Published in J Clin Endocrinol Metab on July 01, 1990
Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus. J Clin Invest (2008) 2.36
Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport. PLoS One (2010) 1.27
The TITAN5 gene of Arabidopsis encodes a protein related to the ADP ribosylation factor family of GTP binding proteins. Plant Cell (2000) 1.17
Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene. Rev Endocr Metab Disord (2010) 1.08
A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto). J Clin Invest (1992) 0.92
INS-gene mutations: from genetics and beta cell biology to clinical disease. Mol Aspects Med (2014) 0.86
Foxa3 (HNF-3gamma) binds to and activates the rat proglucagon gene promoter but is not essential for proglucagon gene expression. Biochem J (2002) 0.80
Pathophysiology of non-insulin-dependent diabetes and the search for candidate genes: dangerous liaisons? Acta Diabetol (1996) 0.76
Sequencing analysis of insulin receptor defects and detection of two novel mutations in INSR gene. Mol Genet Metab Rep (2014) 0.76
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med (2001) 16.51
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
Procedure for identifying nonsense mutations. J Bacteriol (1968) 8.16
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell (1998) 8.10
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol Cell (1999) 7.56
Ultrastructural localization of intracellular antigens by the use of protein A-gold complex. J Histochem Cytochem (1978) 7.15
Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae. J Cell Biol (1982) 6.67
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A (1974) 5.73
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature (1994) 5.33
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09
The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest (2001) 4.93
Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons. Proc Natl Acad Sci U S A (1981) 4.85
Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci U S A (1999) 4.84
Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue. J Histochem Cytochem (1981) 4.62
Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature (1982) 4.22
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Cluster of genes controlling proline degradation in Salmonella typhimurium. J Bacteriol (1978) 4.04
Insulin stimulates phosphorylation of the forkhead transcription factor FKHR on serine 253 through a Wortmannin-sensitive pathway. J Biol Chem (1999) 3.95
PCR-induced (ligase-free) subcloning: a rapid reliable method to subclone polymerase chain reaction (PCR) products. Nucleic Acids Res (1990) 3.93
The glycosylation of hemoglobin: relevance to diabetes mellitus. Science (1978) 3.87
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J Clin Invest (1998) 3.76
Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes. Biochem Biophys Res Commun (1971) 3.74
A simple method to estimate populational 24-h urinary sodium and potassium excretion using a casual urine specimen. J Hum Hypertens (2002) 3.67
Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. Proc Natl Acad Sci U S A (1971) 3.65
Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation. Cell (1985) 3.54
Hybrid DNA artifact from PCR of closely related target sequences. Nucleic Acids Res (1989) 3.54
Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann Intern Med (2000) 3.44
Insulin interactions with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun (1973) 3.41
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet (1996) 3.40
The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins. J Bacteriol (1999) 3.17
Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis. Gene (1989) 3.11
Insulin receptors are widely distributed in the central nervous system of the rat. Nature (1978) 3.07
Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J Biol Chem (1988) 3.05
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. J Biol Chem (1974) 3.04
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
Site-site interactions among insulin receptors. Characterization of the negative cooperativity. J Biol Chem (1976) 3.01
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo. J Clin Invest (1976) 3.00
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol (1998) 2.97
Regulation of the major proline permease gene of Salmonella typhimurium. J Bacteriol (1978) 2.87
Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus. J Clin Endocrinol Metab (1977) 2.84
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J Biol Chem (1973) 2.80
Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation. J Biol Chem (1972) 2.78
Distinct and overlapping functions of insulin and IGF-I receptors. Endocr Rev (2001) 2.78
Influence of left ventricular function on outcome of patients treated with implantable defibrillators. Circulation (1992) 2.77
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem (1998) 2.72
