PubRank

C Guthrie

Author PubWeight™ 219.84‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell 1998 10.95
2 Exportin 1 (Crm1p) is an essential nuclear export factor. Cell 1997 10.32
3 Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA. Cell 1987 6.08
4 PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature 1991 6.07
5 Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature 1988 5.48
6 Structure and function of E. coli ribosomes. 8. Cold-sensitive mutants defective in ribosome assembly. Proc Natl Acad Sci U S A 1969 5.09
7 Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet 1994 4.83
8 A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell 1992 4.62
9 5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. Genes Dev 1988 3.65
10 Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science 1993 3.62
11 An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p. Mol Cell 1999 3.37
12 Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome. EMBO J 1986 3.35
13 An essential yeast snRNA with a U5-like domain is required for splicing in vivo. Cell 1987 3.22
14 A precursor to a minor species of yeast tRNASer contains an intervening sequence. Cell 1979 3.21
15 RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol 1998 3.17
16 A novel role for a U5 snRNP protein in 3' splice site selection. Genes Dev 1995 3.10
17 A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing. Cell 1990 3.06
18 A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J 1992 2.96
19 A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. Genes Dev 1991 2.78
20 A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates. Cell 1993 2.70
21 Saccharomyces cerevisiae has a U1-like small nuclear RNA with unexpected properties. Science 1987 2.64
22 Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 1996 2.62
23 Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1. Genetics 1993 2.58
24 A point mutation in the conserved hexanucleotide at a yeast 5' splice junction uncouples recognition, cleavage, and ligation. Cell 1985 2.56
25 The second catalytic step of pre-mRNA splicing. RNA 1995 2.50
26 An essential splicing factor, SLU7, mediates 3' splice site choice in yeast. Genes Dev 1992 2.45
27 A U-rich tract enhances usage of an alternative 3' splice site in yeast. Cell 1991 2.45
28 Yeast contains small nuclear RNAs encoded by single copy genes. Cell 1983 2.40
29 Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs. Genes Dev 1991 2.39
30 Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position. Genes Dev 1990 2.33
31 Multiple roles for U6 snRNA in the splicing pathway. Genes Dev 1990 2.29
32 A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles. Science 1998 2.26
33 Alternative 3'-end processing of U5 snRNA by RNase III. Genes Dev 1997 2.25
34 Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Genes Dev 2001 2.24
35 Structure of intron-containing tRNA precursors. Analysis of solution conformation using chemical and enzymatic probes. J Biol Chem 1984 2.21
36 Deletion of a yeast small nuclear RNA gene impairs growth. EMBO J 1985 2.17
37 Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. Genes Dev 1999 2.12
38 Small nuclear RNAs from Saccharomyces cerevisiae: unexpected diversity in abundance, size, and molecular complexity. Proc Natl Acad Sci U S A 1986 2.12
39 An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA. Cell 1987 2.07
40 The question remains: is the spliceosome a ribozyme? Nat Struct Biol 2000 2.02
41 Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol 1992 2.01
42 Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. RNA 1995 2.00
43 Genetic analysis of small nuclear RNAs in Saccharomyces cerevisiae: viable sextuple mutant. Mol Cell Biol 1988 1.99
44 A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Genes Dev 1987 1.99
45 A subset of yeast snRNA's contains functional binding sites for the highly conserved Sm antigen. Science 1987 1.97
46 A U4-like small nuclear RNA is dispensable in yeast. Cell 1983 1.96
47 Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site. EMBO J 1990 1.95
48 Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. Genetics 1996 1.94
49 Randomization-selection analysis of snRNAs in vivo: evidence for a tertiary interaction in the spliceosome. Genes Dev 1994 1.93
50 Food and activity preferences in children of lean and obese parents. Int J Obes Relat Metab Disord 2001 1.92
51 Eight transfer RNAs induced by infection of Escherichia coli with bacteriophage T4. Proc Natl Acad Sci U S A 1972 1.89
52 Conservation in budding yeast of a kinase specific for SR splicing factors. Proc Natl Acad Sci U S A 1999 1.82
53 Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF). Science 1996 1.79
54 Electrophoretic and immunological studies on ribosomal proteins of 100 Escherichia coli revertants from streptomycin dependence. Mol Gen Genet 1973 1.78
55 Splicing a spliceosomal RNA. Nature 1989 1.75
56 Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo. Genes Dev 1990 1.73
57 Phosphorylation by Sky1p promotes Npl3p shuttling and mRNA dissociation. RNA 2001 1.69
58 The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro. Curr Biol 1998 1.66
