Published in Biochem Biophys Res Commun on July 23, 1969
Cyclic AMP receptor protein of E. coli: its role in the synthesis of inducible enzymes. Proc Natl Acad Sci U S A (1970) 13.26
Elevation of guanosine 3',5'-cyclic phosphate in rat heart after perfusion with acetylcholine. Proc Natl Acad Sci U S A (1970) 3.48
Cyclic adenosine 3':5'-monophosphate-stimulated phosphorylation of isolated neurotubule subunits. Proc Natl Acad Sci U S A (1970) 2.56
The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol Brain (2012) 2.43
Mechanism of activation by adenosine 3':5'-cyclic monophosphate of a protein phosphokinase from rabbit reticulocytes. Proc Natl Acad Sci U S A (1970) 2.02
Interconversion of phospho- and dephospho- forms of pig heart pyruvate dehydrogenase. Proc Natl Acad Sci U S A (1970) 1.57
Role of calcium and adenosine-3':5'-cyclic monophosphate in controlling fly salivary gland secretion. Proc Natl Acad Sci U S A (1972) 1.51
Interaction of the subunits of adenosine 3':5'-cyclic monophosphate-dependent protein kinase of muscle. Proc Natl Acad Sci U S A (1971) 1.42
Interconversion of cyclic nucleotide-activated and cyclic nucleotide-independent forms of a protein kinase from beef heart. Proc Natl Acad Sci U S A (1971) 1.20
Protein phospholinase reactions in mammalian testis. Stimulatory effects of adenosine 3':5'-cyclic monophosphate on the phosphorylation of basic proteins. Biochem J (1971) 1.06
ATP-dependent and cyclic AMP-dependent activation of rat adipose tissue lipase by protein kinase from rabbit skeletal muscle. Proc Natl Acad Sci U S A (1970) 1.04
Inhibition of hormone-stimulated lipolysis by clofibrate. A possible mechanism for its hypolipidemic action. J Clin Invest (1975) 0.97
Adenosine 3':5'-cyclic monophosphate-dependent and plasma-membrane-associated protein kinase(s) from bovine corpus luteum. Biochem J (1975) 0.84
Synaptic therapy in Alzheimer's disease: a CREB-centric approach. Neurotherapeutics (2015) 0.79
New perspectives in cyclic nucleotide-mediated functions in the CNS: the emerging role of cyclic nucleotide-gated (CNG) channels. Pflugers Arch (2013) 0.79
A study of 3':5'-cyclic mononucleotide-dependent protein kinase from canine prostate glands. Biochem J (1974) 0.77
Phosphodiesterase 4D: an enzyme to remember. Br J Pharmacol (2015) 0.76
Phosphorylation-dephosphorylation of enzymes. Annu Rev Biochem (1979) 11.34
The MAPK signaling cascade. FASEB J (1995) 10.81
An adenosine 3',5'-monophosphate-dependant protein kinase from rabbit skeletal muscle. J Biol Chem (1968) 8.62
Protein serine/threonine kinases. Annu Rev Biochem (1987) 8.42
Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases. J Biol Chem (1991) 8.03
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell (1985) 5.21
Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol (1987) 5.03
Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase. J Biol Chem (1977) 4.87
Assay of cyclic AMP-dependent protein kinases. Methods Enzymol (1974) 3.84
Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. J Biol Chem (1990) 3.82
Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a myelin basic protein/microtubule-associated protein 2 kinase. J Biol Chem (1991) 3.81
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A (1991) 3.31
Purification and properties of rabbit skeletal muscle adenosine 3',5'-monophosphate-dependent protein kinases. J Biol Chem (1971) 3.18
Substrate specificity determinants for casein kinase II as deduced from studies with synthetic peptides. J Biol Chem (1987) 3.04
Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. EMBO J (1998) 3.03
Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle. Methods Enzymol (1974) 2.97
Protein kinases. Curr Top Cell Regul (1972) 2.96
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. Proc Natl Acad Sci U S A (1989) 2.95
The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues. J Biol Chem (1975) 2.84
Compartmentalization of adenosine 3':5'-monophosphate and adenosine 3':5'-monophosphate-dependent protein kinase in heart tissue. J Biol Chem (1977) 2.80
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol (1988) 2.80
Myb DNA binding inhibited by phosphorylation at a site deleted during oncogenic activation. Nature (1990) 2.65
