Published in Proc Natl Acad Sci U S A on December 01, 1973
Direct identification of the calcium-binding amino acid, gamma-carboxyglutamate, in mineralized tissue. Proc Natl Acad Sci U S A (1975) 3.46
Vitamin K dependent modifications of glutamic acid residues in prothrombin. Proc Natl Acad Sci U S A (1974) 3.24
The presence of protein-bound gamma-carboxyglutamic acid in calcium-containing renal calculi. J Clin Invest (1977) 1.24
The molecular characteristics of a human pancreatic acidic phosphoprotein that inhibits calcium carbonate crystal growth. Biochem J (1984) 1.11
Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X. Proc Natl Acad Sci U S A (1975) 0.98
The N-terminal sequences of blood coagulation factor X1 and X2 light chains. Mass-spectrometric identification of twelve residues of gamma-carboxyglutamic acid in their vitamin K-dependent domains. Biochem J (1978) 0.92
The localization of a vitamin K-induced modification in an N-terminal fragment of human prothrombin. Biochem J (1974) 0.90
Mass-spectrometric identification and sequence location of the ten residues of the new amino acid (gamma-Carboxyglutamic acid) in the N-terminal region of prothrombin. Biochem J (1976) 0.89
Erythrocyte-derived microparticles supporting activated protein C-mediated regulation of blood coagulation. PLoS One (2014) 0.85
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem (1969) 142.11
Use of the dansyl reaction in biochemical analysis. Methods Biochem Anal (1970) 2.22
A polypeptide region of bovine prothrombin specific for binding to phospholipids. Proc Natl Acad Sci U S A (1973) 1.65
A rapid and sensitive method for measuring the binding of radioactive ligands to proteins. Anal Biochem (1969) 1.50
The purification and properties of an abnormal prothrombin protein produced by dicumarol-treated cows. A comparison to normal prothrombin. J Biol Chem (1972) 1.26
Mode of action of vitamin K. Calcium binding properties of bovine prothrombin. Biochemistry (1972) 1.22
Vitamin K and the biosynthesis of prothrombin. 3. Structural comparison of an NH2-terminal fragment from normal and from dicoumarol-induced bovine prothrombin. J Biol Chem (1973) 1.19
Vitamin K and the biosynthesis of prothrombin. I. Identification and purification of a dicoumarol-induced abnormal prothrombin from bovine plasma. J Biol Chem (1972) 1.14
Multiple active forms of thrombin. II. Mechanism of production from prothrombin. J Biol Chem (1971) 1.07
THREONINE AND SERINE LINKAGES IN MUCOPOLYSACCHARIDES AND GLYCOPROTEINS. J Biol Chem (1964) 1.05
Vitamin K and the biosynthesis of prothrombin. II. Structural comparison of normal and dicoumarol-induced bovine prothrombin. J Biol Chem (1972) 1.01
Mechanism of action of vitamin K: demonstration of a liver precursor of prothrombin. Science (1973) 1.00
Mechanism of action of vitamin K: evidence for the conversion of a precursor protein to prothrombin in the rat. Proc Natl Acad Sci U S A (1971) 0.96
The carbohydrate of bovine prothrombin. Partial structural determination demonstrating the presence of -galactose residues. J Biol Chem (1972) 0.89
The activation of prothrombin. I. Isolation and preliminary characterization of intermediates. J Biol Chem (1973) 0.85
The mode of action of vitamin K. Identification of gamma-carboxyglutamic acid as a component of prothrombin. J Biol Chem (1974) 2.59
Vitamin K-dependent formation of gamma-carboxyglutamic acid. Annu Rev Biochem (1977) 2.10
Vitamin K-dependent carboxylase. Annu Rev Biochem (1985) 1.74
A new carboxylation reaction. The vitamin K-dependent incorporation of H-14-CO3- into prothrombin. J Biol Chem (1975) 1.71
Mechanism of action of vitamin K: synthesis of gamma-carboxyglutamic acid. CRC Crit Rev Biochem (1980) 1.68
