PubRank

G W Lucier

Author PubWeight™ 116.17‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Levels of seven urinary phthalate metabolites in a human reference population. Environ Health Perspect 2000 5.63
2 Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 1993 2.76
3 Why not use it all? Environ Health Perspect 1999 2.04
4 Risk from low-dose exposures. Science 1994 1.99
5 Steroid and non-steroid UDP glucuronyltransferase: glucuronidation of synthetic estrogens as steroids. J Steroid Biochem 1977 1.62
6 Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis 1993 1.62
7 Characterization of the dose-response of CYP1B1, CYP1A1, and CYP1A2 in the liver of female Sprague-Dawley rats following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 1999 1.43
8 Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans. Pharmacogenetics 1994 1.31
9 TCDD-induced changes in rat liver microsomal enzymes. Environ Health Perspect 1973 1.24
10 Multiple DNA adducts in lymphocytes of smokers and nonsmokers determined by 32P-postlabeling analysis. Carcinogenesis 1990 1.22
11 Ethnic variation in the CYP2E1 gene: polymorphism analysis of 695 African-Americans, European-Americans and Taiwanese. Pharmacogenetics 1994 1.19
12 A model of acute methyl mercury intoxication in rats. Arch Pathol 1972 1.15
13 The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites. Environ Health Perspect 1989 1.15
14 Medicinal herbs in the United States: research needs. Environ Health Perspect 1999 1.11
15 Serum levels of TCDD and dioxin-like chemicals in Rhesus monkeys chronically exposed to dioxin: correlation of increased serum PCB levels with endometriosis. Toxicol Sci 2001 1.10
16 Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res 1994 1.08
17 Tumor necrosis factor involvement in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated endotoxin hypersensitivity in C57BL/6J mice congenic at the Ah locus. Toxicol Appl Pharmacol 1991 1.06
18 CYP1A1 mRNA levels as a human exposure biomarker: use of quantitative polymerase chain reaction to measure CYP1A1 expression in human peripheral blood lymphocytes. Carcinogenesis 1993 1.05
19 Mercury uptake by renal lysosomes of rats ingesting methyl mercury hydroxide. Ultrastructural observations and energy dispersive x-ray analysis. Arch Pathol 1974 1.05
20 Animal models of human response to dioxins. Environ Health Perspect 1998 1.05
21 Decreased human birth weights after in utero exposure to PCBs and PCDFs are associated with decreased placental EGF-stimulated receptor autophosphorylation capacity. Mol Pharmacol 1987 1.02
22 Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver. Cancer Res 1992 1.02
23 Levels of methyleugenol in a subset of adults in the general U.S. population as determined by high resolution mass spectrometry. Environ Health Perspect 2000 1.02
24 Nature of the enhancement of hepatic uridine diphosphate glucuronyltransferase activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Biochem Pharmacol 1975 1.01
25 Isolation and characterization of a novel gene induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in rat liver. Carcinogenesis 1996 1.01
26 High-affinity lead binding proteins in rat kidney cytosol mediate cell-free nuclear translocation of lead. J Pharmacol Exp Ther 1985 0.99
27 Microsomal rat liver UDP glucuronyltransferase: effects of piperonyl butoxide and other factors on enzyme activity. Arch Biochem Biophys 1971 0.99
28 Glutathione S-transferase mu in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts. Carcinogenesis 1991 0.99
29 Contribution of genetic and nutritional factors to DNA damage in heavy smokers. Carcinogenesis 1997 0.97
30 Glucuronidation and deglucuronidation reactions in hepatic and extrahepatic tissues during perinatal development. Drug Metab Dispos 1977 0.97
31 Toxicological assessment of hexachlorobiphenyl isomers and 2,3,7,8,-tetrachlorodibenzofuran in chicks. II. Effects on drug metabolism and porphyrin accumulation. Toxicol Appl Pharmacol 1976 0.96
32 Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone. Toxicol Appl Pharmacol 1992 0.96
33 A mechanistic model of effects of dioxin on gene expression in the rat liver. Toxicol Appl Pharmacol 1993 0.95
34 The effects of chronic oral methyl mercury exposure on the lysosome system of rat kidney. Morphometric and biochemical studies. Lab Invest 1975 0.95
