Published in Nature on November 22, 1969
The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs. BMC Bioinformatics (2002) 29.41
Lessons from an evolving rRNA: 16S and 23S rRNA structures from a comparative perspective. Microbiol Rev (1994) 9.74
Identifying constraints on the higher-order structure of RNA: continued development and application of comparative sequence analysis methods. Nucleic Acids Res (1992) 7.51
SRP-RNA sequence alignment and secondary structure. Nucleic Acids Res (1991) 4.88
The general structure of transfer RNA molecules. Proc Natl Acad Sci U S A (1974) 4.30
Sequence of Shiga toxin 2 phage 933W from Escherichia coli O157:H7: Shiga toxin as a phage late-gene product. J Bacteriol (1999) 4.08
Automated de novo prediction of native-like RNA tertiary structures. Proc Natl Acad Sci U S A (2007) 3.87
Coarse-grained modeling of large RNA molecules with knowledge-based potentials and structural filters. RNA (2009) 2.63
Evaluation of the suitability of free-energy minimization using nearest-neighbor energy parameters for RNA secondary structure prediction. BMC Bioinformatics (2004) 2.57
RNA folding: conformational statistics, folding kinetics, and ion electrostatics. Annu Rev Biophys (2008) 2.00
Role of RNA structure in arginine recognition of TAR RNA. Proc Natl Acad Sci U S A (1993) 1.94
A model for the tertiary structure of mammalian mitochondrial transfer RNAs lacking the entire 'dihydrouridine' loop and stem. EMBO J (1983) 1.71
Determination of secondary and tertiary structural features of transfer RNA molecules in solution by nuclear magnetic resonance. Proc Natl Acad Sci U S A (1973) 1.70
Essential nucleotide sequences and secondary structure elements of the hairpin ribozyme. EMBO J (1993) 1.69
Phylogenetic evidence for tertiary interactions in 16S-like ribosomal RNA. Nucleic Acids Res (1989) 1.63
Understanding the errors of SHAPE-directed RNA structure modeling. Biochemistry (2011) 1.62
Hydrogen bonding in yeast phenylalanine transfer RNA. Proc Natl Acad Sci U S A (1975) 1.60
Correlation between three-dimensional structure and chemical reactivity of transfer RNA. Nucleic Acids Res (1974) 1.58
A two-dimensional mutate-and-map strategy for non-coding RNA structure. Nat Chem (2011) 1.58
Structural inference of native and partially folded RNA by high-throughput contact mapping. Proc Natl Acad Sci U S A (2008) 1.54
Higher order interactions in 23s rRNA. Proc Natl Acad Sci U S A (1992) 1.50
An unusual RNA tertiary interaction has a role for the specific aminoacylation of a transfer RNA. Proc Natl Acad Sci U S A (1993) 1.47
The secondary structure and sequence optimization of an RNA ligase ribozyme. Nucleic Acids Res (1995) 1.45
Structlre of transfer RNA molecules containing the long variable loop. Nucleic Acids Res (1976) 1.37
Native-like RNA tertiary structures using a sequence-encoded cleavage agent and refinement by discrete molecular dynamics. J Am Chem Soc (2009) 1.33
RNA-Puzzles Round II: assessment of RNA structure prediction programs applied to three large RNA structures. RNA (2015) 1.30
A mutate-and-map strategy accurately infers the base pairs of a 35-nucleotide model RNA. RNA (2011) 1.29
Reproducing the three-dimensional structure of a tRNA molecule from structural constraints. Proc Natl Acad Sci U S A (1993) 1.29
Turning limited experimental information into 3D models of RNA. RNA (2010) 1.27
Highly conserved modified nucleosides influence Mg2+-dependent tRNA folding. Nucleic Acids Res (2002) 1.26
The singular quest for a universal tree of life. Microbiol Mol Biol Rev (2013) 1.24
Aminoacylation of tRNA in the evolution of an aminoacyl-tRNA synthetase. Proc Natl Acad Sci U S A (1998) 1.23
