Published in J Mol Biol on August 01, 1970
In vitro selection and evolution of functional proteins by using ribosome display. Proc Natl Acad Sci U S A (1997) 4.71
Ribosome display efficiently selects and evolves high-affinity antibodies in vitro from immune libraries. Proc Natl Acad Sci U S A (1998) 1.69
In vitro recombination and terminal elongation of RNA by Q beta replicase. EMBO J (1992) 1.61
A replicating RNA molecule suitable for a detailed analysis of extracellular evolution and replication. Proc Natl Acad Sci U S A (1972) 1.55
Challenges and opportunities for small molecule aptamer development. J Nucleic Acids (2012) 1.48
The promise and peril of continuous in vitro evolution. J Mol Evol (2005) 1.00
Ethidium bromide-resistant mutant of Bacillus subtilis. J Bacteriol (1973) 0.91
Nucleotide sequence of microvariant RNA: another small replicating molecule. Proc Natl Acad Sci U S A (1975) 0.87
MIPs and Aptamers for Recognition of Proteins in Biomimetic Sensing. Biosensors (Basel) (2016) 0.87
Long-term experimental evolution in Escherichia coli. X. Quantifying the fundamental and realized niche. BMC Evol Biol (2002) 0.84
The effects of α-lipoic acid against testicular ischemia-reperfusion injury in Rats. ScientificWorldJournal (2012) 0.78
Landscape-Based Biology. J Mol Evol (2015) 0.75
A quantitative assay for DNA-RNA hybrids with DNA immobilized on a membrane. J Mol Biol (1965) 32.99
Electrophoretic separation of viral nucleic acids on polyacrylamide gels. J Mol Biol (1967) 13.29
Selfish DNA: the ultimate parasite. Nature (1980) 9.85
Purification of the DNA polymerase of avian myeloblastosis virus. Biochim Biophys Acta (1971) 6.64
A molecular explanation of the bobbed mutants of Drosophila as partial deficiencies of "ribosomal" DNA. Genetics (1966) 5.94
Specific template requirments of RNA replicases. Proc Natl Acad Sci U S A (1965) 5.90
Characterization of the products of DNA-directed DNA polymerases in oncogenic RNA viruses. Nature (1970) 5.23
DNA-directed DNA polymerase activity in oncogenic RNA viruses. Nature (1970) 4.81
ENZYME FORMATION IN PROTOPLASTS OF BACILLUS MEGATERIUM. Proc Natl Acad Sci U S A (1955) 4.29
CODES WITHOUT COMMAS. Proc Natl Acad Sci U S A (1957) 4.28
Mendelian Inheritance of Adaptive Enzymes. Proc Natl Acad Sci U S A (1944) 3.99
An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. Proc Natl Acad Sci U S A (1967) 3.99
Synthetic DNA-RNA hybrids and RNA-RNA duplexes as templates for the polymerases of the oncogenic RNA viruses. Nature (1970) 3.98
Evolution of the genetic apparatus. J Mol Biol (1968) 3.77
The synthesis of a self-propagating and infectious nucleic acid with a purified enzyme. Proc Natl Acad Sci U S A (1965) 3.71
Simultaneous detection of reverse transcriptase and high molecular weight RNA unique to oncogenic RNA viruses. Science (1971) 3.68
Sodium pyrophosphate inhibition of RNA.DNA hybrid degradation by reverse transcriptase. Proc Natl Acad Sci U S A (1978) 3.43
Synthesis of long prebiotic oligomers on mineral surfaces. Nature (1996) 3.35
Genes and Nucleoproteins in the Synthesis of Enzymes. Science (1946) 3.18
Derivatization of unprotected polynucleotides. Nucleic Acids Res (1983) 2.86
Distinguishing reverse transcriptase of an RNA tumor virus from other known DNA polymerases. Proc Natl Acad Sci U S A (1971) 2.74
Recognition of size and sequence by an RNA replicase. Proc Natl Acad Sci U S A (1965) 2.59
RNA in human leukemic cells related to the RNA of a mouse leukemia virus (leukocytes-RNA-DNA hybridization-rauscher virus-polysomal RNA). Proc Natl Acad Sci U S A (1972) 2.55
Comparison of two serologically distinct ribonucleic acid bacteriophages. I. Properties of the viral particles. J Bacteriol (1966) 2.52
Human leukaemic cells contain reverse transcriptase associated with a high molecular weight virus-related RNA. Nat New Biol (1972) 2.40
Synthesis of full-length DNA copies of avian myeloblastosis virus RNA in high yields. Proc Natl Acad Sci U S A (1977) 2.37
On the chromosomal distribution of DNA complementary to ribosomal and soluble RNA. Natl Cancer Inst Monogr (1966) 2.32
Suppression of and complementation among mutants of the regulatory gene of the lactose operon of Escherichia coli. J Mol Biol (1965) 2.32
Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA. Nature (1972) 2.31
In vitro synthesis of an infectious mutant RNA with a normal RNA replicase. Science (1966) 2.30
SEPARATION OF THE RNA MESSAGE TRANSCRIBED IN RESPONSE TO A SPECIFIC INDUCER. Proc Natl Acad Sci U S A (1963) 2.28
The synthesis of infectious RNA with a replicase purified according to its size and density. Proc Natl Acad Sci U S A (1966) 2.27
On the redundancy of DNA complementary to amino acid tranfer RNA and its absence from the nucleolar organizer region of Drosophila melanogaster. Genetics (1966) 2.21
Detection of specific DNA sequences with short biotin-labeled probes. DNA (1985) 2.13
Mechanisms of carcinogenesis induced by alkylating agents. Biochim Biophys Acta (1985) 2.13
The case for an ancestral genetic system involving simple analogues of the nucleotides. Proc Natl Acad Sci U S A (1987) 2.12
DNA synthesis with methylated poly(dC-dG) templates. Evidence for a competitive nature to miscoding by O(6)-methylguanine. Biochim Biophys Acta (1979) 2.12
Autocatalytic synthesis of a viral RNA in vitro. Science (1965) 2.10
The in vitro synthesis of a noninfectious complex containing biologically active viral RNA. Proc Natl Acad Sci U S A (1966) 2.10
Conditions for the selective synthesis of DNA complementary to template RNA. Biochim Biophys Acta (1973) 2.08
Decreased globin messenger RNA in thalassemia detected by molecular hybridization. Proc Natl Acad Sci U S A (1973) 2.07
4-methoxytetrahydropyran-4-yl. A symmetrical alternative to the tetrahydropyranyl protecting group. Tetrahedron (1970) 2.03
Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers. Proc Natl Acad Sci U S A (1972) 2.02
Human sarcomas contain RNA related to the RNA of a mouse leukemia virus. Science (1972) 1.98
Viral-related RNA in Hodgkins' disease and other human lymphomas. Proc Natl Acad Sci U S A (1972) 1.98
Further extracellular Darwinian experiments with replicating RNA molecules: diverse variants isolated under different selective conditions. Proc Natl Acad Sci U S A (1969) 1.89
Purification and detection of reverse transcriptase in viruses and cells. Methods Enzymol (1974) 1.89
Oligomerization of (guanosine 5'-phosphor)-2-methylimidazolide on poly(C). An RNA polymerase model. J Mol Biol (1982) 1.88
A nonenzymatic RNA polymerase model. Science (1983) 1.86
Template switching between PNA and RNA oligonucleotides. Nature (1995) 1.84
Ageing of clones of mammalian cells. Nature (1973) 1.80
The mechanism of RNA replication. Cold Spring Harb Symp Quant Biol (1968) 1.80
Complete nucleotide sequence of a replicating RNA molecule. Science (1973) 1.78
Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma. Proc Natl Acad Sci U S A (1972) 1.76
Serological analysis of the deoxyribonucleic acid polymerase of avian oncornaviruses. II. Comparison of avian deoxyribonucleic acid polymerases. J Virol (1972) 1.75
Beta structures of alternating polypeptides and their possible prebiotic significance. Nature (1975) 1.74
Catalysis of accurate poly(C)-directed synthesis of 3'-5'-linked oligoguanylates by Zn2+. J Mol Biol (1980) 1.74
Detection of RNA-instructed DNA polymerase and high molecular weight RNA in malignant tissue. Proc Natl Acad Sci U S A (1972) 1.73
Nonenzymatic sequence-specific cleavage of single-stranded DNA. Proc Natl Acad Sci U S A (1985) 1.72
Use of micrococcal nuclease to monitor hybridization reactions with DNA. Anal Biochem (1974) 1.71
An analysis by gel electrophoresis of Q-beta-RNA complexes formed during the latent period of an in vitro synthesis. Proc Natl Acad Sci U S A (1967) 1.67
DNA polymerase activities in varions of visna virus, a causative agent of a "slow" neurological disease. Proc Natl Acad Sci U S A (1971) 1.67
RNA-dependent DNA polymerase activity in virus-like particles isolated from human milk. Nature (1971) 1.63
The kinetics of product appearance and template involvement in the in vitro replication of viral RNA. Proc Natl Acad Sci U S A (1967) 1.59
DNA polymerase activities and nucleic acid components of virions isolated from a spontaneous mammary carcinoma from a rhesus monkey. Proc Natl Acad Sci U S A (1971) 1.57
A replicating RNA molecule suitable for a detailed analysis of extracellular evolution and replication. Proc Natl Acad Sci U S A (1972) 1.55
