Published in Proc Natl Acad Sci U S A on July 01, 1965
Studies on the nature of messenger RNA in germinating wheat embryos. Proc Natl Acad Sci U S A (1968) 2.54
Hybridization of plant ribosomal RNA to DNA: the isolation of a DNA component rich in ribosomal RNA cistrons. Proc Natl Acad Sci U S A (1967) 2.01
The genes for cytoplasmic ribosomal ribonucleic Acid in higher plants. Plant Physiol (1973) 1.97
A comparison between heterogeneous nuclear RNA and polysomal messenger RNA in HeLa cells by RNA-DNA hybridization. J Cell Biol (1970) 1.72
Function of chloroplast DNA. I. Hybridization studies involving nuclear and chloroplast DNA with RNA from cytoplasmic (80S) and chloroplast (70S) ribosomes. Proc Natl Acad Sci U S A (1968) 1.60
Ribosomal RNA homologies among distantly related organisms. Proc Natl Acad Sci U S A (1970) 1.35
Hybridization of hamster cells with high and low folate reductase activity. Proc Natl Acad Sci U S A (1969) 1.30
Hybridization of RNA from Rous sarcoma virus with cellular and viral DNA's. Proc Natl Acad Sci U S A (1969) 1.26
Isolation of nucleoli. A method that combines high yield, structural integrity, and biochemical preservation. J Cell Biol (1971) 1.04
Characterization of the ribonucleic acid synthesized by isolated rat-liver nuclei. Biochem J (1967) 1.01
Pulse labeling of RNA of mammalian cells. Proc Natl Acad Sci U S A (1970) 0.95
Hybridizable ribonucleic acid of rat brain. Biochem J (1968) 0.87
Altered nucleic acids of antibody-forming tissues. Proc Natl Acad Sci U S A (1970) 0.82
DNA-RNA hybridization studies of myeloma tumors in mice. Proc Natl Acad Sci U S A (1967) 0.81
Gene expression in interspecific hybrids. II. RNA synthesis in the lethal cross Arbacia lixula male x Paracentrotus lividus female. Proc Natl Acad Sci U S A (1969) 0.79
Characterization of the rapidly labeled hybridizable RNA synthesized in L5178Y mouse leukemic cells. Hybridization lifetime studies. Biophys J (1971) 0.75
Demonstration of an unstable RNA and of a precursor to ribosomal RNA in HeLa cells. Proc Natl Acad Sci U S A (1963) 8.26
Purification of viral RNA by means of bentonite. Virology (1961) 7.63
A method for the detection of RNA-DNA complexes. Biochem Biophys Res Commun (1963) 6.20
Distinct cistrons for the two ribosomal RNA components. Proc Natl Acad Sci U S A (1963) 4.54
The structure of ribonucleic acids. II. The smaller products of ribonuclease digestion. Biochem J (1952) 4.49
A simplified procedure for purification of large amounts of poliovirus: characterization and amino acid analysis of Type 1 poliovirus. J Biol Chem (1960) 3.94
THE RELATIONSHIP OF THE NUCLEOLUS TO THE SYNTHESIS OF RIBOSOMAL RNA IN HELA CELLS. Proc Natl Acad Sci U S A (1964) 2.90
DETERMINATION OF THE CODING RATIO BASED ON MOLECULAR WEIGHT OF MESSENGER RIBONUCLEIC ACID ASSOCIATED WITH ERGOSOMES OF DIFFERENT AGGREGATE SIZE. Nature (1964) 2.20
Recognition of ribosomal RNA sites in DNA. I. Analysis of the E. coli system. Proc Natl Acad Sci U S A (1965) 2.05
Ribonucleic acids. II. Improved preparation of rat-liver ribonucleic acid. Biochim Biophys Acta (1962) 1.96
On the structure of ribonucleic acids. II. The products of ribonuclease action. J Biol Chem (1953) 1.72
Virus specific protein and a ribo-nucleic acid associated with ribosomes in poliovirus infected HeLa cells. Cold Spring Harb Symp Quant Biol (1962) 1.56
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science (1989) 9.71
tRNA punctuation model of RNA processing in human mitochondria. Nature (1981) 8.48
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science (1999) 5.20
Proportion of HeLa cell genome complementary to transfer RNA and 5 s RNA. J Mol Biol (1971) 5.11
Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase. Nature (1985) 4.96
