Published in Proc Natl Acad Sci U S A on September 01, 1968
Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. Biochem J (1989) 3.34
Insulin receptor deficiency in genetic and acquired obesity. J Clin Invest (1975) 1.79
Human serum proinsulin. J Clin Invest (1970) 1.52
Immunoassay of plasma vasopressin in man. Proc Natl Acad Sci U S A (1970) 1.43
Kinetics of human connecting peptide in normal and diabetic subjects. J Clin Invest (1978) 1.42
The acetylation of insulin. Biochem J (1971) 1.42
The metabolism of proinsulin and insulin by the liver. J Clin Invest (1972) 1.38
Plasminogen activator of islets of Langerhans: modulation by glucose and correlation with insulin production. Proc Natl Acad Sci U S A (1980) 1.14
Plasma insulin: fluctuations in the "big" insulin component in man after glucose and other stimuli. J Clin Invest (1969) 1.10
Proinsulin-like component of circulating insulin in the basal state and in patients and hamsters with islet cell tumors. J Clin Invest (1971) 1.02
Circulating insulin: th proinsulin-like properties of "big" insulin in patients withou islet cell tumors. J Clin Invest (1971) 1.01
A specific anti-proinsulin serum and the presence of proinsulin in calf serum. Proc Natl Acad Sci U S A (1969) 0.99
Biochemical and clinical implications of proinsulin conversion intermediates. J Clin Invest (1985) 0.96
Direct measurement of proinsulin in human plasma by the use of an insulin-degrading enzyme. J Clin Invest (1971) 0.95
Studies on the biological activity of porcine proinsulin. J Clin Invest (1970) 0.90
The pathogenesis of NIDDM. Diabetologia (1994) 0.90
Characterization of proinsulin-insulin intermediates in human plasma. J Clin Invest (1978) 0.88
Insulin secretion and insulin-producing tumors. Expert Rev Endocrinol Metab (2010) 0.81
Disorders of glucose metabolism: post mortem analyses in forensic cases--part II. Int J Legal Med (2010) 0.81
The evolution of diabetes from prediabetes. Postgrad Med J (1970) 0.75
Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature (1962) 64.93
Immunoassay of endogenous plasma insulin in man. J Clin Invest (1960) 25.67
Insulin biosynthesis: evidence for a precursor. Science (1967) 5.05
The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma. Proc Natl Acad Sci U S A (1967) 5.04
Antigenicity of insulin: diabetes induced by specific antibodies. Biochem J (1955) 4.18
Species-specificity of human antibeef, pork insulin serum. J Clin Invest (1959) 2.72
The effects of total starvation upon the levels of circulating glucagon and insulin in man. J Clin Invest (1963) 2.43
Nonprecipitating insulin antibodies. J Clin Invest (1958) 2.00
Some current controversies in diabetes research. Diabetes (1965) 1.92
Insulin in blood and insulin antibodies. Am J Med (1966) 1.34
Heterogeneity of crystalline insulin. Endocrinology (1966) 1.10
REACTION OF FISH INSULINS WITH HUMAN INSULIN ANTISERUMS. POTENTIAL VALUE IN THE TREATMENT OF INSULIN RESISTANCE. N Engl J Med (1964) 1.05
Immunological specificity of human insulin: application to immunoassay of insulin. J Clin Invest (1961) 0.92
The Rous sarcoma virus long terminal repeat is a strong promoter when introduced into a variety of eukaryotic cells by DNA-mediated transfection. Proc Natl Acad Sci U S A (1982) 20.55
Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics. J Mol Biol (1977) 20.29
Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes. Proc Natl Acad Sci U S A (1970) 13.26
Biochemistry of multidrug resistance mediated by the multidrug transporter. Annu Rev Biochem (1993) 10.95
Pleiotropic deficiency of carbohydrate utilization in an adenyl cyclase deficient mutant of Escherichia coli. Biochem Biophys Res Commun (1969) 9.20
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell (1986) 8.53
Procedure for identifying nonsense mutations. J Bacteriol (1968) 8.16
Cyclic adenosine 5'-monophosphate in Escherichia coli. Bacteriol Rev (1976) 7.55
Regulation of beta-galactosidase synthesis in Escherichia coli by cyclic adenosine 3',5'-monophosphate. J Biol Chem (1968) 7.54
Cyclic adenosine monophosphate in bacteria. Science (1970) 7.53
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci U S A (1987) 7.38
Ultrastructural localization of intracellular antigens by the use of protein A-gold complex. J Histochem Cytochem (1978) 7.15
Immunocytochemical localization of galactosyltransferase in HeLa cells: codistribution with thiamine pyrophosphatase in trans-Golgi cisternae. J Cell Biol (1982) 6.67
Biochemical, cellular, and pharmacological aspects of the multidrug transporter. Annu Rev Pharmacol Toxicol (1999) 6.62
Direct visualization of binding, aggregation, and internalization of insulin and epidermal growth factor on living fibroblastic cells. Proc Natl Acad Sci U S A (1978) 6.59
