Published in Nature on October 29, 1971
Evidence for recycling of synaptic vesicle membrane during transmitter release at the frog neuromuscular junction. J Cell Biol (1973) 12.72
Acetylcholine receptor turnover in membranes of developing muscle fibers. J Cell Biol (1975) 4.02
Acetylcholine receptors of muscle grown in vitro. Proc Natl Acad Sci U S A (1972) 3.96
Quantitation of junctional and extrajunctional acetylcholine receptors by electron microscope autoradiography after 125I-alpha-bungarotoxin binding at mouse neuromuscular junctions. J Cell Biol (1976) 3.66
Muscarinic cholinergic binding in rat brain. Proc Natl Acad Sci U S A (1974) 3.35
Binding of -bungarotoxin to acetylcholine receptors in mammalian muscle (snake venom-denervated muscle-neonatal muscle-rat diaphragm-SDS-polyacrylamide gel electrophoresis). Proc Natl Acad Sci U S A (1972) 3.34
Development of acetylcholine receptor clusters on cultured muscle cells. Proc Natl Acad Sci U S A (1973) 2.71
Factors affecting the time course of decay of end-plate currents: a possible cooperative action of acetylcholine on receptors at the frog neuromuscular junction. J Physiol (1975) 2.68
Acetylcholine receptors. Distribution and extrajunctional density in rat diaphragm after denervation correlated with acetylcholine sensitivity. J Gen Physiol (1972) 2.66
Distribution of acetylcholine receptors at frog neuromuscular junctions with a discussion of some physiological implications. J Physiol (1978) 2.58
A physiological mechanism for Hebb's postulate of learning. Proc Natl Acad Sci U S A (1973) 2.39
Appearance of acetylcholine receptors during differentiation of a myogenic cell line. Proc Natl Acad Sci U S A (1972) 2.29
Miniature end-plate currents and potentials generated by quanta of acetylcholine in glycerol-treated toad sartorius fibres. J Physiol (1972) 2.24
Fluorescent staining of acetylcholine receptors in vertebrate skeletal muscle. J Physiol (1974) 2.20
Acetylcholine receptors in regenerating muscle accumulate at original synaptic sites in the absence of the nerve. J Cell Biol (1979) 2.19
The distribution of alpha-bungarotoxin binding sites of mammalian skeletal muscle developing in vivo. J Physiol (1977) 2.00
Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites. Proc Natl Acad Sci U S A (1975) 1.87
Loss of alpha-bungarotoxin from junctional and extrajunctional acetylcholine receptors in rat diaphragm muscle in vivo and in organ culture. J Physiol (1975) 1.87
Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions. Proc Natl Acad Sci U S A (1973) 1.82
The binding of tetrodotoxin and alpha-bungarotoxin to normal and denervated mammalian muscle. J Physiol (1974) 1.73
An upper limit to the number of sodium channels in frog skin epithelium. J Physiol (1973) 1.70
Denervation supersensitivity in skeletal muscle: analysis with a cloned cDNA probe. J Cell Biol (1984) 1.62
Increased extrajunctional acetylcholine sensitivity produced by chronic acetylcholine sensitivity produced by chronic post-synaptic neuromuscular blockade. J Physiol (1975) 1.59
The influence of basal lamina on the accumulation of acetylcholine receptors at synaptic sites in regenerating muscle. J Cell Biol (1984) 1.45
Synthesis of acetylcholine receptor by denervated rat diaphragm muscle. Proc Natl Acad Sci U S A (1975) 1.40
Formation of cholinergic synapses between dissociated sympathetic neurons and skeletal myotubes of the rat in cell culture. Proc Natl Acad Sci U S A (1975) 1.39
Localization of acetylcholine receptors during synaptogenesis in retina. Proc Natl Acad Sci U S A (1976) 1.38
Re-innervation of rat skeleton muscle in the presence of alpha-bungarotoxin. J Physiol (1975) 1.36
Quantitative simulation of endplate currents at neuromuscular junctions based on the reaction of acetylcholine with acetylcholine receptor and acetylcholinesterase. Biophys J (1979) 1.28
Induction and superinduction of serotonin N-acetyltransferase by adrenergic drugs and denervation in rat pineal organ. Proc Natl Acad Sci U S A (1972) 1.23
Two-component desensitization at the neuromuscular junction of the frog. J Physiol (1983) 1.22
Skeletal muscle denervation activates acetylcholine receptor genes. J Cell Biol (1989) 1.21
