Published in J Biol Chem on October 10, 1972
Redox paradox: insulin action is facilitated by insulin-stimulated reactive oxygen species with multiple potential signaling targets. Diabetes (2005) 2.31
Evidence for the involvement of sulfhydryl oxidation in the regulation of fat cell hexose transport by insulin. Proc Natl Acad Sci U S A (1974) 2.06
Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal (2005) 1.60
Increase or decrease hydrogen sulfide exert opposite lipolysis, but reduce global insulin resistance in high fatty diet induced obese mice. PLoS One (2013) 0.79
Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science (1997) 3.91
A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains. J Biol Chem (1997) 3.19
Interaction of cross-linking agents with the insulin effector system of isolated fat cells. Covalent linkage of 125I-insulin to a plasma membrane receptor protein of 140,000 daltons. J Biol Chem (1979) 2.83
Relationship between hormonal activation of phosphatidylinositol hydrolysis, fluid secretion and calcium flux in the blowfly salivary gland. Biochem J (1979) 2.70
The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor. J Biol Chem (1982) 2.62
5-Hydroxytryptamine stimulates inositol phosphate production in a cell-free system from blowfly salivary glands. Evidence for a role of GTP in coupling receptor activation to phosphoinositide breakdown. J Biol Chem (1985) 2.60
The subunit structure of the high affinity insulin receptor. Evidence for a disulfide-linked receptor complex in fat cell and liver plasma membranes. J Biol Chem (1980) 2.51
Tumor-promoting phorbol diesters cause the phosphorylation of epidermal growth factor receptors in normal human fibroblasts at threonine-654. Proc Natl Acad Sci U S A (1985) 2.36
FGF inactivates myogenic helix-loop-helix proteins through phosphorylation of a conserved protein kinase C site in their DNA-binding domains. Cell (1992) 2.28
Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity. J Biol Chem (1984) 2.21
Molecular basis of insulin action. Annu Rev Biochem (1977) 2.16
Electrophoretic resolution of three major insulin receptor structures with unique subunit stoichiometries. Proc Natl Acad Sci U S A (1980) 2.15
Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes. Science (1993) 2.14
Structural basis of 3-phosphoinositide recognition by pleckstrin homology domains. Mol Cell (2000) 2.13
A double leucine within the GLUT4 glucose transporter COOH-terminal domain functions as an endocytosis signal. J Cell Biol (1994) 2.08
Evidence for the involvement of sulfhydryl oxidation in the regulation of fat cell hexose transport by insulin. Proc Natl Acad Sci U S A (1974) 2.06
Effect of growth hormone and dexamethasone on lipolysis and metabolism in isolated fat cells of the rat. J Biol Chem (1965) 1.99
The nature and regulation of the insulin receptor: structure and function. Annu Rev Physiol (1985) 1.98
Regulation of GRP1-catalyzed ADP ribosylation factor guanine nucleotide exchange by phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem (1998) 1.83
Effects of adenosine nucleosides on adenylate cyclase, phosphodiesterase, cyclic adenosine monophosphate accumulation, and lipolysis in fat cells. J Biol Chem (1972) 1.82
Regulation of adenylate cyclase by adenosine. Mol Cell Biochem (1979) 1.74
Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol (1998) 1.68
A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. Science (1988) 1.68
The isolation and metabolism of brown fat cells. J Biol Chem (1967) 1.66
Guanosine 5'-O-thiotriphosphate stimulates phospholipase C activity in plasma membranes of rat hepatocytes. J Biol Chem (1985) 1.65
Fat cell adenylate cyclase and beta-adrenergic receptors in altered thyroid states. J Biol Chem (1978) 1.64
Insulin-like growth factor I and insulin rapidly increase casein kinase II activity in BALB/c 3T3 fibroblasts. J Biol Chem (1988) 1.59
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain. J Biol Chem (1996) 1.58
Inhibition of phosphatidylinositol synthesis and the inactivation of calcium entry after prolonged exposure of the blowfly salivary gland to 5-hydroxytryptamine. Biochem J (1979) 1.57
Insulin stimulates cellular iron uptake and causes the redistribution of intracellular transferrin receptors to the plasma membrane. J Biol Chem (1986) 1.56