Insulin-dependent regulation of insulin receptor concentrations: a direct demonstration in cell culture. Proc Natl Acad Sci U S A (1974) 5.73
Expression of a multidrug-resistance gene in human tumors and tissues. Proc Natl Acad Sci U S A (1987) 5.65
Identification of a functional promoter in the long terminal repeat of Rous sarcoma virus. Cell (1980) 5.51
Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells treated with adenosine-3':5'-cyclic monphosphate and its derivatives. Proc Natl Acad Sci U S A (1971) 5.31
Dansylcadaverine inhibits internalization of 125I-epidermal growth factor in BALB 3T3 cells. J Biol Chem (1980) 5.24
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09
Structure of the promoter for chicken alpha 2 type I collagen gene. Proc Natl Acad Sci U S A (1981) 4.89
Spontaneous tandem genetic duplications in Salmonella typhimurium arise by unequal recombination between rRNA (rrn) cistrons. Proc Natl Acad Sci U S A (1981) 4.85
Enhancement of structural preservation and immunocytochemical staining in low temperature embedded pancreatic tissue. J Histochem Cytochem (1981) 4.62
In vitro transcription of the gal operon requires cyclic adenosine monophosphate and cyclic adenosine monophosphate receptor protein. J Biol Chem (1971) 4.58
Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Proc Natl Acad Sci U S A (1996) 4.49
Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine. Proc Natl Acad Sci U S A (1987) 4.43
Localization of the src gene product of the Harvey strain of MSV to plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell (1980) 4.35
Cell surface protein partially restores morphology, adhesiveness, and contact inhibition of movement to transformed fibroblasts. Proc Natl Acad Sci U S A (1976) 4.32
Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry. Cell (1979) 4.30
Non-coated membrane invaginations are involved in binding and internalization of cholera and tetanus toxins. Nature (1982) 4.22
Cyclic 3'5-AMP: stimulation of beta-galactosidase and tryptophanase induction in E. coli. Biochem Biophys Res Commun (1968) 4.16
Identification of two lysosomal membrane glycoproteins. J Cell Biol (1985) 4.08
Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene. Proc Natl Acad Sci U S A (1985) 4.08
Cluster of genes controlling proline degradation in Salmonella typhimurium. J Bacteriol (1978) 4.04
Epidermal growth factor: morphological demonstration of binding, internalization, and lysosomal association in human fibroblasts. Proc Natl Acad Sci U S A (1978) 4.03
Epidermal-growth-factor-dependent transformation by a human EGF receptor proto-oncogene. Science (1987) 3.93
PCR-induced (ligase-free) subcloning: a rapid reliable method to subclone polymerase chain reaction (PCR) products. Nucleic Acids Res (1990) 3.93
Collection of insulin, EGF and alpha2-macroglobulin in the same patches on the surface of cultured fibroblasts and common internalization. Cell (1978) 3.90
The receptosome: an intermediate organelle of receptor mediated endocytosis in cultured fibroblasts. Cell (1980) 3.88
Regulation of inducible enzyme synthesis in Escherichia coli by cyclic adenosine 3', 5'-monophosphate. J Biol Chem (1969) 3.86
Levels of translatable mRNAs for cell surface protein, collagen precursors, and two membrane proteins are altered in Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.80
Lac DNA, RNA polymerase and cyclic AMP receptor protein, cyclic AMP, lac repressor and inducer are the essential elements for controlled lac transcription. Nat New Biol (1971) 3.79
Monoiodoinsulin: demonstration of its biological activity and binding to fat cells and liver membranes. Biochem Biophys Res Commun (1971) 3.74
The collagen gene: evidence for its evolutinary assembly by amplification of a DNA segment containing an exon of 54 bp. Cell (1980) 3.66
Insulin receptors in the liver: specific binding of ( 125 I)insulin to the plasma membrane and its relation to insulin bioactivity. Proc Natl Acad Sci U S A (1971) 3.65
Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter. Science (1985) 3.59
Cyclic AMP levels in fibroblasts: relationship to growth rate and contact inhibition of growth. Biochem Biophys Res Commun (1971) 3.58
Demonstration of an extensive trans-tubular network continuous with the Golgi apparatus stack that may function in glycosylation. Cell (1985) 3.54
Hybrid DNA artifact from PCR of closely related target sequences. Nucleic Acids Res (1989) 3.54
Cyclic AMP regulates catabolite and transient repression in E. coli. Nature (1969) 3.42
Modulation of activity of the promoter of the human MDR1 gene by Ras and p53. Science (1992) 3.41
Insulin interactions with its receptors: experimental evidence for negative cooperativity. Biochem Biophys Res Commun (1973) 3.41