Guanosine cyclic 3',5'-phosphate dependent protein kinase, a chimeric protein homologous with two separate protein families. Biochemistry (1984) 2.62
Selective requirement for MAP kinase activation in thymocyte differentiation. Nature (1995) 2.53
Activation of casein kinase II in response to insulin and to epidermal growth factor. Proc Natl Acad Sci U S A (1987) 2.44
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
Translational activation of the lck proto-oncogene. Nature (1988) 2.41
Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins. Proc Natl Acad Sci U S A (1989) 2.40
Antibodies to a defined region of pp60src neutralize the tyrosine-specific kinase activity. J Biol Chem (1983) 2.33
Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1978) 2.32
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci U S A (1993) 2.31
Cyclic nucleotide phosphodiesterases: relating structure and function. Prog Nucleic Acid Res Mol Biol (2001) 2.30
Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts. Proc Natl Acad Sci U S A (1999) 2.29
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J Biol Chem (1992) 2.29
Tissue distribution of phosphodiesterase families and the effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am J Cardiol (1999) 2.25
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line. Proc Natl Acad Sci U S A (1982) 2.25
Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. J Biol Chem (1992) 2.23
Activation of skeletal muscle phosphorylase kinase by Ca2+. II. Identification of the kinase activating factor as a proteolytic enzyme. Biochemistry (1968) 2.23
Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1986) 2.20
Structure and function of cyclic nucleotide-dependent protein kinases. Annu Rev Physiol (1994) 2.20
Regulatory mechanisms in the control of protein kinases. CRC Crit Rev Biochem (1982) 2.20
Association of mitogen-activated protein kinase with the microtubule cytoskeleton. Proc Natl Acad Sci U S A (1995) 2.18
The mitogen-activated protein kinase activator. Curr Opin Cell Biol (1992) 2.14
Primary-structure requirements for inhibition by the heat-stable inhibitor of the cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1986) 2.14
Myc oncoproteins are phosphorylated by casein kinase II. EMBO J (1989) 2.11
The regulation of skeletal muscle phosphorylase kinase by Ca2+. J Biol Chem (1971) 2.07
Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription. Endocrinology (1997) 2.05
Evidence for an epidermal growth factor-stimulated protein kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro. J Biol Chem (1990) 2.03
Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle. J Biol Chem (1975) 2.03
Activation of skeletal muscle phosphorylase kinase by adenosine triphosphate and adenosine 3',5'-monophosphate. J Biol Chem (1968) 2.03
Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase. Proc Natl Acad Sci U S A (1985) 2.00
cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells. Proc Natl Acad Sci U S A (1995) 1.97
Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation. J Clin Invest (1994) 1.97
Inactivation of glycogen synthase kinase-3 by epidermal growth factor is mediated by mitogen-activated protein kinase/p90 ribosomal protein S6 kinase signaling pathway in NIH/3T3 cells. J Biol Chem (1995) 1.95
Identification of an inhibitory region of the heat-stable protein inhibitor of the cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1985) 1.94
Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1977) 1.94
Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase. J Biol Chem (1980) 1.88
Progesterone-stimulated meiotic cell division in Xenopus oocytes. Induction by regulatory subunit and inhibition by catalytic subunit of adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1977) 1.87
Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action. Crit Rev Clin Lab Sci (1999) 1.85
Crystallization and properties of rabbit skeletal muscle phosphofructokinase. J Biol Chem (1966) 1.85
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proc Natl Acad Sci U S A (1992) 1.83
Cyclic nucleotide-binding domains in proteins having diverse functions. J Biol Chem (1992) 1.82
Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J (1987) 1.80
A synthetic peptide substrate specific for casein kinase II. Proc Natl Acad Sci U S A (1985) 1.79
