Published in EMBO J on July 01, 1986
The yeast ubiquitin genes: a family of natural gene fusions. EMBO J (1987) 4.25
A catalogue of splice junction and putative branch point sequences from plant introns. Nucleic Acids Res (1986) 4.21
Spliceosome assembly involves the binding and release of U4 small nuclear ribonucleoprotein. Proc Natl Acad Sci U S A (1988) 3.38
Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicing. EMBO J (1998) 3.02
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J (1992) 2.96
Prp8 protein: at the heart of the spliceosome. RNA (2005) 2.89
Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA. EMBO J (1995) 2.85
Exon ligation is proofread by the DExD/H-box ATPase Prp22p. Nat Struct Mol Biol (2006) 2.75
Perturbation of transcription elongation influences the fidelity of internal exon inclusion in Saccharomyces cerevisiae. RNA (2003) 2.36
The yeast branchpoint sequence is not required for the formation of a stable U1 snRNA-pre-mRNA complex and is recognized in the absence of U2 snRNA. EMBO J (1991) 2.26
RS domains contact splicing signals and promote splicing by a common mechanism in yeast through humans. Genes Dev (2006) 2.25
Spliceosome activation by PRP2 ATPase prior to the first transesterification reaction of pre-mRNA splicing. Mol Cell Biol (1996) 2.23
Functional interactions of Prp8 with both splice sites at the spliceosomal catalytic center. Genes Dev (1999) 2.21
Processing of a dicistronic small nucleolar RNA precursor by the RNA endonuclease Rnt1. EMBO J (1998) 2.20
Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome. Genes Dev (1999) 2.12
Unusual branch point selection in processing of human growth hormone pre-mRNA. Mol Cell Biol (1988) 2.12
Repression of gene expression by an exogenous sequence element acting in concert with a heterogeneous nuclear ribonucleoprotein-like protein, Nrd1, and the putative helicase Sen1. Mol Cell Biol (1996) 2.02
RNA11 protein is associated with the yeast spliceosome and is localized in the periphery of the cell nucleus. Mol Cell Biol (1988) 2.01
Mutagenesis of the yeast gene PRP8 reveals domains governing the specificity and fidelity of 3' splice site selection. Genetics (1996) 1.94
Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. Genes Dev (1999) 1.91
The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs. Mol Cell Biol (1989) 1.87
Nuclear pre-mRNA splicing in the fission yeast Schizosaccharomyces pombe strictly requires an intron-contained, conserved sequence element. EMBO J (1987) 1.82
Accurate in vitro splicing of two pre-mRNA plant introns in a HeLa cell nuclear extract. EMBO J (1986) 1.80
Interactions of PRP2 protein with pre-mRNA splicing complexes in Saccharomyces cerevisiae. Nucleic Acids Res (1990) 1.80
Widespread impact of nonsense-mediated mRNA decay on the yeast intronome. Mol Cell (2008) 1.72
How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing. RNA (2002) 1.64
A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res (1996) 1.57
Specific accessory sequences in Saccharomyces cerevisiae introns control assembly of pre-mRNAs into spliceosomes. EMBO J (1987) 1.53
A conformational rearrangement in the spliceosome sets the stage for Prp22-dependent mRNA release. Mol Cell (2008) 1.52
The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Genes Dev (2005) 1.51
In vivo commitment to splicing in yeast involves the nucleotide upstream from the branch site conserved sequence and the Mud2 protein. EMBO J (1997) 1.47
Conformational dynamics of single pre-mRNA molecules during in vitro splicing. Nat Struct Mol Biol (2010) 1.45
Affinity purification of spliceosomes reveals that the precursor RNA processing protein PRP8, a protein in the U5 small nuclear ribonucleoprotein particle, is a component of yeast spliceosomes. Proc Natl Acad Sci U S A (1990) 1.44
Splicing in Caenorhabditis elegans does not require an AG at the 3' splice acceptor site. Mol Cell Biol (1993) 1.44
Processing of the intron-encoded U18 small nucleolar RNA in the yeast Saccharomyces cerevisiae relies on both exo- and endonucleolytic activities. Mol Cell Biol (1998) 1.38
Introduction of functional artificial introns into the naturally intronless ura4 gene of Schizosaccharomyces pombe. Mol Cell Biol (1989) 1.35
Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe. Mol Cell Biol (2000) 1.34
Human genetic variation recognizes functional elements in noncoding sequence. Genome Res (2009) 1.33
Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast. Mol Cell Biol (2003) 1.33
The yeast PRP8 protein interacts directly with pre-mRNA. Nucleic Acids Res (1991) 1.27
Effects on mRNA splicing of mutations in the 3' region of the Saccharomyces cerevisiae actin intron. Mol Cell Biol (1987) 1.21
Interaction between the first and last nucleotides of pre-mRNA introns is a determinant of 3' splice site selection in S. cerevisiae. Nucleic Acids Res (1994) 1.21
More than one way to splice an RNA: branching without a bulge and splicing without branching in group II introns. RNA (1998) 1.20
DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps. RNA (2010) 1.19
Interaction of intronic boundaries is required for the second splicing step efficiency of a group II intron. EMBO J (1993) 1.19
Splicing removes the Caenorhabditis elegans transposon Tc1 from most mutant pre-mRNAs. Mol Cell Biol (1996) 1.18
The Saccharomyces cerevisiae PRP21 gene product is an integral component of the prespliceosome. Proc Natl Acad Sci U S A (1993) 1.15
A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing. Mol Cell Biol (1999) 1.15
PRP28, a 'DEAD-box' protein, is required for the first step of mRNA splicing in vitro. Nucleic Acids Res (1994) 1.13
Molecular basis of the ribulose-1,5-bisphosphate carboxylase/oxygenase activase mutation in Arabidopsis thaliana is a guanine-to-adenine transition at the 5'-splice junction of intron 3. Plant Physiol (1993) 1.13
Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiae. RNA (1998) 1.11
Differential nuclease sensitivity identifies tight contacts between yeast pre-mRNA and spliceosomes. EMBO J (1986) 1.10
Ordered partitioning reveals extended splice-site consensus information. Genome Res (2004) 1.09
Solid-phase synthesis of branched oligoribonucleotides related to messenger RNA splicing intermediates. Nucleic Acids Res (1992) 1.06
Impairment of yeast pre-mRNA splicing by potential secondary structure-forming sequences near the conserved branchpoint sequence. Nucleic Acids Res (1988) 1.03
Insights into branch nucleophile positioning and activation from an orthogonal pre-mRNA splicing system in yeast. Mol Cell (2009) 1.03
Splicing of the meiosis-specific HOP2 transcript utilizes a unique 5' splice site. Mol Cell Biol (1999) 1.02
Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway. Mol Cell Biol (2010) 1.01
trans-splicing to spliceosomal U2 snRNA suggests disruption of branch site-U2 pairing during pre-mRNA splicing. Mol Cell (2007) 1.01
Formation of the yeast splicing complex A1 and association of the splicing factor PRP19 with the pre-mRNA are independent of the 3' region of the intron. Nucleic Acids Res (1994) 1.00
Genetic interactions between the 5' and 3' splice site consensus sequences and U6 snRNA during the second catalytic step of pre-mRNA splicing. RNA (2001) 1.00
Yeast pre-mRNA splicing requires a minimum distance between the 5' splice site and the internal branch acceptor site. Mol Cell Biol (1987) 1.00
Functional links between the Prp19-associated complex, U4/U6 biogenesis, and spliceosome recycling. RNA (2006) 0.99
The branchpoint residue is recognized during commitment complex formation before being bulged out of the U2 snRNA-pre-mRNA duplex. Mol Cell Biol (1997) 0.98
A conformational switch in PRP8 mediates metal ion coordination that promotes pre-mRNA exon ligation. Nat Struct Mol Biol (2013) 0.98
Kluyveromyces lactis maintains Saccharomyces cerevisiae intron-encoded splicing signals. Mol Cell Biol (1989) 0.98
The Saccharomyces cerevisiae gene CDC40/PRP17 controls cell cycle progression through splicing of the ANC1 gene. Nucleic Acids Res (2004) 0.97
The RNA binding protein Cwc2 interacts directly with the U6 snRNA to link the nineteen complex to the spliceosome during pre-mRNA splicing. Nucleic Acids Res (2009) 0.97
Link of NTR-mediated spliceosome disassembly with DEAH-box ATPases Prp2, Prp16, and Prp22. Mol Cell Biol (2012) 0.95
Splicing of a yeast intron containing an unusual 5' junction sequence. Mol Cell Biol (1989) 0.94
