Published in J Biol Chem on June 25, 1967
Oxidative degradation of squalene by Arthrobacter species. Appl Microbiol (1975) 2.73
Studies in phytosterol biosynthesis. Mechanism of biosynthesis of cycloartenol. Biochem J (1968) 1.40
Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen. Proc Natl Acad Sci U S A (1993) 1.15
Molecular cloning, characterization, and overexpression of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase. Proc Natl Acad Sci U S A (1994) 1.15
Microaerobic steroid biosynthesis and the molecular fossil record of Archean life. Proc Natl Acad Sci U S A (2011) 1.07
Some properties of the microsomal 2,3-oxidosqualene sterol cyclase. Proc Natl Acad Sci U S A (1969) 0.90
Purification and characterization of a cholesterol-binding protein from human pancreas. Biochem J (1982) 0.83
The 2014 Bernard B. Brodie award lecture-epoxide hydrolases: drug metabolism to therapeutics for chronic pain. Drug Metab Dispos (2015) 0.81
Oxidative Cyclization in Natural Product Biosynthesis. Chem Rev (2016) 0.81
On the enzymes catalysing the transformation of squalene to lanosterol. Biochem J (1969) 0.79
The Oxidosqualene Cyclase from the Oomycete Saprolegnia parasitica Synthesizes Lanosterol as a Single Product. Front Microbiol (2016) 0.76
Heme and I. J Biol Chem (2015) 0.75
Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science (1995) 8.58
Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta. Proc Natl Acad Sci U S A (1999) 5.08
Effect of dietary enrichment with eicosapentaenoic and docosahexaenoic acids on in vitro neutrophil and monocyte leukotriene generation and neutrophil function. N Engl J Med (1985) 4.00
AMP-activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett (1999) 3.63
Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4, and LTB4) in human skin. J Invest Dermatol (1983) 3.18
Slow reacting substances of anaphylaxis: identification of leukotrienes C-1 and D from human and rat sources. Proc Natl Acad Sci U S A (1980) 3.18
Inhibition of fatty acid synthetases by the antibiotic cerulenin. Biochem Biophys Res Commun (1972) 3.13
Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro. Proc Natl Acad Sci U S A (1980) 2.94
Crystal structure of human heme oxygenase-1. Nat Struct Biol (1999) 2.64
Identification of the C(6)-S-conjugate of leukotriene A with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity. Biochem Biophys Res Commun (1980) 2.49
Nobel laureates' letter to President Bush. Washington Post (2001) 2.43
The biological synthesis of cholesterol. Science (1965) 2.34
Structure of leukotriene C. Identification of the amino acid part. Biochem Biophys Res Commun (1979) 2.30
Enzymatic desaturation of stearyl acyl carrier protein. J Biol Chem (1968) 2.09
Proteasome inhibitors block development of Plasmodium spp. Antimicrob Agents Chemother (1998) 2.07
Leukotriene B4 action on endothelium mediates augmented neutrophil/endothelial adhesion. Proc Natl Acad Sci U S A (1984) 2.06
Inhibition of lipid synthesis in Escherichia coli cells by the antibiotic cerulenin. Antimicrob Agents Chemother (1973) 2.06
Aromatization of cyclohexanecarboxylic acid. J Biol Chem (1966) 2.04
A FATTY ACID SYNTHETASE FROM E. COLI. Proc Natl Acad Sci U S A (1962) 1.99
Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C4. Proc Natl Acad Sci U S A (1983) 1.91
Bronchoconstrictor effects of leukotriene C in humans. Science (1982) 1.91
Differential effects of cholesterol and lanosterol on artificial membranes. Proc Natl Acad Sci U S A (1977) 1.89
Triflimide activation of a chiral oxazaborolidine leads to a more general catalytic system for enantioselective Diels-Alder addition. J Am Chem Soc (2003) 1.89
Control mechanisms in the synthesis of saturated fatty acids. Annu Rev Biochem (1977) 1.83
Control mechanisms for fatty acid synthesis in Mycobacterium smegmatis. Adv Enzymol Relat Areas Mol Biol (1977) 1.80
Novel acetoxylation and C-C coupling reactions at unactivated positions in alpha-amino acid derivatives. Org Lett (2006) 1.74
Effects of leukotriene D on the airways in asthma. N Engl J Med (1983) 1.69
Rodent models of pulmonary hypertension: harmonisation with the world health organisation's categorisation of human PH. Int J Clin Pract Suppl (2011) 1.69
Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates. J Biol Chem (1980) 1.67
Docosahexaenoic acid is a strong inhibitor of prostaglandin but not leukotriene biosynthesis. Proc Natl Acad Sci U S A (1983) 1.67
Effects of exogenous arachidonic, eicosapentaenoic, and docosahexaenoic acids on the generation of 5-lipoxygenase pathway products by ionophore-activated human neutrophils. J Clin Invest (1984) 1.65
Enzymatic desaturation of stearyl acyl carrier protein. J Biol Chem (1966) 1.64
Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proc Natl Acad Sci U S A (1975) 1.64
Crystal structure of a thermophilic cytochrome P450 from the archaeon Sulfolobus solfataricus. J Biol Chem (2000) 1.63
Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun (1980) 1.62
PHOSPHORYLATED INTERMEDIATES IN THE SYNTHESIS OF SQUALENE. Proc Natl Acad Sci U S A (1958) 1.60
2,3-oxidosqualene, an intermediate in the biological synthesis of sterols from squalene. J Am Chem Soc (1966) 1.60
Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product. J Biol Chem (1984) 1.56
A short synthetic route to (+)-austamide, (+)-deoxyisoaustamide, and (+)-hydratoaustamide from a common precursor by a novel palladium-mediated indole --> dihydroindoloazocine cyclization. J Am Chem Soc (2002) 1.51
Protein purification using immobilised triazine dyes. J Chromatogr (1979) 1.49
Studies on the biosynthesis of ergosterol in yeast. Formation of methylated intermediates. J Biol Chem (1967) 1.48
Computer-assisted design of complex organic syntheses. Science (1969) 1.48
Structure-based design of nonpeptide inhibitors specific for the human immunodeficiency virus 1 protease. Proc Natl Acad Sci U S A (1990) 1.46
Radioimmunoassay of the leukotrienes of slow reacting substance of anaphylaxis. Proc Natl Acad Sci U S A (1981) 1.45
Rat liver heme oxygenase. High level expression of a truncated soluble form and nature of the meso-hydroxylating species. J Biol Chem (1993) 1.44
Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation. J Biol Chem (1996) 1.43
Suicidal inactivation of cytochrome P-450. Formation of a heme-substrate covalent adduct. Biochem Biophys Res Commun (1978) 1.43
Fear-learning deficits in subjects with fibromyalgia syndrome? Eur J Pain (2013) 1.41
On the enzymatic synthesis of unsaturated fatty acids in Escherichia coli. Proc Natl Acad Sci U S A (1967) 1.40
A beta-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci U S A (1994) 1.39
Sterol synergism in yeast. Proc Natl Acad Sci U S A (1983) 1.38
Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats. J Pharmacol Exp Ther (1994) 1.38
Functional characterization of synthetic leukotriene B and its stereochemical isomers. J Exp Med (1981) 1.37
Sterols in membranes: growth characteristics and membrane properties of Mycoplasma capricolum cultured on cholesterol and lanosterol. Biochemistry (1980) 1.36
Metabolic transformation of cholestenediols. J Biol Chem (1965) 1.35
Mode of inhibition of beta-hydroxydecanoyl thioester dehydrase by 3-decynoyl-N-acetylcysteamine. J Biol Chem (1970) 1.34
Inhibition of renal vascular 20-HETE production impairs autoregulation of renal blood flow. Am J Physiol (1994) 1.32
Proteolipid formation in Mycoplasma capricolum. Influence of cholesterol on unsaturated fatty acid acylation of membrane proteins. J Biol Chem (1983) 1.32
Leukotriene E4-induced airway hyperresponsiveness of guinea pig tracheal smooth muscle to histamine and evidence for three separate sulfidopeptide leukotriene receptors. Proc Natl Acad Sci U S A (1984) 1.32
Fatty acid synthases from Mycobacterium phlei. Methods Enzymol (1975) 1.31
Concise total syntheses of palominol, dolabellatrienone, beta-araneosene, and isoedunol via an enantioselective Diels-Alder macrobicyclization. J Am Chem Soc (2006) 1.30
Generation of leukotriene C4 from a subclass of mast cells differentiated in vitro from mouse bone marrow. Proc Natl Acad Sci U S A (1982) 1.30
Expression and characterization of truncated human heme oxygenase (hHO-1) and a fusion protein of hHO-1 with human cytochrome P450 reductase. Biochemistry (1995) 1.30
Desaturation of oleyl phospholipid to linoleyl phospholipid in Torulopsis utilis. J Biol Chem (1973) 1.30
