Published in J Biol Chem on July 30, 2001
New insights into type II NAD(P)H:quinone oxidoreductases. Microbiol Mol Biol Rev (2004) 1.68
Mitochondria-driven changes in leaf NAD status exert a crucial influence on the control of nitrate assimilation and the integration of carbon and nitrogen metabolism. Plant Physiol (2005) 1.39
Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction. Proc Natl Acad Sci U S A (2010) 1.37
Mitochondrial respiratory complex I dysfunction promotes tumorigenesis through ROS alteration and AKT activation. Hum Mol Genet (2011) 1.18
Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model. PLoS One (2010) 1.13
The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. PLoS Genet (2012) 1.06
Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON). Mol Vis (2008) 1.03
BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med (2013) 1.02
The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates. Proc Natl Acad Sci U S A (2012) 1.02
Neuroprotective effect of long-term NDI1 gene expression in a chronic mouse model of Parkinson disorder. Rejuvenation Res (2009) 0.99
Viral degradasome hijacks mitochondria to suppress innate immunity. Cell Res (2013) 0.99
Mitochondrial medicine: to a new era of gene therapy for mitochondrial DNA mutations. J Inherit Metab Dis (2010) 0.97
Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside. J Ophthalmol (2010) 0.96
Restoration of electron transport without proton pumping in mammalian mitochondria. Proc Natl Acad Sci U S A (2008) 0.95
Nuclear suppression of mitochondrial defects in cells without the ND6 subunit. Mol Cell Biol (2006) 0.94
Yeast NDI1 improves oxidative phosphorylation capacity and increases protection against oxidative stress and cell death in cells carrying a Leber's hereditary optic neuropathy mutation. Biochim Biophys Acta (2007) 0.93
mtDNA lineage analysis of mouse L-cell lines reveals the accumulation of multiple mtDNA mutants and intermolecular recombination. Genes Dev (2012) 0.92
Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2005) 0.88
Characterization of the ubiquinone binding site in the alternative NADH-quinone oxidoreductase of Saccharomyces cerevisiae by photoaffinity labeling. Biochemistry (2010) 0.88
No immune responses by the expression of the yeast Ndi1 protein in rats. PLoS One (2011) 0.85
An algal nucleus-encoded subunit of mitochondrial ATP synthase rescues a defect in the analogous human mitochondrial-encoded subunit. Mol Biol Cell (2002) 0.84
NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS. Mol Ther (2013) 0.82
Redefining the roles of mitochondrial DNA-encoded subunits in respiratory Complex I assembly. Biochim Biophys Acta (2015) 0.80
Adeno-associated virus-mediated gene therapy for metabolic myopathy. Hum Gene Ther (2013) 0.80
CFTR activity and mitochondrial function. Redox Biol (2013) 0.79
An update on complex I assembly: the assembly of players. J Bioenerg Biomembr (2014) 0.78
Cell-permeable protein therapy for complex I dysfunction. J Bioenerg Biomembr (2014) 0.77
Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations. Mol Cell (2016) 0.77
The approaches for manipulating mitochondrial proteome. Environ Mol Mutagen (2010) 0.76
Expression, purification, crystallization and preliminary X-ray diffraction analysis of a type II NADH:quinone oxidoreductase from the human pathogen Staphylococcus aureus. Acta Crystallogr F Struct Biol Commun (2015) 0.75
The mechanism of catalysis by type-II NADH:quinone oxidoreductases. Sci Rep (2017) 0.75
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science (1989) 9.71
tRNA punctuation model of RNA processing in human mitochondria. Nature (1981) 8.48
Convenient test for screening metallo-beta-lactamase-producing gram-negative bacteria by using thiol compounds. J Clin Microbiol (2000) 5.69
Amphotropic host range of naturally occuring wild mouse leukemia viruses. J Virol (1976) 5.43
Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1. Nature (1994) 5.33
Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication. Science (1999) 5.20
Proportion of HeLa cell genome complementary to transfer RNA and 5 s RNA. J Mol Biol (1971) 5.11
Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase. Nature (1985) 4.96
A requirement for neuropilin-1 in embryonic vessel formation. Development (1999) 3.95
Expression of the mitochondrial genome in HeLa cells. VI. Size determination of mitochondrial ribosomal RNA by electron microscopy. J Mol Biol (1971) 3.57
Giant-size rapidly labeled nuclear ribonucleic acid and cytoplasmic messenger ribonucleic acid in immature duck erythrocytes. J Mol Biol (1966) 3.29
Endonuclease IV of Escherichia coli is induced by paraquat. Proc Natl Acad Sci U S A (1987) 3.20
Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs. Nature (1981) 3.01
Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice. Neuron (1997) 2.93
Reduced hippocampal LTP and spatial learning in mice lacking NMDA receptor epsilon 1 subunit. Nature (1995) 2.91
Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase. Proc Natl Acad Sci U S A (1997) 2.91
A three-dimensional MRI atlas of the mouse brain with estimates of the average and variability. Cereb Cortex (2004) 2.90
MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts. Proc Natl Acad Sci U S A (1992) 2.82
Structure and synthesis of ribosomal RNA. Annu Rev Biochem (1970) 2.80
Disruption of semaphorin III/D gene causes severe abnormality in peripheral nerve projection. Neuron (1997) 2.77
Constitutive activation of Src family kinases in mouse embryos that lack Csk. Cell (1993) 2.75
Diversity revealed by a novel family of cadherins expressed in neurons at a synaptic complex. Neuron (1998) 2.73
In vitro genetic transfer of protein synthesis and respiration defects to mitochondrial DNA-less cells with myopathy-patient mitochondria. Mol Cell Biol (1991) 2.70
Isolation of human cell lines lacking mitochondrial DNA. Methods Enzymol (1996) 2.70
High molecular weight nonribosomal-type nuclear RNA and cytoplasmic messenger RNA in HeLa cells. Proc Natl Acad Sci U S A (1966) 2.67
Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J (1999) 2.66
Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy. Proc Natl Acad Sci U S A (1992) 2.62
Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor epsilon 2 subunit mutant mice. Neuron (1996) 2.62
The pattern of transcription of the human mitochondrial rRNA genes reveals two overlapping transcription units. Cell (1983) 2.60
Identification of initiation sites for heavy-strand and light-strand transcription in human mitochondrial DNA. Proc Natl Acad Sci U S A (1982) 2.55
The tRNA genes punctuate the reading of genetic information in human mitochondrial DNA. Cell (1980) 2.53
Animal mitochondrial DNA: an extreme example of genetic economy. Int Rev Cytol (1985) 2.44
Two possible roles of bacteriorhodopsin; a comparative study of strains of Halobacterium halobium differing in pigmentation. Biochem Biophys Res Commun (1977) 2.44
Does the type of anomalous arrangement of pancreaticobiliary ducts influence the surgery and prognosis of choledochal cyst? J Pediatr Surg (1992) 2.37
Mice develop normally without tenascin. Genes Dev (1992) 2.35
Interfacial phase-change memory. Nat Nanotechnol (2011) 2.30
Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene (1993) 2.25
Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Cell (1995) 2.25
Association of a protein structure of probable membrane derivation with HeLa cell mitochondrial DNA near its origin of replication. Proc Natl Acad Sci U S A (1977) 2.22
Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation. Hum Mol Genet (1996) 2.22
Electron microscopic visualization of mitochondrial RNA-DNA hybrids. J Mol Biol (1971) 2.20
Nucleotide sequence of a region of human mitochondrial DNA containing the precisely identified origin of replication. Nature (1979) 2.19
An electron microscope study of the relative positions of the 4S and ribosomal RNA genes in HeLa cells mitochondrial DNA. Cell (1976) 2.17
The changing preference of T and B cells for partners as T-dependent antibody responses develop. Immunol Rev (1997) 2.16
Fyn-kinase as a determinant of ethanol sensitivity: relation to NMDA-receptor function. Science (1997) 2.13
Partial sequence analysis of ribosomal RNA from HeLa cells. I. Oligonucleotide pattern of 28 s and 18 s RNA after pancreatic ribonuclease digestion. J Mol Biol (1968) 2.09
Initial events of myelination involve Fyn tyrosine kinase signalling. Nature (1994) 2.08
Rising mortality from motoneuron disease in the USA, 1962-84. Lancet (1989) 2.05
Synthesis and turnover of mitochondrial ribonucleic acid in HeLa cells: the mature ribosomal and messenger ribonucleic acid species are metabolically unstable. Mol Cell Biol (1981) 2.05
Recognition of ribosomal RNA sites in DNA. I. Analysis of the E. coli system. Proc Natl Acad Sci U S A (1965) 2.05
Symmetrical in vivo transcription of mitochondrial DNA in HeLa cells. Proc Natl Acad Sci U S A (1971) 2.04
MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci U S A (2000) 2.04
Right-handed rotation of an actin filament in an in vitro motile system. Nature (1993) 2.04
Membrane-bound ribosomes in HeLa cells. I. Their proportion to total cell ribosomes and their association with messenger RNA. J Mol Biol (1969) 2.00
