Published in J Biol Chem on March 25, 1976
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity. Proc Natl Acad Sci U S A (1980) 2.92
Synthesis and insertion of cytochrome P-450 into endoplasmic reticulum membranes. Proc Natl Acad Sci U S A (1980) 1.88
Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens. Br J Clin Pharmacol (1980) 1.69
Single-step selection of clones of a mouse hepatoma line deficient in aryl hydrocarbon hydroxylase. Proc Natl Acad Sci U S A (1979) 1.61
Role of haem in the synthesis and assembly of cytochrome P-450. Biochem J (1977) 0.90
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. Biochem J (1979) 0.90
Asymmetric distribution of cytochrome P-450 and NADPH--cytochrome P-450 (cytochrome c) reductase in vesicles from smooth endoplasmic reticulum of rat liver. Biochem J (1980) 0.89
Induction by phenobarbital of the mRNA for a specific variant of rat liver microsomal cytochrome P-450. Biochem J (1981) 0.82
Measurement of the metabolism of cytochrome P-450 in cultured hepatocytes by a quantitative and specific immunochemical method. Biochem J (1982) 0.80
Interaction of chemical carcinogens and drug-metabolizing enzymes in primary cultures of hepatic cells from the rat. Am J Pathol (1976) 0.79
Pyrolysis products from amino acids and protein: highest mutagenicity requires cytochrome P1-450. Proc Natl Acad Sci U S A (1979) 0.78
The induction of microsomal electron transport enzymes. Mol Cell Biochem (1983) 0.78
Introductory remarks: Session on genetic factors affecting pollutant toxicity. Environ Health Perspect (1979) 0.76
The use of proteinases to determine the topological location of cytochrome P-450 in vesicles derived from smooth endoplasmic reticulum of rat liver. Biochem J (1981) 0.75
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics (1996) 6.12
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol (1993) 4.92
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol (1991) 3.73
Oxygen activation by cytochrome P-450. Annu Rev Biochem (1980) 3.44
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA (1989) 3.03
Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing. Proc Natl Acad Sci U S A (1983) 2.98
The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95
Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans. J Biol Chem (1970) 2.89
Enzymatic omega-oxidation. I. Electon carriers in fatty acid and hydrocarbon hydroxylation. J Biol Chem (1966) 2.83
Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. J Biol Chem (1991) 2.68
Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation. J Biol Chem (1967) 2.62
Effect of superoxide generation and dismutation on hydroxylation reactions catalyzed by liver microsomal cytochrome P-450. J Biol Chem (1971) 2.35
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes. J Biol Chem (1968) 1.92
Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J Biol Chem (1969) 1.84
Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon, and drug hydroxylation. J Biol Chem (1970) 1.76
Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J Biol Chem (1982) 1.71
Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes. J Biol Chem (1974) 1.69
Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states. J Biol Chem (1978) 1.68
Enzymatic omega-oxidation. 3. Purification and properties of rubredoxin, a component of the omega-hydroxylation system of Pseudomonas oleovorans. J Biol Chem (1968) 1.56
Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1981) 1.56
Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450. Arch Biochem Biophys (1976) 1.54
On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction. J Biol Chem (1984) 1.52
Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. J Biol Chem (1976) 1.50
Structural features of liver microsomal NADPH-cytochrome P-450 reductase. Hydrophobic domain, hydrophilic domain, and connecting region. J Biol Chem (1982) 1.45
Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450LM4 (rabbit liver). Methods Enzymol (1978) 1.42
Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system. J Biol Chem (1980) 1.40
Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant. Proc Natl Acad Sci U S A (1998) 1.40
Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms. J Biol Chem (1975) 1.39
Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4. Proc Natl Acad Sci U S A (1996) 1.39
