Published in J Biol Chem on December 10, 1972
Inactivation of the vitamin D receptor enhances susceptibility of murine skin to UV-induced tumorigenesis. J Invest Dermatol (2008) 2.08
FGF23 decreases renal NaPi-2a and NaPi-2c expression and induces hypophosphatemia in vivo predominantly via FGF receptor 1. Am J Physiol Renal Physiol (2009) 1.70
Dietary intake of phosphorus modulates the circadian rhythm in serum concentration of phosphorus. Implications for the renal production of 1,25-dihydroxyvitamin D. J Clin Invest (1987) 1.59
Effect of dietary phosphorus on circulating concentrations of 1,25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency. J Clin Invest (1984) 1.44
Oral intake of phosphorus can determine the serum concentration of 1,25-dihydroxyvitamin D by determining its production rate in humans. J Clin Invest (1986) 1.41
Physiologic regulation of the serum concentration of 1,25-dihydroxyvitamin D by phosphorus in normal men. J Clin Invest (1989) 1.34
Control of renal vitamin D hydroxylases in birds by sex hormones. Proc Natl Acad Sci U S A (1976) 1.21
Measurement of mammalian 25-hydroxyvitamin D3 24R-and 1 alpha-hydroxylase. Proc Natl Acad Sci U S A (1981) 1.11
In vitro metabolism of 25-hydroxyvitamin D3 by isolated rat kidney cells. Proc Natl Acad Sci U S A (1980) 1.05
Regulation of the metabolism of 25-hydroxyvitamin D3 in primary cultures of chick kidney cells. J Clin Invest (1979) 1.04
Regulation of vitamin D metabolism: factors influencing the rate of formation of 1,25-dihydroxycholecalciferol by kidney homogenates. Biochem J (1973) 1.02
Cytochrome P450-mediated metabolism of vitamin D. J Lipid Res (2013) 1.00
Magnesium and osteoporosis: current state of knowledge and future research directions. Nutrients (2013) 0.96
Enterohepatic physiology of 1,25-dihydroxyvitamin D3. J Clin Invest (1980) 0.94
The ionic control of 1,25-dihydroxyvitamin D3 synthesis in isolated chick renal mitochondria. The role of calcium as influenced by inorganic phosphate and hydrogen-ion. J Clin Invest (1975) 0.92
Production, degradation, and circulating levels of 1,25-dihydroxyvitamin D in health and in chronic glucocorticoid excess. J Clin Invest (1980) 0.89
Cellular and subcellular localization of 1,25-(OH)2-vitamin D3 in rat kidney: comparison with localization of parathyroid hormone and estradiol. Proc Natl Acad Sci U S A (1980) 0.87
Exaggerated phosphaturic response to circulating parathyroid hormone in patients with familial X-linked hypophosphatemic rickets. J Clin Invest (1976) 0.87
Vitamin D and the kidney. Arch Biochem Biophys (2012) 0.86
Effect of age on the conversion of 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 by kidney of rat. J Clin Invest (1980) 0.81
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells. J Neurochem (2012) 0.80
Differences in the side-chain metabolism of vitamin D3 between chickens and rats. Proc Natl Acad Sci U S A (1985) 0.78
Purification and characterization of the ferredoxin component of 25-hydroxycholecalciferol 1 alpha-hydroxylase. Biochem J (1979) 0.77
FGF-23 regulates CYP27B1 transcription in the kidney and in extra-renal tissues. PLoS One (2013) 0.77
Transformation of 25- and 1 alpha-hydroxyvitamin D3 to 1 alpha, 25-dihydroxyvitamin D3 by using Streptomyces sp. strains. Appl Environ Microbiol (1991) 0.76
Low vitamin D-modulated calcium-regulating proteins in psoriasis vulgaris plaques: S100A7 overexpression depends on joint involvement. Int J Mol Med (2016) 0.75
Low Magnesium Exacerbates Osteoporosis in Chronic Kidney Disease Patients with Diabetes. Int J Endocrinol (2015) 0.75
Metabolism and biological activity of 25-fluorocholecalciferol, 24-dehydrocholecalciferol and 25-dehydrocholecalciferol in the rat. Biochem J (1979) 0.75
Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment. Endocr Rev (2016) 0.75
