Published in Cell on April 24, 1987
Multiple alignment using simulated annealing: branch point definition in human mRNA splicing. Nucleic Acids Res (1992) 12.08
Exon definition may facilitate splice site selection in RNAs with multiple exons. Mol Cell Biol (1990) 8.17
The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles. J Cell Biol (1991) 5.73
A U1 snRNA:pre-mRNA base pairing interaction is required early in yeast spliceosome assembly but does not uniquely define the 5' cleavage site. EMBO J (1988) 4.34
Connections between transcriptional activators, silencers, and telomeres as revealed by functional analysis of a yeast DNA-binding protein. Mol Cell Biol (1988) 3.69
A new kind of informational suppression in the nematode Caenorhabditis elegans. Genetics (1989) 3.69
Different effects of intron nucleotide composition and secondary structure on pre-mRNA splicing in monocot and dicot plants. EMBO J (1991) 3.12
Scanning and competition between AGs are involved in 3' splice site selection in mammalian introns. Mol Cell Biol (1993) 2.98
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Pre-mRNA splicing by complementation with purified human U1, U2, U4/U6 and U5 snRNPs. Nucleic Acids Res (1988) 2.86
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Differential binding of heterogeneous nuclear ribonucleoproteins to mRNA precursors prior to spliceosome assembly in vitro. Mol Cell Biol (1992) 2.66
Characterization of an SNR gene locus in Saccharomyces cerevisiae that specifies both dispensible and essential small nuclear RNAs. Mol Cell Biol (1988) 2.65
Early commitment of yeast pre-mRNA to the spliceosome pathway. Mol Cell Biol (1988) 2.64
Splicing-dependent RNA polymerase pausing in yeast. Mol Cell (2010) 2.49
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A. Genes Dev (2011) 2.45
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Small nuclear ribonucleoprotein (RNP) U2 contains numerous additional proteins and has a bipartite RNP structure under splicing conditions. Mol Cell Biol (1993) 2.36
Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein. Mol Cell Biol (1991) 2.33
Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. Mol Cell Biol (1999) 2.32
Nuclear pre-mRNA processing in plants: distinct modes of 3'-splice-site selection in plants and animals. Mol Cell Biol (1988) 2.32
Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for binding. EMBO J (1988) 2.32
Evidence for a base-pairing interaction between U6 small nuclear RNA and 5' splice site during the splicing reaction in yeast. Proc Natl Acad Sci U S A (1992) 2.28
The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA. EMBO J (1991) 2.26
RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes Dev (2006) 2.25
Nuclear pre-mRNA introns: analysis and comparison of intron sequences from Tetrahymena thermophila and other eukaryotes. Nucleic Acids Res (1990) 2.25
UACUAAC is the preferred branch site for mammalian mRNA splicing. Proc Natl Acad Sci U S A (1989) 2.22
Molecular evolution of eukaryotic genomes: hemiascomycetous yeast spliceosomal introns. Nucleic Acids Res (2003) 2.21
Nucleotide sequence determination and secondary structure of Xenopus U3 snRNA. Nucleic Acids Res (1988) 2.20
Unusual branch point selection in processing of human growth hormone pre-mRNA. Mol Cell Biol (1988) 2.12
Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucleic Acids Res (1997) 2.05
Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assembly. Mol Cell Biol (1994) 2.03
The spliceosomal snRNAs of Caenorhabditis elegans. Nucleic Acids Res (1990) 2.03
Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1. Mol Cell Biol (1996) 2.02
Three recognition events at the branch-site adenine. EMBO J (1996) 2.01
Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol (1992) 2.01
Domains of U4 and U6 snRNAs required for snRNP assembly and splicing complementation in Xenopus oocytes. EMBO J (1990) 1.96
PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. Mol Cell Biol (1989) 1.95
An abundant U6 snRNP found in germ cells and embryos of Xenopus laevis. EMBO J (1989) 1.94
RNA folding in Drosophila shows a distance effect for compensatory fitness interactions. Genetics (1993) 1.94
Smooth muscle-specific switching of alpha-tropomyosin mutually exclusive exon selection by specific inhibition of the strong default exon. EMBO J (1994) 1.91
Isolation and sequence of four small nuclear U RNA genes of Trypanosoma brucei subsp. brucei: identification of the U2, U4, and U6 RNA analogs. Mol Cell Biol (1989) 1.89
cis-acting intron mutations that affect the efficiency of avian retroviral RNA splicing: implication for mechanisms of control. J Virol (1988) 1.88