35 The potentiation of barbiturate-induced narcosis by procarbazine. J Pharmacol Exp Ther 1976 0.95
36 Postnatal stimulation of hepatic microsomal enzymes following administration of TCDD to pregnant rats. Chem Biol Interact 1975 0.94
37 The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice. Environ Res 1979 0.93
38 Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase mu. Environ Health Perspect 1992 0.93
39 Workshop overview. National Toxicology Program Studies: principles of dose selection and applications to mechanistic based risk assessment. Fundam Appl Toxicol 1996 0.93
40 Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Biol Interact 1975 0.93
41 Ovarian tumors in rats induced by chronic 2,3,7,8-tetrachlorodibenzo-p-dioxin treatment. Cancer Res 2000 0.93
42 Altered sexual differentiation of hepatic uridine diphosphate glucuronyltransferase by neonatal hormone treatment in rats. Biochem J 1979 0.92
43 Rat CYP1B1: an adrenal cytochrome P450 that exhibits sex-dependent expression in livers and kidneys of TCDD-treated animals. Carcinogenesis 1995 0.91
44 Altered ontogeny of hepatic steroid-metabolizing enzymes by pure polychlorinated biphenyl congeners. Biochem Pharmacol 1979 0.89
45 A mechanistic model of effects of dioxin on thyroid hormones in the rat. Toxicol Appl Pharmacol 1996 0.89
46 Induction of hepatic 8-oxo-deoxyguanosine adducts by 2,3,7,8-tetrachlorodibenzo-p-dioxin in Sprague-Dawley rats is female-specific and estrogen-dependent. Chem Res Toxicol 2001 0.89
47 Alterations in rat liver microsomal and lysosomal -glucuronidase by compounds which induce hepatic drug metabolizing enzymes. Biochim Biophys Acta 1972 0.89
48 Sex differences in estrogen binding by cytosolic and nuclear components of rat liver. J Steroid Biochem 1980 0.89
49 Increases in cytochrome P-450 mediated 17 beta-estradiol 2-hydroxylase activity in rat liver microsomes after both acute administration and subchronic administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin in a two-stage hepatocarcinogenesis model. Carcinogenesis 1988 0.88
50 Mechanism of action of toxic halogenated aromatics. Environ Health Perspect 1985 0.87
51 Induction of lung lesions in female rats following chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Pathol 2000 0.85
52 Metabolic activation/deactivation reactions during perinatal development. Environ Health Perspect 1979 0.85
53 Structural requirements for the accumulation of chlorinated biphenyl metabolites in the fetal rat intestine. Drug Metab Dispos 1979 0.85
54 Dose-dependent localization of TCDD in isolated centrilobular and periportal hepatocytes. Toxicol Sci 1999 0.85
55 DNA, RNA, and protein synthesis in brain, liver, and kidneys of asymptomatic methylmercury treated rats. Exp Mol Pathol 1973 0.85
56 The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the hepatic estrogen and glucocorticoid receptors in congenic strains of Ah responsive and Ah nonresponsive C57BL/6J mice. Toxicol Appl Pharmacol 1991 0.84
57 Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria. Carcinogenesis 1998 0.84
58 Influence of the Ah locus on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the hepatic epidermal growth factor receptor. Mol Pharmacol 1991 0.84
59 Involvement of cytochrome P-450c in alpha-naphthoflavone metabolism by rat liver microsomes. Mol Pharmacol 1990 0.84
60 The right to know is for everyone. Environ Health Perspect 2000 0.83
61 Accumulation of polychlorinated dibenzo-p-dioxins and dibenzofurans in liver of control laboratory rats. Fundam Appl Toxicol 1994 0.83
62 Increased tumor necrosis factor-alpha production by peripheral blood leukocytes from TCDD-exposed rhesus monkeys. Toxicol Sci 2001 0.83
63 Translocation of 4S and 5S forms of estrogen-receptors into rat liver nuclei in vitro. Biochem Biophys Res Commun 1978 0.83
64 Risk assessment: good science for good decisions. Environ Health Perspect 1993 0.82
65 Effects of methylmercury on microsomal mixed-function oxidase components of rodents. Mol Pharmacol 1973 0.82
66 Ultrastructural changes in rat liver cells following a single oral dose of TCDD. Environ Health Perspect 1973 0.82
