Published in N Engl J Med on April 19, 1973
Endothelial dysfunction in diabetes. Br J Pharmacol (2000) 3.13
Therapies for hyperglycaemia-induced diabetic complications: from animal models to clinical trials. Nat Rev Drug Discov (2009) 2.24
Refractive changes in diabetic patients during intensive glycaemic control. Br J Ophthalmol (2000) 1.88
Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes. J Clin Invest (1975) 1.81
Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose. J Clin Invest (1989) 1.63
Refractive properties of the healthy human eye during acute hyperglycemia. Graefes Arch Clin Exp Ophthalmol (2008) 1.51
Gap junctions in the control of vascular function. Antioxid Redox Signal (2009) 1.47
The polyol pathway as a mechanism for diabetic retinopathy: attractive, elusive, and resilient. Exp Diabetes Res (2007) 1.35
Free and lipid myo-inositol in tissues from rats with acute and less severe streptozotocin-induced diabetes. Biochem J (1977) 1.30
Diabetic complications and dysregulated innate immunity. Front Biosci (2008) 1.28
Ocular complications of diabetes mellitus. World J Diabetes (2015) 1.27
Transient hyperopia with lens swelling at initial therapy in diabetes. Br J Ophthalmol (1993) 1.26
Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms. Nat Rev Nephrol (2010) 1.16
The biochemistry of diabetes. Biochem J (1988) 1.14
Regulation of metabolic pathways in liver and kidney during experimental diabetes: Effects of antidiabetic compounds. Indian J Clin Biochem (1998) 1.12
Characterization of the osmotic response element of the human aldose reductase gene promoter. Proc Natl Acad Sci U S A (1996) 1.08
The role of abnormal hemorrheodynamics in the pathogenesis of diabetic retinopathy. Trans Am Ophthalmol Soc (1976) 1.07
Erythrocyte aldose reductase activity and sorbitol levels in diabetic retinopathy. Mol Vis (2008) 1.05
Neutrophil phagocytosis and killing in insulin-dependent diabetes. Clin Exp Immunol (1986) 1.05
Peripheral nerve abnormalities related to galactose administration in rats. J Neurol Neurosurg Psychiatry (1976) 1.04
Ascorbate synthesis pathway: dual role of ascorbate in bone homeostasis. J Biol Chem (2010) 1.03
Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts. Cardiovasc Diabetol (2008) 1.02
Vascular dysfunction in the diabetic placenta: causes and consequences. J Anat (2009) 0.98
Coronary microvascular dysfunction in diabetes mellitus: A review. World J Cardiol (2010) 0.96
Pathogenesis of chronic hyperglycemia: from reductive stress to oxidative stress. J Diabetes Res (2014) 0.95
Effect of systemic medications on onset and progression of diabetic retinopathy. Nat Rev Endocrinol (2010) 0.94
The reduction of glyceraldehyde by human erythrocytes. L-hexonate dehydrogenase activity. J Clin Invest (1974) 0.92
Ocular disease, knowledge and technology applications in patients with diabetes. Am J Med Sci (2013) 0.92
Relative growth and maturation of axon size and myelin thickness in the tibial nerve of the rat. 2. Effect of streptozotocin-induced diabetes. Acta Neuropathol (1990) 0.91
Molecular mechanisms of diabetic retinopathy, general preventive strategies, and novel therapeutic targets. Biomed Res Int (2014) 0.89
Substrate specificity of sheep liver sorbitol dehydrogenase. Biochem J (1998) 0.88
Molecular mechanisms of diabetic retinopathy: potential therapeutic targets. Middle East Afr J Ophthalmol (2015) 0.88
Myenteric neurons and intestinal mucosa of diabetic rats after ascorbic acid supplementation. World J Gastroenterol (2008) 0.87
The polyol pathway. A historical review. Drugs (1986) 0.87
Relationship of cerebrospinal fluid glucose metabolites to MRI deep white matter hyperintensities and treatment resistance in bipolar disorder patients. Bipolar Disord (2008) 0.87
Effects of aldose reductase inhibitor treatment in diabetic polyneuropathy - a clinical and neurophysiological study. J Neurol Neurosurg Psychiatry (1981) 0.87
Inhibitory effect of streptozotocin-induced diabetes on non-cholinergic motor transmission in rat detrusor and its prevention by sorbinil. Br J Pharmacol (1990) 0.85
Activated and unactivated forms of human erythrocyte aldose reductase. Proc Natl Acad Sci U S A (1985) 0.84
Retinal cotton-wool spots: an early finding in diabetic retinopathy? Br J Ophthalmol (1986) 0.84
Role of insulin signaling impairment, adiponectin and dyslipidemia in peripheral and central neuropathy in mice. Dis Model Mech (2014) 0.83
Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia. PLoS One (2012) 0.83
Optical quality of the diabetic eye: a review. Eye (Lond) (2014) 0.82
