Published in N Engl J Med on September 27, 1973
Antigenic variants of herpes simplex virus selected with glycoprotein-specific monoclonal antibodies. J Virol (1983) 4.04
Rapid detection and identification of herpes simplex virus in cell culture by a direct immunoperoxidase staining procedure. J Clin Microbiol (1983) 2.46
Natural killing of herpes simplex virus type 1-infected target cells: normal human responses and influence of antiviral antibody. Infect Immun (1979) 1.94
Prevalence of antibodies to herpes simplex virus types 1 and 2 in pregnant women, and estimated rates of infection. J Epidemiol Community Health (1989) 1.92
Rapid typing of herpes simplex virus strains using the indirect immunoperoxidase method. Appl Microbiol (1974) 1.75
Identification and typing of herpes simplex viruses with monoclonal antibodies. J Clin Microbiol (1982) 1.68
Comparison of risk factors for four sexually transmitted infections: results from a study of attenders at three genitourinary medicine clinics in England. Sex Transm Infect (2000) 1.64
Differences in attachment between herpes simplex type 1 and type 2 viruses to neurons and glial cells. Infect Immun (1980) 1.53
Cellular immunity to herpes simplex virus mediated by interferon. J Exp Med (1974) 1.52
Genital herpesvirus hominis infection in mice. I. Development of an experimental model. Infect Immun (1975) 1.41
Role of macrophages in hepatitis induced by Herpes simplex virus types 1 and 2 in mice. Infect Immun (1977) 1.35
Clinical evaluation of commercial conjugates for direct immunofluorescence of herpes simplex virus. J Clin Microbiol (1977) 1.31
Passive immunization in experimental Herpesvirus hominis infection of newborn mice. Infect Immun (1975) 1.31
Immune interferon production by lymphoid cells: role in the inhibition of herpesviruses. Infect Immun (1976) 1.29
Type specificity of complement-fixing antibody against herpes simplex virus type 2 AG-4 early antigen in patients with asymptomatic infection. J Clin Microbiol (1986) 1.19
Herpes simplex virus latency in isolated human neurons. Proc Natl Acad Sci U S A (1984) 1.18
Herpes simplex type 2 encephalitis concurrent with known cerebral metastases. Acta Neuropathol (1979) 1.13
Immune response to herpes simplex virus infections: virus-specific antibodies in sera from patients with recurrent facial infections. Infect Immun (1981) 1.11
Typing of herpes simplex virus with type-specific human immunoglobulin M in an indirect immunofluorescence assay. J Clin Microbiol (1982) 1.05
Human antibody response to herpes simplex virus-specific polypeptides after primary and recurrent infection. J Clin Microbiol (1986) 0.94
Detection of herpes simplex virus type 1, 2 and varicella zoster virus DNA in recipient corneal buttons. Br J Ophthalmol (2000) 0.94
Detection of asymptomatic herpes simplex virus infections after vaccination. J Virol (1987) 0.93
Herpes simplex virus-specific serum immunoglobulin a: detection in patients with primary or recurrent herpes infections and in healthy adults. Infect Immun (1982) 0.93
Recovery of mice from herpes simplex virus type 2 hepatitis: adoptive transfer of recovery with immune spleen cells. Infect Immun (1981) 0.91
Herpes simplex virus, type 1 invasion of the rabbit and mouse nervous systems revealed by in situ hybridization. Acta Neuropathol (1987) 0.91
Serum antibodies to herpes simplex virus type 1 during active oral herpes infection. Infect Immun (1980) 0.90
Beneficial effects of human viruses. Yale J Biol Med (1981) 0.89
Immune responses to herpes simplex virus in patients with recurrent herpes labialis: I. Development of cell-mediated cytotoxic responses. Clin Exp Immunol (1986) 0.88
Immune responses in mice against herpes simplex virus: mechanisms of protection against facial and ganglionic infections. Infect Immun (1981) 0.88
Systemic immunity in herpetic keratitis. Br J Ophthalmol (1981) 0.86
Discrimination of herpes simplex virus types 1 and 2 cerebral infections in a rat model. Acta Neuropathol (1991) 0.83
Humoral immune response to herpes simplex virus type 2 glycoproteins in patients receiving a glycoprotein subunit vaccine. J Virol (1985) 0.83
X-linked resistance of mice to high doses of herpes simplex virus type 2 correlates with early interferon production. Infect Immun (1983) 0.81
Efficacy of oral administration of live herpes simplex virus type 1 as a vaccine. J Virol (1992) 0.80
Herpes simplex keratitis in renal transplant recipients. Can Med Assoc J (1981) 0.80