Anti-acetylcholine receptor antibodies. J Neurol Neurosurg Psychiatry (1980) 1.20
Synthesis of acetylcholine receptors by cultured chick myotubes and denervated mouse extensor digitorum longus muscles. Proc Natl Acad Sci U S A (1976) 1.19
The effect of alpha-bungarotoxin on acetylcholine receptors. Br J Pharmacol (1973) 1.19
Effects of chronic treatment with various neuromuscular blocking agents on the number and distribution of acetylcholine receptors in the rat diaphragm. J Physiol (1975) 1.18
beta-adrenergic receptors in rat liver: effects of adrenalectomy. Proc Natl Acad Sci U S A (1976) 1.16
Isolation and characterization of the mouse acetylcholine receptor delta subunit gene: identification of a 148-bp cis-acting region that confers myotube-specific expression. J Cell Biol (1988) 1.13
Effects of a snake alpha-neurotoxin on the development of innervated skeletal muscles in chick embryo. Proc Natl Acad Sci U S A (1973) 1.11
Stereochemistry of a curare alkaloid: O,O',N-trimethyl-d-tubocurarine. Proc Natl Acad Sci U S A (1972) 1.11
Uncoupling of in vivo torque production from EMG in mouse muscles injured by eccentric contractions. J Physiol (1999) 1.09
Substructure of amphibian motor end plate. Evidence for a granular component projecting from the outer surface of the receptive membrane. J Cell Biol (1974) 1.07
Acetylcholine receptors at neuromuscular synapses: phylogenetic differences detected by snake alpha-neurotoxins. Proc Natl Acad Sci U S A (1975) 1.07
N,O-di and N,N,O-tri ( 3 H) acetyl -bungarotoxins as specific labelling agents of cholinergic receptors. Br J Pharmacol (1973) 1.07
Density and distribution of alpha-bungarotoxin-binding sites in postsynaptic structures of regenerated rat skeletal muscle. J Cell Biol (1981) 1.02
Induction of transporting sites in a sodium transporting epithelium. J Physiol (1976) 1.01
Temperature and end-plate currents in rat diaphragm. J Physiol (1983) 0.99
In vitro analysis of the general properties and junctional receptor characteristics of skeletal muscle membranes. Isolation, purification, and partial characterization of sarcolemmal fragments. Proc Natl Acad Sci U S A (1974) 0.99
Cholinergic activity regulates muscarinic receptors in central nervous system cultures. Proc Natl Acad Sci U S A (1979) 0.98
Desensitization of the beta-adrenoceptor of lymphocytes from normal subjects and patients with phaeochromocytoma: studies in vivo. Br J Clin Pharmacol (1978) 0.97
Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis. Proc Natl Acad Sci U S A (1989) 0.95
Localization of acetylcholine receptors in central synapses. J Cell Biol (1977) 0.95
Presynaptic and postsynaptic effects of the venom of the Australian tiger snake at the neuromuscular junction. Br J Pharmacol (1973) 0.91
Muscarinic cholinergic receptors in murine lymphocytes: demonstration by direct binding. Proc Natl Acad Sci U S A (1978) 0.90
Sodium entry in rat diaphragm induced by depolarizing drugs. J Physiol (1977) 0.88
Selective effects of ascorbic acid on acetylcholine receptor number and distribution. J Cell Biol (1986) 0.88
Influence of chronic neostigmine treatment on the number of acetylcholine receptors and the release of acetylcholine from the rat diaphragm. J Physiol (1973) 0.87
Tunicamycin increases desensitization of acetylcholine receptors in cultured mouse muscle cells. Proc Natl Acad Sci U S A (1991) 0.86
Influence of SKF-525A congeners, strophanthidin and tissue-culture media on desensitization in frog skeletal muscle. Br J Pharmacol (1974) 0.86
Interaction of di-iodinated 125I-labelled alpha-bungarotoxin and reversible cholinergic ligands with intact synaptic acetylcholine receptors on isolated skeletal-muscle fibres from the rat. Biochem J (1979) 0.86
Desensitization to gamma-aminobutyric acid in crustacean muscle fibres. J Physiol (1976) 0.84
Acetylcholinesterase activity in intact and homogenized skeletal muscle of the frog. J Physiol (1984) 0.83
An autoradiographic analysis of [3H]alpha-bungarotoxin distribution in the rat brain after intraventricular injection. J Cell Biol (1976) 0.83
Studies on curare-like action of 2,2',2''-tripyridine in the mouse phrenic nerve-diaphragm. Br J Pharmacol (1992) 0.82
