Published in N Engl J Med on March 23, 1972
Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med (1993) 6.22
An analysis of major errors and equipment failures in anesthesia management: considerations for prevention and detection. Anesthesiology (1984) 5.32
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The pulmonary vascular lesions of the adult respiratory distress syndrome. Am J Pathol (1983) 1.88
Low concentrations of nitric oxide increase oxygen affinity of sickle erythrocytes in vitro and in vivo. J Clin Invest (1997) 1.87
Sustained pulmonary hypertension and right ventricular hypertrophy after chronic hypoxia in mice with congenital deficiency of nitric oxide synthase 3. J Clin Invest (1998) 1.72
Pulmonary vasoconstriction and hypertension in mice with targeted disruption of the endothelial nitric oxide synthase (NOS 3) gene. Circ Res (1997) 1.63
Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology (1993) 1.63
Nebulized sildenafil is a selective pulmonary vasodilator in lambs with acute pulmonary hypertension. Crit Care Med (2001) 1.58
Localizing antithrombotic and vasodilatory activity with a novel, ultrafast nitric oxide donor. J Med Chem (1996) 1.54
Inhaled nitric oxide improves exercise capacity in patients with severe heart failure and right ventricular dysfunction. Am J Cardiol (1998) 1.47
Platelet factor 4 injection produces acute pulmonary hypertension in the awake lamb. Anesthesiology (1995) 1.46
Henry Isaiah Dorr was the first person to hold the title professor of anaesthesia. Anesthesiology (2000) 1.40
Does clinical anesthesia need new neuromuscular blocking agents? Anesthesiology (1975) 1.37
Acute left ventricular dysfunction during unsuccessful weaning from mechanical ventilation. Anesthesiology (1988) 1.35
Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest (1992) 1.34
Seal lungs collapse during free diving: evidence from arterial nitrogen tensions. Science (1985) 1.30
Thromboxane receptor blockade prevents pulmonary hypertension induced by heparin-protamine reactions in awake sheep. Circulation (1990) 1.28
Pulmonary fibrosis in severe acute respiratory failure. Am Rev Respir Dis (1979) 1.27
Inhaled nitric oxide in congenital heart disease. Circulation (1993) 1.26
Hemoglobin concentrations and blood gas tensions of free-diving Weddell seals. J Appl Physiol (1985) (1986) 1.25
Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction. Science (1982) 1.23
Platelet consumption and sequestration in severe acute respiratory failure. Am Rev Respir Dis (1980) 1.22
Editorial: And yet another crisis: research funding in anesthesiology. Anesthesiology (1974) 1.22
Regional blood flow during simulated diving in the conscious Weddell seal. J Appl Physiol Respir Environ Exerc Physiol (1979) 1.21
Chronic inhalation of nitric oxide inhibits neointimal formation after balloon-induced arterial injury. Circ Res (1996) 1.19
Congenital deficiency of nitric oxide synthase 2 protects against endotoxin-induced myocardial dysfunction in mice. Circulation (2000) 1.19
Cyclic-GMP-binding, cyclic-GMP-specific phosphodiesterase (PDE5) gene expression is regulated during rat pulmonary development. Pediatr Res (1998) 1.16
Inhaled nitric oxide. A selective pulmonary vasodilator of heparin-protamine vasoconstriction in sheep. Anesthesiology (1991) 1.15
Pulmonary artery remodeling and pulmonary hypertension after exposure to hyperoxia for 7 days. A morphometric and hemodynamic study. Am J Pathol (1984) 1.15
Neutralization of low molecular weight heparin by polybrene prevents thromboxane release and severe pulmonary hypertension in awake sheep. Circulation (1990) 1.12
Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol (1994) 1.08
Early bedside detection of pulmonary vascular occlusion during acute respiratory failure. Am Rev Respir Dis (1981) 1.07
Continuous nitric oxide inhalation reduces pulmonary arterial structural changes, right ventricular hypertrophy, and growth retardation in the hypoxic newborn rat. Circ Res (1995) 1.06
C5a and thromboxane generation associated with pulmonary vaso- and broncho-constriction during protamine reversal of heparin. Anesthesiology (1987) 1.06
Inhaled nitric oxide. A bronchodilator in mild asthmatics with methacholine-induced bronchospasm. Am J Respir Crit Care Med (1996) 1.04
Three-dimensional echocardiographic assessment of left ventricular wall motion abnormalities in mouse myocardial infarction. J Am Soc Echocardiogr (1999) 1.03
Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Effects on pulmonary hemodynamics and oxygenation. Anesthesiology (1994) 1.03
Splenic contraction, catecholamine release, and blood volume redistribution during diving in the Weddell seal. J Appl Physiol (1985) (1996) 1.02
Pulmonary vascular remodeling in adult respiratory distress syndrome. Am Rev Respir Dis (1982) 1.01
Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology (2000) 1.00
Hypoxic pulmonary blood flow redistribution and arterial oxygenation in endotoxin-challenged NOS2-deficient mice. J Clin Invest (1999) 0.97
Teaching effectiveness: evaluation of computer-assisted instruction for cardiopulmonary resuscitation. Anesth Analg (1975) 0.97
The effect of tubocurarine on indirectly elicited train-of-four muscle response and respiratory measurements in humans. Br J Anaesth (1975) 0.97
Vascular components of ARDS. Clinical pulmonary hemodynamics and morphology. Am Rev Respir Dis (1987) 0.96