67 Relationships among benzo(a)pyrene metabolism, benzo(a)pyrene-diol-epoxide:DNA adduct formation, and sister chromatid exchanges in human lymphocytes from smokers and nonsmokers. Cancer Res 1989 0.82
68 Comparison of DNA adduct levels in human placenta from polychlorinated biphenyl exposed women and smokers in which CYP 1A1 levels are similarly elevated. Teratog Carcinog Mutagen 1994 0.82
69 Persistence of TCDD-induced hepatic cell proliferation and growth of enzyme altered foci after chronic exposure followed by cessation of treatment in DEN initiated female rats. Carcinogenesis 1995 0.81
70 Alterations in thyroid function in female Sprague-Dawley rats following chronic treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol 1995 0.81
71 Growth stimulation followed by growth inhibition in livers of female rats treated with ethinyl estradiol. Carcinogenesis 1994 0.81
72 Nondetectable concentrations of human placental Ah receptors are associated with potent induction of microsomal benzo[a]pyrene hydroxylase in individuals exposed to polychlorinated biphenyls, quaterphenyls, and dibenzofurans. Toxicol Appl Pharmacol 1986 0.81
73 Increased oxidative DNA damage in livers of 2,3,7,8-tetrachlorodibenzo-p-dioxin treated intact but not ovariectomized rats. Cancer Lett 1996 0.81
74 TCDD reduces rat hepatic epidermal growth factor receptor: comparison of binding, immunodetection, and autophosphorylation. Toxicol Appl Pharmacol 1995 0.80
75 Dose-dependent elevation of Ah receptor binding by TCDD in rat liver. Toxicol Appl Pharmacol 1987 0.80
76 Decreased ligand binding to the hepatic glucocorticoid and epidermal growth factor receptors after 2,3,4,7,8-pentachlorodibenzofuran and 1,2,3,4,7,8-hexachlorodibenzofuran treatment of pregnant mice. Toxicol Appl Pharmacol 1989 0.80
77 Dieldrin metabolism, excretion, and storage in male and female rats. J Agric Food Chem 1972 0.80
78 Quantitative analysis of constitutive and 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced cytochrome P450 1B1 expression in human lymphocytes. Cancer Epidemiol Biomarkers Prev 1999 0.80
79 Receptor-mediated events and the evaluation of the Environmental Protection Agency (EPA) of dioxin risks. Mutat Res 1995 0.80
80 Induced gene transcription: implications for biomarkers. Clin Chem 1995 0.80
81 Dioxin in soil: bioavailability after ingestion by rats and guinea pigs. Science 1984 0.80
82 The differential response of isolated intestinal crypt and tip cells to the inductive actions of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chem Biol Interact 1978 0.80
83 Metabolic activation of alpha-naphthoflavone by 2,3,7,8-tetrachlorodibenzodioxin-induced rat liver microsomes. Chem Biol Interact 1988 0.79
84 Binding properties of zearalenone mycotoxins to hepatic estrogen receptors. Mol Pharmacol 1981 0.79
85 Cautionary reflections. Environ Health Perspect 1998 0.79
86 Sex differences in pituitary-gonadal regulation of hepatic 5 alpha-reductase and 16 alpha-hydroxylase. J Steroid Biochem 1980 0.79
87 Programming of hepatic histidase following prenatal administration of diethylstilbestrol. J Steroid Biochem 1978 0.79
88 Estrogen receptor levels and occupancy in hepatic sinusoidal endothelial and Kupffer cells are enhanced by initiation with diethylnitrosamine and promotion with 17alpha-ethinylestradiol in rats. Carcinogenesis 1996 0.79
89 Altered ontogeny of glutathione S-transferases by 2,4,5-2',4',5'-hexachlorobiphenyl. Toxicol Appl Pharmacol 1979 0.79
90 TCDD-mediated changes in hepatic epidermal growth factor receptor may be a critical event in the hepatocarcinogenic action of TCDD. Carcinogenesis 1993 0.79
91 Nature of oxidative metabolites of dimethoate formed in rats, liver microsomes, and bean plants. J Agric Food Chem 1970 0.79
92 alpha-Naphthoflavone metabolized by 2,3,7,8-tetrachlorodibenzo(p)dioxin-induced rat liver microsomes: a potent clastogen in Chinese hamster ovary cells. Cancer Res 1987 0.79
93 Placental transfer of cadmium in rats: influence of dose and gestational age. Environ Health Perspect 1975 0.79
94 A perspective on biologically-based approaches to dioxin risk assessment. Risk Anal 1991 0.78
95 Perinatal development of conjugative enzyme systems. Environ Health Perspect 1976 0.78
96 Characterization of 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated decreases in dexamethasone binding to rat hepatic cytosolic glucocorticoid receptor. Mol Pharmacol 1989 0.78