Interactions across exons can influence splice site recognition in plant nuclei. Plant Cell (1996) 0.93
Splicing and spliceosome formation of the yeast MATa1 transcript require a minimum distance from the 5' splice site to the internal branch acceptor site. Nucleic Acids Res (1988) 0.91
Characterization of U4 and U6 interactions with the 5' splice site using a S. cerevisiae in vitro trans-splicing system. Genes Dev (2001) 0.91
Activation of a cryptic 5' splice site by U1 snRNA. RNA (2001) 0.90
Nonsense-mediated mRNA decay mutes the splicing defects of spliceosome component mutations. RNA (2009) 0.89
DExD/H-box Prp5 protein is in the spliceosome during most of the splicing cycle. RNA (2009) 0.89
A temperature-sensitive phenotype of avian myeloblastosis virus: determinants that influence the production of viral mRNAs. J Virol (1990) 0.89
Trans-complementation of the second step of pre-mRNA splicing by exogenous 5' exons. RNA (1999) 0.88
Splicing fidelity: DEAD/H-box ATPases as molecular clocks. RNA Biol (2013) 0.87
Electron microscopic identification of the yeast spliceosome. EMBO J (1988) 0.87
Population genomics of intron splicing in 38 Saccharomyces cerevisiae genome sequences. Genome Biol Evol (2009) 0.87
Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis. Mol Cell Biol (2013) 0.86
Saccharomyces cerevisiae NineTeen complex (NTC)-associated factor Bud31/Ycr063w assembles on precatalytic spliceosomes and improves first and second step pre-mRNA splicing efficiency. J Biol Chem (2012) 0.85
A homolog of lariat-debranching enzyme modulates turnover of branched RNA. RNA (2014) 0.84
An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. RNA (2013) 0.83
In vitro reconstitution of yeast splicing with U4 snRNA reveals multiple roles for the 3' stem-loop. RNA (2012) 0.81
Small sequence insertions within the branch point region dictate alternative sites of lariat formation in a yeast intron. Nucleic Acids Res (1992) 0.80
Identification of new branch points and unconventional introns in Saccharomyces cerevisiae. RNA (2016) 0.80
Diverse mechanisms for spliceosome-mediated 3' end processing of telomerase RNA. Nat Commun (2015) 0.79
Using yeast genetics to study splicing mechanisms. Methods Mol Biol (2014) 0.78
Cooperative interaction of branch signals in the actin intron of Saccharomyces cerevisiae. Nucleic Acids Res (1998) 0.75
Structural requirement of Ntc77 for spliceosome activation and first catalytic step. Nucleic Acids Res (2014) 0.75
The 1997 Thomas Hunt Morgan Medal. Oliver Evans Nelson, Jr. Genetics (1998) 0.75
Genetics and biochemistry remain essential in the structural era of the spliceosome. Methods (2017) 0.75
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Transformation of intact yeast cells treated with alkali cations. J Bacteriol (1983) 100.26
A catalogue of splice junction sequences. Nucleic Acids Res (1982) 39.41
Antibodies to small nuclear RNAs complexed with proteins are produced by patients with systemic lupus erythematosus. Proc Natl Acad Sci U S A (1979) 14.61
Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell (1982) 12.12
Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 11.24
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
The U1 small nuclear RNA-protein complex selectively binds a 5' splice site in vitro. Cell (1983) 9.00
U2 as well as U1 small nuclear ribonucleoproteins are involved in premessenger RNA splicing. Cell (1985) 8.85
A mechanism for RNA splicing. Proc Natl Acad Sci U S A (1980) 7.76
Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences. Cell (1985) 7.49
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts. Cell (1983) 6.48
A multicomponent complex is involved in the splicing of messenger RNA precursors. Cell (1985) 6.27
Comparison of fungal mitochondrial introns reveals extensive homologies in RNA secondary structure. Biochimie (1982) 5.98
The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction. Science (1985) 5.82
Intron sequences involved in lariat formation during pre-mRNA splicing. Cell (1985) 5.30
Making ends meet: a model for RNA splicing in fungal mitochondria. Nature (1982) 5.27
Conservation of RNA secondary structures in two intron families including mitochondrial-, chloroplast- and nuclear-encoded members. EMBO J (1983) 5.17
Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences. Proc Natl Acad Sci U S A (1983) 4.78
The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein. Science (1985) 4.56
The molecular organization of the Antennapedia locus of Drosophila. Cell (1983) 4.50
The generality of self-splicing RNA: relationship to nuclear mRNA splicing. Cell (1986) 4.23
An RNA processing activity that debranches RNA lariats. Science (1985) 4.14
Evidence for the biochemical role of an internal sequence in yeast nuclear mRNA introns: implications for U1 RNA and metazoan mRNA splicing. Cell (1983) 4.13
Mechanism of action of a yeast RNA ligase in tRNA splicing. Cell (1983) 3.78
A self-splicing RNA excises an intron lariat. Cell (1986) 3.74
Sequence of U1 RNA from Drosophila melanogaster: implications for U1 secondary structure and possible involvement in splicing. Nucleic Acids Res (1981) 3.65
Genomic and cDNA clones of the homeotic locus Antennapedia in Drosophila. EMBO J (1983) 3.47
Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease. Cell (1983) 3.13
Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro. Cell (1985) 2.75
Mutations in a yeast intron demonstrate the importance of specific conserved nucleotides for the two stages of nuclear mRNA splicing. Cell (1986) 2.73
tRNA gene transcription in yeast: effects of specified base substitutions in the intragenic promoter. Cell (1983) 2.73
A point mutation in the conserved hexanucleotide at a yeast 5' splice junction uncouples recognition, cleavage, and ligation. Cell (1985) 2.56
Yeast contains small nuclear RNAs encoded by single copy genes. Cell (1983) 2.40
In vivo characterization of yeast mRNA processing intermediates. Cell (1984) 2.33
RNA splicing in neurospora mitochondria: self-splicing of a mitochondrial intron in vitro. Cell (1984) 2.20
A quantitative analysis of the effects of 5' junction and TACTAAC box mutants and mutant combinations on yeast mRNA splicing. Cell (1985) 2.14
Cleavage of 5' splice site and lariat formation are independent of 3' splice site in yeast mRNA splicing. Nature (1985) 2.04
Construction of a yeast actin gene intron deletion mutant that is defective in splicing and leads to the accumulation of precursor RNA in transformed yeast cells. Proc Natl Acad Sci U S A (1982) 2.00
Close relationship between certain nuclear and mitochondrial introns. Implications for the mechanism of RNA splicing. J Mol Biol (1983) 1.98
Self-splicing of yeast mitochondrial ribosomal and messenger RNA precursors. Cell (1985) 1.88
Fractionation and characterization of a yeast mRNA splicing extract. Proc Natl Acad Sci U S A (1986) 1.56
Lessons from mutant globins. Nature (1983) 1.06
Activation of a cryptic TACTAAC box in the Saccharomyces cerevisiae actin intron. Mol Cell Biol (1986) 1.05
Isolation and sequence of the gene for actin in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1980) 11.24
Mechanical devices of the spliceosome: motors, clocks, springs, and things. Cell (1998) 10.95
Exportin 1 (Crm1p) is an essential nuclear export factor. Cell (1997) 10.32
Genetic regulation: the Lac control region. Science (1975) 9.48
A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation. Genes Dev (1993) 9.28
Lariat structures are in vivo intermediates in yeast pre-mRNA splicing. Cell (1984) 8.71
A rapid method for localized mutagenesis of yeast genes. Yeast (1992) 7.79
Deadenylation of the unstable mRNA encoded by the yeast MFA2 gene leads to decapping followed by 5'-->3' digestion of the transcript. Genes Dev (1994) 7.57
Degradation of mRNA in eukaryotes. Cell (1995) 6.81
Directed deletion of a yeast transfer RNA intervening sequence. Science (1980) 6.67
An essential component of the decapping enzyme required for normal rates of mRNA turnover. Nature (1996) 6.15
Requirement of the RNA helicase-like protein PRP22 for release of messenger RNA from spliceosomes. Nature (1991) 6.12
Recognition of the TACTAAC box during mRNA splicing in yeast involves base pairing to the U2-like snRNA. Cell (1987) 6.08
PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome. Nature (1991) 6.07
Premature translational termination triggers mRNA decapping. Nature (1994) 6.05
