Published in J Biol Chem on June 25, 1979
Regulation of glutathione synthesis. Mol Aspects Med (2008) 3.40
Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci U S A (1985) 2.37
Glutathione synthesis. Biochim Biophys Acta (2012) 2.11
Role of glutathione in cancer progression and chemoresistance. Oxid Med Cell Longev (2013) 1.68
Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer. PLoS One (2011) 1.35
Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine. Mol Biol Cell (1997) 1.26
Sequencing and expression of a cDNA for human glutathione synthetase. Biochem J (1995) 1.14
Amino acid sequence of rat kidney glutathione synthetase. Proc Natl Acad Sci U S A (1995) 1.13
A Medicago truncatula homoglutathione synthetase is derived from glutathione synthetase by gene duplication. Plant Physiol (2001) 1.05
Formation of gamma-glutamycyst(e)ine in vivo is catalyzed by gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1981) 0.94
Identification of an essential cysteine residue in human glutathione synthase. Biochem J (1997) 0.93
Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes. Biochem J (1988) 0.87
Kinetic properties of missense mutations in patients with glutathione synthetase deficiency. Biochem J (2000) 0.83
Valine 44 and valine 45 of human glutathione synthetase are key for subunit stability and negative cooperativity. Biochem Biophys Res Commun (2011) 0.78
Aspartate 458 of human glutathione synthetase is important for cooperativity and active site structure. Biochem Biophys Res Commun (2011) 0.78
Human hereditary glutathione synthetase deficiency: kinetic properties of mutant enzymes. Biochem J (2004) 0.75
The role of strong electrostatic interactions at the dimer interface of human glutathione synthetase. Protein J (2014) 0.75
Glutathione. Annu Rev Biochem (1983) 15.18
Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem (1980) 10.52
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine). J Biol Chem (1979) 7.16
Glutathione and related gamma-glutamyl compounds: biosynthesis and utilization. Annu Rev Biochem (1976) 3.84
Selective modification of glutathione metabolism. Science (1983) 3.64
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci U S A (1990) 3.28
On the enzymology of amino acid transport. Science (1973) 3.24
Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J Biol Chem (1975) 3.23
High resistance to cisplatin in human ovarian cancer cell lines is associated with marked increase of glutathione synthesis. Proc Natl Acad Sci U S A (1992) 3.22
Interaction of gamma-glutamyl transpeptidase with amino acids, dipeptides, and derivatives and analogs of glutathione. J Biol Chem (1974) 3.18
The gamma-glutamyl cycle: a possible transport system for amino acids. Proc Natl Acad Sci U S A (1970) 3.13
Rivaroxaban versus placebo in patients with acute coronary syndromes (ATLAS ACS-TIMI 46): a randomised, double-blind, phase II trial. Lancet (2009) 3.13
NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? Biochem Biophys Res Commun (1989) 3.11
Studies on the mechanism of inhibition of glutamine synthetase by methionine sulfoximine. Biochemistry (1969) 3.10
Cytologically integrated physical restriction fragment length polymorphism maps for the barley genome based on translocation breakpoints. Genetics (2000) 3.05
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun (1990) 2.77
Glutathione: interorgan translocation, turnover, and metabolism. Proc Natl Acad Sci U S A (1979) 2.71
Mammalian nitric oxide synthases. Adv Enzymol Relat Areas Mol Biol (1992) 2.66
Epidemiology of trauma deaths. Am J Surg (1980) 2.58
Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J Biol Chem (1982) 2.48
Prevention of nonvertebral fractures by alendronate. A meta-analysis. Alendronate Osteoporosis Treatment Study Groups. JAMA (1997) 2.46
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifs. Genes Dev (1990) 2.46
N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. J Biol Chem (1991) 2.38
Origin and turnover of mitochondrial glutathione. Proc Natl Acad Sci U S A (1985) 2.37
Glutathione regulates activation-dependent DNA synthesis in highly purified normal human T lymphocytes stimulated via the CD2 and CD3 antigens. Proc Natl Acad Sci U S A (1990) 2.22