Assay variation confounds the diagnosis of hypovitaminosis D: a call for standardization. J Clin Endocrinol Metab (2004) 6.41
Current understanding of the molecular actions of vitamin D. Physiol Rev (1998) 4.05
Metabolism of vitamin D3-3H in human subjects: distribution in blood, bile, feces, and urine. J Clin Invest (1967) 3.69
Biologically active metabolite of vitamin D3 from bone, liver, and blood serum. J Lipid Res (1966) 3.39
25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3. Biochemistry (1968) 3.01
1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proc Natl Acad Sci U S A (1996) 2.95
Biological activity of 25-hydroxyergocalciferol in rats. J Nutr (1970) 2.85
Expression of 1,25-dihydroxyvitamin D(3) receptor in the immune system. Arch Biochem Biophys (2000) 2.65
Target cells for 1,25-dihydroxyvitamin D3 in intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science (1979) 2.57
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture. Science (1972) 2.50
Isolation and identification of 1,25-dihydroxycholecalciferol. A metabolite of vitamin D active in intestine. Biochemistry (1971) 2.50
Metabolism and mechanism of action of vitamin D. Annu Rev Biochem (1976) 2.49
Mechanism of action and metabolic fate of vitamin D. Vitam Horm (1967) 2.42
"Activation" of vitamin D by the liver. J Clin Invest (1969) 2.42
Regulation by calcium of in vivo synthesis of 1,25-dihydroxycholecalciferol and 21,25-dihydroxycholecalciferol. Proc Natl Acad Sci U S A (1971) 2.27
A sensitive, precise, and convenient method for determination of 1,25-dihydroxyvitamin D in human plasma. Arch Biochem Biophys (1976) 2.23
The role of the liver in the metabolism of vitamin D. J Clin Invest (1969) 2.22
Intestinal calcium absorption and serum vitamin D metabolites in normal subjects and osteoporotic patients: effect of age and dietary calcium. J Clin Invest (1979) 2.21
A rapid assay for 25-OH-vitamin D3 without preparative chromatography. J Clin Endocrinol Metab (1974) 2.20
A new chromatographic system for vitamin D3 and its metabolites: resoluation of a new vitamin D3 metabolite. J Lipid Res (1971) 2.12
1,25-Dihydroxycholecalciferol inhibits the progression of arthritis in murine models of human arthritis. J Nutr (1998) 2.06
Evidence that increased circulating 1 alpha, 25-dihydroxyvitamin D is the probable cause for abnormal calcium metabolism in sarcoidosis. J Clin Invest (1979) 2.02
Identification of a DNA sequence responsible for binding of the 1,25-dihydroxyvitamin D3 receptor and 1,25-dihydroxyvitamin D3 enhancement of mouse secreted phosphoprotein 1 (SPP-1 or osteopontin) gene expression. Proc Natl Acad Sci U S A (1990) 1.99
Vitamin D: recent advances. Annu Rev Biochem (1983) 1.99
The synthesis of [1,2-3H]vitamin D3 and the tissue localization of a 0.25-mu-g (10 IU) dose per rat. Biochemistry (1966) 1.99
Vitamin D metabolism: the role of kidney tissue. Science (1971) 1.91
Vitamin D deficiency suppresses cell-mediated immunity in vivo. Arch Biochem Biophys (1993) 1.89
Regulation of vitamin D metabolism and function. Physiol Rev (1973) 1.88
Isolation and characterization of a novel cDNA from HL-60 cells treated with 1,25-dihydroxyvitamin D-3. Biochim Biophys Acta (1994) 1.85
Identification of 1,25-dihydroxycholecalciferol, a form of vitamin D3 metabolically active in the intestine. Proc Natl Acad Sci U S A (1971) 1.78
Biological activity of 1,25-dihydroxycholecalciferol. Biochemistry (1971) 1.77
DNA sequences in the rat osteocalcin gene that bind the 1,25-dihydroxyvitamin D3 receptor and confer responsiveness to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1990) 1.77
Cloning of the human 1 alpha,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements. Biochim Biophys Acta (1995) 1.69
21,25-dihydroxycholecalciferol. A metabolite of vitamin D3 preferentially active on bone. Biochemistry (1970) 1.65
