Published in Nature on December 15, 1972
On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97
Molecular evolution of human and rabbit beta-globin mRNAs. Proc Natl Acad Sci U S A (1977) 2.70
Cloning, sequencing, and evolutionary analysis of the mouse erythropoietin gene. Mol Cell Biol (1986) 1.58
Weak selection and protein evolution. Genetics (2012) 1.09
Neutral and nonneutral mutations: the creative mix--evolution of complexity in gene interaction systems. J Mol Evol (1997) 0.88
The isolation and partial characterization of ribonuclease A from Bison bison. Biochem J (1973) 0.78
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation. Proc Natl Acad Sci U S A (1992) 16.64
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science (2001) 11.22
Functional mapping of the human visual cortex by magnetic resonance imaging. Science (1991) 6.93
Sexual transmission of HIV. N Engl J Med (1997) 6.84
The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science (1989) 6.80
Patterns of brain activation in people at risk for Alzheimer's disease. N Engl J Med (2000) 6.72
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. Nature (2001) 6.70
An extracellular H2O2-requiring enzyme preparation involved in lignin biodegradation by the white rot basidiomycete Phanerochaete chrysosporium. Biochem Biophys Res Commun (1983) 6.04
Potent antiretroviral treatment of HIV-infection results in suppression of the seminal shedding of HIV. The Swiss HIV Cohort Study. AIDS (2000) 4.91
Viral burden in genital secretions determines male-to-female sexual transmission of HIV-1: a probabilistic empiric model. AIDS (2001) 4.76
Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol Cell Biol (2000) 4.64
Optic nerve decompression may improve the progressive form of nonarteritic ischemic optic neuropathy. Arch Ophthalmol (1989) 4.48
Quantitating the multiplicity of infection with human immunodeficiency virus type 1 subtype C reveals a non-poisson distribution of transmitted variants. J Virol (2009) 4.40
Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: underrepresentation of X4 variants. J Virol (1999) 4.16
Purification and characterization of an extracellular Mn(II)-dependent peroxidase from the lignin-degrading basidiomycete, Phanerochaete chrysosporium. Arch Biochem Biophys (1985) 4.14
Purification and characterization of an extracellular H2O2-requiring diarylpropane oxygenase from the white rot basidiomycete, Phanerochaete chrysosporium. Arch Biochem Biophys (1984) 3.83
Manganese(II) oxidation by manganese peroxidase from the basidiomycete Phanerochaete chrysosporium. Kinetic mechanism and role of chelators. J Biol Chem (1992) 3.79
High levels of human immunodeficiency virus type 1 in blood and semen of seropositive men in sub-Saharan Africa. J Infect Dis (1998) 3.46
In vitro depolymerization of lignin by manganese peroxidase of Phanerochaete chrysosporium. Biochem Biophys Res Commun (1991) 3.43
Effect of antiviral treatment on the shedding of HIV-1 in semen. AIDS (1997) 3.42
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice. J Clin Invest (2000) 3.41
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest (2001) 3.41
Cloning and functional expression of a brain G-protein-coupled ATP receptor. FEBS Lett (1993) 3.38
Cholinergic receptor molecules and cholinesterase molecules at mouse skeletal muscle junctions. Nature (1971) 3.32
The microbicidal mechanisms of human neutrophils and eosinophils. Rev Infect Dis (1981) 3.29
Trichomonas vaginalis as a cause of urethritis in Malawian men. Sex Transm Dis (1999) 3.12
Mechanism of the luminol-dependent chemiluminescence of human neutrophils. J Immunol (1982) 3.11
Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice. Eur J Immunol (1996) 2.90
Mn(II) oxidation is the principal function of the extracellular Mn-peroxidase from Phanerochaete chrysosporium. Arch Biochem Biophys (1986) 2.77
Azithromycin for empirical treatment of the nongonococcal urethritis syndrome in men. A randomized double-blind study. JAMA (1995) 2.71
Preventing sexual transmission of HIV--new ideas from sub-Saharan Africa. N Engl J Med (2000) 2.67
