Published in J Biol Chem on April 25, 1969
Branched-chain amino acid catabolism in bacteria. Bacteriol Rev (1976) 1.99
Alpha-isopropylmalate synthase from yeast: purification, kinetic studies, and effect of ligands on stability. J Bacteriol (1972) 1.66
Amino acid biosynthesis in the spirochete Leptospira: evidence for a novel pathway of isoleucine biosynthesis. J Bacteriol (1974) 1.60
Crystal structure of LeuA from Mycobacterium tuberculosis, a key enzyme in leucine biosynthesis. Proc Natl Acad Sci U S A (2004) 1.44
Re-citrate synthase from Clostridium kluyveri is phylogenetically related to homocitrate synthase and isopropylmalate synthase rather than to Si-citrate synthase. J Bacteriol (2007) 1.26
Wild-type isopropylmalate isomerase in Salmonella typhimurium is composed of two different subunits. J Bacteriol (1981) 1.24
Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens. J Bacteriol (2008) 1.23
Norvaline is accumulated after a down-shift of oxygen in Escherichia coli W3110. Microb Cell Fact (2008) 1.08
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway. J Bacteriol (2004) 1.05
Kinetic and chemical mechanism of alpha-isopropylmalate synthase from Mycobacterium tuberculosis. Biochemistry (2006) 1.03
Reversible, coenzyme-A-mediated inactivation of biosynthetic condensing enzymes in yeast: a possible regulatory mechanism. Proc Natl Acad Sci U S A (1975) 1.01
Host plant genome overcomes the lack of a bacterial gene for symbiotic nitrogen fixation. Nature (2009) 1.00
Effect of 4-azaleucine upon leucine metabolism in Salmonella typhimurium. J Bacteriol (1971) 0.95
Regulation of tryptophan biosynthesis in Methanobacterium thermoautotrophicum Marburg. J Bacteriol (1994) 0.89
Construction and characterization of Salmonella typhimurium strains that accumulate and excrete alpha- and beta-isopropylmalate. J Bacteriol (1980) 0.88
Multiple new genes that determine activity for the first step of leucine biosynthesis in Saccharomyces cerevisiae. Genetics (1988) 0.86
Trace element associated reduction of norleucine and norvaline accumulation during oxygen limitation in a recombinant Escherichia coli fermentation. Microb Cell Fact (2013) 0.83
Cation induced differential effect on structural and functional properties of Mycobacterium tuberculosis alpha-isopropylmalate synthase. BMC Struct Biol (2007) 0.83
Characterization of alpha-isopropylmalate synthases containing different copy numbers of tandem repeats in Mycobacterium tuberculosis. BMC Microbiol (2009) 0.79
Simultaneous analysis of the non-canonical amino acids norleucine and norvaline in biopharmaceutical-related fermentation processes by a new ultra-high performance liquid chromatography approach. Amino Acids (2013) 0.79
Alternative pathways for biosynthesis of leucine and other amino acids in Bacteroides ruminicola and Bacteroides fragilis. Appl Environ Microbiol (1984) 0.76
Subdomain II of α-isopropylmalate synthase is essential for activity: inferring a mechanism of feedback inhibition. J Biol Chem (2014) 0.76
Inhibition of Escherichia coli isoleucine biosynthesis by isoleucine tetrazole. J Bacteriol (1975) 0.75
Amino acid biosynthesis and its regulation. Annu Rev Biochem (1978) 7.13
Yeast LEU2. Repression of mRNA levels by leucine and primary structure of the gene product. J Biol Chem (1984) 5.84
Isoleucine and valine metabolism of Escherichia coli. XV. Biochemical properties of mutants resistant to thiaisoleucine. J Bacteriol (1968) 3.70
Isoleucine and valine metabolism of Escherichia coli. XVI. Pattern of multivalent repression in strain K-12. J Bacteriol (1968) 3.15
Expression of the leucine operon. J Bacteriol (1966) 3.12
Isoleucine and valine metabolism of Escherichia coli. XIV. Effect of thiaisoleucine. J Bacteriol (1968) 2.98
Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants. J Bacteriol (1969) 2.88
Regulation of amino acid metabolism. Annu Rev Biochem (1969) 2.88
Polarity and the regulation of the ilv gene cluster in Escherichia coli strain K-12. Mol Gen Genet (1976) 2.78
Nucleotide sequence of ilvGEDA operon attenuator region of Escherichia coli. Proc Natl Acad Sci U S A (1980) 2.61
Regulation of isoleucine-valine biosynthesis in an ilvDAC deletion strain of Escherichia coli K-12. Biochem Biophys Res Commun (1974) 2.35
Isoleucine and valine metabolism in Escherichia coli. XXII. A pleiotropic mutation affecting induction of isomeroreductase activity. J Bacteriol (1973) 2.31
Pleiotropy of hisT mutants blocked in pseudouridine synthesis in tRNA: leucine and isoleucine-valine operons. Proc Natl Acad Sci U S A (1974) 2.31