Translocation of intracellular glutathione to membrane-bound gamma-glutamyl transpeptidase as a discrete step in the gamma-glutamyl cycle: glutathionuria after inhibition of transpeptidase. Proc Natl Acad Sci U S A (1979) 2.20
Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem (1993) 2.13
An efficient screen for reproductive pathways using mature seeds of monocots and dicots. Plant J (2000) 2.11
Overproduction of nitric oxide in cytokine-mediated and septic shock. J Natl Cancer Inst (1992) 2.05
Serine-borate complex as a transition-state inhibitor of gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1978) 2.03
gamma-Glutamyl transpeptidase: catalytic, structural and functional aspects. Mol Cell Biochem (1981) 1.98
Inhibition of glutathione biosynthesis by prothionine sulfoximine (S-n-propyl homocysteine sulfoximine), a selective inhibitor of gamma-glutamylcysteine synthetase. J Biol Chem (1979) 1.91
The specificity of glutamine synthetase and its relationship to substrate conformation at the active site. Adv Enzymol Relat Areas Mol Biol (1968) 1.91
Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle. Proc Natl Acad Sci U S A (1971) 1.90
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain. Biochemistry (1969) 1.89
Glutathione monoethyl ester: preparation, uptake by tissues, and conversion to glutathione. Arch Biochem Biophys (1985) 1.82
Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR-sulfoximine that inhibits glutamine synthetase. Biochemistry (1969) 1.82
gamma-Glutamyl transpeptidase, a lymphoid cell-surface marker: relationship to blastogenesis, differentiation, and neoplasia. Proc Natl Acad Sci U S A (1976) 1.78
Glutathione export by human lymphoid cells: depletion of glutathione by inhibition of its synthesis decreases export and increases sensitivity to irradiation. Proc Natl Acad Sci U S A (1981) 1.77
Evidence that the gamma-glutamyl cycle functions in vivo using intracellular glutathione: effects of amino acids and selective inhibition of enzymes. Proc Natl Acad Sci U S A (1978) 1.77
Studies on glutamine synthetase from Escherichia coli. Formation of pyrrolidone carboxylate and inhibition by methionine sulfoximine. J Biol Chem (1973) 1.76
L-arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivo. Biochem Biophys Res Commun (1989) 1.76
Histone H4 acetylation of euchromatin and heterochromatin is cell cycle dependent and correlated with replication rather than with transcription. Plant Cell (2000) 1.75
Phosphorylation of methionine sulfoximine by glutamine synthetase. Proc Natl Acad Sci U S A (1968) 1.72
Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochem Biophys Res Commun (1990) 1.72
Evaluation of an institution-based protocol for postpartum rubella vaccination. CMAJ (2001) 1.71
L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. J Biol Chem (1990) 1.70
gamma-Glutamyl transpeptidase from kidney. Methods Enzymol (1985) 1.69
Mitochondrial damage in muscle occurs after marked depletion of glutathione and is prevented by giving glutathione monoester. Proc Natl Acad Sci U S A (1989) 1.66
Association of Enzymatic Activity with Submicroscopic Particles. Science (1952) 1.65
Gamma-glutamyl transpeptidase. Methods Enzymol (1981) 1.63
Control of Escherichia coli carbamyl phosphate synthetase by purine and pyrimidine nucleotides. Biochemistry (1966) 1.58
-Glutamyl cyclotransferase. Distribution, isozymic forms, and specificity. J Biol Chem (1973) 1.56
Inhibition of glutathione synthesis as a chemotherapeutic strategy for trypanosomiasis. J Exp Med (1981) 1.53
Interconversion of leukotrienes catalyzed by purified gamma-glutamyl transpeptidase: concomitant formation of leukotriene D4 and gamma-glutamyl amino acids. Proc Natl Acad Sci U S A (1982) 1.52
Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase. J Biol Chem (1993) 1.52
Glutathione synthetase deficiency, an inborn error of metabolism involving the gamma-glutamyl cycle in patients with 5-oxoprolinuria (pyroglutamic aciduria). Proc Natl Acad Sci U S A (1974) 1.51
