Published in J Med Chem on December 01, 1974
SCE-129, antipseudomonal cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother (1978) 5.24
Affinities of penicillins and cephalosporins for the penicillin-binding proteins of Escherichia coli K-12 and their antibacterial activity. Antimicrob Agents Chemother (1979) 3.27
In vitro potentiation of cephalosporins by alafosfalin against urinary tract bacteria. Antimicrob Agents Chemother (1982) 0.75
Crystal structure of the calcium pump of sarcoplasmic reticulum at 2.6 A resolution. Nature (2000) 9.44
Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature (1986) 7.73
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
The action of the vagus on the spleen. J Physiol (1927) 4.90
Recombination and clonal groupings within Helicobacter pylori from different geographical regions. Mol Microbiol (1999) 4.72
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (1997) 4.19
Demonstration that antigen-binding cells are precursors of antibody-producing cells after purification with a fluorescence-activated cell sorter. Proc Natl Acad Sci U S A (1972) 3.77
Systematic isolation of transducing phages for Myxococcus xanthus. Virology (1978) 3.76
Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med (2000) 3.74
Isolation of simian immunodeficiency virus from African green monkeys and seroepidemiologic survey of the virus in various non-human primates. Int J Cancer (1988) 3.60
Cloning and sequencing of the cDNA for human monocyte chemotactic and activating factor (MCAF). Biochem Biophys Res Commun (1989) 3.09
Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Cell (1995) 3.08
Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol (1997) 2.89
Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India. J Bacteriol (2000) 2.81
NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med (1997) 2.66
Hyperammonaemia and Helicobacter pylori. Lancet (1995) 2.59
Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1985) 2.55
Tracheostomy can fatally exacerbate sleep-disordered breathing in multiple system atrophy. Neurology (2007) 2.37
Reduction of risk of pneumonia associated with use of angiotensin I converting enzyme inhibitors in elderly inpatients. Am J Hypertens (1999) 2.36
Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene (2007) 2.34
Histone deacetylase inhibitor activates the WAF1/Cip1 gene promoter through the Sp1 sites. Biochem Biophys Res Commun (1997) 2.22
Polycystin-L is a calcium-regulated cation channel permeable to calcium ions. Nature (1999) 2.17
Telaprevir-based triple therapy for chronic hepatitis C patients with advanced fibrosis: a prospective clinical study. Aliment Pharmacol Ther (2013) 2.13
Central role for cdc45 in establishing an initiation complex of DNA replication in Xenopus egg extracts. Genes Cells (2000) 2.12
Butyrate activates the WAF1/Cip1 gene promoter through Sp1 sites in a p53-negative human colon cancer cell line. J Biol Chem (1997) 2.10
Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor. Nucleic Acids Res (1985) 2.06
DNA packaging steps in bacteriophage lambda head assembly. J Mol Biol (1975) 2.05
Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. Am J Cardiol (2001) 2.03
Evidence for a prophage excision gene in lambda. J Mol Biol (1970) 2.00
The appearance of T cells bearing self-reactive T cell receptor in the livers of mice injected with bacteria. J Exp Med (1991) 1.99
The chromosomal gene structure and two mRNAs for human granulocyte colony-stimulating factor. EMBO J (1986) 1.98
Complete nucleotide sequence of the gene for human interleukin 1 alpha. Nucleic Acids Res (1986) 1.95
Anterior sagittal anorectoplasty for rectovestibular and anovestibular fistula. J Pediatr Surg (1992) 1.89
Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem (1999) 1.87
Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2001) 1.84
Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs. EMBO J (1997) 1.83
Distinct mechanisms of neonatal tolerance induced by dendritic cells and thymic B cells. J Exp Med (1991) 1.82
Generation and characterization of a human immunodeficiency virus type 1 (HIV-1) mutant resistant to an HIV-1 protease inhibitor. J Virol (1994) 1.80
Cloning of chlorophyllase, the key enzyme in chlorophyll degradation: finding of a lipase motif and the induction by methyl jasmonate. Proc Natl Acad Sci U S A (1999) 1.79
Focal nodular hyperplasia of the liver: direct evidence of circulatory disturbances. J Gastroenterol Hepatol (2000) 1.78
Primary hepatic lymphoma associated with primary biliary cirrhosis. Am J Gastroenterol (1999) 1.77
Chemical modification of erythromycins. I. Synthesis and antibacterial activity of 6-O-methylerythromycins A. J Antibiot (Tokyo) (1984) 1.71
Semisynthetic -lactam antibiotics. 2. Synthesis and properties of D- and L- -sulfobenzylpenicillins. J Med Chem (1972) 1.70
Why do phospholipid polymers reduce protein adsorption? J Biomed Mater Res (1998) 1.70
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res (2000) 1.70
Fate of the human immunodeficiency virus type 1 provirus in infected cells: a role for vpr. J Virol (1995) 1.69
Histologic diagnostic rate of cardiac sarcoidosis: evaluation of endomyocardial biopsies. Am Heart J (1999) 1.62
Relationship between intraocular pressure and obesity in Japan. Int J Epidemiol (2000) 1.61
Cloning of the gene for monogalactosyldiacylglycerol synthase and its evolutionary origin. Proc Natl Acad Sci U S A (1997) 1.57
