Published in Cell on April 07, 1995
Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J Cell Biol (1996) 3.97
Degeneracy and complexity in biological systems. Proc Natl Acad Sci U S A (2001) 3.81
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest (1999) 3.38
The actin-based nanomachine at the leading edge of migrating cells. Biophys J (1999) 3.19
Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J Cell Biol (1997) 2.66
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci U S A (2003) 2.34
Signaling to actin dynamics. J Cell Biol (1999) 2.26
Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J (1998) 2.23
Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem J (2004) 2.08
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol (2000) 2.07
Calpain regulates actin remodeling during cell spreading. J Cell Biol (1998) 1.90
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol (2002) 1.88
Coordinated regulation of platelet actin filament barbed ends by gelsolin and capping protein. J Cell Biol (1996) 1.85
Fc receptor-mediated phagocytosis requires CDC42 and Rac1. EMBO J (1998) 1.78
Neuroprotection mediated by changes in the endothelial actin cytoskeleton. J Clin Invest (2000) 1.76
Not just scaffolding: plectin regulates actin dynamics in cultured cells. Genes Dev (1998) 1.71
Actin turnover-dependent fast dissociation of capping protein in the dendritic nucleation actin network: evidence of frequent filament severing. J Cell Biol (2006) 1.70
Profilin I is essential for cell survival and cell division in early mouse development. Proc Natl Acad Sci U S A (2001) 1.68
Actin organization, bristle morphology, and viability are affected by actin capping protein mutations in Drosophila. J Cell Biol (1996) 1.63
Rac1-null mouse embryonic fibroblasts are motile and respond to platelet-derived growth factor. Mol Biol Cell (2006) 1.60
Capping protein terminates but does not initiate chemoattractant-induced actin assembly in Dictyostelium. J Cell Biol (1997) 1.57
Late onset lattice corneal dystrophy with systemic familial amyloidosis, amyloidosis V, in an English family. Br J Ophthalmol (2000) 1.45
A role for gelsolin in actuating epidermal growth factor receptor-mediated cell motility. J Cell Biol (1996) 1.45
Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils. J Cell Biol (2000) 1.44
Phosphatidylinositol 4,5-bisphosphate induces actin stress-fiber formation and inhibits membrane ruffling in CV1 cells. J Cell Biol (2001) 1.43
Regulation of the pollen-specific actin-depolymerizing factor LlADF1. Plant Cell (2002) 1.40
Delayed retraction of filopodia in gelsolin null mice. J Cell Biol (1997) 1.39
Actin filament barbed-end capping activity in neutrophil lysates: the role of capping protein-beta 2. Mol Biol Cell (1995) 1.38
Neuroprotective effects of gelsolin during murine stroke. J Clin Invest (1999) 1.38
Impaired platelet aggregation and sustained bleeding in mice lacking the fibrinogen motif bound by integrin alpha IIb beta 3. EMBO J (1996) 1.33
Gelsolin-induced epithelial cell invasion is dependent on Ras-Rac signaling. EMBO J (2002) 1.31
Alpha-adducin dissociates from F-actin and spectrin during platelet activation. J Cell Biol (2003) 1.25
Regulation of the formation of osteoclastic actin rings by proline-rich tyrosine kinase 2 interacting with gelsolin. J Cell Biol (2003) 1.24
Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts. Proc Natl Acad Sci U S A (2002) 1.23
A novel type of protein kinase phosphorylates actin in the actin-fragmin complex. EMBO J (1996) 1.18
Plasma gelsolin depletion and circulating actin in sepsis: a pilot study. PLoS One (2008) 1.17
Inhibition of apoptosis by the actin-regulatory protein gelsolin. EMBO J (1997) 1.16
Determination of the gelsolin binding site on F-actin: implications for severing and capping. Biophys J (1998) 1.15
Cell biology of embryonic migration. Birth Defects Res C Embryo Today (2008) 1.14
Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity. J Cell Biol (2008) 1.14
Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Mol Cell Biol (2002) 1.13
A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin. Proc Natl Acad Sci U S A (1998) 1.11
Comparisons of CapG and gelsolin-null macrophages: demonstration of a unique role for CapG in receptor-mediated ruffling, phagocytosis, and vesicle rocketing. J Cell Biol (2001) 1.11
Lipid rafts and regulation of the cytoskeleton during T cell activation. Philos Trans R Soc Lond B Biol Sci (2005) 1.11
Stimulation of actin polymerization by filament severing. Biophys J (2005) 1.08
CNS myelin wrapping is driven by actin disassembly. Dev Cell (2015) 1.08