Identification and typing of herpes simplex virus by enzyme immunoassay with monoclonal antibodies. J Clin Microbiol (1984) 0.80
Mechanisms of photodynamic inactivation of herpes simplex viruses: comparison between methylene blue, light plus electricity, and hematoporhyrin plus light. J Clin Invest (1980) 0.79
Neurological involvement in mice after infection with a cold-adapted herpes simplex type 2 virus. Infect Immun (1982) 0.78
Endogenous dissemination of genital Herpesvirus hominis type 2 to the eye. Br J Ophthalmol (1980) 0.78
Radiculomyelopathy associated with herpes simplex genitalis treated with adenosine arabinoside. Postgrad Med J (1983) 0.77
Herpesvirus hominis infection in pregnancy. Proc R Soc Med (1975) 0.75
Antiviral activity of PHA767491 against human herpes simplex virus in vitro and in vivo. BMC Infect Dis (2017) 0.75
Herpes simplex virus meningitis complicated by ascending paralysis. Proc (Bayl Univ Med Cent) (2013) 0.75
Seroepidemiological study of infectious mononucleosis in older patients. J Clin Microbiol (1989) 0.75
Herpes simplex virus and the nervous system. Postgrad Med J (1984) 0.75
Characterization of herpes simplex virus strains differing in their effects on social behaviour of infected cells. J Gen Virol (1968) 26.67
Regulation of herpesvirus macromolecular synthesis. I. Cascade regulation of the synthesis of three groups of viral proteins. J Virol (1974) 26.25
Proteins specified by herpes simplex virus. V. Purification and structural proteins of the herpesvirion. J Virol (1972) 17.28
Size, composition, and structure of the deoxyribonucleic acid of herpes simplex virus subtypes 1 and 2. J Virol (1971) 17.07
Proteins specified by herpes simplex virus. XII. The virion polypeptides of type 1 strains. J Virol (1974) 16.33
Proteins specified by herpes simplex virus. XI. Identification and relative molar rates of synthesis of structural and nonstructural herpes virus polypeptides in the infected cell. J Virol (1973) 12.48
Proteins specified by herpes simplex virus. 8. Characterization and composition of multiple capsid forms of subtypes 1 and 2. J Virol (1972) 11.71
Regulation of alpha genes of herpes simplex virus: expression of chimeric genes produced by fusion of thymidine kinase with alpha gene promoters. Cell (1981) 11.62
Regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. Proc Natl Acad Sci U S A (1975) 11.52
Anatomy of herpes simplex virus (HSV) DNA. X. Mapping of viral genes by analysis of polypeptides and functions specified by HSV-1 X HSV-2 recombinants. J Virol (1978) 11.19
Anatomy of herpes simplex virus DNA: evidence for four populations of molecules that differ in the relative orientations of their long and short components. Proc Natl Acad Sci U S A (1975) 10.59
Anatomy of herpes simplex virus DNA. II. Size, composition, and arrangement of inverted terminal repetitions. J Virol (1975) 9.49
A generalized technique for deletion of specific genes in large genomes: alpha gene 22 of herpes simplex virus 1 is not essential for growth. Cell (1981) 8.56
Characterization of the herpes simplex virion-associated factor responsible for the induction of alpha genes. J Virol (1983) 8.31
Regulation of herpesvirus macromolecular synthesis. V. Properties of alpha polypeptides made in HSV-1 and HSV-2 infected cells. Virology (1977) 8.24
Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells. J Virol (1979) 8.05
Preparation of herpes simplex virus of high titer. J Virol (1968) 7.64
Herpes simplex virus type 2 in the United States, 1976 to 1994. N Engl J Med (1997) 7.59
Structural features of the herpes simplex virus alpha gene 4, 0, and 27 promoter-regulatory sequences which confer alpha regulation on chimeric thymidine kinase genes. J Virol (1982) 7.35
The structure and isomerization of herpes simplex virus genomes. Cell (1979) 6.79
Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture. Science (1990) 6.70
Cloning of reiterated and nonreiterated herpes simplex virus 1 sequences as BamHI fragments. Proc Natl Acad Sci U S A (1980) 6.66
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc Natl Acad Sci U S A (1997) 6.08
Anatomy of herpes simplex virus DNA. IX. Apparent exclusion of some parental DNA arrangements in the generation of intertypic (HSV-1 X HSV-2) recombinants. J Virol (1977) 5.98
Regulation of herpesvirus macromolecular synthesis: nuclear retention of nontranslated viral RNA sequences. Proc Natl Acad Sci U S A (1974) 5.96
Ampicillin-resistant Haemophilus influenzae type B infection. JAMA (1974) 5.90