Ligands internalized through coated or noncoated invaginations follow a common intracellular pathway. Proc Natl Acad Sci U S A (1987) 3.33
Glucose depletion accounts for the induction of two transformation-sensitive membrane proteinsin Rous sarcoma virus-transformed chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 3.26
Regulation of lac mRNA synthesis in a soluble cell-free system. Nat New Biol (1971) 3.25
Isolation and characterization of myosin from cloned mouse fibroblasts. Proc Natl Acad Sci U S A (1972) 3.24
Isolation and genetic characterization of human KB cell lines resistant to multiple drugs. Somat Cell Mol Genet (1985) 3.23
Human multidrug-resistant cell lines: increased mdr1 expression can precede gene amplification. Science (1986) 3.22
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
A key role of starburst amacrine cells in originating retinal directional selectivity and optokinetic eye movement. Neuron (2001) 3.18
The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins. J Bacteriol (1999) 3.17
Reduced drug accumulation in multiply drug-resistant human KB carcinoma cell lines. Cancer Res (1985) 3.15
The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation. J Biol Chem (1987) 3.13
Effect of adenosine 3',5'-monophosphate analogues on the activity of the cyclic adenosine 3',5'-monophosphate receptor in Escherichia coli. J Biol Chem (1972) 3.08
Insulin receptors are widely distributed in the central nervous system of the rat. Nature (1978) 3.07
The major cell surface glycoprotein of chick embryo fibroblasts is an agglutinin. Proc Natl Acad Sci U S A (1975) 3.06
Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells. Science (1984) 3.06
Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Major sialoglycoproteins carrying polylactosaminoglycan. J Biol Chem (1988) 3.05
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. J Biol Chem (1974) 3.04
Site-site interactions among insulin receptors. Characterization of the negative cooperativity. J Biol Chem (1976) 3.01
Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts. Cell (1977) 2.99
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
Multiple drug-resistant human KB carcinoma cells independently selected for high-level resistance to colchicine, adriamycin, or vinblastine show changes in expression of specific proteins. J Biol Chem (1986) 2.93
Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli. Cell (1987) 2.93
The role of the lac promotor locus in the regulation of beta-galactosidase synthesis by cyclic 3',5'-adenosine monophosphate. Proc Natl Acad Sci U S A (1968) 2.92
The visualization of fluorescent proteins in living cells by video intensification microscopy (VIM). Cell (1978) 2.89
Regulation of the major proline permease gene of Salmonella typhimurium. J Bacteriol (1978) 2.87
HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry (1998) 2.87
Regulation of cell growth by cyclic adenosine 3',5'-monophosphate. Effect of cell density and agents which alter cell growth on cyclic adenosine 3',5'-monophosphate levels in fibroblasts. J Biol Chem (1972) 2.85
Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J Biol Chem (1973) 2.80
Insulin interactions with liver plasma membranes. Independence of binding of the hormone and its degradation. J Biol Chem (1972) 2.78
Influence of left ventricular function on outcome of patients treated with implantable defibrillators. Circulation (1992) 2.77
Multiple-drug resistance in human cancer. N Engl J Med (1987) 2.76
Forty-eight-hour fast: the diagnostic test for insulinoma. J Clin Endocrinol Metab (2000) 2.75
Adenovirus-induced release of epidermal growth factor and pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis. Cell (1983) 2.74
Effect of Rho on transcription of bacterial operons. Nat New Biol (1973) 2.74
The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem (1998) 2.72
Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N Engl J Med (2001) 2.65
Characteristics of the human lymphocyte insulin receptor. J Biol Chem (1973) 2.61
The multidrug transporter, a double-edged sword. J Biol Chem (1988) 2.61
Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem (1997) 2.57
Plasma insulin and growth hormone levels in obesity and diabetes. Ann N Y Acad Sci (1965) 2.56
Selective killing of HIV-infected cells by recombinant human CD4-Pseudomonas exotoxin hybrid protein. Nature (1988) 2.55
Fluorescent cellular indicators are extruded by the multidrug resistance protein. J Biol Chem (1993) 2.52
Induction of two transformation-sensitive membrane polypeptides in normal fibroblasts by a block in glycoprotein synthesis or glucose deprivation. Cell (1977) 2.52
Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Int J Cancer (1992) 2.50
125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. J Clin Invest (1978) 2.47