Arginylation regulates intracellular actin polymer level by modulating actin properties and binding of capping and severing proteins. Mol Biol Cell (2010) 1.07
Regulation of cell motility by tyrosine phosphorylated villin. Mol Biol Cell (2004) 1.06
Arp2/3 complex is required for actin polymerization during platelet shape change. Blood (2002) 1.06
Loss of annexin A7 leads to alterations in frequency-induced shortening of isolated murine cardiomyocytes. Mol Cell Biol (2001) 1.04
Gelsolin and ADF/cofilin enhance the actin dynamics of motile cells. Proc Natl Acad Sci U S A (2000) 1.03
VASP protects actin filaments from gelsolin: an in vitro study with implications for platelet actin reorganizations. Cell Motil Cytoskeleton (2000) 1.02
Regulation of the actin cycle in vivo by actin filament severing. Proc Natl Acad Sci U S A (2000) 1.01
Gelsolin amyloidosis: genetics, biochemistry, pathology and possible strategies for therapeutic intervention. Crit Rev Biochem Mol Biol (2012) 1.01
Targeted ablation of plectin isoform 1 uncovers role of cytolinker proteins in leukocyte recruitment. Proc Natl Acad Sci U S A (2005) 1.01
Ca2+ regulation of gelsolin activity: binding and severing of F-actin. Biophys J (1998) 1.00
Actin dynamics in platelets. Int Rev Cytol (2002) 0.99
Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type. Proc Natl Acad Sci U S A (1999) 0.98
Gelsolin, a protein that caps the barbed ends and severs actin filaments, enhances the actin-based motility of Listeria monocytogenes in host cells. Infect Immun (1998) 0.97
Cytoskeletal rearrangements in synovial fibroblasts as a novel pathophysiological determinant of modeled rheumatoid arthritis. PLoS Genet (2005) 0.97
2E4 (kaptin): a novel actin-associated protein from human blood platelets found in lamellipodia and the tips of the stereocilia of the inner ear. Eur J Cell Biol (1999) 0.97
Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis. Mol Endocrinol (2011) 0.96
Gelsolin mediates collagen phagocytosis through a rac-dependent step. Mol Biol Cell (2003) 0.95
Transcriptional profiling of mycobacterial antigen-induced responses in infants vaccinated with BCG at birth. BMC Med Genomics (2009) 0.95
Gelsolin plays a role in the actin polymerization complex of hair cell stereocilia. PLoS One (2010) 0.94
Molecular and mutational analysis of a gelsolin-family member encoded by the flightless I gene of Drosophila melanogaster. Genetics (1995) 0.93
Emergent complexity of the cytoskeleton: from single filaments to tissue. Adv Phys (2013) 0.92
Inhibition of angiogenesis in vitro: a central role for beta-actin dependent cytoskeletal remodeling. Microvasc Res (2009) 0.90
Separate functions of gelsolin mediate sequential steps of collagen phagocytosis. Mol Biol Cell (2005) 0.90
Villin severing activity enhances actin-based motility in vivo. Mol Biol Cell (2006) 0.89
Nm23-h1 binds to gelsolin and inactivates its actin-severing capacity to promote tumor cell motility and metastasis. Cancer Res (2013) 0.89
beta-Actin regulates platelet nitric oxide synthase 3 activity through interaction with heat shock protein 90. Proc Natl Acad Sci U S A (2007) 0.88
A CapG gain-of-function mutant reveals critical structural and functional determinants for actin filament severing. EMBO J (2006) 0.88
Proteomic investigation of human burn wounds by 2D-difference gel electrophoresis and mass spectrometry. J Surg Res (2007) 0.88
Role of tumor suppressor p53 in megakaryopoiesis and platelet function. Exp Hematol (2011) 0.87
The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Genetics (2007) 0.87
Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade. PLoS One (2012) 0.87
Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes. Mol Cell Biol (1998) 0.86
Polyphosphoinositides-dependent regulation of the osteoclast actin cytoskeleton and bone resorption. BMC Cell Biol (2004) 0.86
Innate-like functions of natural killer T cell subsets result from highly divergent gene programs. Nat Immunol (2016) 0.85
Anti-apoptotic function of gelsolin in fas antibody-induced liver failure in vivo. Am J Pathol (2006) 0.85
The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic. Biochemistry (2009) 0.85
Actin reorganization as the molecular basis for the regulation of apoptosis in gastrointestinal epithelial cells. Cell Death Differ (2012) 0.84
Granzyme B-induced and caspase 3-dependent cleavage of gelsolin by mouse cytotoxic T cells modifies cytoskeleton dynamics. J Biol Chem (2010) 0.83
Gelsolin mediates calcium-dependent disassembly of Listeria actin tails. Proc Natl Acad Sci U S A (2005) 0.83
H-prune-nm23-H1 protein complex and correlation to pathways in cancer metastasis. J Bioenerg Biomembr (2006) 0.83