RNA editing of larch mitochondrial tRNA(His) precursors is a prerequisite for processing. Nucleic Acids Res (1996) 1.23
Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase. EMBO J (2002) 1.20
Comprehensive survey and geometric classification of base triples in RNA structures. Nucleic Acids Res (2011) 1.11
Modeling large RNAs and ribonucleoprotein particles using molecular mechanics techniques. Biophys J (1994) 1.10
Unwinding RNA's secrets: advances in the biology, physics, and modeling of complex RNAs. Curr Opin Struct Biol (2008) 1.10
Proton nuclear magnetic resonance of spin-labeled Escherichia coli tRNAf1MET. Proc Natl Acad Sci U S A (1975) 1.08
Single nucleotide RNA choreography. Nucleic Acids Res (2006) 1.06
Knowledge-based instantiation of full atomic detail into coarse-grain RNA 3D structural models. Bioinformatics (2009) 1.06
Inferring the conformation of RNA base pairs and triples from patterns of sequence variation. Nucleic Acids Res (1997) 1.04
Mg2+ binding and archaeosine modification stabilize the G15 C48 Levitt base pair in tRNAs. RNA (2007) 1.03
Sites of methylation of purified transfer ribonucleic acid preparations by enzymes from normal tissues and from tumours induced by dimethylnitrosamine and 1,2-dimethylhydrazine. Biochem J (1974) 1.01
The cap-binding translation initiation factor, eIF4E, binds a pseudoknot in a viral cap-independent translation element. Structure (2011) 1.00
Predicting coaxial helical stacking in RNA junctions. Nucleic Acids Res (2011) 0.99
RNA structure determination using SAXS data. J Phys Chem B (2010) 0.99
Coarse-grained model for simulation of RNA three-dimensional structures. J Phys Chem B (2010) 0.98
Detection of a key tertiary interaction in the highly conserved GTPase center of large subunit ribosomal RNA. Proc Natl Acad Sci U S A (1991) 0.97
The nucleotide sequence of a major glycine transfer RNA from the posterior silk gland of Bombyx mori L. Nucleic Acids Res (1977) 0.96
Predicting and modeling RNA architecture. Cold Spring Harb Perspect Biol (2011) 0.95
Fidelity of secondary and tertiary interactions in tRNA. Nucleic Acids Res (1988) 0.93
Correlation of RNA secondary structure statistics with thermodynamic stability and applications to folding. J Mol Biol (2009) 0.91
Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding. Nat Commun (2011) 0.90
Quantifying the relationship between sequence and three-dimensional structure conservation in RNA. BMC Bioinformatics (2010) 0.89
Determining RNA three-dimensional structures using low-resolution data. J Struct Biol (2012) 0.87
High-resolution shadowing of transfer RNA. Proc Natl Acad Sci U S A (1972) 0.87
Enzymatic methylations: III. Cadaverine-induced conformational changes of E. coli tRNA fMet as evidenced by the availability of a specific adenosine and a specific cytidine residue for methylation. Nucleic Acids Res (1974) 0.85
Progress and Current Challenges in Modeling Large RNAs. J Mol Biol (2015) 0.83
Bacterial noncoding Y RNAs are widespread and mimic tRNAs. RNA (2014) 0.82
Computational modeling of RNA 3D structures, with the aid of experimental restraints. RNA Biol (2014) 0.82
3D RNA and Functional Interactions from Evolutionary Couplings. Cell (2016) 0.82
Zika virus produces noncoding RNAs using a multi-pseudoknot structure that confounds a cellular exonuclease. Science (2016) 0.82
Sequence coevolution between RNA and protein characterized by mutual information between residue triplets. PLoS One (2012) 0.81
Bridging the gap between in vitro and in vivo RNA folding. Q Rev Biophys (2016) 0.78
Fragmentation of the large subunit ribosomal RNA gene in oyster mitochondrial genomes. BMC Genomics (2010) 0.78
Fidelity in archaeal information processing. Archaea (2010) 0.76