Spliceosome assembly in yeast. Genes Dev (1987) 6.00
Yeast Sm-like proteins function in mRNA decapping and decay. Nature (2000) 5.95
The transcription factor associated Ccr4 and Caf1 proteins are components of the major cytoplasmic mRNA deadenylase in Saccharomyces cerevisiae. Cell (2001) 5.86
Turnover mechanisms of the stable yeast PGK1 mRNA. Mol Cell Biol (1995) 5.83
The "spliceosome": yeast pre-messenger RNA associates with a 40S complex in a splicing-dependent reaction. Science (1985) 5.82
Provision of preventive care to unannounced standardized patients. CMAJ (1998) 5.78
Spliceosomal RNA U6 is remarkably conserved from yeast to mammals. Nature (1988) 5.48
Yeast mRNA splicing in vitro. J Biol Chem (1985) 5.48
Identification and comparison of stable and unstable mRNAs in Saccharomyces cerevisiae. Mol Cell Biol (1990) 5.47
Structure and function of E. coli ribosomes. 8. Cold-sensitive mutants defective in ribosome assembly. Proc Natl Acad Sci U S A (1969) 5.09
The DCP2 protein is required for mRNA decapping in Saccharomyces cerevisiae and contains a functional MutT motif. EMBO J (1999) 5.08
Transcription and processing of intervening sequences in yeast tRNA genes. Cell (1978) 5.07
Isolation and characterization of pre-mRNA splicing mutants of Saccharomyces cerevisiae. Genes Dev (1989) 5.00
Dynamic RNA-RNA interactions in the spliceosome. Annu Rev Genet (1994) 4.83
The DEAD box helicase, Dhh1p, functions in mRNA decapping and interacts with both the decapping and deadenylase complexes. RNA (2001) 4.80
A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome. Cell (1992) 4.62
Yeast exosome mutants accumulate 3'-extended polyadenylated forms of U4 small nuclear RNA and small nucleolar RNAs. Mol Cell Biol (2000) 4.57
RNA processing and the intervening sequence problem. Annu Rev Biochem (1979) 4.54
Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae. Mol Cell Biol (1999) 4.35
Mechanisms and control of mRNA turnover in Saccharomyces cerevisiae. Microbiol Rev (1996) 4.34
Mutations affecting stability and deadenylation of the yeast MFA2 transcript. Genes Dev (1992) 4.20
An early hierarchic role of U1 small nuclear ribonucleoprotein in spliceosome assembly. Science (1988) 4.16
Splicing of yeast tRNA precursors: a two-stage reaction. Cell (1979) 4.15
Multiple functions for the poly(A)-binding protein in mRNA decapping and deadenylation in yeast. Genes Dev (1995) 4.15
Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs. Mol Cell (2001) 4.12
Pre-mRNA splicing in yeast. Trends Genet (1991) 3.98
A small segment of the MAT alpha 1 transcript promotes mRNA decay in Saccharomyces cerevisiae: a stimulatory role for rare codons. Mol Cell Biol (1993) 3.91
Mechanism of action of a yeast RNA ligase in tRNA splicing. Cell (1983) 3.78
Quality control of mRNA 3'-end processing is linked to the nuclear exosome. Nature (2001) 3.69
5' splice site selection in yeast: genetic alterations in base-pairing with U1 reveal additional requirements. Genes Dev (1988) 3.65
Mutations in U6 snRNA that alter splice site specificity: implications for the active site. Science (1993) 3.62
Mutations in trans-acting factors affecting mRNA decapping in Saccharomyces cerevisiae. Mol Cell Biol (1996) 3.58
Splicing of yeast tRNA precursors: structure of the reaction intermediates. Cell (1979) 3.56
Effect of fixation on the amplification of nucleic acids from paraffin-embedded material by the polymerase chain reaction. J Histochem Cytochem (1991) 3.51
The Puf3 protein is a transcript-specific regulator of mRNA degradation in yeast. EMBO J (2000) 3.38
An RNA switch at the 5' splice site requires ATP and the DEAD box protein Prp28p. Mol Cell (1999) 3.37
Differential effects of translational inhibition in cis and in trans on the decay of the unstable yeast MFA2 mRNA. J Biol Chem (1994) 3.37
An essential yeast snRNA with a U5-like domain is required for splicing in vivo. Cell (1987) 3.22
A precursor to a minor species of yeast tRNASer contains an intervening sequence. Cell (1979) 3.21
Mutations in the lactose operon caused by bacteriophage Mu. J Mol Biol (1972) 3.17
RNA unwinding in U4/U6 snRNPs requires ATP hydrolysis and the DEIH-box splicing factor Brr2. Curr Biol (1998) 3.17