Urea-inorganic phosphate mixtures as prebiotic phosphorylating agents. Science (1971) 1.54
Nonenzymatic synthesis of oligoadenylates on a polyuridylic acid template. Proc Natl Acad Sci U S A (1968) 1.53
An estimation of genetic messages in the unfertilized echinoid egg. Proc Natl Acad Sci U S A (1966) 1.52
Detection in human breast carcinomas of an antigen immunologically related to a group-specific antigen of mouse mammary tumor virus. Proc Natl Acad Sci U S A (1978) 1.51
Evolution in vitro: sequence and phenotype of a mutant RNA resistant to ethidium bromide. J Mol Biol (1974) 1.51
Properties of retrovirus-like particles produced by a human breast carcinoma cell line: immunological relationship with mouse mammary tumor virus proteins. Proc Natl Acad Sci U S A (1984) 1.50
Chiral selection in poly(C)-directed synthesis of oligo(G). Nature (1984) 1.49
Absence of polymerase protein in virions of alpha-type rous sarcoma virus. Science (1972) 1.46
Burkitt's tumors contain particles encapsulating RNA-instructed DNA polymerase and high molecular weight virus-related RNA. Proc Natl Acad Sci U S A (1973) 1.44
Comparison of two serologically distinct ribonucleic acid bacteriophages. II. Properties of the nucleic acids and coat proteins. J Bacteriol (1966) 1.44
A search for an intermediate involving a complement during synchronous synthesis by a purified RNA replicase. Proc Natl Acad Sci U S A (1966) 1.43
Non-enzymatic template-directed synthesis on RNA random copolymers. Poly(C, U) templates. J Mol Biol (1984) 1.41
Determination of natural host taxonomy of RNA tumor viruses by molecular hybridization: application to RD-114, a candidate human virus. Proc Natl Acad Sci U S A (1973) 1.40
The purification of a gs antigen of the murine mammary tumor virus and its quantitation by radioimmunoassay. Virology (1976) 1.39
The sequence at the 5' terminus of a self-replicating variant of viral Q-beta ribonucleic acid. Biochemistry (1968) 1.39
Autocatalytic synthesis of a tetranucleotide analogue. Nature (1987) 1.38
The dissociation of Q-beta-replicase and the relation of one of the components to a poly-C-dependent poly-G-polymerase. Proc Natl Acad Sci U S A (1967) 1.37
RNA primer used in synthesis of anticomplementary DNA by reverse transcriptase of avian myeloblastosis virus. Proc Natl Acad Sci U S A (1980) 1.37
The maintenance of the accuracy of protein synthesis and its relevance to ageing: a correction. Proc Natl Acad Sci U S A (1970) 1.37
Studies in prebiotic synthesis. VI. Synthesis of purine nucleosides. J Mol Biol (1972) 1.36
Virus-related RNA in human and mouse mammary tumors. J Natl Cancer Inst (1972) 1.34
Studies in prebiotic synthesis. V. Synthesis and photoanomerization of pyrimidine nucleosides. J Mol Biol (1970) 1.33
Plasma levels of a viral protein as a diagnostic signal for the presence of tumor : the murine mammary tumor model. Proc Natl Acad Sci U S A (1976) 1.33
Repair of alkylated purines in the hepatic DNA of mitochondria and nuclei in the rat. Carcinogenesis (1988) 1.32
In vitro integration of human immunodeficiency virus type 1 cDNA into targets containing protein-induced bends. Proc Natl Acad Sci U S A (1995) 1.32
Nuclear DNA sequences present in human leukemic cells and absent in normal leukocytes. Proc Natl Acad Sci U S A (1972) 1.32
Deoxyribonucleic acid polymerase of Rous sarcoma virus: reaction conditions and analysis of the reaction product nucleic acids. J Virol (1971) 1.29
Catalysts for the self-polymerization of adenosine cyclic 2', 3'-phosphate. J Mol Evol (1973) 1.29
Detection of high-molecular-weight RNA in particles from human milk. Science (1972) 1.27
The stability of different forms of double-stranded decoy DNA in serum and nuclear extracts. Nucleic Acids Res (1992) 1.26
Human breast carcinoma antigen is immunologically related to the polypeptide of the group-specific glycoprotein of mouse mammary tumor virus. Proc Natl Acad Sci U S A (1979) 1.26
Oligomerization of activated derivatives of 3'-amino-3'-deoxyguanosine on poly(C) and poly(dC) templates. Nucleic Acids Res (1985) 1.24
Ligation of oligonucleotides to nucleic acids or proteins via disulfide bonds. Nucleic Acids Res (1988) 1.24