Challenges and surprises that arise with nucleic acids during model building and refinement. Acta Crystallogr D Biol Crystallogr (2012) 0.75
Chemical and Conformational Diversity of Modified Nucleosides Affects tRNA Structure and Function. Biomolecules (2017) 0.75
Methodology for constructing problem definitions in bioinformatics. Bioinform Biol Insights (2008) 0.75
Altered biochemical specificity of G-quadruplexes with mutated tetrads. Nucleic Acids Res (2016) 0.75
How Does Mg(2+) Modulate the RNA Folding Mechanism: A Case Study of the G:C W:W Trans Basepair. Biophys J (2017) 0.75
The ASTRAL compendium for protein structure and sequence analysis. Nucleic Acids Res (2000) 11.38
Theoretical studies of enzymic reactions: dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme. J Mol Biol (1976) 9.91
p53: a frequent target for genetic abnormalities in lung cancer. Science (1989) 7.51
A simplified representation of protein conformations for rapid simulation of protein folding. J Mol Biol (1976) 7.06
Structure of nucleosome core particles of chromatin. Nature (1977) 6.24
Structural patterns in globular proteins. Nature (1976) 5.95
Studies on the mechanism of action of nalidixic acid. Antimicrob Agents Chemother (1973) 5.64
Computer simulation of protein folding. Nature (1975) 5.34
Conformations of immunoglobulin hypervariable regions. Nature (1990) 5.31
Protein normal-mode dynamics: trypsin inhibitor, crambin, ribonuclease and lysozyme. J Mol Biol (1985) 4.56
Helix to helix packing in proteins. J Mol Biol (1981) 4.24
Conformational preferences of amino acids in globular proteins. Biochemistry (1978) 4.00
Desire for death in the terminally ill. Am J Psychiatry (1995) 3.87
Energy functions that discriminate X-ray and near native folds from well-constructed decoys. J Mol Biol (1996) 3.86
Measuring the quality of life of cancer patients: the Functional Living Index-Cancer: development and validation. J Clin Oncol (1984) 3.76
How many base-pairs per turn does DNA have in solution and in chromatin? Some theoretical calculations. Proc Natl Acad Sci U S A (1978) 3.55
Refinement of protein conformations using a macromolecular energy minimization procedure. J Mol Biol (1969) 3.21
The PRESAGE database for structural genomics. Nucleic Acids Res (1999) 3.03
Comprehensive assessment of automatic structural alignment against a manual standard, the scop classification of proteins. Protein Sci (1998) 2.60
Structure of proteins: packing of alpha-helices and pleated sheets. Proc Natl Acad Sci U S A (1977) 2.60
Structural similarity of DNA-binding domains of bacteriophage repressors and the globin core. Curr Biol (1993) 2.53
Protein folding by restrained energy minimization and molecular dynamics. J Mol Biol (1983) 2.51
Molecular dynamics of native protein. II. Analysis and nature of motion. J Mol Biol (1983) 2.29
Automatic identification of secondary structure in globular proteins. J Mol Biol (1977) 2.25
Energy refinement of hen egg-white lysozyme. J Mol Biol (1974) 2.24
A humanized antibody that binds to the interleukin 2 receptor. Proc Natl Acad Sci U S A (1989) 2.23
Stabilization of phage T4 lysozyme by engineered disulfide bonds. Proc Natl Acad Sci U S A (1989) 2.17
Decoys 'R' Us: a database of incorrect conformations to improve protein structure prediction. Protein Sci (2000) 2.10
Ab initio construction of protein tertiary structures using a hierarchical approach. J Mol Biol (2000) 2.05
Molecular dynamics simulation of photodissociation of carbon monoxide from hemoglobin. Proc Natl Acad Sci U S A (1985) 1.94
A brighter future for protein structure prediction. Nat Struct Biol (1999) 1.93
Molecular dynamics simulations of helix denaturation. J Mol Biol (1992) 1.92