Antiinflammatory properties of inducible nitric oxide synthase in acute hyperoxic lung injury. Am J Respir Cell Mol Biol (2001) 0.96
New approaches to acute lung injury. Br J Anaesth (1996) 0.96
Binding and neutralization of endotoxin by Limulus antilipopolysaccharide factor. Infect Immun (1992) 0.96
Oxygen toxicity and restructuring of pulmonary arteries--a morphometric study. The response to 4 weeks' exposure to hyperoxia and return to breathing air. Am J Pathol (1985) 0.96
Diaphragmatic shortening after thoracic surgery in humans. Effects of mechanical ventilation and thoracic epidural anesthesia. Anesthesiology (1993) 0.95
Vascular obstruction causes pulmonary hypertension in severe acute respiratory failure. Chest (1977) 0.95
Determination of right ventricular structure and function in normoxic and hypoxic mice: a transesophageal echocardiographic study. Circulation (1998) 0.94
Attenuation of hypoxic pulmonary vasoconstriction by endotoxemia requires 5-lipoxygenase in mice. Circ Res (2001) 0.94
Inhaled nitric oxide increases coronary artery patency after thrombolysis. Circulation (1996) 0.93
Echocardiographic determination of risk area size in a murine model of myocardial ischemia. Am J Physiol (1999) 0.93
Myoglobin saturation in free-diving Weddell seals. J Appl Physiol (1985) (1995) 0.92
cAMP regulates soluble guanylate cyclase beta 1-subunit gene expression in RFL-6 rat fetal lung fibroblasts. Am J Physiol (1993) 0.92
Exhaled nitric oxide as a marker for organic nitrate tolerance. Circulation (1994) 0.91
Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep. Circ Res (1982) 0.91
Altered factor VIII in acute respiratory failure. N Engl J Med (1982) 0.91
Splenic contraction during breath-hold diving in the Korean ama. J Appl Physiol (1985) (1990) 0.90
Nitric oxide inhalation decreases pulmonary artery remodeling in the injured lungs of rat pups. Circ Res (2000) 0.90
Pulmonary vasodilation by nitric oxide gas and prodrug aerosols in acute pulmonary hypertension. J Appl Physiol (1985) (1998) 0.90
Pulmonary vascular lesions in the adult respiratory distress syndrome caused by inhalation of zinc chloride smoke: a morphometric study. Hum Pathol (1992) 0.89
Bedside measurement of pulmonary capillary pressure in patients with acute respiratory failure. Anesthesiology (1987) 0.89
Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol (1995) 0.89
Inhaled nitric oxide reverses pulmonary vasoconstriction in the hypoxic and acidotic newborn lamb. Circ Res (1993) 0.89
Heart rate and body temperature during free diving of Weddell seals. Am J Physiol (1987) 0.89
Cyclooxygenase blockade elevates leukotriene E4 production during acute anaphylaxis in sheep. J Exp Med (1986) 0.88
Extended term (to 16 days) partial extracorporeal blood gas exchange with the spiral membrane lung in unanesthetized lambs. Trans Am Soc Artif Intern Organs (1971) 0.87
Identification of acetylcholine in fresh rat brain by combined gas chromatography-mass spectrometry. Nature (1968) 0.87
Mode of action of trichloroethylene on squid axon membranes. J Pharmacol Exp Ther (1976) 0.87
Hormonal regulatory adjustments during voluntary diving in Weddell seals. Comp Biochem Physiol B Biochem Mol Biol (1995) 0.86
Microcomputer-assisted metabolic studies of voluntary diving of Weddell seals. Am J Physiol (1986) 0.85
A study in vitro of new short-acting, non-depolarizing neuromuscular blocking agents. Biochem Pharmacol (1969) 0.84
Artificial placenta: two days of total extrauterine support of the isolated premature lamb fetus. Science (1969) 0.84
ARDS after accidental inhalation of zinc chloride smoke. Intensive Care Med (1988) 0.84
The reaction of acetylcholinesterase with methanesulfonyl esters of quaternary quinolinium compounds. Biochem Pharmacol (1969) 0.84
Platelet function in acute respiratory failure. Am J Hematol (1987) 0.83
Positive airway pressure in lambs spontaneously breathing air and oxygen. J Surg Res (1976) 0.83
Effects of leukotrienes B4 and C4 on coronary circulation and myocardial contractility. Surgery (1983) 0.83
On the question: is acetylcholinesterase an allosteric protein? Mol Pharmacol (1970) 0.83
Protective metabolic mechanisms during liver ischemia: transferable lessons from long-diving animals. Mol Cell Biochem (1988) 0.82
Congenital NOS2 deficiency protects mice from LPS-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology (1999) 0.82
Effects of inhaled nitric oxide on pulmonary hemodynamics and gas exchange in an ovine model of ARDS. J Appl Physiol (1985) (1994) 0.82
A comparison of pulmonary artery occlusion pressure and left ventricular end-diastolic pressure during mechanical ventilation with PEEP in patients with severe ARDS. Anesthesiology (1989) 0.82
A nordic ECMO saga or whither ECMO? Intensive Care Med (1991) 0.81
Rat pulmonary artery wall injury by chronic intermittent infusions of Escherichia coli endotoxin. Obliterative vasculitis and vascular occlusion. Lab Invest (1986) 0.81
Diving adaptations of the Weddell seal. Sci Am (1987) 0.81
The reaction of acetylcholinesterase with O-dimethylcarbamyl esters of quaternary quinolinium compounds. Biochem Pharmacol (1967) 0.81
Pulmonary arterial wall injury and remodelling by hyperoxia. Chest (1983) 0.81
Thoracic epidural anesthesia increases diaphragmatic shortening after thoracotomy in the awake lamb. Anesthesiology (1993) 0.80