Monoclonal antibodies to the porcine intestinal receptor for 1,25-dihydroxyvitamin D3: interaction with distinct receptor domains. Biochemistry (1986) 1.64
The response of intestinal calcium transport to 25-hydroxy and 1,25-dihydroxy vitamin D in nephrectomized rats. Endocrinology (1972) 1.63
Isolation and identification of 24,25-dihydroxycholecalciferol, a metabolite of vitamin D made in the kidney. Biochemistry (1972) 1.62
Subcellular location of vitamin D and its metabolites in intestinal mucosa after a 10-IU dose. Biochemistry (1967) 1.61
1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells. Proc Natl Acad Sci U S A (1983) 1.60
Vitamin-D-dependent rickets type II. Resistance of target organs to 1,25-dihydroxyvitamin D. N Engl J Med (1978) 1.59
25-hydroxycholecalciferol. The probable metabolically active form of vitamin D3: its identification and subcellular site of action. Arch Intern Med (1969) 1.58
Determination of vitamin D and its metabolites in plasma from normal and anephric man. Biochem J (1979) 1.58
The kidney as an endocrine organ for the production of 1,25-dihydroxyvitamin D 3 , a calcium-mobilizing hormone. N Engl J Med (1973) 1.54
The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the pseudovitamin D-deficiency rickets (PDDR) disease locus. J Bone Miner Res (1997) 1.53
Pathogenesis of hereditary vitamin-D-dependent rickets. An inborn error of vitamin D metabolism involving defective conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D. N Engl J Med (1973) 1.50
In vitro production of 25-hydroxycholecalciferol. Biochem Biophys Res Commun (1969) 1.48
Mitochondrial cytochrome p450. A component of chick kidney 25-hydrocholecalciferol-1alpha-hydroxylase. J Biol Chem (1974) 1.45
Rat intestinal 25-hydroxyvitamin D3- and 1alpha,25-dihydroxyvitamin D3-24-hydroxylase. J Biol Chem (1978) 1.44
Current concepts. Vitamin D. N Engl J Med (1969) 1.43
Parabiosis suggests a humoral factor is involved in X-linked hypophosphatemia in mice. J Bone Miner Res (1989) 1.43
Dietary calcium is a major factor in 1,25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice. J Nutr (1999) 1.41
1,25-dihydroxyvitamin D3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4. J Immunol (1998) 1.41
Sequences in the human parathyroid hormone gene that bind the 1,25-dihydroxyvitamin D3 receptor and mediate transcriptional repression in response to 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1992) 1.41
25,26-dihydroxycholecalciferol, a metabolite of vitamin D3 with intestinal calcium transport activity. Biochemistry (1970) 1.40
Serum 1,25-dihydroxyvitamin D levels in normal subjects and in patients with hereditary rickets or bone disease. N Engl J Med (1978) 1.40
The vitamin D system in the regulation of calcium and phosphorus metabolism. Nutr Rev (1979) 1.39
A specific high-affinity binding macromolecule for 1,25-dihydroxyvitamin D3 in fetal bone. Science (1977) 1.38
All members of primary care team are aware of importance of evidence based medicine. BMJ (1998) 1.38
Parathyroid hormone activation of the 25-hydroxyvitamin D3-1alpha-hydroxylase gene promoter. Proc Natl Acad Sci U S A (1998) 1.38
Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues. Cancer Res (1984) 1.37
Effect of estrogen on calcium absorption and serum vitamin D metabolites in postmenopausal osteoporosis. J Clin Endocrinol Metab (1980) 1.37
Metabolism of tritiated vitamin D3 in familial vitamin D-resistant rickets with hypophosphatemia. J Pediatr (1967) 1.37
Vitamin D: the vitamin and the hormone. Fed Proc (1974) 1.36
Nutritional status in a healthy elderly population: vitamin D. Am J Clin Nutr (1982) 1.35
Vitamin D stimulated, calcium-dependent adenosine triphosphatase from brush borders of rat small intestine. Biochem Biophys Res Commun (1969) 1.35