CoMFA and CoMSIA analysis of 2,4-thiazolidinediones derivatives as aldose reductase inhibitors. J Mol Model (2009) 0.82
Effect of ranirestat, a new aldose reductase inhibitor, on diabetic retinopathy in SDT rats. J Diabetes Res (2014) 0.81
The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. Br J Pharmacol (1994) 0.81
Treatment with aldose reductase inhibitor or with myo-inositol arrests deterioration of the electroretinogram of diabetic rats. J Clin Invest (1985) 0.80
Sources and implications of NADH/NAD(+) redox imbalance in diabetes and its complications. Diabetes Metab Syndr Obes (2016) 0.80
Metabolomics in diabetic complications. Mol Biosyst (2016) 0.79
Neuroprotection as a Therapeutic Target for Diabetic Retinopathy. J Diabetes Res (2016) 0.79
Protective Pleiotropic Effect of Flavonoids on NAD⁺ Levels in Endothelial Cells Exposed to High Glucose. Oxid Med Cell Longev (2015) 0.79
Retinal insulin receptor signaling in hyperosmotic stress. Vitam Horm (2009) 0.79
Effects of long-term treatment with ranirestat, a potent aldose reductase inhibitor, on diabetic cataract and neuropathy in spontaneously diabetic torii rats. J Diabetes Res (2013) 0.79
Prevention of defects of axonal transport in experimental diabetes by aldose reductase inhibitors. Drugs (1986) 0.78
Plants used in the management of diabetic complications. Indian J Pharm Sci (2014) 0.78
Oxidative Stress-Related Mechanisms and Antioxidant Therapy in Diabetic Retinopathy. Oxid Med Cell Longev (2017) 0.77
In vitro expression of rat lens aldose reductase in Escherichia coli. Proc Natl Acad Sci U S A (1990) 0.77
The role of Cys-298 in aldose reductase function. J Biol Chem (2010) 0.77
Fructose levels are markedly elevated in cerebrospinal fluid compared to plasma in pregnant women. PLoS One (2015) 0.77
Phospho-Site-Specific Antibody Microarray to Study the State of Protein Phosphorylation in the Retina. J Proteomics Bioinform (2008) 0.76
The human brain produces fructose from glucose. JCI Insight (2017) 0.76
Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases. Adv Nutr (2017) 0.76
Litsea japonica Extract Inhibits Aldose Reductase Activity and Hyperglycemia-Induced Lenticular Sorbitol Accumulation in db/db Mice. Evid Based Complement Alternat Med (2015) 0.76
Caloric restriction counteracts age-related changes in the activities of sorbitol metabolizing enzymes from mouse liver. Biogerontology (2008) 0.75
Management of diabetes mellitus in children. Can Med Assoc J (1976) 0.75
Surgical decompression of painful diabetic peripheral neuropathy: the role of pain distribution. PLoS One (2014) 0.75
Up-regulation of aldolase A and methylglyoxal production in adipocytes. Br J Pharmacol (2013) 0.75
Effect of hyperglycaemia as assessed by glycosylated haemoglobin concentrations on red cell enzyme activities in diabetes mellitus. J Clin Pathol (1981) 0.75
Characterization of WY 14,643 and its Complex with Aldose Reductase. Sci Rep (2016) 0.75
A fluorimetric method for red blood cell sorbitol dehydrogenase activity. J Clin Pathol (1983) 0.75
Galactose ingestion increases vascular permeability and collagen solubility in normal male rats. J Clin Invest (1987) 0.75
Metabolism of the aldose reductase inhibitor ALO1567 in man. Br J Clin Pharmacol (1991) 0.75
Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract. BMC Complement Altern Med (2016) 0.75
Proceedings of the joint meeting of the Scandinavian and British Pharmacological Societies. Stockholm--Sweden. 5th and 6th July, 1982. Br J Pharmacol (1982) 0.75
Effects of long-acting somatostatin analogues on redox systems in rat lens in experimental diabetes. Int J Exp Pathol (2014) 0.75
Dual-color immunofluorescent labeling with quantum dots of the diabetes-associated proteins aldose reductase and Toll-like receptor 4 in the kidneys of diabetic rats. Int J Nanomedicine (2015) 0.75
Galactose neuropathy. Permeability studies, mechanism of edema, and mast cell abnormalities. Acta Neuropathol (1981) 0.75
Acute Incapacitating Hyperopia during Hypoglycemic Treatment. Med J Armed Forces India (2011) 0.75
Induced fit docking, pharmacophore modeling, and molecular dynamic simulations on thiazolidinedione derivatives to explore key interactions with Tyr48 in polyol pathway. J Mol Model (2014) 0.75
The polyol pathway for glucose metabolism in tissues from normal, diabetic, and ketotic Chinese hamsters. Diabetologia (1974) 0.75
Metabolomics of Diabetic Retinopathy. Curr Diab Rep (2017) 0.75
Genetic and epigenetic modifications in the pathogenesis of diabetic retinopathy: a molecular link to regulate gene expression. New Front Ophthalmol (2016) 0.75
