Published in Biochem J on August 01, 1967
Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochem J (1970) 3.09
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J (1971) 2.60
Lysis and killing of bacteria by lysosomal proteinases. Infect Immun (1976) 1.50
The nature of the collagenolytic cathepsin of rat liver and its distribution in other rat tissues. Biochem J (1972) 1.32
A specific antiserum to lysosomal cathepsin D. Immunology (1969) 1.23
Ionic milieu controls the compartment-specific activation of pro-opiomelanocortin processing in AtT-20 cells. Mol Biol Cell (1995) 1.14
The action of cathepsin D in human articular cartilage on proteoglycans. J Clin Invest (1973) 1.12
Effect of X-irradiation on various functions of murine macrophages. Clin Exp Immunol (1974) 1.03
Cathepsin B, the lysosomal thiol proteinase of calf liver. Biochem J (1969) 0.97
The interaction of carcinogenic metals with tissues and body fluids. Cobalt and horse serum. Br J Cancer (1969) 0.94
Inhibition of cathepsin D-type proteinase of macrophages by pepstatin, a specific pepsin inhibitor, and other substances. Infect Immun (1973) 0.94
Studies on the cathepsins in elastic cartilage. Biochem J (1969) 0.93
Effects of lysosomal collagenolytic enzymes, anti-inflammatory drugs and other substances on some properties of insoluble collagen. Biochem J (1969) 0.91
Protease and ribonuclease activities in bovine pituitary lobes. Biochem J (1971) 0.90
Pharmacological interference with tissue hypercatabolism in tumour-bearing rats. Biochem J (1994) 0.88
Cathepsins in pathology: an immunoenzymic study. Biochem J (1969) 0.87
Purification and characterization of lysosomal -glucuronidase from human placenta. Biochem J (1972) 0.87
Control of cell protein catabolism in rat liver. Effects of starvation and administration of cycloheximide. Biochem J (1982) 0.87
Effect of lytic enzymes of Acanthamoeba castellanii on bacterial cell walls. J Bacteriol (1969) 0.86
Cathepsin D-mediated processing of procollagen: lysosomal enzyme involvement in secretory processing of procollagen. Proc Natl Acad Sci U S A (1984) 0.86
The heterogeneous distribution of acid hydrolases within a homogeneous population of cultured mammalian cells. Biochem J (1973) 0.83
Confirmation of direct angiotensin formation by kallikrein. Biochem J (1983) 0.82
Cell-free protein synthesis in heart and skeletal muscles from polymyopathic hamsters. Biochem J (1973) 0.81
Uptake and degradation of a polypeptide antigen by stimulated and unstimulated macrophages from responder and non-responder mice. Immunology (1974) 0.80
The locations of cathepsin activity and beta-glucuronidase in the Guerin T8 tumour. Biochem J (1970) 0.78
Cardiac hypoxia and subsequent reoxygenation: sensitivity to L-arginine methylester. Br J Pharmacol (1986) 0.77
Purification and properties of the cathepsin D types proteinase from beef and rabbit lung and its identification in macrophages. Infect Immun (1973) 0.76
Characterization of two acid proteinases found in rabbit skin homografts. Biochem J (1978) 0.75
Experimental arthritis of rabbits caused by intra-articular injection of autologous Fab2 produced by digestion of IgG with cathepsin D. Ann Rheum Dis (1976) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS. Ann N Y Acad Sci (1964) 127.96
Estimation of the molecular weights of proteins by Sephadex gel-filtration. Biochem J (1964) 35.63
The gel-filtration behaviour of proteins related to their molecular weights over a wide range. Biochem J (1965) 30.51
DISC ELECTROPHORESIS. I. BACKGROUND AND THEORY. Ann N Y Acad Sci (1964) 26.94
Influence of inorganic phosphate in the formation of phosphatases by Escherichia coli. Biochim Biophys Acta (1960) 14.35
DITHIOTHREITOL, A NEW PROTECTIVE REAGENT FOR SH GROUPS. Biochemistry (1964) 10.04
The preparation and properties of two new chromogenic substrates of trypsin. Arch Biochem Biophys (1961) 9.47
Direct evidence for the presence of histidine in the active center of chymotrypsin. Biochemistry (1963) 4.26
Distribution of enzymes between subcellular fractions in animal tissues. Adv Enzymol Relat Subj Biochem (1962) 3.65
Studies on the mode of action of excess of vitamin A. 6. Lysosomal protease and the degradation of cartilage matrix. Biochem J (1963) 3.20
The isolation and properties of a proteolytic enzyme, cathepsin D, from bovine spleen. Biochem J (1960) 2.94
Proteolytic enzymes. Annu Rev Biochem (1960) 2.90
Purification and properties of beef spleen cathepsin B. J Biol Chem (1957) 2.48
The degradation of cartilage matrix by an intracellular protease. Biochem J (1964) 2.34
The purification and properties of a proteolytic enzyme, rabbit cathepsin E, and further studies on rabbit cathepsin D. Biochem J (1962) 1.91
Study of a proteolytic enzyme from rabbit spleen. Biochem J (1960) 1.72
Purification and properties of dipeptidyl transferase (Cathepsin C). Biochemistry (1966) 1.43
The in vitro inactivation and formation of plasma kinins by spleen cathepsins. Br J Pharmacol Chemother (1966) 1.35
