Published in Biochem Biophys Res Commun on August 15, 1969
Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2. Biochemistry (2005) 1.31
An evaluation of methods for the reconstitution of cytochromes P450 and NADPH P450 reductase into lipid vesicles. Drug Metab Dispos (2006) 0.94
Effect of homomeric P450-P450 complexes on P450 function. Biochem J (2012) 0.88
Physical incorporation of NADPH-cytochrome P450 reductase and cytochrome P450 into phospholipid vesicles using glycocholate and Bio-Beads. Drug Metab Dispos (2007) 0.83
Effects of membrane mimetics on cytochrome P450-cytochrome b5 interactions characterized by NMR spectroscopy. J Biol Chem (2015) 0.80
Interactions between cytochromes P450 2B4 (CYP2B4) and 1A2 (CYP1A2) lead to alterations in toluene disposition and P450 uncoupling. Biochemistry (2013) 0.76
A professional and personal odyssey. J Biol Chem (2009) 0.75
The metabolism in vitro and hepatic microsomal interactions of some enantiomeric drug substrates. Biochem J (1970) 0.75
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics (1996) 6.12
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol (1993) 4.92
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol (1991) 3.73
Oxygen activation by cytochrome P-450. Annu Rev Biochem (1980) 3.44
N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen. Proc Natl Acad Sci U S A (1984) 3.09
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA (1989) 3.03
Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing. Proc Natl Acad Sci U S A (1983) 2.98
The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95
Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans. J Biol Chem (1970) 2.89
Enzymatic omega-oxidation. I. Electon carriers in fatty acid and hydrocarbon hydroxylation. J Biol Chem (1966) 2.83
Role of pharmacokinetics and metabolism in drug discovery and development. Pharmacol Rev (1997) 2.74
Glutathione S-transferases: gene structure, regulation, and biological function. Annu Rev Biochem (1989) 2.70
Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. J Biol Chem (1991) 2.68
Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation. J Biol Chem (1967) 2.62
Bringing a family practice model of health to the People's Republic of China. Fam Med (2001) 2.52
Multiplicity of mammalian microsomal cytochromes P-45. Pharmacol Rev (1979) 2.50
Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital. J Biol Chem (1984) 2.38
Effect of superoxide generation and dismutation on hydroxylation reactions catalyzed by liver microsomal cytochrome P-450. J Biol Chem (1971) 2.35
Rat liver glutathione S-transferases. Construction of a cDNA clone complementary to a Yc mRNA and prediction of the complete amino acid sequence of a Yc subunit. J Biol Chem (1985) 2.06
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes. Drug Metab Dispos (1995) 2.01
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes. J Biol Chem (1968) 1.92
Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J Biol Chem (1969) 1.84
Evolution of cytochrome P-450 proteins. Mol Biol Evol (1987) 1.83
Rat liver glutathione S-transferases. Nucleotide sequence analysis of a Yb1 cDNA clone and prediction of the complete amino acid sequence of the Yb1 subunit. J Biol Chem (1985) 1.83
On the membrane topology of vertebrate cytochrome P-450 proteins. J Biol Chem (1988) 1.83
Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon, and drug hydroxylation. J Biol Chem (1970) 1.76
Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J Biol Chem (1982) 1.71
Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes. J Biol Chem (1974) 1.69
Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states. J Biol Chem (1978) 1.68
Inhibition and induction of cytochrome P450 and the clinical implications. Clin Pharmacokinet (1998) 1.61
Enzymatic omega-oxidation. 3. Purification and properties of rubredoxin, a component of the omega-hydroxylation system of Pseudomonas oleovorans. J Biol Chem (1968) 1.56
Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1981) 1.56
Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450. Arch Biochem Biophys (1976) 1.54
Purification and properties of NADPH-cytochrome P-450 reductase. Methods Enzymol (1978) 1.53
On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction. J Biol Chem (1984) 1.52
Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. J Biol Chem (1976) 1.50
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations. J Biol Chem (1972) 1.48
Structural features of liver microsomal NADPH-cytochrome P-450 reductase. Hydrophobic domain, hydrophilic domain, and connecting region. J Biol Chem (1982) 1.45
Rat liver glutathione S-transferases. DNA sequence analysis of a Yb2 cDNA clone and regulation of the Yb1 and Yb2 mRNAs by phenobarbital. J Biol Chem (1986) 1.42
Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450LM4 (rabbit liver). Methods Enzymol (1978) 1.42
Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system. J Biol Chem (1980) 1.40
Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant. Proc Natl Acad Sci U S A (1998) 1.40
The resolution and reconstitution of the liver microsomal hydroxylation system. Biochim Biophys Acta (1974) 1.39
Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms. J Biol Chem (1975) 1.39
Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4. Proc Natl Acad Sci U S A (1996) 1.39
Stereospecificity and other properties of highly purified beta-hydroxy-beta-methylglutaryl coenzyme A cleavage enzyme from bovine liver. J Biol Chem (1968) 1.36
Identification of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein requiring phospholipid for catalytic activity. Biochem Biophys Res Commun (1974) 1.35
Identification of the high and low potential flavins of liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1978) 1.35
