PubRank

N B Ruderman

Author PubWeight™ 125.46‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The "metabolically-obese," normal-weight individual. Am J Clin Nutr 1981 2.71
2 Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J 1971 2.66
3 Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J Lipid Res 1967 2.58
4 Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. J Biol Chem 1997 2.54
5 Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin. J Clin Invest 1982 2.41
6 The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem 1994 2.09
7 Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. Biochem J 1976 1.90
8 The formation of glutamine and alanine in skeletal muscle. J Biol Chem 1974 1.90
9 Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle. J Biol Chem 1993 1.88
10 Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J 1974 1.78
11 Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. Biochem J 1975 1.71
12 Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat. Biochem J 1977 1.69
13 Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle. Biochem J 1986 1.66
14 Glucose regulation of hepatic gluconeogenesis. Am J Physiol 1968 1.64
15 Role of free fatty acids in glucose homeostasis. Arch Intern Med 1969 1.61
16 Muscle amino acid metabolism and gluconeogenesis. Annu Rev Med 1975 1.61
17 Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies and free fatty acids. Diabetes 1974 1.61
18 Acetoacetate as a fuel for perfused rat skeletal muscle. Biochem J 1971 1.54
19 Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol 1980 1.43
20 Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution. J Biol Chem 1992 1.43
21 Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am J Physiol 1982 1.40
22 Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia 2004 1.40
23 Insulin binding and sensitivity in rat skeletal muscle: effect of starvation. Am J Physiol 1981 1.39
24 Diabetes as an atherogenic factor. Prog Cardiovasc Dis 1984 1.35
25 Diabetes and exercise. Am J Med 1981 1.33
26 Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes 1997 1.33
27 An electron microscopic study of lipoprotein production and release by the isolated perfused rat liver. Proc Soc Exp Biol Med 1966 1.33
28 Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem 2000 1.31
29 Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein. Am J Physiol 1980 1.29
30 Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis. Am J Physiol 1981 1.25
31 Enhanced muscle glucose metabolism after exercise: modulation by local factors. Am J Physiol 1984 1.24
32 Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate. Diabetes 1978 1.21
33 Synthesis of essential amino acids from their alpha-keto analogues by perfused rat liver and muscle. J Clin Invest 1973 1.21
34 Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am J Physiol 1999 1.15
35 Stimulation of vascular Na(+)-K(+)-ATPase activity by nitric oxide: a cGMP-independent effect. Am J Physiol 1994 1.14
36 Enhanced muscle glucose metabolism after exercise in the rat: the two phases. Am J Physiol 1984 1.14
37 Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle. Biochem J 1985 1.13
38 Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia 1984 1.13
39 Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab 2000 1.12
40 Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Am J Physiol Endocrinol Metab 2001 1.10
41 Chronic hypoglycemia increases brain glucose transport. Am J Physiol 1986 1.07
42 A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation. Am J Physiol 1995 1.07
43 The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes. Diabetes 1979 1.07
44 Regulation of production and release of lipoprotein by the perfused rat liver. J Lipid Res 1968 1.06
45 Insulin sensitivity of rat skeletal muscle: effects of starvation and aging. Am J Physiol 1979 1.06
46 Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes 1999 1.06
47 The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver. J Biol Chem 1970 1.06
48 Muscle alpha-aminoisobutyric acid transport after exercise: enhanced stimulation by insulin. Am J Physiol 1985 1.04
49 Sites of protein conservation and loss during starvation: influence of adiposity. Am J Physiol 1984 1.04