Contractile activity regulates isoform expression and polysialylation of NCAM in cultured myotubes: involvement of Ca2+ and protein kinase C. J Cell Biol (1996) 0.82
Acetylcholine-gated and chloride conductance channel expression in rat muscle membrane. J Physiol (1989) 0.81
Differential desensitization of functional adrenergic receptors in normal and malignant myeloid cells: relationship to receptor-mediated hormone cytotoxicity. Proc Natl Acad Sci U S A (1978) 0.81
Proceedings: Renal control of kidney growth. J Physiol (1974) 0.80
Desensitization in the innervated and in the chronically denervated soleus muscle of the mouse. Br J Pharmacol (1975) 0.80
beta-Bungarotoxin. Separation of two discrete proteins with different synaptic actions. Biochem J (1978) 0.79
Microtransplantation of acetylcholine receptors from normal or denervated rat skeletal muscles to frog oocytes. J Physiol (2011) 0.78
The effect of receptor desensitization on the action of alpha-bungaro-toxin on cultured skeletal muscle. Br J Pharmacol (1974) 0.77
Functional consequences of ligand-dependent conformational changes in trypsin-solubilized and in membrane particle constrained-acetylcholinesterase. Proc Natl Acad Sci U S A (1978) 0.76
The isolation of an acetylcholine- and decamethonium-binding protein from housefly heads. Biochem J (1972) 0.75
Cholinergic receptor sites in muscle. Nature (1971) 0.75
The decay of end-plate currents in neostigmine-treated frog muscle blocked by acetylcholine or tubocurarine. J Physiol (1980) 0.75
Possible involvement of parotid beta-adrenergic receptors in the etiology of sialadenosis. Arch Otorhinolaryngol (1981) 0.75
A molecular basis for learning and memory. Proc Natl Acad Sci U S A (1972) 0.75
Convulsant and possible anticholinergic actions of dendrotoxin in the amphibian spinal cord. Br J Pharmacol (1981) 0.75
The statistical nature of the acetycholine potential and its molecular components. J Physiol (1972) 13.95
A study of synaptic transmission in the absence of nerve impulses. J Physiol (1967) 9.73
The role of calcium in neuromuscular facilitation. J Physiol (1968) 9.35
Tetrodotoxin-resistant electric activity in presynaptic terminals. J Physiol (1969) 8.31
The release of acetylcholine from nerve endings by graded electric pulses. Proc R Soc Lond B Biol Sci (1967) 7.13
The binding of acetylcholine to receptors and its removal from the synaptic cleft. J Physiol (1973) 7.03
Tetrodotoxin and neuromuscular transmission. Proc R Soc Lond B Biol Sci (1967) 6.14
The effect of temperature on the synaptic delay at the neuromuscular junction. J Physiol (1965) 6.04
A calcium-dependent transient outward current in Xenopus laevis oocytes. Proc R Soc Lond B Biol Sci (1982) 5.60
The action of calcium on neuronal synapses in the squid. J Physiol (1966) 5.40
Cholinergic and catecholaminergic receptors in the Xenopus oocyte membrane. J Physiol (1982) 4.78
The timing of calcium action during neuromuscular transmission. J Physiol (1967) 4.72
Further observations on acetylcholine noise. Nat New Biol (1971) 4.46
Further study of the role of calcium in synaptic transmission. J Physiol (1970) 4.39
Chloride current induced by injection of calcium into Xenopus oocytes. J Physiol (1984) 4.04
Membrane noise produced by acetylcholine. Nature (1970) 3.80
Synthesis, storage and release of [14C]acetylcholine in isolated rat diaphragm muscles. J Physiol (1970) 3.80
Measurement of calcium transients in frog muscle by the use of arsenazo III. Proc R Soc Lond B Biol Sci (1977) 3.68
The characteristics of 'end-plate noise' produced by different depolarizing drugs. J Physiol (1973) 3.62
Tetanic and post-tetanic rise in frequency of miniature end-plate potentials in low-calcium solutions. J Physiol (1971) 3.54
Spontaneous and evoked activity of motor nerve endings in calcium Ringer. J Physiol (1969) 3.50
Transmitter release induced by injection of calcium ions into nerve terminals. Proc R Soc Lond B Biol Sci (1973) 3.49
Isolation of the cholinergic receptor protein of Torpedo electric tissue. Nature (1971) 3.36
Spontaneous synaptic potentials and quantal release of transmitter in the stellate ganglion of the squid. J Physiol (1967) 3.31