Stereospecificity and other properties of highly purified beta-hydroxy-beta-methylglutaryl coenzyme A cleavage enzyme from bovine liver. J Biol Chem (1968) 1.36
Identification of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein requiring phospholipid for catalytic activity. Biochem Biophys Res Commun (1974) 1.35
Identification of the high and low potential flavins of liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1978) 1.35
Enzymatic omega-oxidation. V. Forms of Pseudomonas oleovorans rubredoxin containing one or two iron atoms: structure and function in omega-hydroxylation. J Biol Chem (1971) 1.30
Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes. Proc Natl Acad Sci U S A (1983) 1.30
Subunit structure of rabbit muscle pyruvate kinase. J Biol Chem (1969) 1.29
Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes. Arch Biochem Biophys (1979) 1.25
Effects of varying the dietary concentration of phenobarbital on its enhancement of 2-acetylaminofluorene-induced hepatic tumorigenesis. Cancer Res (1980) 1.17
An analysis of the electron paramagnetic resonance spectrum of pseudomonas oleovorans rubredoxin. A method for determination of the liganids of ferric iron in completely rhombic sites. J Biol Chem (1971) 1.17
P-450 cytochromes: structure and function. Adv Enzymol Relat Areas Mol Biol (1987) 1.16
Role of a hydrophobic polypeptide in the N-terminal region of NADPH-cytochrome P-450 reductase in complex formation with P-450LM. Biochem Biophys Res Commun (1979) 1.15
Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation. J Biol Chem (1972) 1.15
Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450. Arch Biochem Biophys (1977) 1.11
Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation. Proc Natl Acad Sci U S A (1991) 1.11
Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb. Mol Pharmacol (1990) 1.11
Oxidation-reduction states of FMN and FAD in NADPH-cytochrome P-450 reductase during reduction by NADPH. J Biol Chem (1982) 1.09
Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proc Natl Acad Sci U S A (1985) 1.08
Alcohol-inducible cytochrome P-450IIE1 lacking the hydrophobic NH2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli. J Biol Chem (1991) 1.07
Characterization of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein. Arch Biochem Biophys (1977) 1.06
Highly purified detergent-solubilized NADPH-cytochrome P-450 reductase from phenobarbital-induced rat liver microsomes. Biochem Biophys Res Commun (1974) 1.05
Role of lysyl epsilon-amino groups in adenosine diphosphate binding and catalytic activity of pyruvate kinase. J Biol Chem (1971) 1.05
Properties of a solubilized form of the cytochrome P-450-containing mixed-function oxidase of liver microsomes. Mol Pharmacol (1970) 1.05
Reduction of alkyl hydroperoxides to alcohols: role of rubredoxin, an electron carrier in the bacterial hydroxylation of hydrocarbons. Biochem Biophys Res Commun (1971) 1.04
Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols. J Biol Chem (1982) 1.03
Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: similarity to hydrophobic amino-terminal segments of preproteins. Biochem Biophys Res Commun (1977) 1.03
Simple, rapid, and highly efficient separation of amino acid phenylthiohydantoins by reversed-phase high-performance liquid chromatography. Anal Biochem (1982) 1.02
Fatty acid and hydrocarbon hydroxylation in yeast: role of cytochrome P-450 in Candida tropicalis. Biochem Biophys Res Commun (1971) 1.02
Structural resemblance of cytochrome P-450 isolated from Pseudomonas putida and from rabbit liver microsomes. Biochem Biophys Res Commun (1974) 1.01
Mechanism of action of pyruvate kinase. Role of sulfhydryl groups in catalytic activity as determined by disulfide interchange. J Biol Chem (1972) 1.01
Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5. Drug Metab Dispos (1984) 1.01
Properties of a yeast cytochrome P-450-containing enzyme system which catalyzes the hydroxylation of fatty acids, alkanes, and drugs. Eur J Biochem (1973) 1.01
Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen. Biochem Biophys Res Commun (1983) 0.98
Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and membranes. Proc Natl Acad Sci U S A (1993) 0.97
Structural features of isozyme 2 of liver microsomal cytochrome P-450. Identification of a highly conserved cysteine-containing peptide. J Biol Chem (1982) 0.97