Decolorization of Several Polymeric Dyes by the Lignin-Degrading Basidiomycete Phanerochaete chrysosporium. Appl Environ Microbiol (1983) 2.64
Manganese regulation of manganese peroxidase expression and lignin degradation by the white rot fungus Dichomitus squalens. Appl Environ Microbiol (1991) 2.61
Sexual transmission of HIV: infectiousness and prevention. AIDS (1999) 2.59
Quantification of HIV in semen: correlation with antiviral treatment and immune status. AIDS (1997) 2.51
Bacterial adaptation to oxidative stress: implications for pathogenesis and interaction with phagocytic cells. FASEB J (1989) 2.47
Relationship between the cagA 3' repeat region of Helicobacter pylori, gastric histology, and susceptibility to low pH. Gastroenterology (1999) 2.44
Nucleotide receptors. Curr Opin Neurobiol (1997) 2.44
Trichomoniasis: clinical manifestations, diagnosis and management. Sex Transm Infect (2004) 2.43
Induction of colonial growth and replica plating of the white rot basidiomycete Phanaerochaete chrysosporium. Appl Environ Microbiol (1978) 2.41
The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers. Mol Microbiol (1998) 2.33
Fungal infection in chronic granulomatous disease. The importance of the phagocyte in defense against fungi. Am J Med (1981) 2.31
Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits. J Neurosci (1997) 2.31
Manganese regulates expression of manganese peroxidase by Phanerochaete chrysosporium. J Bacteriol (1990) 2.31
Degradation of 2,4-dichlorophenol by the lignin-degrading fungus Phanerochaete chrysosporium. J Bacteriol (1991) 2.19
Mating System and Basidiospore Formation in the Lignin-Degrading Basidiomycete Phanerochaete chrysosporium. Appl Environ Microbiol (1987) 2.19
Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev (2001) 2.18
Functional cerebral imaging by susceptibility-contrast NMR. Magn Reson Med (1990) 2.14
Quantitation of human immunodeficiency virus type 1 RNA in cell free seminal plasma: comparison of NASBA with Amplicor reverse transcription-PCR amplification and correlation with quantitative culture. J Virol Methods (1996) 2.12
Response of Pseudomonas aeruginosa to pyocyanin: mechanisms of resistance, antioxidant defenses, and demonstration of a manganese-cofactored superoxide dismutase. Infect Immun (1992) 2.09
Closed reduction and percutaneous pinning of fractures of the proximal phalanx. J Hand Surg Br (2001) 2.07
Regulation of nigeran accumulation by Aspergillus aculeatus. J Bacteriol (1973) 2.02
Multiple molecular forms of diarylpropane oxygenase, an H2O2-requiring, lignin-degrading enzyme from Phanerochaete chrysosporium. Arch Biochem Biophys (1985) 2.01
Ribonucleases. Annu Rev Biochem (1969) 2.00
Anisotropy of NMR properties of tissues. Magn Reson Med (1994) 1.98
Kimura's disease: two case reports and a literature review. Ann Otol Rhinol Laryngol (1998) 1.97
Manganese peroxidase from the basidiomycete Phanerochaete chrysosporium: spectral characterization of the oxidized states and the catalytic cycle. Biochemistry (1988) 1.94
Intracranial stenting of severe symptomatic intracranial stenosis: results of 100 consecutive patients. AJNR Am J Neuroradiol (2008) 1.93
Multiple gonococcal pilin antigenic variants are produced during experimental human infections. J Clin Invest (1994) 1.93
Manganese peroxidase from the lignin-degrading basidiomycete Phanerochaete chrysosporium. Transient state kinetics and reaction mechanism. J Biol Chem (1989) 1.92
Factors that affect the diagnostic accuracy of liver fibrosis measurement by Fibroscan in patients with chronic hepatitis B. Aliment Pharmacol Ther (2010) 1.92
Qualitative and quantitative evaluation of six algorithms for correcting intensity nonuniformity effects. Neuroimage (2001) 1.90
Brain parenchyma motion: measurement with cine echo-planar MR imaging. Radiology (1992) 1.90
Yeast hexokinase. 3. Sulfhydryl groups and protein dissociation. Biochemistry (1968) 1.89
Breakthrough pneumococcal bacteremia in patients being treated with azithromycin and clarithromycin. Clin Infect Dis (2000) 1.89
Translation of exogenous messenger RNA coding for nicotinic acetylcholine receptors produces functional receptors in Xenopus oocytes. Proc R Soc Lond B Biol Sci (1982) 1.87