Stimulation of 25-hydroxyvitamin D3-1alpha-hydroxylase by phosphate depletion. J Biol Chem (1976) 1.34
Reduction in 1,25-dihydroxyvitamin D in children with increased lead absorption. N Engl J Med (1980) 1.34
Stimulation of 24,25-dihydroxyvitamin D3 production by 1,25-dihydroxyvitamin D3. Science (1974) 1.33
Treatment of hypoparathyroidism and pseudohypoparathyroidism with metabolites of vitamin D: evidence for impaired conversion of 25-hydroxyvitamin D to 1 alpha,25-dihydroxyvitamin D. N Engl J Med (1975) 1.33
Absence of seasonal variation in serum concentrations of 1,25-dihydroxyvitamin D despite a rise in 25-hydroxyvitamin D in summer. J Clin Endocrinol Metab (1981) 1.32
Influence of sodium on calcium transport by the rat small intestine. Am J Physiol (1969) 1.31
Hypercalciuria and stones. Am J Kidney Dis (1991) 1.31
The importance of phosphate in regulating plasma 1,25-(OH)2-vitamin D levels in humans: studies in healthy subjects in calcium-stone formers and in patients with primary hyperparathyroidism. J Clin Endocrinol Metab (1977) 1.30
Direct chemical synthesis of 1 alpha,25-dihydroxy[26,27-3H]vitamin D3 with high specific activity: its use in receptor studies. Biochemistry (1980) 1.30
Subcellular location of rat liver calciferol-25-hydroxylase. Arch Biochem Biophys (1974) 1.29
Identification of the porcine intestinal 1,25-dihydroxyvitamin D3 receptor on sodium dodecyl sulfate/polyacrylamide gels by renaturation and immunoblotting. Proc Natl Acad Sci U S A (1985) 1.29
Biological activity of 25-hydroxycholecalciferol, a metabolite of vitamin D3. Proc Natl Acad Sci U S A (1968) 1.29
The role of vitamin D and its relationship to parathyroid hormone and calcitonin. Recent Prog Horm Res (1971) 1.28
Vitamin D is not directly necessary for bone growth and mineralization. Am J Physiol (1984) 1.28
25-Hydroxyvitamin D3-24-hydroxylase. Subcellular location and properties. Biochemistry (1974) 1.28
Rickets with alopecia: an inborn error of vitamin D metabolism. J Pediatr (1979) 1.27
Association between age, blood lead concentration, and serum 1,25-dihydroxycholecalciferol levels in children. Am J Clin Nutr (1982) 1.26
1,25-Dihydroxyvitamin D in biological fluids: a simplified and sensitive assay. Science (1976) 1.26
1,25-dihydroxycholecalciferol: metabolite of vitamin D3 active on bone in anephric rats. Science (1972) 1.26
Role of vitamin D metabolites in phosphate transport of rat intestine. J Nutr (1974) 1.25
Evidence of an age-related decrease in intestinal responsiveness to vitamin D: relationship between serum 1,25-dihydroxyvitamin D3 and intestinal vitamin D receptor concentrations in normal women. J Clin Endocrinol Metab (1992) 1.24
1 alpha,25-dihydroxyvitamin D3 promotes fusion of mouse alveolar macrophages both by a direct mechanism and by a spleen cell-mediated indirect mechanism. Proc Natl Acad Sci U S A (1983) 1.24
Metaboism of 25-hydroxycholecalciferol in target and nontarget tissues. Biochemistry (1970) 1.24
Effect of I,25-dihydroxycholecalciferol in renal osteodystrophy. Can Med Assoc J (1975) 1.24
Calcium and phosphate metabolism in tumoral calcinosis. Ann Intern Med (1980) 1.22
Effect of vitamin D deficiency on fertility and reproductive capacity in the female rat. J Nutr (1980) 1.22
Control of renal vitamin D hydroxylases in birds by sex hormones. Proc Natl Acad Sci U S A (1976) 1.21
The synthesis of 25-hydroxycholecalciferol. A biologically active metabolite of vitamin D3. Biochemistry (1969) 1.21
Regulation of 25-hydroxyvitamin D3 1alpha-hydroxylase gene expression by parathyroid hormone and 1,25-dihydroxyvitamin D3. Arch Biochem Biophys (2000) 1.21
New 1alpha,25-dihydroxy-19-norvitamin D3 compounds of high biological activity: synthesis and biological evaluation of 2-hydroxymethyl, 2-methyl, and 2-methylene analogues. J Med Chem (1998) 1.21