Left ventricular ejection performance, wall stress, and contractile state in aortic regurgitation before and after aortic valve replacement. Circulation (1990) 1.56
Genetic control of the immune response. Frequency and characteristics of antigen-binding cells in high and low responder mice. J Exp Med (1973) 1.55
Movements of truncated kinesin fragments with a short or an artificial flexible neck. Proc Natl Acad Sci U S A (1997) 1.55
Association of the missense Glu298Asp variant of the endothelial nitric oxide synthase gene with myocardial infarction. J Am Coll Cardiol (1998) 1.53
The heterogeneity of protein kinase C in various rat tissues. Biochem Biophys Res Commun (1988) 1.53
Proteasomes in distal myopathy with rimmed vacuoles. Intern Med (1998) 1.53
CV-3988 - a specific antagonist of platelet activating factor (PAF). Life Sci (1983) 1.52
Traditional Chinese medicine and Kampo: a review from the distant past for the future. J Int Med Res (2006) 1.52
Metallic stents for malignant and benign ureteric obstruction. BJU Int (2000) 1.51
In vitro assembly of bacteriophage Lambda heads. Proc Natl Acad Sci U S A (1973) 1.48
HLA-DRB1*1502 allele, subtype of DR15, is associated with susceptibility to ulcerative colitis and its progression. Dig Dis Sci (1995) 1.45
Membrane-type matrix metalloproteinase 1 is a gelatinolytic enzyme and is secreted in a complex with tissue inhibitor of metalloproteinases 2. Cancer Res (1996) 1.45
Neurosecretory cell: capable of conducting impulse in rats. Science (1966) 1.45
Long-term outcome of rotational acetabular osteotomy: 145 hips followed for 10-23 years. Acta Orthop Scand (1998) 1.44
Acetyl-CoA carboxylase from Escherichia coli: gene organization and nucleotide sequence of the biotin carboxylase subunit. Proc Natl Acad Sci U S A (1991) 1.44
Effect of intravenous cyclophosphamide in systemic lupus erythematosus: relation to lymphocyte subsets and activation markers. Lupus (2000) 1.43
Inactivation of tumor suppressor p53 by mot-2, a hsp70 family member. J Biol Chem (1998) 1.43
An improved method to extract RNA from soil with efficient removal of humic acids. J Appl Microbiol (2009) 1.42
Brain 5alpha-dihydroprogesterone and allopregnanolone synthesis in a mouse model of protracted social isolation. Proc Natl Acad Sci U S A (2001) 1.41
Helicobacter pylori infection induces hyperammonaemia in Mongolian gerbils with liver cirrhosis. Gut (2001) 1.41
DNA ploidy of colorectal carcinoma. Correlation with conventional prognostic variables. J Clin Gastroenterol (1988) 1.41
Deleted HTLV provirus in peripheral blood cells of a patient with T-cell prolymphocytic leukaemia. Br J Haematol (1998) 1.41
Activation of Na+/H+ exchanger is associated with hyperinsulinemia in borderline hypertensive rats. Eur J Clin Invest (2001) 1.40
Multiple free (aorta-coronary) gastroepiploic artery grafting. Ann Thorac Surg (1990) 1.40
CSF tau protein: a new prognostic marker for Guillain-Barré syndrome. Neurology (2006) 1.40
Human pregnancy serum suppresses the proliferative response of lymphocytes to autologous PHA-activated T lymphoblasts. Am J Reprod Immunol (1996) 1.40
The performance of a novel ball-tipped Flush knife for endoscopic submucosal dissection: a case-control study. Aliment Pharmacol Ther (2010) 1.39
Active and passive mechanical characteristics of bovine mesenteric lymphatics. Am J Physiol (1980) 1.39
Impact of human T cell leukemia virus type 1 in living donor liver transplantation. Am J Transplant (2012) 1.39
Intrafamilial transmission of adult T cell leukemia virus. J Infect Dis (1986) 1.38
Tricuspid valve endocarditis in a non-drug addict associated with peliosis hepatis. Intern Med (1997) 1.38
Painless thyroiditis occurring during long-term treatment with interferon alfa in a patient with chronic active hepatitis C. South Med J (1996) 1.38
Neuroprotective effects of gelsolin during murine stroke. J Clin Invest (1999) 1.38
Effect of sodium nitroprusside on norepinephrine overflow and antidiuresis induced by stimulation of renal nerves in anesthetized dogs. J Cardiovasc Pharmacol (1996) 1.37
Multiplicity of virus-encoded helper T-cell epitopes expressed on FBL-3 tumor cells. J Virol (1993) 1.36
In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist. Eur J Pharmacol (2000) 1.36
Junctional amino acids determine the maturation pathway of an antibody. Immunity (1999) 1.36
Multiple proline substitutions cumulatively thermostabilize Bacillus cereus ATCC7064 oligo-1,6-glucosidase. Irrefragable proof supporting the proline rule. Eur J Biochem (1994) 1.34
Sp3, but not Sp1, mediates the transcriptional activation of the p21/WAF1/Cip1 gene promoter by histone deacetylase inhibitor. Cancer Res (1999) 1.33
Full-length sequence analysis of the vacA gene from cytotoxic and noncytotoxic Helicobacter pylori. J Infect Dis (1998) 1.32
Expression of metastasis-related nm23-H1 and nm23-H2 genes in ovarian carcinomas: correlation with clinicopathology, EGFR, c-erbB-2, and c-erbB-3 genes, and sex steroid receptor expression. Cancer Res (1994) 1.32
Usefulness of selective arterial secretin injection test for localization of gastrinoma in the Zollinger-Ellison syndrome. Ann Surg (1987) 1.32
Protective effect of human granulocyte colony-stimulating factor on microbial infection in neutropenic mice. Infect Immun (1987) 1.31
Identification of a third type of lambda light chain in mouse immunoglobulins. Proc Natl Acad Sci U S A (1981) 1.31
Letter: Two cases of T-cell chronic lymphocytic leukemia in Japan. N Engl J Med (1974) 1.30