Proteolytic enzymes of lung. J Biol Chem (1955) 1.30
Purification, properties, and specificity of hog thyroid proteinase. Biochim Biophys Acta (1966) 1.16
Acid hydrolases of the rat uterus in relation to pregnancy, post-partum involution and collagen breakdown. Biochem J (1965) 1.11
Action of proteinase I of bovine lung; hydrolysis of the oxidized B chain of insulin; polymer formation from amino acid esters. J Biol Chem (1955) 1.04
A chemical investigation of the active center of pepsin. Biochem Biophys Res Commun (1966) 1.00
Enzymic processes and vascular changes in the skin radiation reaction. Br J Radiol (1966) 0.98
A peptidohydrolase from mammalian fibroblasts (bovine dental pulp). Biochemistry (1966) 0.97
SPECIFIC AND REVERSIBLE INACTIVATION OF PEPSIN. J Biol Chem (1965) 0.91
Separation of acid and neutral proteinases of brain. Biochem J (1965) 0.89
Proteolytic activity in the serum of rabbits during anaphylaxis. Experientia (1966) 0.88
Lysosomal hydrolases in calf thyroid. Biochem J (1966) 0.82
Comparative biochemistry of myopathies. Ann N Y Acad Sci (1966) 0.81
HYDROLYSIS OF THE A AND B CHAINS OF OXIDISED INSULIN BY ADRENAL ACID PROTEINASE. Biochim Biophys Acta (1964) 0.81
Alpha-keto analogues of amino acids as inhibitors of alpha-chymotrypsin, carboxypeptidase A, and pepsin. Arch Biochem Biophys (1965) 0.81
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta (1986) 13.69
A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res (1982) 7.12
Cathepsin B, Cathepsin H, and cathepsin L. Methods Enzymol (1981) 6.84
The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. Biochem J (1973) 5.99
Evolutionary families of peptidases. Biochem J (1993) 5.81
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J (1982) 5.67
Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med (2000) 4.99
Human cathepsin B1. Purification and some properties of the enzyme. Biochem J (1973) 4.06
The electrophoretically 'slow' and 'fast' forms of the alpha 2-macroglobulin molecule. Biochem J (1979) 3.58
Evolutionary families of metallopeptidases. Methods Enzymol (1995) 3.48
A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen. Anal Biochem (1979) 3.17
Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochem J (1970) 3.09
Families of serine peptidases. Methods Enzymol (1994) 2.94
A new assay for cathepsin B1 and other thiol proteinases. Anal Biochem (1972) 2.93
Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. N Engl J Med (2001) 2.75
High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial. Lancet (2000) 2.75
Cathepsin B1. A lysosomal enzyme that degrades native collagen. Biochem J (1974) 2.65
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J (1971) 2.60
MEROPS: the peptidase database. Nucleic Acids Res (1999) 2.60
Cyclosporin A for the treatment of graft-versus-host disease in man. Lancet (1979) 2.48
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. Nature (1998) 2.44
Cystatin, a protein inhibitor of cysteine proteinases. Improved purification from egg white, characterization, and detection in chicken serum. Biochem J (1983) 2.42
Pectic polysaccharides of growing plant tissues. Biochem J (1967) 2.24
Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone-marrow transplantation. Lancet (1981) 2.22
Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates. Biochem J (1980) 2.20
Neutral proteinases of human spleen. Purification and criteria for homogeneity of elastase and cathepsin G. Biochem J (1976) 2.17
Human liver cathepsin L. Biochem J (1985) 2.16
The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases. Biochem J (1974) 2.11
Diagnostic utility of flow cytometric immunophenotyping in myelodysplastic syndrome. Blood (2001) 2.11
The inhibition of tissue acid proteinases by pepstatin. Biochem J (1972) 2.06
Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J Biol Chem (1986) 2.03
CA074 methyl ester: a proinhibitor for intracellular cathepsin B. Arch Biochem Biophys (1992) 2.03
Hepatitis-associated aplastic anemia. N Engl J Med (1997) 1.98
Families of cysteine peptidases. Methods Enzymol (1994) 1.98
Hypertension and convulsions in children receiving cyclosporin A. Lancet (1982) 1.89
Human cathepsin H. Biochem J (1980) 1.88
An improved color reagent for use in Barrett's assay of Cathepsin B. Anal Biochem (1976) 1.87
Action of rat liver cathepsin L on collagen and other substrates. Biochem J (1982) 1.73
Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin. Biochem J (1986) 1.71
Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin. Biochem J (1984) 1.69
MEROPS: the peptidase database. Nucleic Acids Res (2000) 1.69
Human cathepsin G. Catalytic and immunological properties. Biochem J (1976) 1.65
The many forms and functions of cellular proteinases. Fed Proc (1980) 1.64
Haematological and biochemical monitoring of Ebola infection in rhesus monkeys: implications for patient management. Lancet (1983) 1.64
Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. J Biol Chem (1997) 1.63
Chicken alpha2-proteinase inhibitor: a serum protein homologous with ovoinhibitor of egg white. Biochim Biophys Acta (1974) 1.63
Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1. Biol Chem Hoppe Seyler (1988) 1.63
The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan structure and its susceptibility to proteolysis. Biochem J (1977) 1.63
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. Blood (1997) 1.63
Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. J Biol Chem (1987) 1.61
Human lysosomal elastase. Catalytic and immunological properties. Biochem J (1976) 1.59
The degradation of articular collagen by neutrophil proteinases. Biochim Biophys Acta (1977) 1.59
Lysosomes. Essays Biochem (1976) 1.58
The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem Biophys Res Commun (1984) 1.56
Alpha 2-macroglobulin. Methods Enzymol (1981) 1.55
Human plasma kallikrein. A rapid purification method with high yield. Biochem J (1981) 1.53
Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site. J Biol Chem (1999) 1.52
Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. Biochem J (1980) 1.52
Lysis and killing of bacteria by lysosomal proteinases. Infect Immun (1976) 1.50
Calpain inhibition by peptide epoxides. Biochem J (1985) 1.49
Elastinolytic activity of human cathepsin L. Biochem J (1986) 1.48
The possible role of neutrophil proteinases in damage to articular cartilage. Agents Actions (1978) 1.48
Specific inhibition of cartilage breakdown. Nature (1969) 1.47
The effects of proteolytic enzymes on the mechanical properties of adult human articular cartilage. Biochim Biophys Acta (1976) 1.47
Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses. Blood (1999) 1.47
Massive immune haemolysis after allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility. Br J Haematol (2001) 1.46
Purification of cathepsin B by a new form of affinity chromatography. Biochem J (1986) 1.45
Chymopapain. Chromatographic purification and immunological characterization. Biochem J (1984) 1.45
Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation. Blood (2001) 1.44
The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism. Biochem J (1978) 1.44
Acute myeloid leukaemia relapsing following interleukin-2 treatment expresses the alpha chain of the interleukin-2 receptor. Br J Haematol (1991) 1.42
Covalent binding of proteinases in their reaction with alpha 2-macroglobulin. Biochem J (1980) 1.41
Cellular and cytokine-mediated effects of CD4-positive lymphocyte lines generated in vitro against chronic myelogenous leukemia. Exp Hematol (1995) 1.40
A new family of serine-type peptidases related to prolyl oligopeptidase. Biochem J (1991) 1.40
Inhibition by alpha-macroglobulin and other serum proteins. Biochem J (1973) 1.40
Interaction of human cathepsin D with the inhibitor pepstatin. Biochem J (1976) 1.39
The degradation of human glomerular basement membrane with purified lysosomal proteinases: evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis. Clin Sci Mol Med (1978) 1.38
Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant (2004) 1.37
Cyclosporin A as prophylaxis against graft-versus-host disease in 36 patients. Br Med J (Clin Res Ed) (1982) 1.35
Further characterization of the covalent linking reaction of alpha 2-macroglobulin. Biochem J (1981) 1.35
Evolution of proteins of the cystatin superfamily. J Mol Evol (1990) 1.34
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. FEBS Lett (1998) 1.33
Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases. Biochem J (1986) 1.32
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum (1993) 1.30
Proteoglycan-degrading enzymes. A radiochemical assay method and the detection of a new enzyme cathepsin F. Biochem J (1977) 1.30
Cystatin-like cysteine proteinase inhibitors from human liver. Biochem J (1984) 1.30
Immunoinhibition of intracellular protein digestion in macrophages. J Exp Med (1973) 1.29
Cathepsins BI and D. Action on human cartilage proteoglycans. Biochim Biophys Acta (1973) 1.29
Cathepsin G. Methods Enzymol (1981) 1.29
An alternative quenched fluorescence substrate for Pz-peptidase. Anal Biochem (1990) 1.27
Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population. J Infect Dis (2001) 1.26
Affinity purification and biochemical characterization of histolysin, the major cysteine proteinase of Entamoeba histolytica. Biochem J (1988) 1.26
Graft-versus-leukemia effects in T lineage and B lineage acute lymphoblastic leukemia. Bone Marrow Transplant (1998) 1.25
Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles. Br J Haematol (1998) 1.23
Relapse after allogeneic bone marrow transplantation for acute leukaemia: a survey by the E.B.M.T. of 117 cases. Br J Haematol (1988) 1.23
CMV reactivation is associated with a lower incidence of relapse after allo-SCT for CML. Bone Marrow Transplant (2013) 1.23
Accurate diagnosis of acute graft-versus-host disease using serum proteomic pattern analysis. Exp Hematol (2006) 1.23
Spread of Clostridium difficile among patients receiving non-absorbable antibiotics for gut decontamination. Br Med J (Clin Res Ed) (1981) 1.22