Functional association of essential splicing factor(s) with PRP19 in a protein complex. EMBO J (1994) 1.86
Cross-linking, ligation, and sequencing of hybrids reveals RNA-RNA interactions in yeast. Proc Natl Acad Sci U S A (2011) 1.85
The yeast PRP19 protein is not tightly associated with small nuclear RNAs, but appears to associate with the spliceosome after binding of U2 to the pre-mRNA and prior to formation of the functional spliceosome. Mol Cell Biol (1993) 1.77
Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicing. EMBO J (2004) 1.76
Mapping U2 snRNP--pre-mRNA interactions using biotinylated oligonucleotides made of 2'-OMe RNA. EMBO J (1989) 1.73
Distribution and consensus of branch point signals in eukaryotic genes: a computerized statistical analysis. Nucleic Acids Res (1990) 1.66
Electron microscopy of small nuclear ribonucleoprotein (snRNP) particles U2 and U5: evidence for a common structure-determining principle in the major U snRNP family. Proc Natl Acad Sci U S A (1990) 1.65
The sequence of U3 from Schizosaccharomyces pombe suggests structural divergence of this snRNA between metazoans and unicellular eukaryotes. Nucleic Acids Res (1988) 1.61
Polypyrimidine tract sequences direct selection of alternative branch sites and influence protein binding. Nucleic Acids Res (1994) 1.58
Competition between the ATPase Prp5 and branch region-U2 snRNA pairing modulates the fidelity of spliceosome assembly. Mol Cell (2007) 1.56
Transient interaction of BBP/ScSF1 and Mud2 with the splicing machinery affects the kinetics of spliceosome assembly. RNA (1999) 1.56
Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits. Mol Cell Biol (1996) 1.54
Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes. EMBO J (1987) 1.53
The small subunit of the splicing factor U2AF is conserved in fission yeast. Nucleic Acids Res (1996) 1.48
The 216-nucleotide intron of the E1A pre-mRNA contains a hairpin structure that permits utilization of unusually distant branch acceptors. Mol Cell Biol (1989) 1.48
Evidence that the 60-kDa protein of 17S U2 small nuclear ribonucleoprotein is immunologically and functionally related to the yeast PRP9 splicing factor and is required for the efficient formation of prespliceosomes. Proc Natl Acad Sci U S A (1993) 1.46
The splicing factor PRP2, a putative RNA helicase, interacts directly with pre-mRNA. EMBO J (1994) 1.46
Functional analysis of the U5 snRNA loop 1 in the second catalytic step of yeast pre-mRNA splicing. EMBO J (1998) 1.44
Commitment of yeast pre-mRNA to the splicing pathway requires a novel U1 small nuclear ribonucleoprotein polypeptide, Prp39p. Mol Cell Biol (1994) 1.44
Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo. RNA (1998) 1.44
Interactions between highly conserved U2 small nuclear RNA structures and Prp5p, Prp9p, Prp11p, and Prp21p proteins are required to ensure integrity of the U2 small nuclear ribonucleoprotein in Saccharomyces cerevisiae. Mol Cell Biol (1994) 1.43
Branch point selection in alternative splicing of tropomyosin pre-mRNAs. Nucleic Acids Res (1989) 1.43
Species-specific signals for the splicing of a short Drosophila intron in vitro. Mol Cell Biol (1993) 1.39
Selection of the bovine papillomavirus type 1 nucleotide 3225 3' splice site is regulated through an exonic splicing enhancer and its juxtaposed exonic splicing suppressor. J Virol (1996) 1.39
Thiophosphates in yeast U6 snRNA specifically affect pre-mRNA splicing in vitro. Nucleic Acids Res (1992) 1.39
Homologous genes for mouse 4.5S hybRNA are found in all eukaryotes and their low molecular weight RNA transcripts intermolecularly hybridize with eukaryotic 18S ribosomal RNAs. Nucleic Acids Res (1988) 1.37
Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene. Proc Natl Acad Sci U S A (2003) 1.36
U2 small nuclear RNA is remarkably conserved between Schizosaccharomyces pombe and mammals. Mol Cell Biol (1988) 1.36
Evidence for a Prp24 binding site in U6 snRNA and in a putative intermediate in the annealing of U6 and U4 snRNAs. EMBO J (1995) 1.35
U2AF35 is encoded by an essential gene clustered in an operon with RRM/cyclophilin in Caenorhabditis elegans. RNA (1999) 1.32
Requirements for U2 snRNP addition to yeast pre-mRNA. Nucleic Acids Res (1992) 1.31
Fractionation of HeLa cell nuclear extracts reveals minor small nuclear ribonucleoprotein particles. Proc Natl Acad Sci U S A (1987) 1.29
The yeast omnipotent suppressor SUP46 encodes a ribosomal protein which is a functional and structural homolog of the Escherichia coli S4 ram protein. Genetics (1992) 1.27