On the degeneration of rat neuromuscular junctions after nerve section. J Physiol (1970) 3.28
Release of acetylcholine from a nerve terminal by electric pulses of variable strength and duration. Nature (1965) 3.27
Transmitter leakage from motor nerve endings. Proc R Soc Lond B Biol Sci (1977) 3.03
Electrophysiology and electron-microscopy of rat neuromuscular junctions after nerve degeneration. Proc R Soc Lond B Biol Sci (1968) 2.90
Effects of lanthanum ions on function and structure of frog neuromuscular junctions. Proc R Soc Lond B Biol Sci (1971) 2.89
The effect of procaine on the action of acetylcholine at the neuromuscular junction. J Physiol (1975) 2.71
Strontium and quantal release of transmitter at the neuromuscular junction. J Physiol (1969) 2.60
Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells. J Biol Chem (1992) 2.57
Calcium transients evoked by action potentials in frog twitch muscle fibres. J Physiol (1982) 2.40
Messenger RNA from human brain induces drug- and voltage-operated channels in Xenopus oocytes. Nature (1984) 2.33
Electrophoresis of acetylcholine, choline and related compounds. Biochem Pharmacol (1967) 2.30
The effect of prolonged depolarization on synaptic transfer in the stellate ganglion of the squid. J Physiol (1971) 2.29
Modification of transmitter release by electrical interference with motor nerve endings. Proc R Soc Lond B Biol Sci (1967) 2.27
The effect of local blockage of motor nerve terminals. J Physiol (1968) 2.26
Changes in intracellular calcium and in membrane currents evoked by injection of inositol trisphosphate into Xenopus oocytes. Proc R Soc Lond B Biol Sci (1986) 2.20
Serotonin receptors induced by exogenous messenger RNA in Xenopus oocytes. Proc R Soc Lond B Biol Sci (1983) 2.17
The effect of type D botulinum toxin on frog neuromuscular junctions. J Physiol (1971) 2.15
Post-tetanic increase in frequency of miniature end-plate potentials in calcium-free solutions. J Physiol (1967) 2.14
A re-examination of curare action at the motor endplate. Proc R Soc Lond B Biol Sci (1978) 2.05
Choline acetyltransferase from rat brain. J Biol Chem (1968) 1.94
Acetylcholine receptors in the oocyte membrane. Nature (1978) 1.93
Estimates of quantal content during 'chemical potentiation' of transmitter release. Proc R Soc Lond B Biol Sci (1979) 1.92
Calcium conductance of acetylcholine-induced endplate channels. Nature (1979) 1.90
Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes. Proc R Soc Lond B Biol Sci (1982) 1.87
Characteristics of transmitter release at regenerating frog neuromuscular junctions. J Physiol (1974) 1.83
Transmitter induced calcium entry across the post-synaptic membrane at frog end-plates measured using arsenazo III. J Physiol (1980) 1.83
Glutamate and kainate receptors induced by rat brain messenger RNA in Xenopus oocytes. Proc R Soc Lond B Biol Sci (1984) 1.81
Electron-microscopic structure of denervated skeletal muscle. Proc R Soc Lond B Biol Sci (1969) 1.78
A radiometric microassay of acetylcholinesterase. J Pharmacol Exp Ther (1967) 1.73
Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory. Proc Natl Acad Sci U S A (2006) 1.71
Sensitivity to acetylcholine in rat slow muscle. Nature (1966) 1.69
Calcium transients recorded with arsenazo III in the presynaptic terminal of the squid giant synapse. Proc R Soc Lond B Biol Sci (1981) 1.68
Ultrastructure of isolated membranes of Torpedo electric tissue. Brain Res (1973) 1.68
Single glutamate-activated channels recorded from locust muscle fibres with perfused patch-clamp electrodes. J Physiol (1981) 1.62
Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc Natl Acad Sci U S A (1998) 1.61
Effects of membrane polarization on sarcoplasmic calcium release in skeletal muscle. Proc R Soc Lond B Biol Sci (1981) 1.55
Incorporation of acetylcholine receptors and Cl- channels in Xenopus oocytes injected with Torpedo electroplaque membranes. Proc Natl Acad Sci U S A (1995) 1.53
Calcium transients studied under voltage-clamp control in frog twitch muscle fibres. J Physiol (1983) 1.52
Transmitter action in the giant synapse of the squid. Nature (1969) 1.50