A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase. J Biol Chem (1976) 1.64
Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition. Biochemistry (1978) 1.63
Prothrombin structure, activation, and biosynthesis. Physiol Rev (1977) 1.61
Vitamin K-dependent carboxylase. Requirements of the rat liver microsomal enzyme system. J Biol Chem (1976) 1.53
Dietary intake and adequacy of vitamin K. J Nutr (1998) 1.52
Vitamin K requirement and warfarin tolerance in the hamster. Proc Soc Exp Biol Med (1975) 1.39
Interaction of vitamin K dependent proteins with membranes. Biochemistry (1978) 1.35
Comparison of naturally occurring vitamin K-dependent proteins: correlation of amino acid sequences and membrane binding properties suggests a membrane contact site. Biochemistry (1997) 1.28
Vitamin K-dependent carboxylase. Control of enzyme activity by the "propeptide" region of factor X. J Biol Chem (1987) 1.28
The purification and properties of an abnormal prothrombin protein produced by dicumarol-treated cows. A comparison to normal prothrombin. J Biol Chem (1972) 1.26
Mode of action of vitamin K. Calcium binding properties of bovine prothrombin. Biochemistry (1972) 1.22
Gamma-carboxyglutamic acid: identification and distribution in vitamin K-dependent proteins. Mayo Clin Proc (1974) 1.22
Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid. J Biol Chem (1976) 1.21
Vitamin K-dependent carboxylase. Solubilization and properties. J Biol Chem (1976) 1.20
Vitamin K-dependent carboxylase. Development of a peptide substrate. J Biol Chem (1976) 1.20
Role of substrate in imparting calcium and phospholipid requirements to protein kinase C activation. Biochemistry (1987) 1.19
Vitamin K status of lactating mothers, human milk, and breast-feeding infants. Pediatrics (1991) 1.17
Evidence that warfarin anticoagulant action involves two distinct reductase activities. J Biol Chem (1982) 1.15
Effect of a short period of fluoride ingestion on dental fluorosis in cattle. Am J Vet Res (1971) 1.15
Mechanism of protein kinase C inhibition by sphingosine. Biochem Biophys Res Commun (1987) 1.11
Vitamin K-dependent carboxylase. Stoichiometry of carboxylation and vitamin K 2,3-epoxide formation. J Biol Chem (1981) 1.10
Vitamin K-dependent carboxylase: requirements for carboxylation of soluble peptide and substrate specificity. Biochem Biophys Res Commun (1979) 1.09
The collisional limit: an important consideration for membrane-associated enzymes and receptors. FASEB J (1988) 1.08
Association of congenital deficiency of multiple vitamin K-dependent coagulation factors and the phenotype of the warfarin embryopathy: clues to the mechanism of teratogenicity of coumarin derivatives. Am J Hum Genet (1987) 1.08
Vitamin K-dependent carboxylase: utilization of decarboxylated bone Gla protein and matrix Gla protein as substrates. Biochim Biophys Acta (1991) 1.07
The functional significance of vitamin K action. Difference in phospholipid binding between normal and abnormal prothrombin. J Biol Chem (1975) 1.07
Role of gamma-carboxyglutamic acid. Cation specificity of prothrombin and factor X-phospholipid binding. J Biol Chem (1976) 1.07
Protein kinase C interaction with calcium: a phospholipid-dependent process. Biochemistry (1990) 1.06
Importance of phosphatidylethanolamine for association of protein kinase C and other cytoplasmic proteins with membranes. Biochemistry (1992) 1.06
Equilibria involved in prothrombin- and blood-clotting factor X-membrane binding. Biochemistry (1977) 1.05
Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. J Nutr (1998) 1.05
Vitamin K nutrition and osteoporosis. J Nutr (1995) 1.05
Effect of dietary fluoride on the pattern of food intake in the rat and the development of a programmed pellet dispenser. J Nutr (1968) 1.04
