Published in Biochim Biophys Acta on July 04, 1979
The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin. Biochem J (1987) 1.05
Activation of human protein C by blood coagulation factor Xa in the presence of anionic phospholipids. Enhancement by sulphated polysaccharides. Biochem J (1989) 0.80
The effect of Ca2+, phospholipid and factor V on the anti-(factor Xa) activity of heparin and its high-affinity oligosaccharides. Biochem J (1987) 0.77
In vitro and in vivo characterization of a reversible synthetic heparin analog. Thromb Res (2015) 0.75
Dysfunction of endothelial protein C activation in severe meningococcal sepsis. N Engl J Med (2001) 4.10
Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci U S A (1981) 3.88
Isolation of a membrane-bound cofactor for thrombin-catalyzed activation of protein C. J Biol Chem (1982) 3.51
Protein C prevents the coagulopathic and lethal effects of Escherichia coli infusion in the baboon. J Clin Invest (1987) 3.29
The inhibition of blood coagulation by activated Protein C through the selective inactivation of activated Factor V. Biochim Biophys Acta (1979) 2.83
Overexpressing endothelial cell protein C receptor alters the hemostatic balance and protects mice from endotoxin. J Thromb Haemost (2005) 2.70
The regulation of natural anticoagulant pathways. Science (1987) 2.58
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Proc Natl Acad Sci U S A (1996) 2.58
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem (1994) 2.52
Extracellular histones increase plasma thrombin generation by impairing thrombomodulin-dependent protein C activation. J Thromb Haemost (2011) 2.51
Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity. Proc Natl Acad Sci U S A (1986) 2.43
The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity. J Biol Chem (1979) 2.21
The conversion of prothrombin to thrombin. I. Characterization of the reaction products formed during the activation of bovine prothrombin. J Biol Chem (1974) 2.19
The region of the thrombin receptor resembling hirudin binds to thrombin and alters enzyme specificity. J Biol Chem (1991) 2.14
The interaction of a Ca2+-dependent monoclonal antibody with the protein C activation peptide region. Evidence for obligatory Ca2+ binding to both antigen and antibody. J Biol Chem (1988) 2.06
Complex formation between thrombin and thrombomodulin inhibits both thrombin-catalyzed fibrin formation and factor V activation. J Biol Chem (1982) 2.04
Regulation of activated protein C by a new protein. A possible function for bovine protein S. J Biol Chem (1980) 2.02
Recurrent venous thromboembolism in patients with a partial deficiency of protein S. N Engl J Med (1984) 1.98
Functional properties of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. J Biol Chem (1981) 1.94
Regulation of activated protein C by protein S. The role of phospholipid in factor Va inactivation. J Biol Chem (1981) 1.88
Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest (1984) 1.84
Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Circulation (1997) 1.81
The endothelial cell protein C receptor aids in host defense against Escherichia coli sepsis. Blood (2000) 1.80
Proteolytic formation and properties of gamma-carboxyglutamic acid-domainless protein C. J Biol Chem (1983) 1.77
Phosphatidylethanolamine incorporation into vesicles selectively enhances factor Va inactivation by activated protein C. J Biol Chem (1994) 1.77
Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro. J Clin Invest (1987) 1.74
Non-hematopoietic EPCR regulates the coagulation and inflammatory responses during endotoxemia. J Thromb Haemost (2007) 1.73
A new carboxylation reaction. The vitamin K-dependent incorporation of H-14-CO3- into prothrombin. J Biol Chem (1975) 1.71
A monoclonal antibody against activated protein C allows rapid detection of activated protein C in plasma and reveals a calcium ion dependent epitope involved in factor Va inactivation. J Thromb Haemost (2003) 1.67
A polypeptide region of bovine prothrombin specific for binding to phospholipids. Proc Natl Acad Sci U S A (1973) 1.65
A new vitamin K-dependent protein. A phospholipid-binding zymogen of a serine esterase. J Biol Chem (1976) 1.64
Tumor necrosis factor leads to the internalization and degradation of thrombomodulin from the surface of bovine aortic endothelial cells in culture. Blood (1989) 1.64
Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity. J Biol Chem (1989) 1.63
Inflammation and coagulation: linked processes potentially regulated through a common pathway mediated by protein C. Thromb Haemost (1991) 1.59
Complement proteins C5b-9 induce vesiculation of the endothelial plasma membrane and expose catalytic surface for assembly of the prothrombinase enzyme complex. J Biol Chem (1990) 1.59
Role of coagulation pathways and treatment with activated protein C in hyperoxic lung injury. Thorax (2008) 1.58
A 23bp insertion in the endothelial protein C receptor (EPCR) gene impairs EPCR function. Thromb Haemost (2001) 1.57
The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptor. J Biol Chem (1996) 1.56
Metalloproteolytic release of endothelial cell protein C receptor. J Biol Chem (2000) 1.54
Vitamin K-dependent carboxylase. Requirements of the rat liver microsomal enzyme system. J Biol Chem (1976) 1.53
Endothelial cell protein C receptor plays an important role in protein C activation in vivo. Blood (2001) 1.51
Activated protein C inhibits platelet prothrombin-converting activity. Blood (1979) 1.51
The function of calcium in protein C activation by thrombin and the thrombin-thrombomodulin complex can be distinguished by mutational analysis of protein C derivatives. J Biol Chem (1992) 1.50
Generation of fibrinolytic activity by infusion of activated protein C into dogs. J Clin Invest (1981) 1.50
Protein C activation following coronary artery occlusion in the in situ porcine heart. Circulation (1991) 1.50