Role of phosphatidylinositol turnover in alpha 1 and of adenylate cyclase inhibition in alpha 2 effects of catecholamines. Life Sci (1980) 1.55
ADP-ribosylation factor 6 as a target of guanine nucleotide exchange factor GRP1. J Biol Chem (1999) 1.53
Tumor-promoting phorbol diesters mediate phosphorylation of the epidermal growth factor receptor. J Biol Chem (1984) 1.52
Differential expression of insulin-like growth factor II mRNA in human primary liver cancers, benign liver tumors, and liver cirrhosis. Cancer Res (1988) 1.51
Interactions of Cbl with Grb2 and phosphatidylinositol 3'-kinase in activated Jurkat cells. Mol Cell Biol (1995) 1.48
Lack of correlation between catecholamine effects on cyclic adenosine 3':5'-monophosphate and gluconeogenesis in isolated rat liver cells. J Biol Chem (1973) 1.47
A unique proteolytic cleavage site on the beta subunit of the insulin receptor. J Biol Chem (1981) 1.46
Distinct polyphosphoinositide binding selectivities for pleckstrin homology domains of GRP1-like proteins based on diglycine versus triglycine motifs. J Biol Chem (2000) 1.45
Coordinate modulation of D-glucose transport activity and bilayer fluidity in plasma membranes derived from control and insulin-treated adipocytes. Proc Natl Acad Sci U S A (1980) 1.45
Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor. Proc Natl Acad Sci U S A (1982) 1.44
Interactions of Drosophila Cbl with epidermal growth factor receptors and role of Cbl in R7 photoreceptor cell development. Mol Cell Biol (1997) 1.43
Photoaffinity labeling of the human erythrocyte D-glucose transporter. J Biol Chem (1982) 1.43
Effects of adenosine deaminase on cyclic adenosine monophosphate accumulation, lipolysis, and glucose metabolism of fat cells. J Biol Chem (1975) 1.42
Photoaffinity labeling of insulin-sensitive hexose transporters in intact rat adipocytes. Direct evidence that latent transporters become exposed to the extracellular space in response to insulin. J Biol Chem (1984) 1.40
Hexose transport in isolated brown fat cells. A model system for investigating insulin action on membrane transport. J Biol Chem (1974) 1.39
The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase. J Biol Chem (1996) 1.37
Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem (1990) 1.37
Regulation of phosphoinositide breakdown by guanine nucleotides. Life Sci (1986) 1.36
Adrenergic regulation of adipocyte metabolism. J Lipid Res (1983) 1.35
Biochemical aspects of drug and hormone action on adipose tissue. Pharmacol Rev (1973) 1.35
Stimulation by vasopressin and alpha-catecholamines of phosphatidylinositol formation in isolated rat liver parenchymal cells. J Biol Chem (1980) 1.34
Relationship between phosphatidylinositol synthesis and recovery of 5-hydroxytryptamine-responsive Ca2+ flux in blowfly salivary glands. Biochem J (1979) 1.34
RNAi screens reveal novel metabolic regulators: RIP140, MAP4k4 and the lipid droplet associated fat specific protein (FSP) 27. Acta Physiol (Oxf) (2008) 1.33
Insulin action and the regulation of hexose transport. Diabetes (1980) 1.33
Cytochalasin B-sensitive 2-deoxy-D-glucose transport in adipose cell ghosts. J Biol Chem (1973) 1.31
Cellular basis of insulin insensitivity in large rat adipocytes. J Clin Invest (1976) 1.31
sn-1,2-Dioctanoylglycerol. A cell-permeable diacylglycerol that mimics phorbol diester action on the epidermal growth factor receptor and mitogenesis. J Biol Chem (1985) 1.30
A role for kinesin in insulin-stimulated GLUT4 glucose transporter translocation in 3T3-L1 adipocytes. J Biol Chem (2001) 1.30
Evidence that insulin activates an intrinsic plasma membrane protease in generating a secondary chemical mediator. J Biol Chem (1980) 1.29
Phosphorylation of transcriptional factors and cell-cycle-dependent proteins by casein kinase II. Curr Opin Cell Biol (1991) 1.29
Amiloride directly inhibits growth factor receptor tyrosine kinase activity. J Biol Chem (1985) 1.28
Insulin activates the appearance of insulin-like growth factor II receptors on the adipocyte cell surface. Proc Natl Acad Sci U S A (1984) 1.27
5-Methyltryptamine stimulates phospholipase C-mediated breakdown of exogenous phosphoinositides by blowfly salivary gland membranes. J Biol Chem (1985) 1.26
beta-Adrenergic regulation of insulin and epidermal growth factor receptors in rat adipocytes. J Biol Chem (1983) 1.25
Antilipolytic effect of insulin in isolated fat cells of the rat. Endocrinology (1966) 1.25