Expression of the mitochondrial genome in HeLa cells. VI. Size determination of mitochondrial ribosomal RNA by electron microscopy. J Mol Biol (1971) 3.57
Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes. J Mol Biol (1966) 3.29
Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs. Nature (1981) 3.01
MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proc Natl Acad Sci U S A (1992) 2.82
Structure and synthesis of ribosomal RNA. Annu Rev Biochem (1970) 2.80
In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria. Mol Cell Biol (1991) 2.70
Isolation of human cell lines lacking mitochondrial DNA. Methods Enzymol (1996) 2.70
High molecular weight nonribosomal-type nuclear RNA and cytoplasmic messenger RNA in HeLa cells. Proc Natl Acad Sci U S A (1966) 2.67
Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy. Proc Natl Acad Sci U S A (1992) 2.62
The pattern of transcription of the human mitochondrial rRNA genes reveals two overlapping transcription units. Cell (1983) 2.60
Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA. Proc Natl Acad Sci U S A (1982) 2.55
The tRNA genes punctuate the reading of genetic information in human mitochondrial DNA. Cell (1980) 2.53
Animal mitochondrial DNA: an extreme example of genetic economy. Int Rev Cytol (1985) 2.44
Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication. Proc Natl Acad Sci U S A (1977) 2.22
Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation. Hum Mol Genet (1996) 2.22
Electron microscopic visualization of mitochondrial RNA-DNA hybrids. J Mol Biol (1971) 2.20
Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication. Nature (1979) 2.19
An electron microscope study of the relative positions of the 4S and ribosomal RNA genes in HeLa cells mitochondrial DNA. Cell (1976) 2.17
Partial sequence analysis of ribosomal RNA from HeLa cells. I. Oligonucleotide pattern of 28 s and 18 s RNA after pancreatic ribonuclease digestion. J Mol Biol (1968) 2.09
Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable. Mol Cell Biol (1981) 2.05
Recognition of ribosomal RNA sites in DNA. I. Analysis of the E. coli system. Proc Natl Acad Sci U S A (1965) 2.05
Symmetrical in vivo transcription of mitochondrial DNA in HeLa cells. Proc Natl Acad Sci U S A (1971) 2.04
Membrane-bound ribosomes in HeLa cells. I. Their proportion to total cell ribosomes and their association with messenger RNA. J Mol Biol (1969) 2.00
Human dihydrofolate reductase gene organization. Extensive conservation of the G + C-rich 5' non-coding sequence and strong intron size divergence from homologous mammalian genes. J Mol Biol (1984) 2.00
Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes termination. Cell (1989) 1.97
Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA. Cell (1988) 1.96
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci U S A (2001) 1.94
A detailed physical map of HeLa cell mitochondria DNA and its alignment with the positions of known genetic markers. Plasmid (1977) 1.93
The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme. EMBO J (1998) 1.93
Partial sequence analysis of ribosomal RNA from HeLa cells. II. Evidence for sequences of non-ribosmal type in 45 and 32 s ribosomal RNA precursors. J Mol Biol (1968) 1.91
URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit. Science (1986) 1.87
Use of polarography to detect respiration defects in cell cultures. Methods Enzymol (1996) 1.86
Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J Biol Chem (1998) 1.83
Characterization of an RNase P activity from HeLa cell mitochondria. Comparison with the cytosol RNase P activity. J Biol Chem (1985) 1.83
MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination. Nat Genet (1995) 1.83
Methylation of nucleic acids in HeLa cells. Biochem Biophys Res Commun (1965) 1.78
Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles. Mol Cell Biol (1994) 1.75
Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone. FEBS Lett (1987) 1.74
A small polyadenylated RNA (7 S RNA), containing a putative ribosome attachment site, maps near the origin of human mitochondrial DNA replication. J Mol Biol (1981) 1.71
Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy. J Biol Chem (1996) 1.71
In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. Proc Natl Acad Sci U S A (1997) 1.71
Expression of the mitochondrial genome in HeLa cells. XIV. The relative positions of the 4 S RNA genes and of the ribosomal RNA genes in mitochondrial DNA. J Mol Biol (1972) 1.68
The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression. Mol Cell Biol (1998) 1.67
Sequence analysis and precise mapping of the 3' ends of HeLa cell mitochondrial ribosomal RNAs. J Mol Biol (1982) 1.67
A membrane-associated RNA of cytoplasmic origin in HeLa cells. Proc Natl Acad Sci U S A (1967) 1.65
Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA. Nucleic Acids Res (1980) 1.61
Oligonucleotide pattern after pancreatic ribonuclease digestion and the 3' and 5' termini of 5S ribonucleic acid from HeLa cells. Biochemistry (1969) 1.59
A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity. Hum Mol Genet (2000) 1.56
Effect of protein-bound RNA associated with chick embryo chromatin on template specificity of the chromatin. J Mol Biol (1969) 1.53
The RNase P associated with HeLa cell mitochondria contains an essential RNA component identical in sequence to that of the nuclear RNase P. Mol Cell Biol (2001) 1.51
Nuclear background determines biochemical phenotype in the deafness-associated mitochondrial 12S rRNA mutation. Hum Mol Genet (2001) 1.50
The putative mRNA for subunit II of human cytochrome c oxidase starts directly at the translation initiator codon. Nature (1980) 1.49
The complete nucleotide sequence of the Crossostoma lacustre mitochondrial genome: conservation and variations among vertebrates. Nucleic Acids Res (1992) 1.47
Expression of the mitochondrial genome in HeLa cells. 13. Effect of selective inhibition of cytoplasmic or mitochondrial protein synthesis on mitochondrial nucleic acid synthesis. J Mol Biol (1972) 1.46
Mitochondrial growth and division during the cell cycle in HeLa cells. J Cell Biol (1977) 1.45
Very rare complementation between mitochondria carrying different mitochondrial DNA mutations points to intrinsic genetic autonomy of the organelles in cultured human cells. J Biol Chem (2000) 1.44
Fractionation of mitochondrial RNA from HeLa cells by high-resolution electrophoresis under strongly denaturing conditions. J Mol Biol (1978) 1.44
The sequences of the small ribosomal RNA gene and the phenylalanine tRNA gene are joined end to end in human mitochondrial DNA. Cell (1980) 1.42
Multiple forms of human dihydrofolate reductase messenger RNA. Cloning and expression in Escherichia coli of their DNA coding sequence. J Mol Biol (1982) 1.42
Post-transcriptional regulation of the steady-state levels of mitochondrial tRNAs in HeLa cells. J Biol Chem (1993) 1.41
Precise localization of the origin of replication in a physical map of HeLa cell mitochondrial DNA and isolation of a small fragment that contains it. J Mol Biol (1978) 1.41
Expression of the mitochondrial genome in HeLa cells. I. Properties of the discrete RNA components from the mitochondrial fraction. J Mol Biol (1971) 1.40
Identification and partial characterization of multiple discrete polyadenylic acid containing RNA components coded for by HeLa cell mitochondrial DNA. J Mol Biol (1974) 1.39
Antibodies against synthetic peptides reveal that the unidentified reading frame A6L, overlapping the ATPase 6 gene, is expressed in human mitochondria. Cell (1983) 1.37
The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase. Gene (1983) 1.36