The volume of atoms on the protein surface: calculated from simulation, using Voronoi polyhedra. J Mol Biol (1995) 1.92
Periodicity of deoxyribonuclease I digestion of chromatin. Science (1979) 1.90
Molecular dynamics of native protein. I. Computer simulation of trajectories. J Mol Biol (1983) 1.87
The complexity and accuracy of discrete state models of protein structure. J Mol Biol (1995) 1.86
Recognizing native folds by the arrangement of hydrophobic and polar residues. J Mol Biol (1995) 1.85
Factors affecting the ability of energy functions to discriminate correct from incorrect folds. J Mol Biol (1997) 1.84
Computer simulation of DNA double-helix dynamics. Cold Spring Harb Symp Quant Biol (1983) 1.81
Climate change and the integrity of science. Science (2010) 1.80
A lattice model for protein structure prediction at low resolution. Proc Natl Acad Sci U S A (1992) 1.80
The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure. Science (1986) 1.68
Protein unfolding pathways explored through molecular dynamics simulations. J Mol Biol (1993) 1.67
Expectations from structural genomics. Protein Sci (2000) 1.65
Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core. Nature (1991) 1.65
Exploring conformational space with a simple lattice model for protein structure. J Mol Biol (1994) 1.63
A model of the molten globule state from molecular dynamics simulations. Proc Natl Acad Sci U S A (1992) 1.56
Quantification of the hydrophobic interaction by simulations of the aggregation of small hydrophobic solutes in water. Proc Natl Acad Sci U S A (2001) 1.55
A new class of tyrosine hydroxylase inhibitors and a simple assay of inhibition in vivo. Biochem Pharmacol (1967) 1.54
De novo protein design. II. Plasticity in sequence space. J Mol Biol (1999) 1.53
Realistic simulations of native-protein dynamics in solution and beyond. Annu Rev Biophys Biomol Struct (1993) 1.46
A structural census of the current population of protein sequences. Proc Natl Acad Sci U S A (1997) 1.44
Discontinuation of antistreptococcal prophylaxis. A double-blind study in rheumatic patients free of heart disease. JAMA (1966) 1.42
Using iterative dynamic programming to obtain accurate pairwise and multiple alignments of protein structures. Proc Int Conf Intell Syst Mol Biol (1996) 1.41
Making up inotrope solutions. Anaesthesia (1992) 1.39
Molecular dynamics of hydrogen bonds in bovine pancreatic trypsin inhibitor protein. Nature (1981) 1.38
Pre-operative chemo-radiotherapy in locally advanced rectal cancer: is this the way of future management? Australas Radiol (1999) 1.38
Practice parameters for the management of colonic cancer I: surgical issues. Recommendations of the Colorectal Surgical Society of Australia. Aust N Z J Surg (1999) 1.38
Superiority of alternating non-cross-resistant chemotherapy in extensive small cell lung cancer. A multicenter, randomized clinical trial by the National Cancer Institute of Canada. Ann Intern Med (1987) 1.38
De novo protein design. I. In search of stability and specificity. J Mol Biol (1999) 1.37
Alignment of the amino acid sequences of distantly related proteins using variable gap penalties. Protein Eng (1989) 1.34
Effect of proline residues on protein folding. J Mol Biol (1981) 1.33
Integrating the equations of motion. J Mol Biol (1983) 1.29
Using a hydrophobic contact potential to evaluate native and near-native folds generated by molecular dynamics simulations. J Mol Biol (1996) 1.26
Ab initio protein structure prediction using a combined hierarchical approach. Proteins (1999) 1.26
Hierarchy of structure loss in MD simulations of src SH3 domain unfolding. J Mol Biol (1999) 1.24
Comparison of predicted and experimentally determined secondary structure of adenyl kinase. Nature (1974) 1.21
