Published in Biochem J on April 01, 1972
The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. Biochem J (1973) 5.99
Human cathepsin B1. Purification and some properties of the enzyme. Biochem J (1973) 4.06
Cathepsin B1. A lysosomal enzyme that degrades native collagen. Biochem J (1974) 2.65
A specific collagenase from rabbit fibroblasts in monolayer culture. Biochem J (1974) 2.53
Phosphorylation of troponin and the effects of interactions between the components of the complex. Biochem J (1974) 2.09
Lysis and killing of bacteria by lysosomal proteinases. Infect Immun (1976) 1.50
Synthesis of acetylcholine receptor by denervated rat diaphragm muscle. Proc Natl Acad Sci U S A (1975) 1.40
Interaction of human cathepsin D with the inhibitor pepstatin. Biochem J (1976) 1.39
Proteoglycan-degrading enzymes. A radiochemical assay method and the detection of a new enzyme cathepsin F. Biochem J (1977) 1.30
Bovine spleen cathepsin B1 and collagenolytic cathepsin. A comparative study of the properties of the two enzymes in the degradation of native collagen. Biochem J (1976) 1.03
Autolysis of glycoproteins in rat kidney lysosomes in vitro. Effects on the isoelectric focusing behaviour of glycoproteins, arylsulphatase and beta-glucuronidase. Biochem J (1974) 1.02
Cytotaxin receptors of neutrophils: evidence that F-methionyl peptides and pepstatin share a common receptor. Infect Immun (1979) 1.02
Inhibition by pepstatin of human cartilage degradation. Biochem J (1972) 0.97
Inhibition of cathepsin D-type proteinase of macrophages by pepstatin, a specific pepsin inhibitor, and other substances. Infect Immun (1973) 0.94
Proteoglycan-degrading enzymes of rabbit fibroblasts and granulocytes. Biochem J (1978) 0.92
Leukocyte kininogenases and leukokinins from normal and malignant cells. Am J Pathol (1972) 0.91
Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain. World J Biol Chem (2011) 0.90
Partial purification and characterization of a pyruvate dehydrogenase-complex-inactivating enzyme from rat liver. Biochem J (1978) 0.87
Lymphoproliferative activity of Pseudomonas exotoxin A is dependent on intracellular processing and is associated with the carboxyl-terminal portion. Infect Immun (1992) 0.83
Purification and properties of the cathepsin D types proteinase from beef and rabbit lung and its identification in macrophages. Infect Immun (1973) 0.76
The isolation and properties of a non-pepsin proteinase from human gastric mucosa. Biochem J (1978) 0.75
Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochem J (1970) 3.09
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J (1971) 2.60
Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) (1970) 2.52
Enzyme inhibition in relation to chemotherapy. Proc Soc Exp Biol Med (1949) 1.92
Effect of pepstatin on acid proteases. J Antibiot (Tokyo) (1971) 1.75
On the reaction of diazoacetyl compounds with pepsin. J Biol Chem (1969) 1.68
Effect of protease inhibitors of actinomycetes on lysosomal peptide-hydrolases from swine liver. J Antibiot (Tokyo) (1971) 1.19
On kinetic treatments of enzyme-antienzyme reactions. Biochim Biophys Acta (1970) 1.18
The structure of pepstatin. J Antibiot (Tokyo) (1970) 1.15
Inhibition of cathepsin E by diazoacetyl-norleucine methyl ester. FEBS Lett (1970) 0.94
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta (1986) 13.69
A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res (1982) 7.12
Cathepsin B, Cathepsin H, and cathepsin L. Methods Enzymol (1981) 6.84
The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. Biochem J (1973) 5.99
Evolutionary families of peptidases. Biochem J (1993) 5.81
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J (1982) 5.67
Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med (2000) 4.99
Human cathepsin B1. Purification and some properties of the enzyme. Biochem J (1973) 4.06
The electrophoretically 'slow' and 'fast' forms of the alpha 2-macroglobulin molecule. Biochem J (1979) 3.58
Evolutionary families of metallopeptidases. Methods Enzymol (1995) 3.48