Biosynthesis of branched-chain amino acids in yeast: correlation of biochemical blocks and genetic lesions in leucine auxotrophs. J Bacteriol (1968) 2.25
Biosynthesis of branched-chain amino acids in yeast: regulation of leucine biosynthesis in prototrophic and leucine auxotrophic strains. J Bacteriol (1968) 2.13
Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase. Biochem Biophys Res Commun (1972) 2.07
The metabolism of valine and isoleucine in Escherichia coli. XVII. The role of induction in the derepression of acetohydroxy acid isomeroreductase. Biochem Biophys Res Commun (1969) 1.94
Purification and properties of the acetohydroxy acid isomeroreductase of Salmonella typhimurium. J Biol Chem (1969) 1.92
Acetohydroxy acid synthase I of Escherichia coli: purification and properties. J Bacteriol (1979) 1.90
Regulation of transaminase C synthesis in Escherichia coli: conditional leucine auxotrophy. J Bacteriol (1974) 1.88
Operator constitutive mutations in the leucine operon of Salmonella typhimurium. Genetics (1969) 1.84
Mutations affecting the formation of acetohydroxy acid synthase II in Escherichia coli K-12. Mol Gen Genet (1979) 1.81
Isoleucine and valine metabolism in Escherichia coli. XXI. Mutations affecting derepression and valine resistance. J Bacteriol (1973) 1.75
Role of threonine deaminase in the regulation of isoleucine and valine biosynthesis. Nat New Biol (1973) 1.75
Physical organization of the ilvEDAC genes of Escherichia coli strain K-12. Proc Natl Acad Sci U S A (1978) 1.74
Alpha-isopropylmalate synthase from yeast: purification, kinetic studies, and effect of ligands on stability. J Bacteriol (1972) 1.66
Isoleucine and valine metabolism in Escherichia coli. XIX. Inhibition of isoleucine biosynthesis by glycyl-leucine. J Bacteriol (1972) 1.65
Positive control of ilvC expression in Escherichia coli K-12; identification and mapping of regulatory gene ilvY. J Bacteriol (1979) 1.64
Intracellular Regulatory Mechanisms: Regulation in multicellular forms may be an elaboration upon the pattern evolved in microorganisms. Science (1964) 1.63
On the role of isoleucyl-tRNA synthetase in multivalent repression. Biochem Genet (1972) 1.48
Metabolite analogs as genetic and biochemical probes. Adv Genet (1971) 1.48
Isoleucine and valine metabolism in Escherichia coli. 18. Induction of acetohydroxy acid isomeroreductase. J Bacteriol (1972) 1.48
Nonidentity of the aspartate and the aromatic aminotransferase components of transaminase A in Escherichia coli. J Bacteriol (1972) 1.47
Threonine deaminases. Adv Enzymol Relat Areas Mol Biol (1973) 1.43
Separate regulation of transport and biosynthesis of leucine, isoleucine, and valine in bacteria. J Bacteriol (1975) 1.41
Location of the multivalent control site for the ilvEDA operon of Escherichia coli. J Bacteriol (1980) 1.41
Effect of isoleucine, valine, or leucine starvation on the potential for formation of the branched-chain amino acid biosynthetic enzymes. J Bacteriol (1973) 1.33
Physical characterization of ilv-lac fusions. J Bacteriol (1979) 1.33
Isoleucine and valine metabolism in Escherichia coli K-12: detection and measurement of ilv-specific messenger ribonucleic acid. J Bacteriol (1974) 1.30
Physical location of the ilvO determinant in Escherichia coli K-12 deoxyribonucleic acid. J Bacteriol (1980) 1.29
Characterization of fusions between the lac operon and the ilv gene cluster in Escherichia coli: ilvC-lac fusions. J Bacteriol (1977) 1.28
COLORIMETRIC METHOD FOR THE ESTIMATION OF GROWTH IN CUP ASSAYS. J Bacteriol (1960) 1.26
Role for free isoleucine of glycyl-leucine in the repression of threonine deaminase in Escherichia coli. J Bacteriol (1974) 1.22
A role for a pyridoxne derivative in the multivalent repression of the isoleucine and valine biosynthetic enzymes. Biochem Biophys Res Commun (1973) 1.22
Biosynthesis of branched-chain amino acids in yeast: regulation of synthesis of the enzymes of isoleucine and valine biosynthesis. J Bacteriol (1969) 1.18
Biosynthesis of branched-chain amino acids in yeast: effect of carbon source on leucine biosynthetic enzymes. J Bacteriol (1975) 1.17
Threonine deaminase from Bacillus subtilis. I. Purification of the enzyme. J Biol Chem (1970) 1.16
Regulation of synthesis of the branched-chain amino acids and cognate aminoacyl-transfer ribonucleic acid synthetases of Escherichia coli: a common regulatory element. J Bacteriol (1974) 1.15
In vitro synthesis of beta-galactosidase with ilv-lac fusion deoxyribonucleic acid as template. J Bacteriol (1977) 1.13
Comparison of the regulatory regions of ilvGEDA operons from several enteric organisms. J Bacteriol (1985) 1.13
Role of codon choice in the leader region of the ilvGMEDA operon of Serratia marcescens. J Bacteriol (1987) 1.13
