) homogenate capillary permeability activity.
|
Pathol Eur
|
1969
|
0.75
|
|
112
|
Heterocyclic Quinones. 4. A new highly cytotoxic drug: 6,7-bis(1-aziridinyl)-5,8-quinazolinedione.
|
J Med Chem
|
1983
|
0.75
|
|
113
|
The effects of desogestrel and ethinylestradiol combination in normal and hyperandrogenic young girls: speculations on contraception in adolescence.
|
Acta Eur Fertil
|
1989
|
0.75
|
|
114
|
[Clinical tolerance of CY 216 (Fraxiparin) in the prevention of thromboembolic accidents after neurosurgery].
|
Agressologie
|
1989
|
0.75
|
|
115
|
Stimulation by gamma-carboline derivatives (simplified analogues of antitumor ellipticines) of site specific DNA cleavage by calf DNA topoisomerase II.
|
Biochem Pharmacol
|
1990
|
0.75
|
|
116
|
Comparison of anti-RNA properties of normal and ellipticine functionalized alpha and beta-oligonucleotides.
|
Nucleic Acids Symp Ser
|
1991
|
0.75
|
|
117
|
[The structure of hemoglobins and its functional implications].
|
Ann Biol Clin (Paris)
|
1967
|
0.75
|
|
118
|
[Bipolar disorder: clinical trials with fluoxetine].
|
Minerva Psichiatr
|
1993
|
0.75
|
|
119
|
Ellipticines as potent inhibitors of microsomes-dependent chemical mutagenesis.
|
Chem Biol Interact
|
1979
|
0.75
|
|
120
|
Use of a new DNA intercalating fluorescing probe for studies on the mechanism of frameshift mutagenesis in Salmonella typhimurium.
|
Biochimie
|
1985
|
0.75
|
|
121
|
[Study of the interaction between a diaminosteroid, Irehdiamine A and transfer RNA].
|
C R Acad Sci Hebd Seances Acad Sci D
|
1969
|
0.75
|
|
122
|
[Fluoxetine and depression in the elderly. Clinical experience].
|
Minerva Psichiatr
|
1993
|
0.75
|
|
123
|
Ellipticine, 9-hydroxyellipticine, and 9-hydroxyellipiticinum: some biochemical properties of possible pharmacologic significance.
|
Cancer Treat Rep
|
1981
|
0.75
|
|
124
|
Human and rat urinary metabolites of the antitumor drug Celiptium (N2-methyl-9-hydroxyellipticinium acetate, NSC 264137). Identification of cysteine conjugates supporting the "biooxidative alkylation" hypothesis.
|
Biochem Pharmacol
|
1983
|
0.75
|
|
125
|
Heterocyclic quinones. 17. A new in vivo active antineoplastic drug: 6,7-bis(1-aziridinyl)-4-[[3-(N,N-dimethylamino)propyl]amino]-5,8- quinazolinedione.
|
J Med Chem
|
1991
|
0.75
|
|
126
|
Risk of melanoma following adulthood cancer: a case-control study.
|
Eur J Cancer
|
2005
|
0.75
|
|
127
|
[Action of synthetic estrogens on some hematochemical constants in cattle, with special reference to calcium, phosphorus, magnesium and citric acid].
|
Arch Vet Ital
|
1969
|
0.75
|
|
128
|
[In vitro stimulation by ellipticine derivatives of DNA cleavage induced by DNA topoisomerase II: a structure-activity relationship].
|
Bull Cancer
|
1994
|
0.75
|
|
129
|
Frameshift mutagenesis in Escherichia coli by reversible DNA intercalators: sequence specificity.
|
Mutat Res
|
1988
|
0.75
|
|
130
|
The hydroxylation of the antitumor agent, ellipticine, by liver microsomes from differently pretreated rats.
|
Biochem Pharmacol
|
1977
|
0.75
|
|
131
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