Association of protein kinase C with phospholipid vesicles. Biochemistry (1987) 1.03
Mechanism of action of vitamin K: demonstration of a liver precursor of prothrombin. Science (1973) 1.00
Pentraxin family of proteins interact specifically with phosphorylcholine and/or phosphorylethanolamine. Biochemistry (1992) 0.99
Warfarin metabolism and vitamin K requirement in the warfarin-resistant rat. Am J Physiol (1969) 0.99
Extensive segregation of acidic phospholipids in membranes induced by protein kinase C and related proteins. Biochemistry (1991) 0.99
Association of a protein with membrane vesicles at the collisional limit: studies with blood coagulation factor Va light chain also suggest major differences between small and large unilamellar vesicles. Biochemistry (1987) 0.99
Vitamin K dependent carboxylase: subcellular location of the carboxylase and enzymes involved in vitamin K metabolism in rat liver. Biochemistry (1980) 0.98
Interaction of prothrombin and blood-clotting factor X with membranes of varying composition. Biochemistry (1977) 0.98
Isolation and characterization of vitamin K-dependent region of bovine blood clotting factor X. Proc Natl Acad Sci U S A (1975) 0.98
Mechanism of coumarin action: sensitivity of vitamin K metabolizing enzymes of normal and warfarin-resistant rat liver. Biochemistry (1982) 0.97
Prothrombin association with phospholipid monolayers. Biochemistry (1983) 0.96
Inhibition of vitamin K-dependent carboxylase in vitro by cefamandole and its structural analogs. J Infect Dis (1983) 0.96
Role of substrate in determining the phospholipid specificity of protein kinase C activation. Biochemistry (1987) 0.96
Vitamin K supplementation reduces serum concentrations of under-gamma-carboxylated osteocalcin in healthy young and elderly adults. Am J Clin Nutr (2000) 0.96
Mechanism of action of vitamin K: evidence for the conversion of a precursor protein to prothrombin in the rat. Proc Natl Acad Sci U S A (1971) 0.96
[3H]diborane reduction of vitamin K-dependent calcium-binding proteins. Identification of a unique amino acid. J Biol Chem (1975) 0.95
Vitamin K and gamma-carboxyglutamate biosynthesis. Vitam Horm (1977) 0.95
The mechanism of action of uridine diphosphoglucose dehydrogenase. Uridine diphosphohexodialdoses as intermediates. J Biol Chem (1971) 0.95
Recent advances in hepatic vitamin K metabolism and function. Hepatology (1987) 0.94
Relationship between vitamin K-dependent carboxylation and vitamin K epoxidation. Fed Proc (1978) 0.94
Structure of the prothrombin- and blood clotting factor X-membrane complexes. Biochemistry (1977) 0.94
Membrane permeability to macromolecules mediated by the membrane attack complex. Biochemistry (1989) 0.94
Kinetic properties of enzyme populations in vivo: alkaline phosphatase of the Escherichia coli periplasm. Biochemistry (1992) 0.94
The vitamin K dependent, in vitro production of prothrombin. Biochem Biophys Res Commun (1974) 0.93
Vitamin K-dependent carboxylase: evidence for a hydroperoxide intermediate in the reaction. Proc Natl Acad Sci U S A (1978) 0.93
Independent association of serum amyloid P component, protein S, and complement C4b with complement C4b-binding protein and subsequent association of the complex with membranes. J Biol Chem (1990) 0.93
Relationship of dithiothreitol-dependent microsomal vitamin K quinone and vitamin K epoxide reductases inhibition of epoxide reduction by vitamin K quinone. Biochim Biophys Acta (1984) 0.93
Vitamin K-dependent carboxylase: purification of the rat liver microsomal enzyme. Arch Biochem Biophys (1980) 0.93
Purification of an apparent rat liver prothrombin precursor: characterization and comparison to normal rat prothrombin. Biochemistry (1975) 0.93