50 Oxygen consumption in perfused skeletal muscle. Effect of perfusion with aged, fresh and aged-rejuvenated erythrocytes on oxygen consumption, tissue metabolites and inhibition of glucose utilization by acetoacetate. Biochem J 1980 1.04
51 Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle. Am J Physiol 1989 1.03
52 Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem 1988 1.03
53 Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol Endocrinol 1991 1.02
54 Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol 1997 1.00
55 Glucose uptake and insulin sensitivity in rat muscle: changes during 3-96 weeks of age. Am J Physiol 1983 0.99
56 Regulation of ketone body metabolism in skeletal muscle. Am J Physiol 1973 0.98
57 Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. Am J Physiol 1999 0.97
58 Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus. Diabetes Care 1992 0.96
59 Muscle nitrogen metabolism in chronic hepatic insufficiency. Metabolism 1976 0.95
60 A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia. J Clin Invest 1971 0.95
61 Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest 1992 0.95
62 Inhibition of hepatic gluconeogenesis and fatty acid oxidation by pent-4-enoic acid. Am J Physiol 1970 0.94
63 Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation. Metabolism 1986 0.92
64 Amino acid metabolism in skeletal muscle. Regulation of glutamine and alanine release in the perfused rat hindquarter. Isr J Med Sci 1972 0.92
65 Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles. Endocrinology 1992 0.90
66 Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance. Diabetes 1991 0.90
67 Intrinsic differences of insulin receptor kinase activity in red and white muscle. J Biol Chem 1986 0.90
68 Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter. Fed Proc 1977 0.90
69 Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. Diabetes 2000 0.89
70 Obesity-associated disorders in normal-weight individuals: some speculations. Int J Obes 1982 0.89
71 Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. Acta Physiol Scand 1982 0.89
72 Diacylglycerol-protein kinase C signalling in skeletal muscle: a possible link to insulin resistance. Trans Assoc Am Physicians 1991 0.88
73 Additive effects of prior exercise and insulin on glucose and AIB uptake by rat muscle. Am J Physiol 1986 0.87
74 Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol. Am J Physiol 1994 0.87
75 Substrate utilization in perfused skeletal muscle. Diabetes 1979 0.87
76 Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise. Am J Physiol 1986 0.86
77 Diabetes-induced alterations of glucose metabolism in rat cerebral microvessels. Am J Physiol 1984 0.86
78 Ketosis. Trans Am Clin Climatol Assoc 1973 0.86
79 Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle. Am J Physiol 1993 0.86
80 Insulin and exercise stimulate muscle alpha-aminoisobutyric acid transport by a Na+-K+-ATPase independent pathway. Biochem Biophys Res Commun 1986 0.85
81 Role of endothelium-derived nitric oxide in stimulation of Na(+)-K(+)-ATPase activity by endothelin in rabbit aorta. Am J Physiol 1994 0.84
82 Dichloroacetate: effects on exercise endurance in untrained rats. Metabolism 1981 0.83
83 Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. Am J Physiol Endocrinol Metab 2001 0.83
84 Differential stimulation of Na+ pump activity by insulin and nitric oxide in rabbit aorta. Am J Physiol 1996 0.83
85 Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis. Am J Physiol 1974 0.83
86 Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake. Biochem J 1986 0.82
87 Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta. Am J Physiol 1991 0.82
88 Regulation of alanine formation and release in rat muscle in vivo: effect of starvation and diabetes. Am J Physiol 1977 0.82
89 Effect of oleate concentration on its metabolism by the perfused rat liver. Biochim Biophys Acta 1968 0.82
90 Ornithine decarboxylase activity in insulin-deficient states. Biochem J 1980 0.82
91 Effect of diabetes on the induction of ornithine decarboxylase by refeeding. Life Sci 1979 0.81
92 Glucogenic substrate levels in fasting man. Adv Enzyme Regul 1975 0.81
93 Vasodilator responses in the forearm skin of patients with insulin-dependent diabetes mellitus. Vasc Med 1996 0.80
94 Insulin increases a biochemically distinct pool of diacylglycerol in the rat soleus muscle. Am J Physiol 1994 0.80