Glu-192----Gln substitution in thrombin mimics the catalytic switch induced by thrombomodulin. Proc Natl Acad Sci U S A (1991) 1.46
The active site of thrombin is altered upon binding to thrombomodulin. Two distinct structural changes are detected by fluorescence, but only one correlates with protein C activation. J Biol Chem (1991) 1.44
The natural anticoagulant protein S is decreased in male smokers. Am Heart J (1991) 1.41
Inflammation, innate immunity and blood coagulation. Hamostaseologie (2010) 1.39
Total synthesis of the L-hexoses. Science (1983) 1.38
DEGR-factor Xa blocks disseminated intravascular coagulation initiated by Escherichia coli without preventing shock or organ damage. Blood (1991) 1.36
The active site of blood coagulation factor Xa. Its distance from the phospholipid surface and its conformational sensitivity to components of the prothrombinase complex. J Biol Chem (1987) 1.36
The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotype. J Thromb Haemost (2006) 1.34
An abnormal plasma distribution of protein S occurs in functional protein S deficiency. Blood (1986) 1.33
Thrombomodulin blocks the ability of thrombin to activate platelets. J Biol Chem (1983) 1.33
Origin of the magnetoelectric coupling effect in Pb(Zr0.2Ti0.8)O{3}/La{0.8}Sr{0.2}MnO{3} Multiferroic heterostructures. Phys Rev Lett (2010) 1.32
Identification of functional endothelial protein C receptor in human plasma. J Clin Invest (1997) 1.31
Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. Blood (2000) 1.30
Protein C. Prog Hemost Thromb (1984) 1.30
Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. J Biol Chem (2000) 1.29
The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. J Biol Chem (1996) 1.28
Endogenous activated protein C signaling is critical to protection of mice from lipopolysaccaride-induced septic shock. J Thromb Haemost (2009) 1.28
Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation. J Biol Chem (1999) 1.27
Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem (1991) 1.24
Protein S alters the active site location of activated protein C above the membrane surface. A fluorescence resonance energy transfer study of topography. J Biol Chem (1997) 1.24
Expression and purification of a soluble tissue factor fusion protein with an epitope for an unusual calcium-dependent antibody. Protein Expr Purif (1992) 1.24
The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. J Immunol (2000) 1.23
The fifth and sixth growth factor-like domains of thrombomodulin bind to the anion-binding exosite of thrombin and alter its specificity. J Biol Chem (1992) 1.21
Vitamin K-dependent carboxylase. Solubilization and properties. J Biol Chem (1976) 1.20
Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo. Blood (2000) 1.20
Activation of protein C in vivo. J Clin Invest (1982) 1.20
Protein C inhibitor is a potent inhibitor of the thrombin-thrombomodulin complex. J Biol Chem (1995) 1.19
Down-regulation of endothelial expression of endothelial cell protein C receptor and thrombomodulin in coronary atherosclerosis. Am J Pathol (2001) 1.19
A 10-kDa cyanogen bromide fragment from the epidermal growth factor homology domain of rabbit thrombomodulin contains the primary thrombin binding site. J Biol Chem (1988) 1.19
Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest (1993) 1.17
Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation. J Clin Invest (1988) 1.17
New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK. Structure (1997) 1.17
Cultured bovine aortic endothelial cells promote activated protein C-protein S-mediated inactivation of factor Va. J Biol Chem (1986) 1.16
Functional and immunologic protein S levels are decreased during pregnancy. Blood (1986) 1.15
Regulated endothelial protein C receptor shedding is mediated by tumor necrosis factor-alpha converting enzyme/ADAM17. J Thromb Haemost (2006) 1.15
Infection of vascular endothelial cells with herpes simplex virus enhances tissue factor activity and reduces thrombomodulin expression. Proc Natl Acad Sci U S A (1990) 1.14
Reconstitution of rabbit thrombomodulin into phospholipid vesicles. J Biol Chem (1987) 1.14
On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity. J Biol Chem (1986) 1.14
Influenza, pneumococcal, and tetanus toxioid vaccination of adults--United States, 1993-7. MMWR CDC Surveill Summ (2000) 1.13
Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. J Biol Chem (1995) 1.13
Complement proteins C5b-9 stimulate procoagulant activity through platelet prothrombinase. Blood (1986) 1.13
Protein S is required for bovine platelets to support activated protein C binding and activity. J Biol Chem (1985) 1.12
Microthrombomodulin. Residues 310-486 from the epidermal growth factor precursor homology domain of thrombomodulin will accelerate protein C activation. J Biol Chem (1989) 1.11
Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid. J Biol Chem (1983) 1.11
Derivatives of blood coagulation factor IX contain a high affinity Ca2+-binding site that lacks gamma-carboxyglutamic acid. J Biol Chem (1984) 1.11
Protein-C: biochemistry, physiology, and clinical implications. Blood (1983) 1.10
The conversion of prothrombin to thrombin. II. Differentiation between thrombin- and factor Xa-catalyzed proteolyses. J Biol Chem (1974) 1.10
Protein S and the regulation of activated protein C. Semin Thromb Hemost (1984) 1.10
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101. J Biol Chem (1994) 1.09
Recombinant human protein C derivatives: altered response to calcium resulting in enhanced activation by thrombin. EMBO J (1990) 1.09
A model for thrombin protection against endotoxin. Thromb Res (1984) 1.09
Loss of prothrombin and of factor Xa-factor Va interactions upon inactivation of factor Va by activated protein C. J Biol Chem (1984) 1.08