Expression of mammalian gamma-aminobutyric acid receptors with distinct pharmacology in Xenopus oocytes. Proc Natl Acad Sci U S A (1991) 1.50
Properties of acetylcholine receptors translated by cat muscle mRNA in Xenopus oocytes. EMBO J (1982) 1.50
Structural and functional changes of frog neuromuscular junctions in high calcium solutions. Proc R Soc Lond B Biol Sci (1971) 1.50
The antagonism between botulinum toxin and calcium in motor nerve terminals. Proc R Soc Lond B Biol Sci (1982) 1.47
The effect of atropine on acetylcholine action at the neuromuscular junction. Proc R Soc Lond B Biol Sci (1973) 1.46
Glutamate receptor-mediated toxicity in optic nerve oligodendrocytes. Proc Natl Acad Sci U S A (1997) 1.45
Threonine-for-leucine mutation within domain M2 of the neuronal alpha(7) nicotinic receptor converts 5-hydroxytryptamine from antagonist to agonist. Proc Natl Acad Sci U S A (1996) 1.44
Induction of the action potential mechanism in slow muscle fibres of the frog. J Physiol (1971) 1.42
Non-transmitting neuromuscular junctions during an early stage of end-plate reinnervation. J Physiol (1974) 1.42
End-plate currents and acetylcholine noise at normal and myasthenic human end-plates. J Physiol (1979) 1.42
Lack of correspondence between the amplitudes of spontaneous potentials and unit potentials evoked by nerve impulses at regenerating neuromuscular junctions. Nat New Biol (1971) 1.41
A serum factor that activates the phosphatidylinositol phosphate signaling system in Xenopus oocytes. Proc Natl Acad Sci U S A (1990) 1.40
Lysophosphatidic acid-induced neurite retraction in PC12 cells: control by phosphoinositide-Ca2+ signaling and Rho. J Neurochem (1996) 1.40
Uptake of propranolol by isolated guinea-pig atria. J Pharmacol Exp Ther (1967) 1.39
Glutamate current noise: post-synaptic channel kinetics investigated under voltage clamp. J Physiol (1978) 1.38
Purification and properties of choline acetyltransferase from ox brain striate nuclei. J Neurochem (1971) 1.37
Isolation and characterization of presynaptically acting neurotoxins from the venom of Bungarus snakes. Eur J Biochem (1977) 1.36
Lanthanum ions abolish the "calcium response" of nerve terminals. Nature (1971) 1.35
On the release of transmitter at normal, myasthenia gravis and myasthenic syndrome affected human end-plates. J Physiol (1980) 1.34
Design and in vitro pharmacology of a selective gamma-aminobutyric acidC receptor antagonist. Mol Pharmacol (1996) 1.33
A calcium-independent chloride current activated by hyperpolarization in Xenopus oocytes. Proc R Soc Lond B Biol Sci (1988) 1.33
Intracellular calcium and desensitization of acetylcholine receptors. Proc R Soc Lond B Biol Sci (1980) 1.33
Calcium transients in frog skeletal muscle fibres following conditioning stimuli. J Physiol (1983) 1.32
Calcium transients in mammalian muscles. Nature (1980) 1.32
Electrical synapses between motoneurons in the spinal cord of the newborn rat. Proc R Soc Lond B Biol Sci (1980) 1.30
Glutamate and quisqualate noise in voltage-clamped locust muscle fibres. Nature (1976) 1.29
Injection of inositol 1,3,4,5-tetrakisphosphate into Xenopus oocytes generates a chloride current dependent upon intracellular calcium. Proc R Soc Lond B Biol Sci (1987) 1.29
A monovalent cationic conductance that is blocked by extracellular divalent cations in Xenopus oocytes. J Physiol (1995) 1.28
A study of frog muscle maintained in organ culture. J Physiol (1972) 1.27
Partial purification and functional expression of brain mRNAs coding for neurotransmitter receptors and voltage-operated channels. Proc Natl Acad Sci U S A (1984) 1.27
Heterogeneity of glycine receptors and their messenger RNAs in rat brain and spinal cord. Science (1988) 1.27
Lysophosphatidic acid possesses dual action in cell proliferation. Proc Natl Acad Sci U S A (1994) 1.27
A transient inward current elicited by hyperpolarization during serotonin activation in Xenopus oocytes. Proc R Soc Lond B Biol Sci (1985) 1.27
Loss of M2 muscarine receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science (1985) 1.26
Suppression of transmitter release at the neuromuscular junction. Proc R Soc Lond B Biol Sci (1977) 1.26