95 Insulin-like growth factor I binding and receptor kinase in red and white muscle. FEBS Lett 1988 0.80
96 Dissociation of 5' AMP-activated protein kinase activation and glucose uptake stimulation by mitochondrial uncoupling and hyperosmolar stress: differential sensitivities to intracellular Ca2+ and protein kinase C inhibition. Biochem Biophys Res Commun 2001 0.80
97 Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels. Am J Physiol 1990 0.79
98 Myopathic disorder associated with mitochondrial abnormalities, hyperglycaemia, and hyperketonaemia. Lancet 1971 0.78
99 Protein conservation during starvation: possible role of lipid fuels. Prog Clin Biol Res 1982 0.78
100 Effect of acute insulin deprivation on rat liver glucokinase. Diabetes 1968 0.78
101 Malonyl coenzyme A and adiposity in the Dahl salt-sensitive rat: effects of pioglitazone. Metabolism 1996 0.77
102 Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. Am J Physiol 1988 0.77
103 Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes. Metabolism 1987 0.77
104 Polymyxin B inhibits contraction-stimulated glucose uptake in rat skeletal muscle. J Appl Physiol (1985) 1991 0.77
105 Energy state of bovine cerebral microvessels: comparison of isolation methods. Microvasc Res 1988 0.77
106 Enzymes of carbohydrate and fat metabolism in anti-insulin serum diabetes; inactivation by free fatty acids and the protective effect of cellular protein. Diabetologia 1974 0.77
107 Prior exercise potentiates the thermic effect of a carbohydrate load. Metabolism 1986 0.76
108 Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrations. Microvasc Res 1988 0.76
109 The postexercise state: altered effects of insulin on skeletal muscle and their physiologic relevance. Diabetes Metab Rev 1986 0.76
110 Insulin preservation of glucokinase activity in isolated perfused rat liver. Am J Physiol 1967 0.76
111 Effect of insulin on protein synthesis and degradation in skeletal muscle after exercise. Am J Physiol 1990 0.76
112 Impaired fibrinolytic response to exercise in type II diabetes: effects of exercise and physical training. Metabolism 1988 0.76
113 Influence of muscle use on amino acid metabolism. Exerc Sport Sci Rev 1982 0.75
114 Cutting the Gordian knot. Addition of metformin to insulin therapy in a patient with uncontrolled diabetes and schizophrenia. Diabetes Care 1999 0.75
115 Exercise and type I diabetes mellitus. Exerc Sport Sci Rev 1988 0.75
116 Reduced Na(+)-K+ pump activity in diabetic rabbit carotid artery: reversal by aldose reductase inhibition. Am J Physiol 1993 0.75
117 Could intranasal insulin be useful in the treatment of non-insulin-dependent diabetes mellitus? Diabetes Res Clin Pract 1991 0.75
118 Exercise and physical training in the treatment of diabetes mellitus. Compr Ther 1986 0.75
119 Muscle glucose oxidation. Am J Physiol 1985 0.75
120 Exercise and the insulin-dependent diabetic. Hosp Pract (Off Ed) 1986 0.75
121 Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels. Am J Physiol 1993 0.75
122 Partial characterization of an insulin-dependent serum factor that regulates ornithine decarboxylase in skeletal muscle. Diabetes 1982 0.75
123 Non-beta-cell tumor hypoglycemia associated with increased nonsuppressible insulin-like protein (NSILP). Am J Med 1979 0.75
124 Regulation of ornithine decarboxylase in skeletal muscle: evidence for the involvement of an insulin-dependent serum factor. Diabetes 1981 0.75
125 Brain metabolism in diabetes. Horm Metab Res Suppl 1980 0.75
126 Insulin-enhanced thermogenesis in skeletal muscle after exercise: regulatory factors. Am J Physiol 1986 0.75
127 Skeletal muscle: reservoir for exogenous L-dopa. J Pharmacol Exp Ther 1974 0.75
128 Inhibition of hepatic gluconeogenesis by 4-pentenoic acid. Hoppe Seylers Z Physiol Chem 1970 0.75
129 Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium. Diabetologia 1988 0.75
130 Acute and chronic metabolism changes following exercise: mechanisms and physiological relevance. Curr Concepts Nutr 1986 0.75
131 Effect of prior exercise and insulin on potential thermogenic systems in rat skeletal muscle. J Appl Physiol (1985) 1992 0.75
132 Insulin increases thermogenesis in rat skeletal muscle following exercise. Am J Physiol 1985 0.75
133 H.D.L. in diabetes. Lancet 1979 0.75
134 Physical training and cardiovascular disease in the diabetic. Curr Probl Clin Biochem 1982 0.75