97 32P-postlabeling analysis of the formation and persistence of DNA adducts in mammary glands of parous and nulliparous mice treated with benzo[a]pyrene. Carcinogenesis 1992 0.78
98 The effects of methylmercury on protein synthesis in rat liver. Biochem Biophys Res Commun 1971 0.78
99 Feminization of the concentrations of hepatic estrogen-binding proteins by ectopic pituitary. Endocrinology 1983 0.78
100 Cytogenetic and chemical detection of human exposure to polyhalogenated aromatic hydrocarbons. Environ Mol Mutagen 1988 0.78
101 Ingestion of soil contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters hepatic enzyme activities in rats. Fundam Appl Toxicol 1986 0.78
102 Changes in estrogen receptor, DNA ploidy, and estrogen metabolism in rat hepatocytes during a two-stage model for hepatocarcinogenesis using 17 alpha-ethinylestradiol as the promoting agent. Cancer Res 1989 0.77
103 Comparative dosimetry of inhaled materials: differences among animal species and extrapolation to man. Fundam Appl Toxicol 1991 0.77
104 Regulation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced tumor promotion by 17 beta-estradiol in female Sprague--Dawley rats. Toxicol Appl Pharmacol 2001 0.77
105 Phenobarbital protection against methyl mercury neophrotoxicity. Proc Soc Exp Biol Med 1975 0.77
106 Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci 2000 0.77
107 Smoking-related alterations in epidermal growth factor and insulin receptors in human placenta. Mol Pharmacol 1988 0.77
108 Hepatic and extrahepatic N-acetyltransferase. Perinatal development using a new radioassay. Biochim Biophys Acta 1975 0.77
109 Imprinting of hepatic estrogen-binding proteins by neonatal androgens. Endocrinology 1983 0.77
110 In vivo oestrogenicity and binding characteristics of alpha-zearalanol (P-1496) to different classes of oestrogen binding proteins in rat liver. J Steroid Biochem 1985 0.76
111 Omeprazole, cytochrome P450, and chemical carcinogenesis. Gastroenterology 1992 0.76
112 Estrogen receptor, epidermal growth factor receptor and cellular ploidy in elutriated subpopulations of hepatocytes during liver tumor promotion by 17 alpha-ethinylestradiol in rats. Carcinogenesis 1991 0.76
113 Receptor-mediated carcinogenesis: the role of biological effect modeling for risk assessment of dioxin and tamoxifen. Prog Clin Biol Res 1996 0.76
114 Altered sex differentiation of hepatic ethylmorphine N-demethylation in the male rat following neonatal methadone exposure. Pediatr Pharmacol (New York) 1981 0.76
115 The importance of biological realism in dioxin risk assessment models. Risk Anal 1994 0.76
116 Synergy, antagonism, and scientific process. Environ Health Perspect 1997 0.75
117 Sex differences in hepatic oestrogen-binding proteins. Biochem J 1981 0.75
118 Considerations concerning the murine hepatocarcinogenicity of selected chlorinated hydrocarbons. Prog Clin Biol Res 1995 0.75
119 Public health policy and the National Toxicology Program. Environ Health Perspect 1998 0.75
120 Methylmercury-cholinesterase interactions in rats. Environ Health Perspect 1975 0.75
121 Toxicity of chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in diethylnitrosamine-initiated ovariectomized rats implanted with subcutaneous 17 beta-estradiol pellets. Toxicol Sci 2000 0.75
122 Preparing for the new millennium. Environ Health Perspect 1999 0.75
123 Endotoxin (lipopolysaccharide)-induced nitric oxide production in 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated Fischer rats: detection of nitrosyl hemoproteins by EPR spectroscopy. Chem Res Toxicol 2000 0.75
124 Neonatal treatment with testosterone proprionate or diethylstilbestrol alters sex differentiation of 5 alpha-reductase and 16 alpha-hydroxylase. J Steroid Biochem 1980 0.75
125 Endocrine regulation of cadmium-sensitive cytochrome P-450 in rat liver. Mol Pharmacol 1982 0.75
126 Neonatal feminization of hepatic mono-oxygenase in adult male rats: altered sexual dimorphic response to cadmium. J Pharmacol Exp Ther 1980 0.75
127 Sex differentiation of liver protein synthesis. Prog Clin Biol Res 1985 0.75
128 Nuclear interactions of zearalanol-oestrogen receptor complexes in rat liver: a comparison with oestradiol-17 beta. J Steroid Biochem 1986 0.75