Precise excision of intervening sequences from precursor tRNAs by a membrane-associated yeast endonuclease. Cell (1983) 3.13
A novel role for a U5 snRNP protein in 3' splice site selection. Genes Dev (1995) 3.10
A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing. Cell (1990) 3.06
mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E. Mol Cell Biol (2000) 3.06
Primary care in Canada: so much innovation, so little change. Health Aff (Millwood) (2001) 3.05
tRNA identity. Annu Rev Biochem (1989) 3.03
Construction of two Escherichia coli amber suppressor genes: tRNAPheCUA and tRNACysCUA. Proc Natl Acad Sci U S A (1986) 3.00
Splicing of yeast nuclear pre-mRNA in vitro requires a functional 40S spliceosome and several extrinsic factors. Genes Dev (1987) 3.00
Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA. Nature (1968) 2.98
Mechanisms of mRNA degradation in eukaryotes. Trends Biochem Sci (1994) 2.96
A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis. EMBO J (1992) 2.96
Survival with the acquired immunodeficiency syndrome. Experience with 5833 cases in New York City. N Engl J Med (1987) 2.91
Nucleotide sequence changes produced by mutations in the lac promoter of Escherichia coli. J Mol Biol (1977) 2.84
Isolation and characterization of Dcp1p, the yeast mRNA decapping enzyme. EMBO J (1998) 2.82
A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family. Genes Dev (1991) 2.78
Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro. Cell (1985) 2.75
Cloning of yeast transfer RNA genes in Escherichia coli. Science (1977) 2.73
Mechanisms of mRNA surveillance in eukaryotes. Annu Rev Genet (1999) 2.73
tRNA gene transcription in yeast: effects of specified base substitutions in the intragenic promoter. Cell (1983) 2.73
The exosome: a proteasome for RNA? Cell (1999) 2.72
Function of the ski4p (Csl4p) and Ski7p proteins in 3'-to-5' degradation of mRNA. Mol Cell Biol (2000) 2.71
A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates. Cell (1993) 2.70
Prevention of premature birth by screening and treatment for common genital tract infections: results of a prospective controlled evaluation. Am J Obstet Gynecol (1995) 2.69
Oxaliplatin, tetraplatin, cisplatin, and carboplatin: spectrum of activity in drug-resistant cell lines and in the cell lines of the National Cancer Institute's Anticancer Drug Screen panel. Biochem Pharmacol (1996) 2.67
Mechanisms and control of mRNA decapping in Saccharomyces cerevisiae. Annu Rev Biochem (2000) 2.66
Saccharomyces cerevisiae has a U1-like small nuclear RNA with unexpected properties. Science (1987) 2.64
Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics (1996) 2.62
An ancient developmental induction: heat-shock proteins induced in sporulation and oogenesis. Science (1986) 2.60
Changes in tonsillectomy rates associated with feedback and review. Pediatrics (1977) 2.60
Mutational analysis of pre-mRNA splicing in Saccharomyces cerevisiae using a sensitive new reporter gene, CUP1. Genetics (1993) 2.58
A point mutation in the conserved hexanucleotide at a yeast 5' splice junction uncouples recognition, cleavage, and ligation. Cell (1985) 2.56
Changing the identity of a transfer RNA. Nature (1986) 2.53
Nucleolytic processing of a tRNAArg-tRNAAsp dimeric precursor by a homologous component from Saccharomyces cerevisiae. J Biol Chem (1985) 2.52
Heteroduplex structures of bacteriophage Mu DNA. Virology (1973) 2.52
The second catalytic step of pre-mRNA splicing. RNA (1995) 2.50
A critical analysis of studies of state drug reimbursement policies: research in need of discipline. Milbank Q (1993) 2.49
The yeast RNA gene products are essential for mRNA splicing in vitro. Cell (1986) 2.49
The UK colorectal cancer screening pilot: results of the second round of screening in England. Br J Cancer (2007) 2.48
A yeast mutant, PRP20, altered in mRNA metabolism and maintenance of the nuclear structure, is defective in a gene homologous to the human gene RCC1 which is involved in the control of chromosome condensation. Mol Gen Genet (1990) 2.48
An essential splicing factor, SLU7, mediates 3' splice site choice in yeast. Genes Dev (1992) 2.45
A U-rich tract enhances usage of an alternative 3' splice site in yeast. Cell (1991) 2.45