Efficient selection and characterization of mutants of a human cell line which are defective in mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase. Mol Cell Biol (1995) 1.35
Expression of the mitochondrial genome in HeLa cells. V. Transcription of mitochondrial DNA in relationship to the cell cycle. J Mol Biol (1971) 1.35
Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria. Mol Cell Biol (2000) 1.35
High-resolution electrophoretic fractionation and partial characterization of the mitochondrial translation products from HeLa cells. Biochemistry (1982) 1.32
Stability of cytoplasmic messenger RNA in HeLa cels. Proc Natl Acad Sci U S A (1973) 1.30
Identification of competence-repressing factors during log-phase growth of Haemophilus influenzae. J Bacteriol (1972) 1.29
Uniparental propagation of mitochondrial DNA in mouse-human cell hybrids. Proc Natl Acad Sci U S A (1980) 1.28
Lack of complex I activity in human cells carrying a mutation in MtDNA-encoded ND4 subunit is corrected by the Saccharomyces cerevisiae NADH-quinone oxidoreductase (NDI1) gene. J Biol Chem (2001) 1.28
Expression of the mitochondrial genome in HeLa cells. II. Evidence for complete transcription of mitochondrial DNA. J Mol Biol (1971) 1.28
A human dihydrofolate reductase pseudogene and its relationship to the multiple forms of specific messenger RNA. J Mol Biol (1983) 1.26
Search for differences in post-transcriptional modification patterns of mitochondrial DNA-encoded wild-type and mutant human tRNALys and tRNALeu(UUR). Nucleic Acids Res (1999) 1.26
Expression of the mitochondria genome in HeLa cells. IV. Titration of mitochondrial genes for 16 s, 12 s and 4 s RNA. J Mol Biol (1971) 1.26
Intercalating drugs and low temperatures inhibit synthesis and processing of ribosomal RNA in isolated human mitochondria. J Mol Biol (1984) 1.24
Expression of the mitochondrial genome in HeLa cells. IX. Replication of mitochondrial DNA in relationship to cell cycle in HeLa cells. J Mol Biol (1972) 1.24
Highly efficient RNA-synthesizing system that uses isolated human mitochondria: new initiation events and in vivo-like processing patterns. Mol Cell Biol (1984) 1.24
Molecular characterization of the transcription termination factor from human mitochondria. J Biol Chem (1993) 1.23
In vivo control of respiration by cytochrome c oxidase in human cells. Free Radic Biol Med (2000) 1.22
Photochemical studies of the carotenoid biosynthetic pathway in Neurospora crassa. Arch Biochem Biophys (1969) 1.21
Discrete human dihydrofolate reductase gene transcripts present in polysomal RNA map with their 5' ends several hundred nucleotides upstream of the main mRNA start site. Mol Cell Biol (1985) 1.20
Platelet-mediated transformation of mtDNA-less human cells: analysis of phenotypic variability among clones from normal individuals--and complementation behavior of the tRNALys mutation causing myoclonic epilepsy and ragged red fibers. Am J Hum Genet (1994) 1.19
Human dihydrofolate reductase gene is located in chromosome 5 and is unlinked to the related pseudogenes. Proc Natl Acad Sci U S A (1984) 1.17
Amino acid specificity of the transfer RNA species coded for by HeLa cell mitochondrial DNA. J Mol Biol (1976) 1.17
Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver. Proc Natl Acad Sci U S A (1988) 1.15
Relationship between HeLa cell ribosomal RNA and its precursors studied by high resolution RNA-DNA hybridization. J Mol Biol (1969) 1.15
Isolation, subunit composition, and site of synthesis of human cytochrome c oxidase. Biochemistry (1980) 1.15
Expression of the mitochondrial genome in HeLa cells. XIX. Occurrence in mitochondria of polyadenylic acid sequences, "free" and covalently linked to mitochondrial DNA-coded RNA. J Mol Biol (1974) 1.15