Published in N Engl J Med on January 20, 1972
Cytochalasin B: effect on lysosomal enzyme release from human leukocytes. Proc Natl Acad Sci U S A (1973) 3.63
Prostaglandin-stimulated bone resorption by rheumatoid synovia. A possible mechanism for bone destruction in rheumatoid arthritis. J Clin Invest (1975) 3.24
Mechanisms of lysosomal enzyme release from human leukocytes. I. Effect of cyclic nucleotides and colchicine. J Cell Biol (1973) 2.33
Experimental Mycoplasma pulmonis infection in pathogen-free mice. Models for studying mycoplasmosis of the respiratory tract. Am J Pathol (1973) 2.14
Acute inflammation. A review. Am J Pathol (1977) 2.06
Auto-oxidative damage in Behçet's disease--endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Clin Exp Immunol (1982) 1.29
Neutral proteases and cathepsin D in human articular cartilage. J Clin Invest (1974) 1.10
Immunomodulatory effects of granulocyte and monocyte adsorption apheresis as a treatment for patients with ulcerative colitis. Dig Dis Sci (2002) 1.09
Inhibition of cartilage breakdown by hydrocortisone in a tissue culture model of rheumatoid arthritis. Ann Rheum Dis (1983) 1.09
Leucocyte infiltration and cartilage proteoglycan loss in immune arthritis in the rabbit. Br J Pharmacol (1988) 1.08
Attacking the multi-tiered proteolytic pathology of COPD: new insights from basic and translational studies. Pharmacol Ther (2008) 0.99
Stimulating effect of neutral proteases on cells in vitro. Agents Actions (1976) 0.88
Comparison of serial synovial fluid cytology in rheumatoid arthritis: delineation of subgroups with prognostic implications. Ann Rheum Dis (1988) 0.84
Complement activating properties of complexes containing rheumatoid factor in synovial fluids and sera from patients with rheumatoid arthritis. Clin Exp Immunol (1985) 0.83
Anti-inflammatory effect of granulocyte and monocyte adsorption apheresis in a rabbit model of immune arthritis. Inflammation (2002) 0.81
Enhancement of in vitro immunoglobulin synthesis of human lymphocytes by lysosomal enzymes from polymorphonuclear leucocytes. Clin Exp Immunol (1977) 0.81
Synovial fluid beta 2 microglobulin and hydroxyproline fractions in rheumatoid arthritis and nonautoimmune arthropathies. Ann Rheum Dis (1980) 0.81
Value of colonoscopy for prediction of prognosis in patients with ulcerative colitis. World J Gastroenterol (2008) 0.80
The biology of the rheumatoid synovial cell. West J Med (1977) 0.80
Therapeutic alteration of immune responses in rheumatoid arthritis: is it relevant? J R Soc Med (1978) 0.79
Inhibition of human neutrophils by auranofin: chemotaxis and metabolism of arachidonate via the 5-lipoxygenase pathway. Ann Rheum Dis (1989) 0.78
Efficacy of Bacopa monniera (L.) Wettst in alleviating lysosomal instability in adjuvant-induced arthritis in rats. Inflammation (2011) 0.77
Xanthones from Securidaca inappendiculata exert significant therapeutic efficacy on adjuvant-induced arthritis in mice. Inflammation (2014) 0.77
Dextran sulphate induced arthritis in rabbits. Ann Rheum Dis (1980) 0.76
Hydrolysis of the elastase substrate succinyltrialanine nitroanilide by a metal-dependent enzyme in rheumatoid synovial fluid. J Clin Invest (1977) 0.75
Identification of a myeloperoxidase inhibitor from normal human serum. Clin Exp Immunol (1991) 0.75
Adjuvant-induced inflammatory disease in the rat: plasma levels of peptide hydrolases and protease inhibitors reflect disease activity. Agents Actions (1979) 0.75
Lack of hidden complement fixing IgM rheumatoid factor in adult seronegative rheumatoid arthritis. Ann Rheum Dis (1980) 0.75
Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis. J Clin Invest (1975) 6.25
Mechanisms of lysosomal enzyme release from human leukocytes: microtubule assembly and membrane fusion induced by a component of complement. Proc Natl Acad Sci U S A (1973) 4.58