The glycosylation of hemoglobin: relevance to diabetes mellitus. Science (1978) 3.87
The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest (1976) 3.00
Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84
Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8. Diabetes (1990) 2.69
Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature (1984) 2.69
Pancreatic beta-cell web: its possible role in insulin secretion. Science (1972) 2.63
The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. J Biol Chem (1989) 2.59
Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c. Biochem Biophys Res Commun (1975) 2.46
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science (1992) 2.37
Familial hyperproinsulinemia: partial characterization of circulating proinsulin-like material. Proc Natl Acad Sci U S A (1979) 1.61
Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes. Science (1966) 1.60
Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells. Cancer Res (1986) 1.58
Extended major histocompatibility complex haplotypes in type I diabetes mellitus. J Clin Invest (1984) 1.58
Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene. J Biol Chem (1997) 1.47
Retinal circulatory abnormalities in type 1 diabetes. Invest Ophthalmol Vis Sci (1994) 1.44
Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme. Biochemistry (1994) 1.43
Hyperglycemia, polyol metabolism, and complications of diabetes mellitus. Annu Rev Med (1975) 1.41
Familial hyperproinsulinemia. An autosomal dominant defect. N Engl J Med (1976) 1.40
Hemoglobin carbamylation in uremia. N Engl J Med (1981) 1.39
Genetic marker for insulin-dependent diabetes mellitus. Lancet (1979) 1.36
Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme. Biochemistry (1995) 1.36
Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation. J Biol Chem (1979) 1.30
Hypoglycemia of infancy and nesidioblastosis. Studies with somatostatin. N Engl J Med (1977) 1.30
Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262. J Biol Chem (1991) 1.29
Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein. J Biol Chem (1988) 1.23
"Somatostatinoma": a somatostatin-containing tumor of the endocrine pancreas. N Engl J Med (1977) 1.22
Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain. J Biol Chem (1992) 1.21
The insulinopathies. N Engl J Med (1980) 1.18
An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate. Biochemistry (1994) 1.16
Hyperglycemia and plasma lipid levels: a prospective study of young insulin-dependent diabetic patients. N Engl J Med (1980) 1.11
The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity. Biochemistry (1996) 1.11
Glycosylated hemoglobins: increased glycosylation of hemoglobin A in diabetic patients. Diabetes (1979) 1.10
Kinetics of an orally absorbed aldose reductase inhibitor, sorbinil. Clin Pharmacol Ther (1981) 1.09
Characterization of the osmotic response element of the human aldose reductase gene promoter. Proc Natl Acad Sci U S A (1996) 1.08
The sorbitol pathway. Enzyme localization and content in normal and diabetic nerve and cord. Diabetes (1968) 1.08
Mechanism of human aldehyde reductase: characterization of the active site pocket. Biochemistry (1995) 1.06
Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor. Science (1973) 1.06
Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase. J Biol Chem (1999) 1.04
Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition. Biochemistry (1995) 1.03
Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene. Diabetes (1993) 1.02
Somatostatin and pancreatic polypeptide secretion: effects of glucagon, insulin, and arginine. Diabetes (1979) 1.02
Aldose reductase inhibition improves nerve conduction velocity in diabetic patients. N Engl J Med (1983) 1.02
Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors. Biochemistry (1994) 1.01
Aldose reductase in retinal mural cells. Invest Ophthalmol Vis Sci (1977) 0.99
The search for IDDM susceptibility genes: the next generation. Diabetes (1996) 0.97
The infant of the diabetic mother: correlation of increased cord C-peptide levels with macrosomia and hypoglycemia. N Engl J Med (1979) 0.97
The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes. Diabetes (1995) 0.96
Characterization of the human aldose reductase gene promoter. J Biol Chem (1993) 0.94
Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs. Am J Hum Genet (1994) 0.94
The sorbitol pathway in diabetes and galactosemia: enzyme and sobstrate localization and changes in kidney. Diabetes (1968) 0.94