A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen. Anal Biochem (1979) 3.17
Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochem J (1970) 3.09
Families of serine peptidases. Methods Enzymol (1994) 2.94
A new assay for cathepsin B1 and other thiol proteinases. Anal Biochem (1972) 2.93
Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. N Engl J Med (2001) 2.75
High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial. Lancet (2000) 2.75
Cathepsin B1. A lysosomal enzyme that degrades native collagen. Biochem J (1974) 2.65
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J (1971) 2.60
MEROPS: the peptidase database. Nucleic Acids Res (1999) 2.60
Cyclosporin A for the treatment of graft-versus-host disease in man. Lancet (1979) 2.48
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. Nature (1998) 2.44
Cystatin, a protein inhibitor of cysteine proteinases. Improved purification from egg white, characterization, and detection in chicken serum. Biochem J (1983) 2.42
Distribution of lysosomal enzymes in the spermatozoa and cytoplasmic droplets of bull and ram. Exp Cell Res (1968) 2.25
Pectic polysaccharides of growing plant tissues. Biochem J (1967) 2.24
Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone-marrow transplantation. Lancet (1981) 2.22
Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates. Biochem J (1980) 2.20
Synthesis of connective-tissue components. The effect of retinol and hydrocortisone on cultured limb-bone rudiments. Biochem J (1966) 2.20
Neutral proteinases of human spleen. Purification and criteria for homogeneity of elastase and cathepsin G. Biochem J (1976) 2.17
Human liver cathepsin L. Biochem J (1985) 2.16
Lysosomal acid proteinase of rabbit liver. Biochem J (1967) 2.12
The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases. Biochem J (1974) 2.11
A cartilage catabolic factor from synovium. Biochem J (1979) 2.11
Diagnostic utility of flow cytometric immunophenotyping in myelodysplastic syndrome. Blood (2001) 2.11
Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J Biol Chem (1986) 2.03
CA074 methyl ester: a proinhibitor for intracellular cathepsin B. Arch Biochem Biophys (1992) 2.03
Heberden oration 1978. Recent studies on the control of joint damage: the contribution of the Strangeways Research Laboratory. Ann Rheum Dis (1979) 1.98
Hepatitis-associated aplastic anemia. N Engl J Med (1997) 1.98
Families of cysteine peptidases. Methods Enzymol (1994) 1.98
Hypertension and convulsions in children receiving cyclosporin A. Lancet (1982) 1.89
Human cathepsin H. Biochem J (1980) 1.88
An improved color reagent for use in Barrett's assay of Cathepsin B. Anal Biochem (1976) 1.87
Action of rat liver cathepsin L on collagen and other substrates. Biochem J (1982) 1.73
Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin. Biochem J (1986) 1.71
Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin. Biochem J (1984) 1.69
MEROPS: the peptidase database. Nucleic Acids Res (2000) 1.69
Human cathepsin G. Catalytic and immunological properties. Biochem J (1976) 1.65
Human mononuclear cell factors mediate cartilage matrix degradation through chondrocyte activation. J Clin Invest (1981) 1.64
The many forms and functions of cellular proteinases. Fed Proc (1980) 1.64
Haematological and biochemical monitoring of Ebola infection in rhesus monkeys: implications for patient management. Lancet (1983) 1.64
Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. J Biol Chem (1997) 1.63
Chicken alpha2-proteinase inhibitor: a serum protein homologous with ovoinhibitor of egg white. Biochim Biophys Acta (1974) 1.63
Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1. Biol Chem Hoppe Seyler (1988) 1.63
The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan structure and its susceptibility to proteolysis. Biochem J (1977) 1.63
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. Blood (1997) 1.63
Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. J Biol Chem (1987) 1.61