Studies on lysosomes. XI. Characterization of a hydrolase-rich fraction from human lymphocytes. J Cell Biol (1968) 4.22
Effect of cyclic AMP on release of lysosomal enzymes from phagocytes. Nat New Biol (1971) 4.09
Mechanisms of lysosomal enzyme release from human leukocytes. II. Effects of cAMP and cGMP, autonomic agonists, and agents which affect microtubule function. J Clin Invest (1974) 3.65
Cytochalasin B: effect on lysosomal enzyme release from human leukocytes. Proc Natl Acad Sci U S A (1973) 3.63
Mechanisms of lysosomal enzyme release from leukocytes exposed to immune complexes and other particles. J Exp Med (1971) 3.38
Release of inflammatory mediators from stimulated neutrophils. N Engl J Med (1980) 3.35
Calcium-induced lysozyme secretion from human polymorphonuclear leukocytes. Biochem Biophys Res Commun (1974) 3.24
A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Proc Natl Acad Sci U S A (1992) 2.79
Lysosomal enzyme release from human leukocytes: mediation by the alternate pathway of complement activation. J Immunol (1973) 2.66
Lysosome. N Engl J Med (1965) 2.49
Changes in membrane potential of human granulocytes antecede the metabolic responses to surface stimulation. Proc Natl Acad Sci U S A (1978) 2.33
Mechanisms of lysosomal enzyme release from human leukocytes. I. Effect of cyclic nucleotides and colchicine. J Cell Biol (1973) 2.33
Interaction of alytic polypeptide, melittin, with lipid membrane systems. J Biol Chem (1969) 2.31
Effect of cyclic 3',5'-adenosine monophosphate and theophylline on lymphocyte transformation. Proc Soc Exp Biol Med (1970) 2.30
Tumor necrosis factor provokes superoxide anion generation from neutrophils. Biochem Biophys Res Commun (1986) 2.27
Leukocytic proteases and the immunologic release of lysosomal enzymes. Am J Pathol (1972) 2.26
Adenosine: a physiological modulator of superoxide anion generation by human neutrophils. J Exp Med (1983) 2.18
Potassium and amino acid transport in human leukocytes exposed to phagocytic stimuli. J Cell Biol (1974) 2.16
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest (1973) 2.16
The action of steroids and streptolysin S on the permeability of phospholipid structures to cations. J Mol Biol (1965) 2.10
Concanavalin A induces microtubule assembly and specific granule discharge in human polymorphonuclear leukocytes. J Cell Biol (1976) 2.08
Generation of C5-derived lysosomal enzyme-releasing activity (C5a) by lysates of leukocyte lysosomes. J Immunol (1974) 2.02
Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem Biophys Res Commun (1982) 2.02
Breakdown of cartilage proteinpolysaccharide by lysosomes. Arthritis Rheum (1968) 1.99
Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils. J Immunol (1985) 1.96
Lysosomes and joint disease. Arthritis Rheum (1966) 1.90
Phospholipid spherules (liposomes) as a model for biological membranes. J Lipid Res (1968) 1.89
Mechanisms of lysosomal enzyme release from human polymorphonuclear leukocytes. Effects of phorbol myristate acetate. J Cell Biol (1975) 1.87
Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors. J Immunol (1992) 1.84
Stimulus response coupling in the human neutrophil. II. Temporal analysis of changes in cytosolic calcium and calcium efflux. J Biol Chem (1984) 1.84
Ceruloplasmin. A scavenger of superoxide anion radicals. J Biol Chem (1979) 1.84
The adhesion molecules of inflammation. Arthritis Rheum (1993) 1.83
The role of lysosomes in inflammation and disease. Annu Rev Med (1967) 1.76
Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells. J Clin Invest (1986) 1.76
A general method for the introduction of enzymes, by means of immunoglobulin-coated liposomes, into lysosomes of deficient cells. Proc Natl Acad Sci U S A (1975) 1.76
Degranulation, membrane addition, and shape change during chemotactic factor-induced aggregation of human neutrophils. J Cell Biol (1982) 1.75
Carboxyl methylation of Ras-related proteins during signal transduction in neutrophils. Science (1993) 1.72