Crystallographic refinement of lignin peroxidase at 2 A. J Biol Chem (1993) 1.86
Characterization of a cDNA encoding a manganese peroxidase, from the lignin-degrading basidiomycete Phanerochaete chrysosporium. J Biol Chem (1989) 1.84
Generation of hydroxyl radical and its involvement in lignin degradation by Phanerochaete chrysosporium. Biochem Biophys Res Commun (1982) 1.83
Manganese peroxidase gene transcription in Phanerochaete chrysosporium: activation by manganese. J Bacteriol (1991) 1.83
Gonococcal infection: a model of molecular pathogenesis. N Engl J Med (1985) 1.82
Degradation of 2,7-dichlorodibenzo-p-dioxin by the lignin-degrading basidiomycete Phanerochaete chrysosporium. J Bacteriol (1992) 1.82
Acetylcholine receptor and ion conductance modulator sites at the murine neuromuscular junction: evidence from specific toxin reactions. Proc Natl Acad Sci U S A (1973) 1.82
Multiple gonococcal opacity proteins are expressed during experimental urethral infection in the male. J Exp Med (1994) 1.80
Sexually transmitted diseases in the People's Republic of China in Y2K: back to the future. Sex Transm Dis (2000) 1.80
The molecular cloning and characterisation of cDNA coding for the alpha subunit of the acetylcholine receptor. Nucleic Acids Res (1982) 1.80
Degradation of 2,4-dinitrotoluene by the lignin-degrading fungus Phanerochaete chrysosporium. Appl Environ Microbiol (1992) 1.78
Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder. Arch Gen Psychiatry (1996) 1.77
Comparison of surgical conditions during propofol or sevoflurane anaesthesia for endoscopic sinus surgery. Br J Anaesth (2007) 1.76
The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration. AIDS (1999) 1.76
Degradation of 2,4,5-trichlorophenol by the lignin-degrading basidiomycete Phanerochaete chrysosporium. Appl Environ Microbiol (1993) 1.76
Laparoscopic complications in markedly obese urologic patients (a multi-institutional review) Urology (1996) 1.75
Metabolism of Radiolabeled beta-Guaiacyl Ether-Linked Lignin Dimeric Compounds by Phanerochaete chrysosporium. Appl Environ Microbiol (1980) 1.75
Acquiring simultaneous EEG and functional MRI. Clin Neurophysiol (2000) 1.75
A gamma-aminobutyric acid/benzodiazepine receptor complex of bovine cerebral cortex. J Biol Chem (1983) 1.71
Antiretroviral-drug concentrations in semen: implications for sexual transmission of human immunodeficiency virus type 1. Antimicrob Agents Chemother (1999) 1.68
Types and locations of cholinergic receptor-like molecules in muscle fibres. Nat New Biol (1973) 1.67
Free radicals and phagocytic cells. FASEB J (1995) 1.65
Chancroid, primary syphilis, genital herpes, and lymphogranuloma venereum in Antananarivo, Madagascar. J Infect Dis (1999) 1.64
Serum sensitivity of Neisseria gonorrhoeae: the role of lipopolysaccharide. J Infect Dis (1984) 1.64
Degradation of azo dyes by the lignin-degrading fungus Phanerochaete chrysosporium. Appl Environ Microbiol (1992) 1.64
Thiol-mediated oxidation of nonphenolic lignin model compounds by manganese peroxidase of Phanerochaete chrysosporium. J Biol Chem (1989) 1.64
Adequacy of fellowship training: results of a survey of recently graduated fellows. Clin Infect Dis (2001) 1.63
A new deal in HIV prevention: lessons from the global approach. Ann Intern Med (1994) 1.63
Oxidation of phenolic arylglycerol beta-aryl ether lignin model compounds by manganese peroxidase from Phanerochaete chrysosporium: oxidative cleavage of an alpha-carbonyl model compound. Biochemistry (1992) 1.63
Rotational mobility of the membrane-bound acetylcholine receptor of Torpedo electric organ measured by phosphorescence depolarisation. FEBS Lett (1980) 1.62
Molecular typing of Neisseria gonorrhoeae causing repeated infections: evolution of porin during passage within a community. J Infect Dis (1999) 1.62
Active multi-subunit ACh receptor assembled by translation of heterologous mRNA in Xenopus oocytes. Nature (1981) 1.61
Quantitation of human immunodeficiency virus type 1 RNA in different biological compartments. J Clin Microbiol (2000) 1.60