Sequential recognition of the pre-mRNA branch point by U2AF65 and a novel spliceosome-associated 28-kDa protein. RNA (1995) 1.26
Factors affecting authentic 5' splice site selection in plant nuclei. Mol Cell Biol (1993) 1.26
The PRP31 gene encodes a novel protein required for pre-mRNA splicing in Saccharomyces cerevisiae. Nucleic Acids Res (1996) 1.25
Dual function for U2AF(35) in AG-dependent pre-mRNA splicing. Mol Cell Biol (2001) 1.21
Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon. Mol Cell Biol (1997) 1.21
Combinatorial splicing of exon pairs by two-site binding of U1 small nuclear ribonucleoprotein particle. Mol Cell Biol (1991) 1.19
Functional analysis of a C. elegans trans-splice acceptor. Nucleic Acids Res (1993) 1.19
Interaction of intronic boundaries is required for the second splicing step efficiency of a group II intron. EMBO J (1993) 1.19
Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome. RNA (2006) 1.19
Unusual branch point selection involved in splicing of the alternatively processed Calcitonin/CGRP-I pre-mRNA. Nucleic Acids Res (1988) 1.18
Alternate trans splicing in Trypanosoma equiperdum: implications for splice site selection. Mol Cell Biol (1988) 1.17
AU-rich intronic elements affect pre-mRNA 5' splice site selection in Drosophila melanogaster. Mol Cell Biol (1993) 1.16
Crystal structure of a model branchpoint-U2 snRNA duplex containing bulged adenosines. RNA (2001) 1.14
Spliceosomal snRNA modifications and their function. RNA Biol (2010) 1.13
Antisense probes targeted to an internal domain in U2 snRNP specifically inhibit the second step of pre-mRNA splicing. Nucleic Acids Res (1992) 1.12
The phylogenetically invariant ACAGAGA and AGC sequences of U6 small nuclear RNA are more tolerant of mutation in human cells than in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.12
Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiae. RNA (1998) 1.11
More than half of yeast U1 snRNA is dispensable for growth. Nucleic Acids Res (1991) 1.11
Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase. Genetics (1994) 1.11
Single-molecule analysis of protein-free U2-U6 snRNAs. Nat Struct Mol Biol (2009) 1.09
Optimization of a weak 3' splice site counteracts the function of a bovine papillomavirus type 1 exonic splicing suppressor in vitro and in vivo. J Virol (2000) 1.08
Mapping of branch sites in trans-spliced pre-mRNAs of Trypanosoma brucei. Mol Cell Biol (1989) 1.07
Limited functional equivalence of phylogenetic variation in small nuclear RNA: yeast U2 RNA with altered branchpoint complementarity inhibits splicing and produces a dominant lethal phenotype. Proc Natl Acad Sci U S A (1991) 1.07
Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell (1998) 10.95
Exportin 1 (Crm1p) is an essential nuclear export factor. Cell (1997) 10.32
A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev (1993) 9.28
A rapid method for localized mutagenesis of yeast genes. Yeast (1992) 7.79
Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. Genes Dev (1994) 7.57
Degradation of mRNA in eukaryotes. Cell (1995) 6.81
An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature (1996) 6.15
PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature (1991) 6.07
Premature translational termination triggers mRNA decapping. Nature (1994) 6.05
Yeast Sm-like proteins function in mRNA decapping and decay. Nature (2000) 5.95
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell (2001) 5.86
Turnover mechanisms of the stable yeast PGK1 mRNA. Mol Cell Biol (1995) 5.83
Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature (1988) 5.48
Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae. Mol Cell Biol (1990) 5.47
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Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet (1994) 4.83
The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA (2001) 4.80
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell (1992) 4.62
Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs. Mol Cell Biol (2000) 4.57
Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae. Mol Cell Biol (1999) 4.35
Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev (1996) 4.34
Mutations affecting stability and deadenylation of the yeast MFA2 transcript. Genes Dev (1992) 4.20
Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast. Genes Dev (1995) 4.15
Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs. Mol Cell (2001) 4.12
A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons. Mol Cell Biol (1993) 3.91
Quality control of mRNA 3'-end processing is linked to the nuclear exosome. Nature (2001) 3.69