Human lysosomal elastase. Catalytic and immunological properties. Biochem J (1976) 1.59
The degradation of articular collagen by neutrophil proteinases. Biochim Biophys Acta (1977) 1.59
Lysosomes. Essays Biochem (1976) 1.58
The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem Biophys Res Commun (1984) 1.56
Alpha 2-macroglobulin. Methods Enzymol (1981) 1.55
Human plasma kallikrein. A rapid purification method with high yield. Biochem J (1981) 1.53
Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site. J Biol Chem (1999) 1.52
Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. Biochem J (1980) 1.52
Lysis and killing of bacteria by lysosomal proteinases. Infect Immun (1976) 1.50
Calpain inhibition by peptide epoxides. Biochem J (1985) 1.49
Breakdown of proteoglycan and collagen induced in pig articular cartilage in organ culture. Ann Rheum Dis (1975) 1.49
The breakdown of embryonic cartilage and bone cultivated in the presence of complement-sufficient antiserum. 2. Biochemical changes and the role of the lysosomal system. Int Arch Allergy Appl Immunol (1967) 1.48
Elastinolytic activity of human cathepsin L. Biochem J (1986) 1.48
The possible role of neutrophil proteinases in damage to articular cartilage. Agents Actions (1978) 1.48
Specific inhibition of cartilage breakdown. Nature (1969) 1.47
The effects of proteolytic enzymes on the mechanical properties of adult human articular cartilage. Biochim Biophys Acta (1976) 1.47
Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses. Blood (1999) 1.47
Massive immune haemolysis after allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility. Br J Haematol (2001) 1.46
Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture. Biochem Biophys Res Commun (1980) 1.45
Purification of cathepsin B by a new form of affinity chromatography. Biochem J (1986) 1.45
Chymopapain. Chromatographic purification and immunological characterization. Biochem J (1984) 1.45
Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation. Blood (2001) 1.44
The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism. Biochem J (1978) 1.44
Acute myeloid leukaemia relapsing following interleukin-2 treatment expresses the alpha chain of the interleukin-2 receptor. Br J Haematol (1991) 1.42
Covalent binding of proteinases in their reaction with alpha 2-macroglobulin. Biochem J (1980) 1.41
Cellular and cytokine-mediated effects of CD4-positive lymphocyte lines generated in vitro against chronic myelogenous leukemia. Exp Hematol (1995) 1.40
A new family of serine-type peptidases related to prolyl oligopeptidase. Biochem J (1991) 1.40
Inhibition by alpha-macroglobulin and other serum proteins. Biochem J (1973) 1.40
Interaction of human cathepsin D with the inhibitor pepstatin. Biochem J (1976) 1.39
The degradation of human glomerular basement membrane with purified lysosomal proteinases: evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis. Clin Sci Mol Med (1978) 1.38
Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant (2004) 1.37
Cyclosporin A as prophylaxis against graft-versus-host disease in 36 patients. Br Med J (Clin Res Ed) (1982) 1.35
Further characterization of the covalent linking reaction of alpha 2-macroglobulin. Biochem J (1981) 1.35
Evolution of proteins of the cystatin superfamily. J Mol Evol (1990) 1.34
The secretion of enzymes into the pericellular environment. Philos Trans R Soc Lond B Biol Sci (1975) 1.34
The breakdown of embryonic (chick) cartilage and bone cultivated in the presence of complement-sufficient antiserum. I. Morphological changes, their reversibility and inhibition. Int Arch Allergy Appl Immunol (1966) 1.33
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. FEBS Lett (1998) 1.33
Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases. Biochem J (1986) 1.32
The effect of synovial catabolin on cartilage synthetic activity. Connect Tissue Res (1984) 1.31
Proteoglycan-degrading enzymes. A radiochemical assay method and the detection of a new enzyme cathepsin F. Biochem J (1977) 1.30