Glutathione biosynthesis; gamma-glutamylcysteine synthetase from rat kidney. Methods Enzymol (1985) 1.50
Identity of maleate-stimulated glutaminase with gamma-glutamyl transpeptidase in rat kidney. J Biol Chem (1975) 1.50
Asparagine synthetase activity of mouse leukemias. Science (1968) 1.49
Tripeptide (glutathione) synthetase. Purification, properties, and mechanism of action. Biochemistry (1967) 1.46
Affinity labeling of gamma-glutamyl transpeptidase and location of the gamma-glutamyl binding site on the light subunit. Proc Natl Acad Sci U S A (1977) 1.45
Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis. Proc Natl Acad Sci U S A (1983) 1.45
Glutamine-dependent asparagine synthetase from leukemia cells. Chloride dependence, mechanism of action, and inhibition. J Biol Chem (1972) 1.45
Glutathione, a first line of defense against cadmium toxicity. FASEB J (1987) 1.44
Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits. J Biol Chem (1984) 1.44
Enzymes of the gamma-glutamyl cycle in the ciliary body and lens. Proc Natl Acad Sci U S A (1973) 1.43
Glutathione deficiency leads to mitochondrial damage in brain. Proc Natl Acad Sci U S A (1991) 1.43
Glutathione is required for intestinal function. Proc Natl Acad Sci U S A (1990) 1.43
Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress. Proc Natl Acad Sci U S A (1991) 1.43
The gamma-glutamyl cycle. Diseases associated with specific enzyme deficiencies. Ann Intern Med (1974) 1.43
Translocation of glutathione from lymphoid cells that have markedly different gamma-glutamyl transpeptidase activities. Proc Natl Acad Sci U S A (1979) 1.43
Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl Acad Sci U S A (1991) 1.40
Transport of gamma-glutamyl amino acids: role of glutathione and gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1979) 1.38
Resolution of the light-harvesting chlorophyll a/b-protein of vicia faba chloroplasts into two different chlorophyll-protein complexes. Biochim Biophys Acta (1979) 1.38
Accumulation of 5-oxoproline in mouse tissues after inhibition of 5-oxoprolinase and administration of amino acids: evidence for function of the gamma-glutamyl cycle. Proc Natl Acad Sci U S A (1974) 1.37
Glutathione ester prevents buthionine sulfoximine-induced cataracts and lens epithelial cell damage. Proc Natl Acad Sci U S A (1989) 1.37
Stimulation of the hydrolytic activity and decrease of the transpeptidase activity of gamma-glutamyl transpeptidase by maleate; identity of a rat kidney maleate-stimulated glutaminase and gamma-glutamyl transpeptidase. Proc Natl Acad Sci U S A (1974) 1.37
Regulation of rat liver glutamine synthetase: activation by alpha-ketoglutarate and inhibition by glycine, alanine, and carbamyl phosphate. Proc Natl Acad Sci U S A (1971) 1.37
Hydrolysis and transfer reactions catalyzed by gamma-glutamyl transpeptidase; evidence for separate substrate sites and for high affinity of L-cystine. Biochem Biophys Res Commun (1976) 1.36
Rat liver glutamine synthetase. Preparation, properties, and mechanism of inhibition by carbamyl phosphate. J Biol Chem (1972) 1.36
Glutamine-binding subunit of glutamate synthase and partial reactions catalyzed by this glutamine amidotransferase. Proc Natl Acad Sci U S A (1974) 1.36
Inhibition of 5-oxoprolinase by 2-imidazolidone-4-carboxylic acid. Proc Natl Acad Sci U S A (1973) 1.36
Design of isoform-selective inhibitors of nitric oxide synthase. Curr Opin Chem Biol (1998) 1.36
Reversible dissociation of carbamyl phosphate synthetase into a regulated synthesis subunit and a subunit required for glutamine utilization. Proc Natl Acad Sci U S A (1971) 1.35
Radioprotection by glutathione ester: transport of glutathione ester into human lymphoid cells and fibroblasts. Proc Natl Acad Sci U S A (1984) 1.35
Transport of glutathione, as gamma-glutamylcysteinylglycyl ester, into liver and kidney. Proc Natl Acad Sci U S A (1983) 1.35
The -glutamyl cycle in the choroid plexus: its possible function in amino acid transport. Proc Natl Acad Sci U S A (1973) 1.35
Inhibition of gamma-glutamylcysteine synthetase by cystamine: an approach to a therapy of 5-oxoprolinuria (pyroglutamic aciduria). Biochem Biophys Res Commun (1977) 1.34