Published in J Biol Chem on November 10, 1981
The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol Cell Biol (1993) 2.95
Familial protein S deficiency is associated with recurrent thrombosis. J Clin Invest (1984) 1.84
Natural anticoagulant mechanisms. J Clin Invest (1984) 1.75
Participation of endothelial cells in the protein C-protein S anticoagulant pathway: the synthesis and release of protein S. J Cell Biol (1986) 1.68
Purification of human vitamin K-dependent protein S and its limited proteolysis by thrombin. Biochem J (1983) 1.51
Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b. Proc Natl Acad Sci U S A (1983) 1.47
Primary structure of bovine vitamin K-dependent protein S. Proc Natl Acad Sci U S A (1986) 1.26
Protein S binds to and inhibits factor Xa. Proc Natl Acad Sci U S A (1994) 1.25
Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1. Exp Cell Res (2006) 1.22
Isolation and sequence of the cDNA for human protein S, a regulator of blood coagulation. Proc Natl Acad Sci U S A (1986) 1.22
beta-Hydroxyasparagine in domains homologous to the epidermal growth factor precursor in vitamin K-dependent protein S. Proc Natl Acad Sci U S A (1987) 1.20
Acquired deficiencies of protein S. Protein S activity during oral anticoagulation, in liver disease, and in disseminated intravascular coagulation. J Clin Invest (1988) 1.17
Occurrence of beta-hydroxylated asparagine residues in non-vitamin K-dependent proteins containing epidermal growth factor-like domains. Proc Natl Acad Sci U S A (1987) 1.08
Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain. Proc Natl Acad Sci U S A (1990) 1.04
Inactivation of human factor VIII by activated protein C. Cofactor activity of protein S and protective effect of von Willebrand factor. J Clin Invest (1988) 1.01
Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states. J Clin Invest (1986) 0.99
Norepinephrine down-regulates the activity of protein S on endothelial cells. J Cell Biol (1988) 0.97
Suppression of hemostatic system activation by oral anticoagulants in the blood of patients with thrombotic diatheses. J Clin Invest (1987) 0.97
Elevated factor Xa activity in the blood of asymptomatic patients with congenital antithrombin deficiency. J Clin Invest (1985) 0.94
Activated protein C enhances cell motility of endothelial cells and MDA-MB-231 breast cancer cells by intracellular signal transduction. Exp Cell Res (2009) 0.91
Vitamin K-dependent protein S is similar to rat androgen-binding protein. Biochem J (1987) 0.90
A theoretical model for the Gla-TSR-EGF-1 region of the anticoagulant cofactor protein S: from biostructural pathology to species-specific cofactor activity. J Comput Aided Mol Des (1997) 0.87
Cleavage of protein S by a platelet membrane protease. J Clin Invest (1987) 0.87
Protein C promoter polymorphisms associate with sepsis in children with systemic meningococcemia. Hum Genet (2007) 0.87
The interaction between complement component C4b-binding protein and the vitamin K-dependent protein S forms a link between blood coagulation and the complement system. Biochem J (1991) 0.86
A genome-wide association study of the Protein C anticoagulant pathway. PLoS One (2011) 0.85
The effect of Arg306-->Ala and Arg506-->Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S. Protein Sci (1997) 0.85
Cloning and characterization of human liver cDNA encoding a protein S precursor. Proc Natl Acad Sci U S A (1987) 0.85
Protein C activation on endothelial cells by prothrombin activation products generated in situ: meizothrombin is a better protein C activator than alpha-thrombin. Biochem J (1996) 0.85
Characterization of mini-protein S, a recombinant variant of protein S that lacks the sex hormone binding globulin-like domain. Biochem J (1998) 0.85
Models of the serine protease domain of the human antithrombotic plasma factor activated protein C and its zymogen. Protein Sci (1994) 0.84
Detailed mechanisms of the inactivation of factor VIIIa by activated protein C in the presence of its cofactors, protein S and factor V. J Biol Chem (2008) 0.83
Chemical synthesis and spontaneous folding of a multidomain protein: anticoagulant microprotein S. Proc Natl Acad Sci U S A (2000) 0.82
Structure of the gene coding for the alpha polypeptide chain of the human complement component C4b-binding protein. J Exp Med (1991) 0.82
Identification of candidate residues for interaction of protein S with C4b binding protein and activated protein C. Biochem J (1995) 0.81
Prediction of solution structures of the Ca2+-bound gamma-carboxyglutamic acid domains of protein S and homolog growth arrest specific protein 6: use of the particle mesh Ewald method. Biophys J (1997) 0.81
Modeling of human factor Va inactivation by activated protein C. BMC Syst Biol (2012) 0.79
Inhibition of the anticoagulant activity of protein S by prothrombin. J Clin Invest (1988) 0.79
Genetic determinants of variation in the plasma levels of the C4b-binding protein (C4BP) in Spanish families. Immunogenetics (2003) 0.78
Protein S as an in vivo cofactor to activated protein C in prevention of microarterial thrombosis in rabbits. J Clin Invest (1995) 0.78
Enhancement of rabbit protein S anticoagulant cofactor activity in vivo by modulation of the protein S C4B binding protein interaction. J Clin Invest (1990) 0.76
Intraventricular Hemorrhage in a Term Neonate: Manifestation of Protein S Deficiency- A Case Report. Iran J Public Health (2016) 0.75
Implication of protein S thrombin-sensitive region with membrane binding via conformational changes in the gamma-carboxyglutamic acid-rich domain. Biochem J (2001) 0.75
Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase. Thromb Res (2013) 0.75
Human activated protein C variants in a rat model of arterial thrombosis. Thromb J (2008) 0.75
LPS-Toll-Like Receptor-Mediated Signaling on Expression of Protein S and C4b-Binding Protein in the Liver. Gastroenterol Res Pract (2010) 0.75
Cutaneous necrosis associated with protein S deficiency. J R Soc Med (1990) 0.75
The inhibition of blood coagulation by activated Protein C through the selective inactivation of activated Factor V. Biochim Biophys Acta (1979) 2.83
Regulation of activated protein C by a new protein. A possible function for bovine protein S. J Biol Chem (1980) 2.02
Total synthesis of the L-hexoses. Science (1983) 1.38
Origin of the magnetoelectric coupling effect in Pb(Zr0.2Ti0.8)O{3}/La{0.8}Sr{0.2}MnO{3} Multiferroic heterostructures. Phys Rev Lett (2010) 1.32
Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem (1991) 1.24
Influenza, pneumococcal, and tetanus toxioid vaccination of adults--United States, 1993-7. MMWR CDC Surveill Summ (2000) 1.13
Protein S and the regulation of activated protein C. Semin Thromb Hemost (1984) 1.10
Identification of a new protein involved in the regulation of the anticoagulant activity of activated protein C. Protein S-binding protein. J Biol Chem (1986) 1.07
Regulation of vitamin K-dependent protein S. Inactivation by thrombin. J Biol Chem (1984) 0.98
Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom). Biochemistry (1980) 0.97
Inactivation of factor VIII by activated protein C and protein S. Arch Biochem Biophys (1987) 0.96
Interface-induced polarization and inhibition of ferroelectricity in epitaxial SrTiO₃/Si. Phys Rev Lett (2010) 0.95
von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation. J Biol Chem (1991) 0.94
Regulation of bovine activated protein C by protein S: the role of the cofactor protein in species specificity. Thromb Res (1981) 0.90
Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562. J Biol Chem (1994) 0.87
Intrinsic interfacial phenomena in manganite heterostructures. J Phys Condens Matter (2015) 0.84
Materials science. Atomically engineered oxide interfaces. Science (2009) 0.83
Interactions between heparin and factor Xa. Inhibition of prothrombin activation. Biochim Biophys Acta (1979) 0.82
Inactivation of human factor VIII by activated protein C: evidence that the factor VIII light chain contains the activated protein C binding site. Biochim Biophys Acta (1989) 0.82
The effects of phospholipid and factor Va on the inhibition of factor Xa by antithrombin III. Biochem Biophys Res Commun (1979) 0.81
Dynamic evanescent phonon coupling across the La(1-x)Sr(x)MnO3/SrTiO3 interface. Phys Rev Lett (2011) 0.81
Purification of a protein C activator from the venom of the southern copperhead snake (Agkistrodon contortrix contortrix). Biochemistry (1986) 0.80
Role of strontium in oxide epitaxy on silicon (001). Phys Rev Lett (2008) 0.79
The effect of prothrombin fragment 2 on the inhibition of thrombin by antithrombin III. J Biol Chem (1979) 0.79
Atomic structure of the epitaxial BaO/Si(001) interface. Phys Rev Lett (2009) 0.78
Endogenous anticoagulation during extracorporeal perfusion: generation of a heparinlike inhibitor. Am J Physiol (1980) 0.78
Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase. J Biol Chem (1996) 0.78
Physical structure and inversion charge at a semiconductor interface with a crystalline oxide. Science (2001) 0.77
Enhancement of rabbit protein S anticoagulant cofactor activity in vivo by modulation of the protein S C4B binding protein interaction. J Clin Invest (1990) 0.76
Species specificity of the fibrinolytic effects of activated protein C. Thromb Res (1991) 0.76
The molecular mechanisms of heparin action: II. Separation of functionally different heparins by affinity chromatography. Thromb Res (1979) 0.76
Effect of rabbit activated protein C on thrombin generation and fibrinolysis in a species-specific in vivo model: effect of modulation of protein S activity. Semin Thromb Hemost (1993) 0.76
Properties of chemically modified protein S: effect of the conversion of gamma-carboxyglutamic acid to gamma-methyleneglutamic acid on functional properties. Biochemistry (1986) 0.76
The molecular mechanisms of heparin action III. The anticoagulant properties of polyanetholesulfonate. Biochem Biophys Res Commun (1978) 0.76
X-ray microdiffraction analysis of radiation-induced defects in single grains of polycrystalline Fe. J Synchrotron Radiat (2010) 0.75
Rifampin-induced immune thrombocytopenia. A case report. Vox Sang (1989) 0.75
Protein S and thrombosis. Ann Clin Lab Sci (1989) 0.75
The modification of ferroelectric LiNbO3(0001) surfaces using chromium oxide thin films. Phys Chem Chem Phys (2015) 0.75
The interface phase and the Schottky barrier for a crystalline dielectric on silicon. Science (2003) 0.75
Ultrahigh vacuum-compatible fabrication and electrical characterization systems for environmentally sensitive metal oxide semiconductor capacitors. Rev Sci Instrum (2007) 0.75
Purification and preliminary characterization of rabbit vitamin K-dependent coagulation proteins. Thromb Res (1990) 0.75
The thrombotic diathesis associated with the presence of phospholipid antibodies may be due to low levels of free protein S. Am J Med (1992) 0.75
Observations from the CDC: promoting women's health through age-appropriate vaccination. J Womens Health Gend Based Med (1999) 0.75