Molecular properties and biological functions of microsomal epoxide hydrase. Annu Rev Pharmacol Toxicol (1980) 1.33
Enzymatic omega-oxidation. V. Forms of Pseudomonas oleovorans rubredoxin containing one or two iron atoms: structure and function in omega-hydroxylation. J Biol Chem (1971) 1.30
Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes. Proc Natl Acad Sci U S A (1983) 1.30
Liver microsomal expoxide hydrase. Solubilization, purification, and characterization. J Biol Chem (1975) 1.29
Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides. Cancer Res (1976) 1.29
Subunit structure of rabbit muscle pyruvate kinase. J Biol Chem (1969) 1.29
Metabolism of benzo[a]pyrene: conversion of (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene to highly mutagenic 7,8-diol-9,10-epoxides. Proc Natl Acad Sci U S A (1976) 1.27
Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes. Arch Biochem Biophys (1979) 1.25
The catalytic mechanism of glutathione S-transferase (GST). Spectroscopic determination of the pKa of Tyr-9 in rat alpha 1-1 GST. J Biol Chem (1993) 1.24
Effects of inducers and epoxide hydrase on the metabolism of benzo(a)pyrene by liver microsomes and a reconstituted system: analysis by high pressure liquid chromatography. Proc Natl Acad Sci U S A (1974) 1.21
Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics. Chem Res Toxicol (2001) 1.20
Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital. J Biol Chem (1976) 1.19
Secondary structure prediction of 52 membrane-bound cytochromes P450 shows a strong structural similarity to P450cam. Biochemistry (1989) 1.19
An analysis of the electron paramagnetic resonance spectrum of pseudomonas oleovorans rubredoxin. A method for determination of the liganids of ferric iron in completely rhombic sites. J Biol Chem (1971) 1.17
P-450 cytochromes: structure and function. Adv Enzymol Relat Areas Mol Biol (1987) 1.16
Role of a hydrophobic polypeptide in the N-terminal region of NADPH-cytochrome P-450 reductase in complex formation with P-450LM. Biochem Biophys Res Commun (1979) 1.15
Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation. J Biol Chem (1972) 1.15
Lipid peroxidation and the degradation of cytochrome P-450 heme. Arch Biochem Biophys (1973) 1.15
A simple and rapid procedure for the purification of phenobarbital-inducible cytochrome P-450 from rat liver microsomes. Arch Biochem Biophys (1979) 1.14
Metabolism of benzo(a)pyrene and benzo (a)pyrene derivatives to mutagenic products by highly purified hepatic microsomal enzymes. J Biol Chem (1976) 1.14
Biotransformation of lovastatin. IV. Identification of cytochrome P450 3A proteins as the major enzymes responsible for the oxidative metabolism of lovastatin in rat and human liver microsomes. Arch Biochem Biophys (1991) 1.14
Identification of epoxide hydrase as the preneoplastic antigen in rat liver hyperplastic nodules. Proc Natl Acad Sci U S A (1978) 1.13
Identification of a glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicumarol-binding site in rat liver NAD(P)H:quinone oxidoreductase by site-directed mutagenesis. J Biol Chem (1992) 1.13
Studies on the association of cytochrome P-450 and NADPH-cytochrome c reductase during catalysis in a reconstituted hydroxylating system. J Biol Chem (1979) 1.12
Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450. Arch Biochem Biophys (1977) 1.11
Multiple forms of rat liver cytochrome P-450. Immunochemical evidence with antibody against cytochrome P-448. J Biol Chem (1976) 1.11
Human cytochrome P-450 3A4: in vitro drug-drug interaction patterns are substrate-dependent. Drug Metab Dispos (2000) 1.11
Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation. Proc Natl Acad Sci U S A (1991) 1.11
Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb. Mol Pharmacol (1990) 1.11
Cytochrome P-450-mediated redox cycling of estrogens. J Biol Chem (1986) 1.09
Rat liver NAD(P)H: quinone reductase nucleotide sequence analysis of a quinone reductase cDNA clone and prediction of the amino acid sequence of the corresponding protein. J Biol Chem (1987) 1.09
Oxidation-reduction states of FMN and FAD in NADPH-cytochrome P-450 reductase during reduction by NADPH. J Biol Chem (1982) 1.09
Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proc Natl Acad Sci U S A (1985) 1.08
Alcohol-inducible cytochrome P-450IIE1 lacking the hydrophobic NH2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli. J Biol Chem (1991) 1.07
Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds and endogenous substrates. I. Determination of substrate specificity by the cytochrome P-450 and P-448 fractions. Biochem Biophys Res Commun (1971) 1.06
Characterization of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein. Arch Biochem Biophys (1977) 1.06
Human cytochrome P450 3A4-catalyzed testosterone 6 beta-hydroxylation and erythromycin N-demethylation. Competition during catalysis. Drug Metab Dispos (1997) 1.06
Role of lysyl epsilon-amino groups in adenosine diphosphate binding and catalytic activity of pyruvate kinase. J Biol Chem (1971) 1.05
Highly purified detergent-solubilized NADPH-cytochrome P-450 reductase from phenobarbital-induced rat liver microsomes. Biochem Biophys Res Commun (1974) 1.05
Properties of a solubilized form of the cytochrome P-450-containing mixed-function oxidase of liver microsomes. Mol Pharmacol (1970) 1.05
Reduction of alkyl hydroperoxides to alcohols: role of rubredoxin, an electron carrier in the bacterial hydroxylation of hydrocarbons. Biochem Biophys Res Commun (1971) 1.04
Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat liver. Biochem Biophys Res Commun (1975) 1.04
Role of cytochrome b5 in hydroxylation by a reconstituted cytochrome P-450-containing system. J Biol Chem (1974) 1.03
Rat liver cytosolic azoreductase. Purification and characterization. J Biol Chem (1979) 1.03