Role of microtubule assembly in lysosomal enzyme secretion from human polymorphonuclear leukocytes. A reevaluation. J Cell Biol (1977) 1.69
Leukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis. Biochem Biophys Res Commun (1982) 1.69
Reciprocal effects of cAMP and cGMP on microtubule-dependent release of lysosomal enzymes. Ann N Y Acad Sci (1975) 1.68
The action of polyene antibiotics on phospholipid-cholesterol structures. J Biol Chem (1967) 1.67
The roles of extracellular and intracellular calcium in lysosomal enzyme release and superoxide anion generation by human neutrophils. Biochim Biophys Acta (1981) 1.65
Crystal deposition disease. Diagnosis by electron microscopy. Am J Med (1977) 1.63
The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthritis Rheum (1989) 1.63
Incorporation of lysozyme into liposomes. A model for structure-linked latency. J Biol Chem (1970) 1.62
Sudden blindness in acute pancreatitis. Possible role of complement-induced retinal leukoembolization. Arch Intern Med (1981) 1.62
Molecular basis of gouty inflammation: interaction of monosodium urate crystals with lysosomes and liposomes. Nat New Biol (1972) 1.59
Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes. J Biol Chem (1981) 1.59
Studies on lysosomes. XII. Redistribution of acid hydrolases in human lymphocytes stimulated by phytohemagglutinin. J Cell Biol (1968) 1.58
Thromboxane generation by human peripheral blood polymorphonuclear leukocytes. J Exp Med (1978) 1.57
Dissociation between increased surface expression of gp165/95 and homotypic neutrophil aggregation. J Immunol (1988) 1.56
Arthritis induced in rabbits by lysates of granulocyte lysosomes. Arthritis Rheum (1969) 1.55
Stimulus response coupling in the human neutrophil. I. Kinetic analysis of changes in calcium permeability. J Biol Chem (1984) 1.52
C-reactive protein in systemic lupus erythematosus. Arthritis Rheum (1977) 1.52
The role of lysosomes in immune responses. Adv Immunol (1970) 1.47
Characterization of a neutral protease from lysosomes of rabbit polymorphonuclear leucocytes. Biochem J (1971) 1.45
Effects of indomethacin, 5,8,11,14-eicosatetraynoic acid, and p-bromophenacyl bromide on lysosomal enzyme release and superoxide anion generation by human polymorphonuclear leukocytes. Biochem Pharmacol (1980) 1.44
Enhancement of nitroblue tetrazolium dye reduction by leukocytes exposed to a component of complement in the absence of phagocytosis. J Immunol (1975) 1.43
Influence of divalent cations upon complement-mediated enzyme release from human polymorphonuclear leukocytes. J Immunol (1975) 1.43
Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways. Proc Natl Acad Sci U S A (1991) 1.43
Up-regulation of the iC3b receptor (CR3) is neither necessary nor sufficient to promote neutrophil aggregation. J Clin Invest (1988) 1.42
Influence of local anesthetics upon human polymorphonuclear leukocyte function in vitro. Reduction of lysosomal enzyme release and superoxide anion production. J Exp Med (1977) 1.36
Increased levels of cyclic adenosine-3',5'-monophosphate in human polymorphonuclear leukocytes after surface stimulation. J Clin Invest (1980) 1.36
Salicylates and sulfasalazine, but not glucocorticoids, inhibit leukocyte accumulation by an adenosine-dependent mechanism that is independent of inhibition of prostaglandin synthesis and p105 of NFkappaB. Proc Natl Acad Sci U S A (1999) 1.36
Stimulus-response coupling in the human neutrophil. Transmembrane potential and the role of extracellular Na+. Biochim Biophys Acta (1980) 1.35
Appearance of hydrolase rich granules in human lymphocytes induced by phytohemagglutinin and antigens. Blood (1967) 1.35
Increased levels of plasma anaphylatoxins in systemic lupus erythematosus predict flares of the disease and may elicit vascular injury in lupus cerebritis. Arthritis Rheum (1988) 1.34