The role of tonsils in predisposing to streptococcal infections and recurrences of rheumatic fever. N Engl J Med (1970) 1.17
Structure-based conformational preferences of amino acids. Proc Natl Acad Sci U S A (1999) 1.13
Finite-difference solution of the Poisson-Boltzmann equation: Complete elimination of self-energy. J Comput Chem (1996) 1.12
Protein conformation, dynamics, and folding by computer simulation. Annu Rev Biophys Bioeng (1982) 1.12
A combined approach for ab initio construction of low resolution protein tertiary structures from sequence. Pac Symp Biocomput (1999) 1.11
Constructing side chains on near-native main chains for ab initio protein structure prediction. Protein Eng (2000) 1.09
Orientation of double-helical segments in crystals of yeast phenylalanine transfer RNA. J Mol Biol (1973) 1.07
Lactate provocation of panic attacks. I. Clinical and behavioral findings. Arch Gen Psychiatry (1984) 1.06
Compounds affecting the central nervous system. 4. 3 Beta-phenyltropane-2-carboxylic esters and analogs. J Med Chem (1973) 1.05
The nonerythropoietic component of early bilirubin. J Clin Invest (1968) 1.05
Treatment of chronic anal fissure with topical glyceryl trinitrate. Dis Colon Rectum (1999) 1.04
Neutrophilia-inducing activity in plasma of neutropenic human beings. Blood (1971) 1.02
Production and elimination of sulfur-containing gases in the rat colon. Am J Physiol (1998) 1.01
Rubidium: biochemical, behavioral, and metabolic studies in humans. Am J Psychiatry (1973) 1.00
Improved therapeutic index of methotrexate with "leucovorin rescue". Cancer Res (1973) 0.99
Protein decoy assembly using short fragments under geometric constraints. Biopolymers (2003) 0.99
Simulating the minimum core for hydrophobic collapse in globular proteins. Protein Sci (1997) 0.99
Genetic screening and ethics: European perspectives. J Med Philos (1998) 0.98
Energy expenditure in obesity in fasting and postprandial state. Am J Physiol (1983) 0.98
Induced peptide conformations in different antibody complexes: molecular modeling of the three-dimensional structure of peptide-antibody complexes using NMR-derived distance restraints. Biochemistry (1992) 0.97
Different protein sequences can give rise to highly similar folds through different stabilizing interactions. Protein Sci (1994) 0.97
The ethics and impact on behaviour of knowledge about one's own genome. Interview by Judy Jones. BMJ (1999) 0.97
A novel method for sampling alpha-helical protein backbones. J Mol Biol (2001) 0.97
Homosexuality and the Israel defense forces: did lifting the gay ban undermine military performance? Armed Forces Soc (2001) 0.96
Folding and stability of helical proteins: carp myogen. J Mol Biol (1976) 0.95
Towards a complete map of the protein space based on a unified sequence and structure analysis of all known proteins. Proc Int Conf Intell Syst Mol Biol (2000) 0.95
Prophylaxis of recurrent rheumatic fever. Therapeutic-continuous oral penicillin vs monthly injections. JAMA (1968) 0.95
Conversion of L-tyrosine to 3,4-dihydroxyphenylalanine by cell-free preparations of brain and sympathetically innervated tissues. Biochem Biophys Res Commun (1964) 0.95
Insights into human colonic physiology obtained from the study of flatus composition. Am J Physiol (1997) 0.94
Reduction of cardiac tyrosine hydroxylase activity in experimental congestive heart failure. Its role in the depletion of cardiac norepinephrine stores. Circ Res (1967) 0.93
Contribution of tryptophan residues to the combining site of a monoclonal anti dinitrophenyl spin-label antibody. Biochemistry (1987) 0.93
Differentiation of mouth versus gut as site of origin of odoriferous breath gases after garlic ingestion. Am J Physiol (1999) 0.92