Protein phosphorylation and signal transduction. Pharmacol Ther (1999) 1.79
Both phosphorylation and caspase-mediated cleavage contribute to regulation of the Ste20-like protein kinase Mst1 during CD95/Fas-induced apoptosis. J Biol Chem (2001) 1.76
Covalently bound myristate in a lymphoma tyrosine protein kinase. Proc Natl Acad Sci U S A (1984) 1.76
Activation of protein kinase by physiological concentrations of cyclic AMP. Proc Natl Acad Sci U S A (1974) 1.75
Synthetic hexapeptide substrates and inhibitors of 3':5'-cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1976) 1.75
Amino acid sequence of the regulatory subunit of bovine type I adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry (1984) 1.74
p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1. J Biol Chem (1999) 1.72
Phosphorylation of the inhibitor component of troponin by phosphorylase kinase. J Biol Chem (1972) 1.71
Activation of multiple protein kinases during the burst in protein phosphorylation that precedes the first meiotic cell division in Xenopus oocytes. J Biol Chem (1988) 1.69
Okadaic acid mimics the action of insulin in stimulating protein kinase activity in isolated adipocytes. The role of protein phosphatase 2a in attenuation of the signal. J Biol Chem (1990) 1.68
Substrate specificity of the cyclic AMP-dependent protein kinase. Proc Natl Acad Sci U S A (1975) 1.68
Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues. J Biol Chem (1977) 1.67
Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction. J Cell Biol (1995) 1.66
High biochemical selectivity of tadalafil, sildenafil and vardenafil for human phosphodiesterase 5A1 (PDE5) over PDE11A4 suggests the absence of PDE11A4 cross-reaction in patients. Int J Impot Res (2005) 1.66
Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase. Determinants of substrate specificity. J Biol Chem (1986) 1.61
Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase. J Biol Chem (1983) 1.61
Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. Diabetes (1999) 1.59
Primary structure of the regulatory subunit of type II cAMP-dependent protein kinase from bovine cardiac muscle. Proc Natl Acad Sci U S A (1982) 1.58
Purification and characterization of the catalytic subunit of adenosine 3':5'-cyclic monophosphate-dependent protein kinase from bovine liver. Biochem J (1976) 1.57
Inactivation of glycogen synthetase and activation of phosphorylase kinase by muscle adenosine 3',5'-monophosphate-dependent protein kinases. J Biol Chem (1970) 1.57
Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci U S A (1997) 1.56
Expression of a human T-cell protein-tyrosine-phosphatase in baby hamster kidney cells. Proc Natl Acad Sci U S A (1990) 1.52
Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds. Mol Pharmacol (1999) 1.50
Regulation of oocyte maturation. Curr Top Cell Regul (1980) 1.50
Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP. Am J Physiol (1992) 1.50
Direct evidence for cross-activation of cGMP-dependent protein kinase by cAMP in pig coronary arteries. J Biol Chem (1992) 1.49
The amino acid sequences of the phosphorylated sites in troponin-I from rabbit skeletal muscle. FEBS Lett (1974) 1.49
Interaction of glucocorticoids with glucagon and epinephrine in the control of gluconeogenesis and glycogenolysis in liver and of lipolysis in adipose tissue. J Biol Chem (1972) 1.49
The phosphorylation of proteins: a major mechanism for biological regulation. Fourteenth Sir Frederick Gowland Hopkins memorial lecture. Biochem Soc Trans (1985) 1.48
Amino acid sequence of the heat-stable inhibitor of the cAMP-dependent protein kinase from rabbit skeletal muscle. Proc Natl Acad Sci U S A (1985) 1.47
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem (2000) 1.46
A lymphoma cell line expressing elevated levels of tyrosine protein kinase activity. J Biol Chem (1983) 1.45
Amino acid sequence of the beta subunit of bovine lung casein kinase II. Proc Natl Acad Sci U S A (1987) 1.44
A cyclic 3',5'-amp-stimulated protein kinase from cardiac muscle. Adv Enzyme Regul (1970) 1.44
Separation of regulatory and catalytic subunits of the cyclic 3',5'-adenosine monophosphate-dependent protein kinase(s) of rabbit skeletal muscle. Biochem Biophys Res Commun (1971) 1.44