Oligonucleotide probes for HLA-DQA and DQB genes define susceptibility to type 1 (insulin-dependent) diabetes mellitus. Diabetologia (1988) 0.92
Purification and immunologic identification of aldose reductases. Diabetes (1974) 0.92
Primary association of HLA-DQw8 with type I diabetes in DR4 patients. Diabetes (1989) 0.91
A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes. Diabetologia (1985) 0.90
The effect of an aldose reductase inhibitor on the galactose-exposed rabbit lens. Biochim Biophys Acta (1968) 0.90
Inhibition of glucose-induced release of insulin by aldose reductase inhibitors. Proc Natl Acad Sci U S A (1972) 0.89
Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction. J Clin Endocrinol Metab (1990) 0.89
Formation of biologically active peptides. Proc R Soc Lond B Biol Sci (1980) 0.88
Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver. J Biol Chem (1986) 0.88
Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase. J Mol Biol (1994) 0.88
Chemical quantitation of hemoglobin glycosylation: fluorometric detection of formaldehyde released upon periodate oxidation of glycoglobin. Anal Biochem (1981) 0.87
Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme. Biochemistry (1995) 0.87
Primary structure of aldehyde reductase from human liver. Prog Clin Biol Res (1987) 0.87
Glycosylation of variant hemoglobins in normal and diabetic subjects. Diabetes Care (1981) 0.86
T-cell-defined DR4 subtypes as markers for type 1 diabetes. Hum Immunol (1988) 0.86
The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant. Biochemistry (1997) 0.85
Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35. Diabetes (1997) 0.85
Aldose reductase inhibition: studies with alrestatin. Metabolism (1979) 0.85
Characterization of a novel murine aldo-keto reductase. Adv Exp Med Biol (1997) 0.85
Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier. J Clin Invest (1972) 0.83
Editorial: Glycosylated hemoglobin and diabetic control. N Engl J Med (1976) 0.82
Muscle capillary basement-membrane thickness and long-term glycemia in type I diabetes mellitus. N Engl J Med (1984) 0.81
Hyperglycemia and plasma lipid levels: covariations in insulin-dependent diabetes. Diabetes Care (1983) 0.81
Characterization of the human aldehyde reductase gene and promoter. Genomics (1999) 0.81
Mechanism of development and possible prevention of sugar cataracts. Isr J Med Sci (1973) 0.81
Role of sorbitol pathway in neuropathy. Adv Metab Disord (1973) 0.80
Factors affecting counteraction by methylamines of urea effects on aldose reductase. Proc Natl Acad Sci U S A (1999) 0.80
Effect of puberty on insulinlike growth factor I and HbA1 in type I diabetes. Diabetes Care (1991) 0.80
Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases. Hum Hered (1997) 0.80
Cyclosporine A inhibits the adaptive responses to hypertonicity: a potential mechanism of nephrotoxicity. J Am Soc Nephrol (2001) 0.79
Purification and immunological identification of bovine retinal aldose reductase. Isr J Med Sci (1973) 0.79
HLA antigens of insulin-dependent diabetics. I. PLT colonies detecting Dw10 and a new class II determinant distinct from HLA-D, DR, MB(DC), MT, and SB. Tissue Antigens (1984) 0.79
Effects of E coli endotoxin on pancreatic hormones and blood flow. Circ Shock (1980) 0.78
Cys298 is responsible for reversible thiol-induced variation in aldose reductase activity. Adv Exp Med Biol (1993) 0.77
Vesicular binesis: glucose effect on insulin secretory vesicles. Science (1975) 0.76
Glycosylated hemoglobin and diabetes mellitus. Med Clin North Am (1982) 0.76
Ultrastructural localization of pancreatic polypeptide in human pancreas. J Clin Endocrinol Metab (1977) 0.76
Isolation and characterization of immunoreactive somatostatin from fish pancreatic islets. J Clin Invest (1980) 0.75
Aldose reductases from mammalian tissues. Methods Enzymol (1975) 0.75
Human pancreatic polypeptide: studies in fasting and in the growth hormone deficient state. Horm Metab Res (1980) 0.75
Aldehyde reductase. Catalytic mechanism and substrate recognition. Adv Exp Med Biol (1997) 0.75
Umbilical cord glycosylated hemoglobin in infants of diabetic mothers: relationships to neonatal hypoglycemia, macrosomia, and cord serum C-peptide. Diabetes Care (1987) 0.75
Characterization of an element resembling an androgen response element (ARE) in the human aldose reductase promoter. Adv Exp Med Biol (1997) 0.75
Growth hormone, sorbitol, and diabetic capillary disease. Lancet (1971) 0.75
The development and regulation of the endocrine pancreas. J Pediatr (1977) 0.75
[The biochemical basis of the complications of diabetes]. Journ Annu Diabetol Hotel Dieu (1984) 0.75