129 Correlation of hepatic cytosolic androgen binding proteins with androgen induction of hepatic microsomal ethylmorphine N-demethylase in the rat. J Steroid Biochem 1984 0.75
130 Hepatic estrogen responsiveness. Possible mechanisms for sexual dimorphism. Mol Pharmacol 1983 0.75
131 Effects of polychlorinated biphenyls on the development of intestinal and serum marker enzymes. J Toxicol Environ Health 1982 0.75
132 EHP: history and objectives. Environ Health Perspect 1974 0.75
133 Attitudes affect behavior. Environ Health Perspect 1995 0.75
134 Endocrine regulation of xenobiotic conjugation enzymes. Basic Life Sci 1983 0.75
135 Effect of gonadectomy on the ontogeny of estrogen-binding components in rat liver cytosol. Endocrinology 1981 0.75
136 Differential enhancement of sister-chromatid exchange frequencies by alpha-naphthoflavone in cultured lymphocytes from smokers and non-smokers. Mutat Res 1985 0.75
137 Not your average Joe. Environ Health Perspect 1995 0.75
138 Characterization of a cytosolic steroid-binding protein in the liver of the winter flounder, Pseudopleuronectes americanus. Gen Comp Endocrinol 1984 0.75
139 Nature of neutral phosphorus ester metabolites of phosphamidon formed in rats and liver microsomes. J Agric Food Chem 1972 0.75
140 Continued development of hepatic gamma-glutamyltranspeptidase-positive foci upon withdrawal of 17 alpha-ethynylestradiol in diethylnitrosamine-initiated rats. Cancer Res 1987 0.75
141 Anniversaries and attitudes. Environ Health Perspect 1997 0.75
142 Hypophysial regulation of cadmium-induced depression of the hepatic monooxygenase system in the rat. Mol Pharmacol 1981 0.75
143 Environmental Health Information Service. Environ Health Perspect 1997 0.75
144 Tetrachlorodibenzo-p-dioxin induction of renal microsomal enzyme systems: ultrastructural effects on pars recta (S3) proximal tubule cells on the rat kidney. J Pharmacol Exp Ther 1977 0.75
145 Dose-response and risk assessment considerations for receptor-mediated effects: case study with a TCDD hepatic tumor promotion model. Prog Clin Biol Res 1994 0.75
146 Increased frequencies of alpha-naphthoflavone induced sister chromatid exchanges in long-term survivors of childhood acute lymphoblastic leukemia. Cancer Lett 1987 0.75
147 Influences of sex steroids on experimental carcinogenesis. IARC Sci Publ 1983 0.75
148 Developmental toxicology of the halogenated aromatics: effects on enzyme development. Ann N Y Acad Sci 1979 0.75
149 Altered imprinting of rat liver monoamine oxidase by o, p'-DDT and methoxychlor. Biochem Pharmacol 1982 0.75
150 Effects of alpha-naphthoflavone on levels of sister chromatid exchanges in lymphocytes from active and passive cigarette smokers: dose-response relationships. Cancer Res 1986 0.75
151 Assessment of exposure to pulmonary toxicants: use of biological markers. Fundam Appl Toxicol 1992 0.75
152 Effects of hycanthone and two of its chlorinated analogs on hepatic microsomes. J Pharmacol Exp Ther 1973 0.75
153 Sexual dimorphism of the chromatographic profiles of I-compounds (endogenous deoxyribonucleic acid modifications) in rat liver. Endocrinology 1991 0.75
154 Dioxin treatment of rats results in increased in vitro induction of sister chromatid exchanges by alpha-naphthoflavone: an animal model for human exposure to halogenated aromatics. Toxicol Appl Pharmacol 1986 0.75
155 Selective actions of growth hormone on rat liver estrogen binding proteins. Biochem Biophys Res Commun 1981 0.75
156 Environmental Health Perspectives, the journal of the National Institute of Environmental Health Sciences. Pol J Occup Med Environ Health 1992 0.75
157 Correlation of hepatic estrogen receptor concentrations and estrogen-mediated elevation of very low density lipoproteins. Endocrinology 1983 0.75
158 Cytosolic and nuclear estrogen receptors in the isolated perfused rat liver. J Pharmacol Exp Ther 1984 0.75
159 Differences in binding of epidermal growth factor to liver membranes of TCDD-resistant and TCDD-sensitive rats after a single dose of TCDD. Environ Toxicol Pharmacol 1996 0.75
160 Differences in kinetics of induction and reversibility of TCDD-induced changes in cell proliferation and CYP1A1 expression in female Sprague-Dawley rat liver. Carcinogenesis 1998 0.75