Variable and tissue-specific hormone resistance in heterotrimeric Gs protein alpha-subunit (Gsalpha) knockout mice is due to tissue-specific imprinting of the gsalpha gene. Proc Natl Acad Sci U S A (1998) 2.71
Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8. Diabetes (1990) 2.69
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell (2000) 2.69
Sequence of cDNA encoding human insulin-like growth factor I precursor. Nature (1984) 2.69
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J Biol Chem (2001) 2.69
Pancreatic beta-cell web: its possible role in insulin secretion. Science (1972) 2.63
Characteristics of the human lymphocyte insulin receptor. J Biol Chem (1973) 2.61
The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases. J Biol Chem (1989) 2.59
Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem (1997) 2.57
Plasma insulin and growth hormone levels in obesity and diabetes. Ann N Y Acad Sci (1965) 2.56
Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase. Science (1999) 2.56
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J Biol Chem (1998) 2.51
The sorbitol pathway and the complications of diabetes. N Engl J Med (1973) 2.51
Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population. Diabetologia (2007) 2.48
Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c. Biochem Biophys Res Commun (1975) 2.46
Impaired glucose tolerance in mice with a targeted impairment of insulin action in muscle and adipose tissue. Nat Genet (1998) 2.44
Nuclear export of the E1B 55-kDa and E4 34-kDa adenoviral oncoproteins mediated by a rev-like signal sequence. EMBO J (1997) 2.44
Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease. Gut (2003) 2.39
An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science (1992) 2.37
Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci U S A (1997) 2.35
Degradation of misfolded endoplasmic reticulum glycoproteins in Saccharomyces cerevisiae is determined by a specific oligosaccharide structure. J Cell Biol (1998) 2.33
Insulin receptors in human circulating cells and fibroblasts. Proc Natl Acad Sci U S A (1972) 2.24
Peptide hormone binding to receptors: a review of direct studies in vitro. Metabolism (1973) 2.23
Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)-deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence. J Biol Chem (1995) 2.23
Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone. Nature (1997) 2.20
Conditional up-regulation of MHC class I in skeletal muscle leads to self-sustaining autoimmune myositis and myositis-specific autoantibodies. Proc Natl Acad Sci U S A (2000) 2.13
Fluctuations in the affinity and concentration of insulin receptors on circulating monocytes of obese patients: effects of starvation, refeeding, and dieting. J Clin Invest (1976) 2.12
Matrix/integrin interaction activates the mitogen-activated protein kinase, p44erk-1 and p42erk-2. J Biol Chem (1995) 2.09
ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. Proc Natl Acad Sci U S A (1970) 2.09
Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science (1999) 2.06
Adiponectin suppresses colorectal carcinogenesis under the high-fat diet condition. Gut (2008) 2.05
Methods for assessing immunologic and biologic properties of iodinated peptide hormones. Methods Enzymol (1975) 2.01
Risk factors for worsening to diabetes in subjects with impaired glucose tolerance. Diabetologia (1984) 1.99
Time of onset of non-insulin-dependent diabetes mellitus and genetic variation in the beta 3-adrenergic-receptor gene. N Engl J Med (1995) 1.99
Inhibition of RXR and PPARgamma ameliorates diet-induced obesity and type 2 diabetes. J Clin Invest (2001) 1.97
Binding of hormone to tissue: the first step in polypeptide hormone action. Proc Natl Acad Sci U S A (1966) 1.96
Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: identification of a Pro12Ala PPAR gamma 2 missense mutation. Biochem Biophys Res Commun (1997) 1.96
Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice. Mol Cell Biol (1996) 1.95
Myeloid-related proteins 8 and 14 are specifically secreted during interaction of phagocytes and activated endothelium and are useful markers for monitoring disease activity in pauciarticular-onset juvenile rheumatoid arthritis. Arthritis Rheum (2000) 1.95
The MDM2 oncoprotein binds specifically to RNA through its RING finger domain. Mol Med (1996) 1.94
Two mammalian heat shock proteins, HSP90 and HSP100, are actin-binding proteins. Proc Natl Acad Sci U S A (1986) 1.93
Defect in insulin binding to receptors in obese man. Amelioration with calorie restriction. J Clin Invest (1975) 1.92
Control of blood glucose and diabetic vascular disease. N Engl J Med (1977) 1.92
The vitamin D endocrine system: steroid metabolism, hormone receptors, and biological response (calcium binding proteins). Endocr Rev (1982) 1.92
The Pro12Ala polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem Biophys Res Commun (2000) 1.91