Constitutive activity of membrane-inserted protein kinase C. Biochem Biophys Res Commun (1988) 0.93
Differences in the effects of phorbol esters and diacylglycerols on protein kinase C. Biochemistry (1989) 0.92
Solubilization and characterization of vitamin K epoxide reductase from normal and warfarin-resistant rat liver microsomes. Arch Biochem Biophys (1984) 0.92
Vitamin K-dependent carboxylase: structural requirements for propeptide activation. Biochim Biophys Acta (1990) 0.92
Potent inhibition of terminal complement assembly by clusterin: characterization of its impact on C9 polymerization. Biochemistry (1997) 0.92
Assessment of vitamin K status in human subjects administered "minidose" warfarin. Am J Clin Nutr (1996) 0.90
Phosphorylation of lens intrinsic membrane proteins by protein kinase C. Eur J Biochem (1986) 0.90
Vitamin K-dependent carboxylase. Demonstration of a vitamin K- and O2-dependent exchange of 3H from 3H2O into glutamic acid residues. J Biol Chem (1983) 0.90
Properties of membrane-inserted protein kinase C. Biochemistry (1988) 0.90
On the role of gamma-carboxyglutamic acid in calcium and phospholipid binding. Biochem Biophys Res Commun (1975) 0.90
Vitamin K-dependent carboxylation and vitamin K epoxidation. Evidence that the warfarin-sensitive microsomal NAD(P)H dehydrogenase reduces vitamin K1 in these reactions. Biochem J (1981) 0.89
Mechanism of the abnormal vitamin K-dependent gamma-carboxylation process in human hepatocellular carcinomas. Cancer (1994) 0.89
Reduced outer membrane permeability of Escherichia coli O157:H7: suggested role of modified outer membrane porins and theoretical function in resistance to antimicrobial agents. Biochemistry (2001) 0.89
Protein structural requirements and properties of membrane binding by gamma-carboxyglutamic acid-containing plasma proteins and peptides. J Biol Chem (1989) 0.89
Vitamin K epoxidase: properties and relationship to prothrombin synthesis. Biochemistry (1977) 0.89
The carbohydrate of bovine prothrombin. Partial structural determination demonstrating the presence of -galactose residues. J Biol Chem (1972) 0.89
Properties of a Ca2+ binding peptide from prothrombin. Biochem Biophys Res Commun (1974) 0.89
Amino-terminal alanine functions in a calcium-specific process essential for membrane binding by prothrombin fragment 1. Biochemistry (1988) 0.88
Recent developments in understanding the mechanism of vitamin K and vitamin K-antagonist drug action and the consequences of vitamin K action in blood coagulation. Prog Hematol (1977) 0.88
Effect of N-methyl-thiotetrazole on rat liver microsomal vitamin K-dependent carboxylation. Biochem Pharmacol (1986) 0.88
Properties of the protein kinase C-phorbol ester interaction. Biochemistry (1989) 0.88
Binding and activation properties of human factor XII, prekallikrein, and derived peptides with acidic lipid vesicles. Biochemistry (1985) 0.88
Kinetic and mechanistic analysis of prothrombin-membrane binding by stopped-flow light scattering. Biochemistry (1982) 0.88
Vitamin K epoxidase: dependence of epoxidase activity on substrates of the vitamin K-dependent carboxylation reaction. FEBS Lett (1980) 0.87
Purification and identification of bovine liver gamma-carboxylase. Proc Natl Acad Sci U S A (1992) 0.87
Vitamin K dependent in vitro production of prothrombin. Biochemistry (1982) 0.87
Kinetic and hydrodynamic analysis of blood clotting factor V-membrane binding. Biochemistry (1982) 0.87
Improving the vitamin K status of breastfeeding infants with maternal vitamin K supplements. Pediatrics (1997) 0.87
Substrate-specific stimulation of protein kinase C by polyvalent anion. Biochem Biophys Res Commun (1987) 0.86
Effects of a vitamin K-deficient diet and antibiotics in normal human volunteers. J Lab Clin Med (1987) 0.86