Regulation of ilvEDA expression occurs upstream of ilvG in Escherichia coli: additional evidence for an ilvGEDA operon. J Bacteriol (1980) 1.11
Threonine deaminase from Bacillus subtilis. II. The steady state kinetic properties. J Biol Chem (1970) 1.09
-isopropylmalate synthase from Salmonella typhimurium. Analysis of the guaternary structure and its relation to function. J Biol Chem (1972) 1.08
Translational coupling between the ilvD and ilvA genes of Escherichia coli. J Bacteriol (1988) 1.06
Biosynthesis of the branched-chain amino acids in yeast: a leucine-binding component and regulation of leucine uptake. J Bacteriol (1970) 1.04
Leucine regulation of the ilvGEDA operon of Serratia marcescens by attenuation is modulated by a single leucine codon. J Bacteriol (1985) 1.03
Physical and genetic localization of ilv regulatory sites in lambda ilv bacteriophages. J Bacteriol (1982) 1.02
Effects of deletion and insertion mutations in the ilvM gene of Escherichia coli. J Bacteriol (1987) 1.01
Biosynthesis of the branched-chain amino acids in yeast: a trifluoroleucine-resistant mutant with altered regulation of leucine uptake. J Bacteriol (1970) 1.00
Continuous liquid-phase piezoelectric biosensor for kinetic immunoassays. Anal Chem (1989) 1.00
Threonine deaminase from Bacillus subtilis. 3. Pre-steady state kinetic properties. J Biol Chem (1970) 0.99
Structure of potato carboxypeptidase inhibitor: disulfide pairing and exposure of aromatic residues. Biochemistry (1979) 0.98
Isolation and analysis of two Escherichia coli K-12 ilv attenuator deletion mutants with high-level constitutive expression of an ilv-lac fusion operon. J Bacteriol (1984) 0.98
Purification of yeast alpha-isopropylmalate isomerase. High ionic strength hydrophobic chromatography. J Biol Chem (1975) 0.96
Dissociation of alpha-isopropylmalate synthase from Salmonella typhimurium by its feedback inhibitor leucine. Biochem Biophys Res Commun (1970) 0.92
Yeast alpha-isopropylmalate isomerase. Factors affecting stability and enzyme activity. J Biol Chem (1976) 0.91
Defective transamination, a mechanism for resistance to ketomycin in Escherichia coli. Antimicrob Agents Chemother (1973) 0.91
Specificity of the stimulation of in vitro ribonucleic acid synthesis by guanosine 5'-diphosphate 3'-diphosphate. Mol Gen Genet (1975) 0.91
ilvU, a locus in Escherichia coli affecting the derepression of isoleucyl-tRNA synthetase and the RPC-5 chromatographic profiles of tRNAIle and tRNAVal. J Biol Chem (1979) 0.89
Specificity of attenuation control in the ilvGMEDA operon of Escherichia coli K-12. J Bacteriol (1991) 0.88
Number and reactivity of the sulfhydryl groups of alpha-isopropylmalate synthase of Salmonella typhimurium. Biochim Biophys Acta (1970) 0.85
Participation of branched-chain amino acid analogues in multivalent repression. J Bacteriol (1973) 0.84
Affinity chromatography of transaminases. Anal Biochem (1971) 0.84
Cross-linking of Salmonella isopropylmalate synthesis with dimethyl suberimidate: evidence for antagonistic effects of leucine and acetyl-CoA on the guaternary structure. Biochem Biophys Res Commun (1971) 0.84
Effect of a leu-linked mutation on the valine sensitivity of acetohydroxy acid synthase activity in Escherichia coli. J Bacteriol (1975) 0.83
Deoxyribonucleic acid-directed in vitro synthesis of ilv-specific messenger ribonucleic acid by extracts of Escherichia coli K-12. J Bacteriol (1974) 0.82
Identity of the tryptic and alpha-chymotryptic reactive sites on soybean trypsin inhibitor (Kunitz). Biochemistry (1972) 0.81
A time-dependent activation of threonine deaminase. Biochem Biophys Res Commun (1968) 0.81
Mutations in the ilvY gene of Escherichia coli K-12 that cause constitutive expression of ilvC. J Bacteriol (1981) 0.80
Exogenous Valine Reduces Conversion of Leucine to 3-Methyl-1-Butanol in Saccharomyces cerevisiae. Appl Environ Microbiol (1983) 0.79
In vitro formation of beta-galactosidase with a template containing the lac genes fused to gene ilvD. J Bacteriol (1980) 0.78
Mutations replacing the leucine codons or altering the length of the amino acid-coding portion of the ilvGMEDA leader region of Escherichia coli. J Bacteriol (1991) 0.78
The absence of branched-chain amino acid and growth rate control at the internal ilvEp promoter of the ilvGMEDA operon. J Bacteriol (1991) 0.78
[Enzymatic and non-enzymatic production of "thiamine pyrophosphate-activated glycolaldehyde"]. Z Naturforsch B (1967) 0.75
A staining procedure for cattle and bison carbonic anhydrase using fluorescein diacetate. Anim Blood Groups Biochem Genet (1978) 0.75