5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. Genes Dev (1988) 3.65
Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science (1993) 3.62
Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol (1996) 3.58
The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast. EMBO J (2000) 3.38
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p. Mol Cell (1999) 3.37
Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem (1994) 3.37
Mutations in conserved intron sequences affect multiple steps in the yeast splicing pathway, particularly assembly of the spliceosome. EMBO J (1986) 3.35
An essential yeast snRNA with a U5-like domain is required for splicing in vivo. Cell (1987) 3.22
A precursor to a minor species of yeast tRNASer contains an intervening sequence. Cell (1979) 3.21
RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol (1998) 3.17
A novel role for a U5 snRNP protein in 3' splice site selection. Genes Dev (1995) 3.10
A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing. Cell (1990) 3.06
mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E. Mol Cell Biol (2000) 3.06
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J (1992) 2.96
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Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO J (1998) 2.82
A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. Genes Dev (1991) 2.78
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The exosome: a proteasome for RNA? Cell (1999) 2.72
Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol (2000) 2.71
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Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics (1996) 2.62
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A point mutation in the conserved hexanucleotide at a yeast 5' splice junction uncouples recognition, cleavage, and ligation. Cell (1985) 2.56
The second catalytic step of pre-mRNA splicing. RNA (1995) 2.50
The UK colorectal cancer screening pilot: results of the second round of screening in England. Br J Cancer (2007) 2.48
An essential splicing factor, SLU7, mediates 3' splice site choice in yeast. Genes Dev (1992) 2.45
A U-rich tract enhances usage of an alternative 3' splice site in yeast. Cell (1991) 2.45
Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast. EMBO J (2000) 2.44
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Yeast contains small nuclear RNAs encoded by single copy genes. Cell (1983) 2.40
Suppressors of a U4 snRNA mutation define a novel U6 snRNP protein with RNA-binding motifs. Genes Dev (1991) 2.39
Transcription of a yeast U6 snRNA gene requires a polymerase III promoter element in a novel position. Genes Dev (1990) 2.33
Multiple roles for U6 snRNA in the splicing pathway. Genes Dev (1990) 2.29
A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles. Science (1998) 2.26
Alternative 3'-end processing of U5 snRNA by RNase III. Genes Dev (1997) 2.25
Deletion of MUD2, the yeast homolog of U2AF65, can bypass the requirement for sub2, an essential spliceosomal ATPase. Genes Dev (2001) 2.24
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Deletion of a yeast small nuclear RNA gene impairs growth. EMBO J (1985) 2.17
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An essential snRNA from S. cerevisiae has properties predicted for U4, including interaction with a U6-like snRNA. Cell (1987) 2.07
Diversity of cytoplasmic functions for the 3' untranslated region of eukaryotic transcripts. Curr Opin Cell Biol (1995) 2.06
The question remains: is the spliceosome a ribozyme? Nat Struct Biol (2000) 2.02
Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol (1992) 2.01
Prp16p, Slu7p, and Prp8p interact with the 3' splice site in two distinct stages during the second catalytic step of pre-mRNA splicing. RNA (1995) 2.00
Genetic analysis of small nuclear RNAs in Saccharomyces cerevisiae: viable sextuple mutant. Mol Cell Biol (1988) 1.99
A trans-acting suppressor restores splicing of a yeast intron with a branch point mutation. Genes Dev (1987) 1.99
Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron. Nature (1993) 1.98
A subset of yeast snRNA's contains functional binding sites for the highly conserved Sm antigen. Science (1987) 1.97
A U4-like small nuclear RNA is dispensable in yeast. Cell (1983) 1.96
Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch Ophthalmol (1996) 1.95
Unexpected flexibility in an evolutionarily conserved protein-RNA interaction: genetic analysis of the Sm binding site. EMBO J (1990) 1.95
Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. Genetics (1996) 1.94
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