Colloidal lanthanum as a marker for impaired plasma membrane permeability in ischemic dog myocardium. Am J Pathol (1975) 1.33
Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions. J Immunol (1990) 1.32
Staphylococcal alpha-toxin: effects on artificial lipid spherules. Science (1966) 1.32
Template activity of nuclei from stimulated lymphocytes. Nature (1969) 1.31
Membrane perturbation: studies employing a calcium-sensitive dye, arsenazo III, in liposomes. Proc Natl Acad Sci U S A (1976) 1.31
Effects of four components of the polyene antibiotic, filipin, on phospholipid spherules (liposomes) and erythrocytes. J Biol Chem (1968) 1.31
Yin/Yang modulation of lysosomal enzyme release from polymorphonuclear leukocytes by cyclic nucleotides. Ann N Y Acad Sci (1975) 1.29
Anion channel blockers inhibit lysosomal enzyme secretion from human neutrophils without affecting generation of superoxide anion. Proc Natl Acad Sci U S A (1980) 1.25
Effects of protein I of Neisseria gonorrhoeae on neutrophil activation: generation of diacylglycerol from phosphatidylcholine via a specific phospholipase C is associated with exocytosis. J Cell Biol (1991) 1.24
Granulocytes without degranulation: neutrophil function in granule-depleted cytoplasts. Proc Natl Acad Sci U S A (1983) 1.22
Superoxide anion generation by human neutrophils exposed to monosodium urate. Arthritis Rheum (1982) 1.22
The mode of action of aspirin-like drugs: effect on inducible nitric oxide synthase. Proc Natl Acad Sci U S A (1995) 1.22
Surface expression of Gp 165/95, the complement receptor CR3, as a marker of disease activity in systemic Lupus erythematosus. Clin Immunol Immunopathol (1988) 1.21
Mg2+-ATPase as a membrane ecto-enzyme of human granulocytes. Inhibitors, activators and response to phagocytosis. Biochim Biophys Acta (1978) 1.21
Mechanisms of lysosomal enzyme release from human leucocytes. III. Quantitative morphologic evidence for an effect of cyclic nucleotides and colchicine on degranulation. Clin Immunol Immunopathol (1974) 1.20
Lysosomes. N Engl J Med (1965) 1.19
Modes of action of aspirin-like drugs. Proc Natl Acad Sci U S A (1985) 1.18
Adenosine promotes neutrophil chemotaxis. J Exp Med (1988) 1.18
Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion. Proc Natl Acad Sci U S A (1998) 1.17
Microfilaments and microtubules in calcium ionophore-induced secretion of lysosomal enzymes from human polymorphonuclear leukocytes. J Cell Biol (1978) 1.17
Activation of neutrophils and the lesions of rheumatoid arthritis. J Lab Clin Med (1982) 1.16
A carbocyanine dye, DiOC6(3), acts as a mitochondrial probe in human neutrophils. Biochem Biophys Res Commun (1982) 1.16
Subcellular distribution of neutral protease and peptidases in rabbit polymorphonuclear leucocytes. Nature (1970) 1.16
Prostaglandins and inflammation: receptor/cyclase coupling as an explanation of why PGEs and PGI2 inhibit functions of inflammatory cells. Adv Prostaglandin Thromboxane Res (1980) 1.14
Cytochemical localization of lysosomal enzyme activity in normal and ischemic dog myocardium. Am J Pathol (1975) 1.14
Mechanisms of lysosomal enzyme release from leukocytes. IV. Interaction of monosodium urate crystals with dogfish and human leukocytes. Arthritis Rheum (1975) 1.14
Colchicine alters the quantitative and qualitative display of selectins on endothelial cells and neutrophils. J Clin Invest (1995) 1.13
Activation of the human neutrophil by calcium-mobilizing ligands. II. Correlation of calcium, diacyl glycerol, and phosphatidic acid generation with superoxide anion generation. J Biol Chem (1988) 1.13
Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization. Biochem J (1988) 1.12
Neutrophil stimulation: receptor, membrane, and metabolic events. Fed Proc (1984) 1.12
Endogenous phospholipid metabolism in stimulated neutrophils differential activation by FMLP and PMA. Biochem Biophys Res Commun (1982) 1.12