Elongation of acyl carrier protein derivatives by bacterial and plant extracts. J Biol Chem (1967) 1.30
Studies on the mechanism of binding of serum albumins to immobilized cibacron blue F3G A. Biochem J (1980) 1.30
Replacement of the proximal histidine iron ligand by a cysteine or tyrosine converts heme oxygenase to an oxidase. Biochemistry (1999) 1.29
Beta-hydroxydecanoyl thioester dehydrase. I. Purification and properties. J Biol Chem (1967) 1.29
Leukotriene A. Isolation from human polymorphonuclear leukocytes. J Biol Chem (1980) 1.28
ON THE MECHANISM OF SQUALENE BIOGENESIS. Proc Natl Acad Sci U S A (1958) 1.28
Phosphatidylcholine and cholesterol interactions in model membranes. Chem Phys Lipids (1983) 1.28
Leukotrienes C4, D4 and E4: effects on human and guinea-pig cardiac preparations in vitro. J Pharmacol Exp Ther (1982) 1.26
Beta-hydroxydecanoly thioester dehydrase. Specificity of substrates and acetylenic inhibitors. J Biol Chem (1968) 1.26
Total synthesis of (+/-)-pentacycloanammoxic acid. J Am Chem Soc (2004) 1.26
Purification and properties of fatty acyl thioesterase I from Escherichia coli. J Biol Chem (1972) 1.25
A two-step total synthesis of the natural pentacycle trichodimerol, a novel inhibitor of TNF-alpha production. Org Lett (1999) 1.25
A new chiral Rh(II) catalyst for enantioselective [2 + 1]-cycloaddition. mechanistic implications and applications. J Am Chem Soc (2004) 1.25
Solubilization and purification of trans-farnesyl pyrophosphate-squalene synthetase. J Biol Chem (1971) 1.25
A total synthesis of ( )-fumagillin. J Am Chem Soc (1972) 1.25
Reaction intermediates and single turnover rate constants for the oxidation of heme by human heme oxygenase-1. J Biol Chem (2000) 1.24
Studies on squalene epoxidase of rat liver. J Biol Chem (1970) 1.24
Solubilization and partial characterization of rat liver squalene epoxidase. J Biol Chem (1975) 1.24
The cytochrome P-450 active site. Regiospecificity of prosthetic heme alkylation by olefins and acetylenes. J Biol Chem (1983) 1.24
A long chain terpenyl pyrophosphate synthetase from Micrococcus lysodeikticus. J Biol Chem (1967) 1.24
Autocatalytic alkylation of the cytochrome P-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an NN-bridged benzyne-protoporphyrin IX adduct. Biochem J (1981) 1.24
Stereocontrolled synthesis of dafachronic acid A, the ligand for the DAF-12 nuclear receptor of Caenorhabditis elegans. J Am Chem Soc (2007) 1.23
Self-catalyzed destruction of cytochrome P-450: covalent binding of ethynyl sterols to prosthetic heme. Proc Natl Acad Sci U S A (1979) 1.23
The myoglobin protein radical. Coupling of Tyr-103 to Tyr-151 in the H2O2-mediated cross-linking of sperm whale myoglobin. J Biol Chem (1988) 1.23
Fatty acid synthetase activity in Mycobacterium phlei: regulation by polysaccharides. Proc Natl Acad Sci U S A (1971) 1.23
A tetradentate ligand for the enantioselective Ti(IV)-promoted oxidation of sulfides to sulfoxides: origin of enantioselectivity. J Am Chem Soc (2012) 1.22
Oxidative inactivation of leukotriene C4 by stimulated human polymorphonuclear leukocytes. Proc Natl Acad Sci U S A (1982) 1.22
Effect of sterol side chains on growth and membrane fatty acid composition of Saccharomyces cerevisiae. J Bacteriol (1980) 1.22
Bronchoconstrictor effects of leukotriene E4 in normal and asthmatic subjects. Am Rev Respir Dis (1987) 1.22
Airway constriction in normal humans produced by inhalation of leukotriene D. Potency, time course, and effect of aspirin therapy. JAMA (1983) 1.21
Comparative aspects of fatty acid synthesis in Bacillus subtilis and Escherichia coli. Eur J Biochem (1970) 1.21
Beta-hydroxydecanoyl thioester dehydrase. II. Mode of action. J Biol Chem (1967) 1.21
Immunologic and ionophore-induced generation of leukotriene B4 from mouse bone marrow-derived mast cells. J Immunol (1983) 1.21
Autocatalytic inactivation of plant cytochrome P-450 enzymes: selective inactivation of cinnamic acid 4-hydroxylase from Helianthus tuberosus by 1-aminobenzotriazole. Arch Biochem Biophys (1982) 1.20
Conversion of leukotriene D4 to leukotriene E4 by a dipeptidase released from the specific granule of human polymorphonuclear leucocytes. Immunology (1983) 1.20
A new assay for fatty acid desaturation. Anal Biochem (1969) 1.19