Purification and properties of a shortened form of cytochrome P-450 2E1: deletion of the NH2-terminal membrane-insertion signal peptide does not alter the catalytic activities. Proc Natl Acad Sci U S A (1991) 0.97
Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes. Cancer Res (1985) 0.96
Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes. Biochemistry (1988) 0.96
Biochemical studies on cytochrome P-450 solubilized from liver microsomes: partial purification and mechanism of catalysis. Ann N Y Acad Sci (1973) 0.96
Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450. Biochem Biophys Res Commun (1976) 0.95
Effects of conditions for reconstitution with cytochrome b5 on the formation of products in cytochrome P-450-catalyzed reactions. Drug Metab Dispos (1986) 0.95
Kinetics of reduction of cytochrome P-450LM4 in a reconstituted liver microsomal enzyme system. J Biol Chem (1979) 0.95
Heme ligand replacement reactions of cytochrome P-450. Characterization of the bonding atom of the axial ligand trans to thiolate as oxygen. J Biol Chem (1982) 0.93
Membrane topology of cytochrome P450 2B4 in Langmuir-Blodgett monolayers. Arch Biochem Biophys (1998) 0.93
Further studies on the properties of liver propionyl coenzyme A holocarboxylase synthetase and the specificity of holocarboxylase formation. J Biol Chem (1966) 0.93
Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal. Mol Pharmacol (1992) 0.92
Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5. J Biol Chem (1982) 0.92
Evidence that isoniazid and ethanol induce the same microsomal cytochrome P-450 in rat liver, an isozyme homologous to rabbit liver cytochrome P-450 isozyme 3a. Arch Biochem Biophys (1986) 0.91
Membrane topology of microsomal cytochrome P-450: saturation transfer EPR and freeze-fracture electron microscopy studies. Biochem Biophys Res Commun (1990) 0.91
On the mechanism of action of cytochrome P-450. Spectral intermediates in the reaction of P-450LM2 with peroxy compounds. J Biol Chem (1980) 0.91
Ethanol oxidation and toxicity: role of alcohol P-450 oxygenase. Alcohol Clin Exp Res (1986) 0.90
Evolutionary and phylogenetic relationships of rubredoxin-containing microbes. Biochem Biophys Res Commun (1971) 0.90
Properties of the oxygenated form of liver microsomal cytochrome P-450. J Biol Chem (1983) 0.90
Hydroxylation of benzphetamine and other drugs by a solubilized form of cytochrome P-450 from liver microsomes: lipid requirement for drug demethylation. Biochem Biophys Res Commun (1969) 0.89
Immunochemical evidence for a role of cytochrome P-450 in liver microsomal ethanol oxidation. Arch Biochem Biophys (1984) 0.89
Aromatization of a bicyclic steroid analog, 3-oxodecalin-4-ene-10-carboxaldehyde, by liver microsomal cytochrome P450 2B4. Biochemistry (1994) 0.88
Regioselective and stereoselective hydroxylation of R and S warfarin by different forms of purified cytochrome P-450 from rabbit liver. J Biol Chem (1978) 0.88
On the amino acid sequence of cytochrome P-450 isozyme 4 from rabbit liver microsomes. Proc Natl Acad Sci U S A (1984) 0.88
On the mechanism of action of cytochrome P-450. Role of peroxy spectral intermediates in substrate hydroxylation. J Biol Chem (1981) 0.88
Sedimentation and other properties of the reconstituted liver microsomal mixed-function oxidase system containing cytochrome P-450, reduced triphosphopyridine nucleotide-cytochrome P-450 reductase, and phosphatidylcholine. Mol Pharmacol (1973) 0.87
EPR spectrometry of cytochrome P450 2B4: effects of mutations and substrate binding. Biochem Biophys Res Commun (2000) 0.87
Subcellular localization, aggregation state, and catalytic activity of microsomal P450 cytochromes modified in the NH2-terminal region and expressed in Escherichia coli. Arch Biochem Biophys (1995) 0.87
On the mechanism of action of cytochrome P450: evaluation of hydrogen abstraction in oxygen-dependent alcohol oxidation. Biochemistry (1994) 0.87
Purification of liver microsomal cytochrome P-450 isozymes 3a and 6 from imidazole-treated rabbits. Evidence for the identity of isozyme 3a with the form obtained by ethanol treatment. Mol Pharmacol (1984) 0.87
Steroid metabolism by rabbit olfactory-specific P450 2G1. Arch Biochem Biophys (1994) 0.86
Hydrocarbon formation in the reductive cleavage of hydroperoxides by cytochrome P-450. Proc Natl Acad Sci U S A (1987) 0.86
Position-specific oxygenation of benzo(a)pyrene by different forms of purified cytochrome P-450 from rabbit liver. Proc Natl Acad Sci U S A (1975) 0.86