Proteins specified by herpes simplex virus. Staining and radiolabeling properties of B capsid and virion proteins in polyacrylamide gels. J Virol (1974) 5.74
Herpes simplex virus phosphoproteins. I. Phosphate cycles on and off some viral polypeptides and can alter their affinity for DNA. J Virol (1980) 5.69
Anatomy of herpes simplex virus DNA VII. alpha-RNA is homologous to noncontiguous sites in both the L and S components of viral DNA. J Virol (1977) 5.31
Genetic relatedness of type 1 and type 2 herpes simplex viruses. J Virol (1972) 5.11
Association of antigenic type of Herpesvirus hominis with site of viral recovery. J Immunol (1967) 5.07
Ribonucleic acid synthesis in cells infected with herpes simplex virus: controls of transcription and of RNA abundance. Proc Natl Acad Sci U S A (1972) 5.02
Proteins specified by herpes simplex virus. 3. Viruses differing in their effects on the social behavior of infected cells specify different membrane glycoproteins. Proc Natl Acad Sci U S A (1970) 4.97
Similarities and Differences in the Development of Laboratory Strains and Freshly Isolated Strains of Herpes Simplex Virus in HEp-2 Cells: Electron Microscopy. J Virol (1969) 4.94
The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells. Proc Natl Acad Sci U S A (1992) 4.90
Differentiation between alpha promoter and regulator regions of herpes simplex virus 1: the functional domains and sequence of a movable alpha regulator. Proc Natl Acad Sci U S A (1982) 4.84
Anatomy of herpes simplex virus DNA: strain differences and heterogeneity in the locations of restriction endonuclease cleavage sites. Proc Natl Acad Sci U S A (1975) 4.79
Regulation of herpesvirus macromolecular synthesis: transcription-initiation sites and domains of alpha genes. Proc Natl Acad Sci U S A (1980) 4.75
Proteins specified by herpes simplex virus. VI. Viral proteins in the plasma membrane. J Virol (1972) 4.57
Molecular engineering of the herpes simplex virus genome: insertion of a second L-S junction into the genome causes additional genome inversions. Cell (1980) 4.47
Herpes simplex virus infections. Lancet (2001) 4.41
Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med (1986) 4.37
Characterization of herpes simplex virus 1 alpha proteins 0, 4, and 27 with monoclonal antibodies. J Virol (1984) 4.37
Structure and role of the herpes simplex virus DNA termini in inversion, circularization and generation of virion DNA. Cell (1982) 4.36
Molecular genetics of herpes simplex virus: demonstration of regions of obligatory and nonobligatory identity within diploid regions of the genome by sequence replacement and insertion. Proc Natl Acad Sci U S A (1978) 4.31
Herpes simplex virus 1 alpha regulatory protein ICP0 interacts with and stabilizes the cell cycle regulator cyclin D3. J Virol (1997) 4.26
Polysomes and protein synthesis in cells infected with a DNA virus. Science (1966) 4.21
Anatomy of herpes simplex virus DNA. III. Characterization of defective DNA molecules and biological properties of virus populations containing them. J Virol (1975) 4.19
Herpes simplex virus 1 mutant deleted in the alpha 22 gene: growth and gene expression in permissive and restrictive cells and establishment of latency in mice. J Virol (1985) 4.17
Entry of herpes simplex virus 1 in BJ cells that constitutively express viral glycoprotein D is by endocytosis and results in degradation of the virus. J Virol (1988) 4.11
Separation of sequences defining basal expression from those conferring alpha gene recognition within the regulatory domains of herpes simplex virus 1 alpha genes. Proc Natl Acad Sci U S A (1984) 4.05
The promoter, transcriptional unit, and coding sequence of herpes simplex virus 1 family 35 proteins are contained within and in frame with the UL26 open reading frame. J Virol (1991) 4.01
Herpes vimplex virus: genome size and redundancy studied by renaturation kinetics. J Virol (1971) 3.92
Infection with herpes-simplex viruses 1 and 2. 3. N Engl J Med (1973) 3.89
Prior herpes simplex virus type 2 infection as a risk factor for HIV infection. JAMA (1988) 3.89
Binding of the virion protein mediating alpha gene induction in herpes simplex virus 1-infected cells to its cis site requires cellular proteins. Proc Natl Acad Sci U S A (1987) 3.87
The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate. J Virol (1991) 3.80
Processing of the herpes simplex virus regulatory protein alpha 22 mediated by the UL13 protein kinase determines the accumulation of a subset of alpha and gamma mRNAs and proteins in infected cells. Proc Natl Acad Sci U S A (1993) 3.77