Human dihydrofolate reductase gene organization. Extensive conservation of the G + C-rich 5' non-coding sequence and strong intron size divergence from homologous mammalian genes. J Mol Biol (1984) 2.00
Termination of transcription in human mitochondria: identification and purification of a DNA binding protein factor that promotes termination. Cell (1989) 1.97
Injection of mitochondria into human cells leads to a rapid replacement of the endogenous mitochondrial DNA. Cell (1988) 1.96
Muscle-specific mutations accumulate with aging in critical human mtDNA control sites for replication. Proc Natl Acad Sci U S A (2001) 1.94
A detailed physical map of HeLa cell mitochondria DNA and its alignment with the positions of known genetic markers. Plasmid (1977) 1.93
The mtDNA-encoded ND6 subunit of mitochondrial NADH dehydrogenase is essential for the assembly of the membrane arm and the respiratory function of the enzyme. EMBO J (1998) 1.93
Partial sequence analysis of ribosomal RNA from HeLa cells. II. Evidence for sequences of non-ribosmal type in 45 and 32 s ribosomal RNA precursors. J Mol Biol (1968) 1.91
Efficient production of Cre-mediated site-directed recombinants through the utilization of the puromycin resistance gene, pac: a transient gene-integration marker for ES cells. Nucleic Acids Res (1998) 1.90
URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit. Science (1986) 1.87
Use of polarography to detect respiration defects in cell cultures. Methods Enzymol (1996) 1.86
Phenylbutazone-warfarin interaction in man: further stereochemical and metabolic considerations. Br J Clin Pharmacol (1983) 1.86
Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB. Curr Biol (1999) 1.85
Low reserve of cytochrome c oxidase capacity in vivo in the respiratory chain of a variety of human cell types. J Biol Chem (1998) 1.83
Characterization of an RNase P activity from HeLa cell mitochondria. Comparison with the cytosol RNase P activity. J Biol Chem (1985) 1.83
MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination. Nat Genet (1995) 1.83
Proteins of the CNR family are multiple receptors for Reelin. Cell (1999) 1.81
Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures. Biochem Biophys Res Commun (1996) 1.79
Methylation of nucleic acids in HeLa cells. Biochem Biophys Res Commun (1965) 1.78
Complementation of mutant and wild-type human mitochondrial DNAs coexisting since the mutation event and lack of complementation of DNAs introduced separately into a cell within distinct organelles. Mol Cell Biol (1994) 1.75
Increased von Willebrand factor in the endocardium as a local predisposing factor for thrombogenesis in overloaded human atrial appendage. J Am Coll Cardiol (2001) 1.75
Photolabelling of a mitochondrially encoded subunit of NADH dehydrogenase with [3H]dihydrorotenone. FEBS Lett (1987) 1.74
Non-divergence theory of evolution: sequence comparison of some proteins from snakes and bacteria. J Biochem (1985) 1.73
A small polyadenylated RNA (7 S RNA), containing a putative ribosome attachment site, maps near the origin of human mitochondrial DNA replication. J Mol Biol (1981) 1.71
Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy. J Biol Chem (1996) 1.71
In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells. Proc Natl Acad Sci U S A (1997) 1.71
Expression of the mitochondrial genome in HeLa cells. XIV. The relative positions of the 4 S RNA genes and of the ribosomal RNA genes in mitochondrial DNA. J Mol Biol (1972) 1.68
Dominant effector genetics in mammalian cells. Nat Genet (2001) 1.68
The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression. Mol Cell Biol (1998) 1.67
Sequence analysis and precise mapping of the 3' ends of HeLa cell mitochondrial ribosomal RNAs. J Mol Biol (1982) 1.67
A membrane-associated RNA of cytoplasmic origin in HeLa cells. Proc Natl Acad Sci U S A (1967) 1.65
Systematic review of intraoperative colonic irrigation vs. manual decompression in obstructed left-sided colorectal emergencies. Int J Colorectal Dis (2009) 1.65
Mapping of nascent light and heavy strand transcripts on the physical map of HeLa cell mitochondrial DNA. Nucleic Acids Res (1980) 1.61
Procaryotic complex I (NDH-1), an overview. Biochim Biophys Acta (1998) 1.60
Oligonucleotide pattern after pancreatic ribonuclease digestion and the 3' and 5' termini of 5S ribonucleic acid from HeLa cells. Biochemistry (1969) 1.59
Two decades of increasing mortality from Parkinson's disease among the US elderly. Arch Neurol (1990) 1.56
A biochemical basis for the inherited susceptibility to aminoglycoside ototoxicity. Hum Mol Genet (2000) 1.56
Recognition of ribosomal RNA sites in DNA. II. The HeLa cell system. Proc Natl Acad Sci U S A (1965) 1.54