Pooled genome-wide analysis to identify novel risk loci for pediatric allergic asthma. PLoS One (2011) 0.83
Gelsolin is a dorsalizing factor in zebrafish. Proc Natl Acad Sci U S A (2003) 0.82
Treatment with gelsolin reduces brain inflammation and apoptotic signaling in mice following thermal injury. J Neuroinflammation (2011) 0.82
Yersinia Effector Protein YopO mediated Phosphorylation of Host Gelsolin Causes Calcium-Independent Activation leading to Disruption of Actin Dynamics. J Biol Chem (2017) 0.81
Plasma gelsolin levels and outcomes after aneurysmal subarachnoid hemorrhage. Crit Care (2013) 0.81
Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1. PLoS One (2008) 0.80
Comparative 2D-DIGE proteomic analysis of bovine mammary epithelial cells during lactation reveals protein signatures for lactation persistency and milk yield. PLoS One (2014) 0.80
Gelsolin gene expression is upregulated in damaged rat and human livers within non-parenchymal cells and not in hepatocytes. Histochem Cell Biol (2003) 0.79
The differential adhesion forces of anterior cruciate and medial collateral ligament fibroblasts: effects of tropomodulin, talin, vinculin, and alpha-actinin. Proc Natl Acad Sci U S A (1996) 0.79
Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1. J Biol Chem (2013) 0.79
Analgesic and Anti-Inflammatory Properties of Gelsolin in Acetic Acid Induced Writhing, Tail Immersion and Carrageenan Induced Paw Edema in Mice. PLoS One (2015) 0.78
Defective erythroid maturation in gelsolin mutant mice. Haematologica (2012) 0.78
Thematic Minireview Series: The State of the Cytoskeleton in 2015. J Biol Chem (2015) 0.78
Gelsolin and non-muscle myosin IIA interact to mediate calcium-regulated collagen phagocytosis. J Biol Chem (2011) 0.78
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity (1995) 14.90
PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol (2001) 12.26
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Natl Acad Sci U S A (1996) 6.29
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science (1997) 6.10
Filamins as integrators of cell mechanics and signalling. Nat Rev Mol Cell Biol (2001) 5.99
Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein. Nature (1979) 5.48
Nonmuscle actin-binding proteins. Annu Rev Cell Biol (1985) 5.46
Kirsten ras mutations in patients with colorectal cancer: the 'RASCAL II' study. Br J Cancer (2001) 5.36
Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (1995) 4.97
Recombination and clonal groupings within Helicobacter pylori from different geographical regions. Mol Microbiol (1999) 4.72
Actin-binding protein requirement for cortical stability and efficient locomotion. Science (1992) 4.66
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol (2000) 4.64
Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell (1995) 4.39
Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis. Science (1997) 4.19
A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity (1996) 4.03
Modulation of gelsolin function by phosphatidylinositol 4,5-bisphosphate. Nature (1987) 3.99
Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell (1992) 3.91
Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation. Immunity (1996) 3.91
Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis. J Cell Biol (1976) 3.84
Human endothelial actin-binding protein (ABP-280, nonmuscle filamin): a molecular leaf spring. J Cell Biol (1990) 3.76
Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med (2000) 3.74
Phagocytosis: recognition and ingestion. Semin Hematol (1975) 3.63
ICOS is critical for CD40-mediated antibody class switching. Nature (2001) 3.63
The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo. Cell (1996) 3.55
Plasma and cytoplasmic gelsolins are encoded by a single gene and contain a duplicated actin-binding domain. Nature (1986) 3.50
Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet (2000) 3.44
Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages. J Biol Chem (1975) 3.41
Isolation and properties of phagocytic vesicles from polymorphonuclear leukocytes. J Clin Invest (1971) 3.39
Tsc2(+/-) mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest (1999) 3.38
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytes. J Cell Biol (1999) 3.26
Intestinal M cells: a pathway for entry of reovirus into the host. Science (1981) 3.23
B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity (1997) 3.22
Quantitative studies of phagocytosis. Kinetic effects of cations and heat-labile opsonin. J Cell Biol (1973) 3.14
Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3. Science (1995) 3.00
SAP controls T cell responses to virus and terminal differentiation of TH2 cells. Nat Immunol (2001) 2.95
Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte hyperplasia in women with tuberous sclerosis. Am J Respir Crit Care Med (2001) 2.94
N-WASP deficiency reveals distinct pathways for cell surface projections and microbial actin-based motility. Nat Cell Biol (2001) 2.91
Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol (1997) 2.89
Interactions between actin, myosin, and an actin-binding protein from rabbit alveolar macrophages. Alveolar macrophage myosin Mg-2+-adenosine triphosphatase requires a cofactor for activation by actin. J Biol Chem (1975) 2.88
Quantitative studies of phagocytosis by polymorphonuclear leukocytes: use of emulsions to measure the initial rate of phagocytosis. J Clin Invest (1972) 2.88
The small GTPase RalA targets filamin to induce filopodia. Proc Natl Acad Sci U S A (1999) 2.87
Actin-binding proteins. Curr Opin Cell Biol (1991) 2.83
Cytochalasin B and the structure of actin gels. J Mol Biol (1979) 2.81
Distinctiveness of genotypes of Helicobacter pylori in Calcutta, India. J Bacteriol (2000) 2.81
Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells. Proc Natl Acad Sci U S A (2006) 2.80
The architecture of actin filaments and the ultrastructural location of actin-binding protein in the periphery of lung macrophages. J Cell Biol (1986) 2.80
Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP. Nat Cell Biol (2001) 2.75
Ca2+ control of actin gelation. Interaction of gelsolin with actin filaments and regulation of actin gelation. J Biol Chem (1980) 2.73
Molecular genetic advances in tuberous sclerosis. Hum Genet (2000) 2.72
Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions. Am J Hum Genet (1996) 2.67
NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med (1997) 2.66
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene. Nat Genet (1997) 2.64
Hyperammonaemia and Helicobacter pylori. Lancet (1995) 2.59
Resemblance of actin-binding protein/actin gels to covalently crosslinked networks. Nature (1990) 2.58
Myosin in polymorphonuclear leukocytes. J Biol Chem (1973) 2.55
Contractile proteins in leukocyte function. Semin Hematol (1983) 2.55
WIP, a protein associated with wiskott-aldrich syndrome protein, induces actin polymerization and redistribution in lymphoid cells. Proc Natl Acad Sci U S A (1997) 2.54
Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene (2010) 2.53
Signaling pathways and cell mechanics involved in wound closure by epithelial cell sheets. Curr Biol (2000) 2.52
The opsonic fragment of the third component of human complement (C3). J Exp Med (1975) 2.51
Genetics of reovirus: identification of the ds RNA segments encoding the polypeptides of the mu and sigma size classes. Virology (1978) 2.51
Distribution of actin-binding protein and myosin in macrophages during spreading and phagocytosis. J Cell Biol (1980) 2.45
Interactions of actin, myosin, and an actin-binding protein of rabbit pulmonary macrophages. III. Effects of cytochalasin B. J Cell Biol (1976) 2.42
Phagocytosis (third of three parts). N Engl J Med (1974) 2.41
CTLA-4 regulates induction of anergy in vivo. Immunity (2001) 2.39
Neutrophil action dysfunction and abnormal neutrophil behavior. N Engl J Med (1974) 2.35
Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells. Oncogene (2007) 2.34
Heparin is essential for the storage of specific granule proteases in mast cells. Nature (1999) 2.34
An inherited abnormality of neutrophil adhesion. Its genetic transmission and its association with a missing protein. N Engl J Med (1980) 2.32
Filamin A, the Arp2/3 complex, and the morphology and function of cortical actin filaments in human melanoma cells. J Cell Biol (2001) 2.29
Myeloperoxidase-mediated iodination by granulocytes. Intracellular site of operation and some regulating factors. J Clin Invest (1974) 2.28
The gelation of actin by actin-binding protein. J Biol Chem (1978) 2.27
Enhanced motility in NIH 3T3 fibroblasts that overexpress gelsolin. Science (1991) 2.26
Serum-dependent phagocytosis of paraffin oil emulsified with bacterial lipopolysaccharide. J Exp Med (1973) 2.25
Evaluation of opsonic and leukocyte function with a spectrophotometric test in patients with infection and with phagocytic disorders. Blood (1973) 2.25
Role of the host cell in persistent viral infection: coevolution of L cells and reovoirus during persistent infection. Cell (1981) 2.23
Gelsolin is a downstream effector of rac for fibroblast motility. EMBO J (1998) 2.23
The mechanical properties of actin gels. Elastic modulus and filament motions. J Biol Chem (1994) 2.23
Actin-binding protein promotes the bipolar and perpendicular branching of actin filaments. J Cell Biol (1980) 2.22