59 Two conserved domains of yeast U2 snRNA are separated by 945 nonessential nucleotides. Cell 1988 1.64
60 Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast. Proc Natl Acad Sci U S A 1995 1.62
61 Identification of tRNA precursor molecules made by phage T4. Nat New Biol 1973 1.61
62 Beat the clock: paradigms for NTPases in the maintenance of biological fidelity. Trends Biochem Sci 1993 1.56
63 Studies on the assembly of ribosomes in vivo. Cold Spring Harb Symp Quant Biol 1969 1.50
64 Initiation of protein synthesis: a critical test of the 30S subunit model. Nature 1968 1.46
65 A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport. Curr Biol 2000 1.45
66 PRP16, a DEAH-box RNA helicase, is recruited to the spliceosome primarily via its nonconserved N-terminal domain. RNA 1998 1.43
67 Prevention of type 2 diabetes. Health promotion helps no one. BMJ 2001 1.38
68 Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs. EMBO J 1995 1.35
69 Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. EMBO J 1996 1.33
70 A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome. Mol Cell Biol 1992 1.29
71 Human U2 snRNA can function in pre-mRNA splicing in yeast. Nature 1990 1.24
72 Architecture of the U5 small nuclear RNA. Mol Cell Biol 1994 1.23
73 The essential yeast RNA binding protein Np13p is methylated. Proc Natl Acad Sci U S A 1996 1.22
74 A functional requirement for modification of the wobble nucleotide in tha anticodon of a T4 suppressor tRNA. Cell 1976 1.19
75 The psu1+ amber suppressor gene of bacteriophage T4: identification of its amino acid and transfer RNA. J Mol Biol 1973 1.16
76 Yeast tRNA precursor mutated at a splice junction is correctly processed in vivo. Proc Natl Acad Sci U S A 1981 1.15
77 The initiation of protein synthesis: joining of the 50S ribosomal subunit to the initiation complex. Proc Natl Acad Sci U S A 1967 1.13
78 PRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitro. Nucleic Acids Res 1994 1.13
79 Transfer RNA biosynthesis: the nucleotide sequence of a precursor to serine and proline transfer RNAs. Proc Natl Acad Sci U S A 1974 1.12
80 More than half of yeast U1 snRNA is dispensable for growth. Nucleic Acids Res 1991 1.11
81 Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. Genetics 1994 1.11
82 Morbidity in patients on L-thyroxine: a comparison of those with a normal TSH to those with a suppressed TSH. Clin Endocrinol (Oxf) 1992 1.09
83 Small nuclear RNAs from budding yeasts: phylogenetic comparisons reveal extensive size variation. Gene 1989 1.07
84 Activation of a cryptic TACTAAC box in the Saccharomyces cerevisiae actin intron. Mol Cell Biol 1986 1.05
85 The nucleotide sequence of the dimeric precursor to glutamine and leucine transfer RNAs coded by bacteriophage T4. J Mol Biol 1975 1.05
86 Conditionally lethal mutants of bacteriophage T4 defective in production of a transfer RNA. J Mol Biol 1973 1.04
87 Recessive lethality of yeast strains carrying the SUP61 suppressor results from loss of a transfer RNA with a unique decoding function. J Mol Biol 1982 1.01
88 Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing. RNA 2001 1.00
89 The assembly of ribosomes. J Cell Physiol 1969 1.00
90 An essential nuclear envelope integral membrane protein, Brr6p, required for nuclear transport. EMBO J 2001 0.98
91 An ochre suppressor of bacteriophage T4 that is associated with a transfer RNA. J Mol Biol 1974 0.98
92 Nucleotide sequence of an arginine transfer ribonucleic acid from bacteriophage T4. J Biol Chem 1977 0.92
93 Yeast ochre suppressor SUQ5-ol is an altered tRNA Ser UCA. Nucleic Acids Res 1981 0.90
94 Rare transfer ribonucleic acid essential for phage growth. Nucleotide sequence comparison of normal and mutant T4 isoleucine-accepting transfer ribonucleic acid. Biochemistry 1979 0.89
95 Asymmetric maturation of a dimeric transfer RNA precursor. J Mol Biol 1980 0.87
96 CRP levels as a measure of surgical trauma: a comparison of different general surgical procedures. J R Coll Surg Edinb 1994 0.87
97 The biology of bacteriophage T4 transfer RNAs. Brookhaven Symp Biol 1975 0.86
98 Human and human-yeast chimeric U6 snRNA genes identify structural elements required for expression in yeast. Nucleic Acids Res 1992 0.82
99 The nucleotide sequence of threonine transfer RNA coded by bacteriophage T4. Nucleic Acids Res 1978 0.78
100 S1 nuclease as a probe for the conformation of a dimeric tRNA precursor. Biochemistry 1979 0.76
101 Childhood obesity. Opportunity for physical activity has been lost. BMJ 2000 0.75
102 The "sunday seminar". Science 1976 0.75
103 The paperless claims program at Blue Cross and Blue Shield of Texas. Tex Hosp 1983 0.75
104 Intraluminal vascular ultrasound: preliminary report of dimensional and morphologic accuracy. Ann Vasc Surg 1990 0.75
105 In vitro thrombogenicity tests of factor IX concentrates. II: effects of phospholipids and heparin. Thromb Haemost 1980 0.75
106 Stenosis following laser thermal angioplasty--a blinded controlled randomized study between aspirin against Probucol. J Surg Res 1991 0.75
107 Intravascular ultrasound: a new potential modality for angioplasty guidance. Angiology 1990 0.75
108 Folding up a transfer RNA molecule is not simple. Q Rev Biol 1980 0.75