Nucleotide sequence and predicted amino acid sequence of a protein encoded in a small herpes simplex virus DNA fragment capable of trans-inducing alpha genes. Proc Natl Acad Sci U S A (1985) 3.75
An African HIV-1 sequence from 1959 and implications for the origin of the epidemic. Nature (1998) 3.69
Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1. Proc Natl Acad Sci U S A (1995) 3.68
Anatomy of the herpes simplex virus 1 strain F glycoprotein B gene: primary sequence and predicted protein structure of the wild type and of monoclonal antibody-resistant mutants. J Virol (1985) 3.67
A trial of topical acyclovir in genital herpes simplex virus infections. N Engl J Med (1982) 3.66
The natural history of herpes simplex virus infection of mother and newborn. Pediatrics (1980) 3.65
Alpha 4, the major regulatory protein of herpes simplex virus type 1, is stably and specifically associated with promoter-regulatory domains of alpha genes and of selected other viral genes. Proc Natl Acad Sci U S A (1986) 3.64
The terminal a sequence of the herpes simplex virus genome contains the promoter of a gene located in the repeat sequences of the L component. J Virol (1986) 3.63
Anatomy of herpes simplex virus DNA. V. Terminally repetitive sequences. J Virol (1976) 3.56
Comparative study of diagnostic procedures for congenital cytomegalovirus infection. Pediatrics (1980) 3.53
Development of a high-throughput quantitative assay for detecting herpes simplex virus DNA in clinical samples. J Clin Microbiol (1999) 3.48
Clustering of genes dispensable for growth in culture in the S component of the HSV-1 genome. Science (1987) 3.45
Site-specific inversion sequence of the herpes simplex virus genome: domain and structural features. Proc Natl Acad Sci U S A (1981) 3.45
Herpesvirus-dependent amplification and inversion of cell-associated viral thymidine kinase gene flanked by viral a sequences and linked to an origin of viral DNA replication. Proc Natl Acad Sci U S A (1982) 3.44
Herpes simplex virus phosphoproteins. II. Characterization of the virion protein kinase and of the polypeptides phosphorylated in the virion. J Virol (1980) 3.31
Antigenic and biologic differences in herpesvirus hominis. Prog Med Virol (1968) 3.31
Regulation of alpha genes of herpes simplex virus: the alpha 27 gene promoter-thymidine kinase chimera is positively regulated in converted L cells. J Virol (1982) 3.28
The herpes simplex virus 1 gene for ICP34.5, which maps in inverted repeats, is conserved in several limited-passage isolates but not in strain 17syn+. J Virol (1990) 3.16
The open reading frames UL3, UL4, UL10, and UL16 are dispensable for the replication of herpes simplex virus 1 in cell culture. J Virol (1991) 3.13
Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture. J Virol (1987) 3.09
The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene. J Virol (1991) 3.06
The UL20 gene of herpes simplex virus 1 encodes a function necessary for viral egress. J Virol (1991) 3.04
Restriction endonuclease fingerprinting of herpes simplex virus DNA: a novel epidemiological tool applied to a nosocomial outbreak. J Infect Dis (1978) 3.00
Concerning the egress of herpes simplex virus from infected cells: electron and light microscope observations. Virology (1969) 2.99
The herpes simplex virus 1 protein kinase US3 is required for protection from apoptosis induced by the virus. Proc Natl Acad Sci U S A (1997) 2.98
Virulence of and establishment of latency by genetically engineered deletion mutants of herpes simplex virus 1. Virology (1988) 2.97
The UL13 gene of herpes simplex virus 1 encodes the functions for posttranslational processing associated with phosphorylation of the regulatory protein alpha 22. Proc Natl Acad Sci U S A (1992) 2.97
Characterization of post-translational products of herpes simplex virus gene 35 proteins binding to the surfaces of full capsids but not empty capsids. J Virol (1984) 2.95
Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage. Proc Natl Acad Sci U S A (1994) 2.94
A seroepidemiologic survey of the prevalence of herpes simplex virus type 2 infection in the United States. N Engl J Med (1989) 2.94
RNA synthesis in cells infected with herpes simplex virus. II. Evidence that a class of viral mRNA is derived from a high molecular weight precursor synthesized in the nucleus. Proc Natl Acad Sci U S A (1969) 2.92
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