Phox homology domains specifically bind phosphatidylinositol phosphates. Biochemistry (2001) 1.24
Hexose transport stimulation and membrane redistribution of glucose transporter isoforms in response to cholera toxin, dibutyryl cyclic AMP, and insulin in 3T3-L1 adipocytes. J Biol Chem (1990) 1.24
Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling. J Biol Chem (1981) 1.23
Regulation of the D-glucose transport system in isolated fat cells. Mol Cell Biochem (1976) 1.22
Coupling of the proto-oncogene product c-Cbl to the epidermal growth factor receptor. J Biol Chem (1995) 1.22
Rapid changes in hepatocyte phosphoinositides induced by vasopressin. J Biol Chem (1983) 1.22
Threonine 1336 of the human insulin receptor is a major target for phosphorylation by protein kinase C. Biochemistry (1990) 1.22
Agonist versus antagonist binding to alpha-adrenergic receptors. Proc Natl Acad Sci U S A (1980) 1.22
The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells. J Biol Chem (1982) 1.21
The ras signaling pathway mimics insulin action on glucose transporter translocation. Proc Natl Acad Sci U S A (1993) 1.20
Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling. J Biol Chem (1982) 1.20
Stimulation of IRS-1-associated phosphatidylinositol 3-kinase and Akt/protein kinase B but not glucose transport by beta1-integrin signaling in rat adipocytes. J Biol Chem (1998) 1.20
Inhibition of adenosine cyclic 3', 5'-monophosphate accumulation in fat cells by adenosine, N6-(phenylisopropyl) adenosine, and related compounds. Mol Pharmacol (1973) 1.19
Studies on the regulation of gluconeogenesis in isolated rat liver cells by epinephrine and glucagon. J Biol Chem (1974) 1.18
Regulation of Ca2+-Mg2+-ATPase activity in hepatocyte plasma membranes by vasopressin and phenylephrine. Endocrinology (1983) 1.18
Evidence for electron transfer reactions involved in the Cu2+ -dependent thiol activation of fat cell glucose utilization. J Biol Chem (1974) 1.17
Activation of the Akt-related cytokine-independent survival kinase requires interaction of its phox domain with endosomal phosphatidylinositol 3-phosphate. Proc Natl Acad Sci U S A (2001) 1.16
Functional roles for the pleckstrin and Dbl homology regions in the Ras exchange factor Son-of-sevenless. J Biol Chem (1995) 1.16
The regulation of gluconeogenesis in isolated rat liver cells by glucagon, insulin, dibutyryl cyclic adenosine monophosphate, and fatty acids. J Biol Chem (1972) 1.16
A role for phospholipase D in GLUT4 glucose transporter translocation. J Biol Chem (2000) 1.15
Characterization of [3H]adenosine binding to fat cell membranes. J Biol Chem (1978) 1.15
Regulation of transferrin receptor expression at the cell surface by insulin-like growth factors, epidermal growth factor and platelet-derived growth factor. EMBO J (1986) 1.15
Effects of pertussis toxin treatment on the metabolism of rat adipocytes. J Biol Chem (1983) 1.14
Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues. J Biol Chem (1981) 1.14
Synergistic activation of rat hepatocyte glycogen phosphorylase by A23187 and phorbol ester. Biochem Biophys Res Commun (1984) 1.13
Stimulation of epidermal growth factor receptor threonine 654 phosphorylation by platelet-derived growth factor in protein kinase C-deficient human fibroblasts. J Biol Chem (1987) 1.13
The type II insulin-like growth factor receptor does not mediate increased DNA synthesis in H-35 hepatoma cells. J Biol Chem (1984) 1.13
Insulin regulation of membrane-associated insulin receptor substrate 1. J Biol Chem (1995) 1.13
Activation of cell surface glucose transporters measured by photoaffinity labeling of insulin-sensitive 3T3-L1 adipocytes. J Biol Chem (1992) 1.13
Insulin-like growth factor I and epidermal growth factor regulate the expression of transferrin receptors at the cell surface by distinct mechanisms. J Biol Chem (1987) 1.13
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654. Proc Natl Acad Sci U S A (1985) 1.12
Studies on the role of cyclic guanosine 3':5'-monophosphate and extracellular Ca2+ in the regulation of glycogenolysis in rat liver cells. J Biol Chem (1976) 1.12
Structural and functional homologies in the receptors for insulin and the insulin-like growth factors. Cell (1982) 1.12
Phosphorylation of the Ras nucleotide exchange factor son of sevenless by mitogen-activated protein kinase. J Biol Chem (1994) 1.12