Published in Biochem J on April 01, 1976
Hemoglobin digestion in blood-feeding ticks: mapping a multipeptidase pathway by functional proteomics. Chem Biol (2009) 1.17
Dynamics of digestive proteolytic system during blood feeding of the hard tick Ixodes ricinus. Parasit Vectors (2010) 1.06
Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases. Parasit Vectors (2008) 0.96
Two-step affinity-chromatographic purification of cathepsin D from pig myometrium with high yield. Biochem J (1981) 0.95
New renin inhibitors homologous with pepstatin. Biochem J (1981) 0.87
Characterization of gut-associated cathepsin D hemoglobinase from tick Ixodes ricinus (IrCD1). J Biol Chem (2012) 0.86
Cathepsin D-mediated processing of procollagen: lysosomal enzyme involvement in secretory processing of procollagen. Proc Natl Acad Sci U S A (1984) 0.86
Protease activities of rumen protozoa. Appl Environ Microbiol (1984) 0.84
Bimane-labelled pepstatin, a fluorescent probe for the subcellular location of cathepsin D. Biochem J (1981) 0.83
Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme. Biochem J (1989) 0.82
The selectivity of action of the aspartic-proteinase inhibitor IA3 from yeast (Saccharomyces cerevisiae). Biochem J (1985) 0.81
Interaction of pepstatin with pig pepsinogen. Biochem J (1976) 0.81
The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D. Biochem J (1982) 0.80
Staphylococcus aureus Strain USA300 Perturbs Acquisition of Lysosomal Enzymes and Requires Phagosomal Acidification for Survival inside Macrophages. Infect Immun (2015) 0.78
An Integrated Microfluidic Processor for DNA-Encoded Combinatorial Library Functional Screening. ACS Comb Sci (2017) 0.78
Dinitrophenyl-pepstatins as active-site-directed localization reagents for cathepsin D. Biochem J (1983) 0.77
Evolution of the thermopsin peptidase family (A5). PLoS One (2013) 0.76
Purification and characterization of recombinant human renin for X-ray crystallization studies. BMC Biochem (2008) 0.76
Comparative proteomics reveals novel components at the plasma membrane of differentiated HepaRG cells and different distribution in hepatocyte- and biliary-like cells. PLoS One (2013) 0.75
Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization. Mar Biotechnol (NY) (2012) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
The effect of pH on the affinities of enzymes for substrates and inhibitors. Biochem J (1953) 17.93
The spectrophotometric determination of tyrosine and tryptophan in proteins. Biochem J (1946) 17.08
High-efficiency liquid-scintillation counting of 14C-labelled material in aqueous solution and determination of specific activity of labelled proteins. Biochem J (1965) 6.04
Human cathepsin B1. Purification and some properties of the enzyme. Biochem J (1973) 4.06
Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochem J (1970) 3.09
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J (1971) 2.60
Pepstatin, a new pepsin inhibitor produced by Actinomycetes. J Antibiot (Tokyo) (1970) 2.52
Examination of the dissociation of multichain proteins in guanidine hydrochloride by membrane osmometry. Biochemistry (1968) 2.18
The inhibition of tissue acid proteinases by pepstatin. Biochem J (1972) 2.06
Effect of pepstatin on acid proteases. J Antibiot (Tokyo) (1971) 1.75
Pancreatic trypsin inhibitor. II. Reaction with trypsin. Biochem J (1953) 1.74
On the reaction of diazoacetyl compounds with pepsin. J Biol Chem (1969) 1.68
Specific and irreversible inactivation of pepsin by substrate-like epoxides. J Biol Chem (1971) 1.34
Immunoinhibition of intracellular protein digestion in macrophages. J Exp Med (1973) 1.29
The inhibition of pepsin action. Biochemistry (1968) 1.20
The structure of pepstatin. J Antibiot (Tokyo) (1970) 1.15
The specificity of cathepsin D. J Biol Chem (1973) 1.14
The binding of inhibitors to alpha-chymotrypsin. Biochem J (1966) 1.11
Kinetics of the reaction between trypsin and the pancreatic trypsin inhibitor. Biochem J (1957) 1.09
Multiple forms of cathepsin D from bovine uterus. J Biol Chem (1972) 1.00
Effect of pepsin inhibitor from Ascaris lumbricoides on cathepsin D and E. Biochim Biophys Acta (1972) 0.90
Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D. Biochem Biophys Res Commun (1972) 0.89
Mechanism of inhibition of pepsin by pepstatin. II. J Antibiot (Tokyo) (1974) 0.85
Specific inhibition of acid proteases from brain, kidney, skeletal muscle, and insectivorous plants by diazoacetyl-DL-norleucine methyl ester and by pepstatin. J Biochem (1974) 0.83
Pepsin inhibitors from Ascaris lumbricoides. Isolation, purification, and some properties. J Biol Chem (1974) 0.83
Inactivation of acid proteases from Rhizopus chinensis, Aspergillus saitoi and Mucor pusillus, and calf rennin by diazoactylnorleucine methyl ester. J Biochem (1972) 0.83
Pepstatin inhibition of human renin. Kinetic studies and estimation of enzyme purity. J Biol Chem (1974) 0.83
Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta (1986) 13.69
A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures. Connect Tissue Res (1982) 7.12
Cathepsin B, Cathepsin H, and cathepsin L. Methods Enzymol (1981) 6.84
The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism. Biochem J (1973) 5.99
Evolutionary families of peptidases. Biochem J (1993) 5.81
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J (1982) 5.67
Regression of metastatic renal-cell carcinoma after nonmyeloablative allogeneic peripheral-blood stem-cell transplantation. N Engl J Med (2000) 4.99
Structural basis of collagen recognition by integrin alpha2beta1. Cell (2000) 4.84
Human cathepsin B1. Purification and some properties of the enzyme. Biochem J (1973) 4.06
The electrophoretically 'slow' and 'fast' forms of the alpha 2-macroglobulin molecule. Biochem J (1979) 3.58
Evolutionary families of metallopeptidases. Methods Enzymol (1995) 3.48
A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen. Anal Biochem (1979) 3.17
Cathepsin D. Purification of isoenzymes from human and chicken liver. Biochem J (1970) 3.09
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3. FEBS Lett (1998) 3.04
Families of serine peptidases. Methods Enzymol (1994) 2.94
A new assay for cathepsin B1 and other thiol proteinases. Anal Biochem (1972) 2.93
Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. N Engl J Med (2001) 2.75
High-dose cyclophosphamide in severe aplastic anaemia: a randomised trial. Lancet (2000) 2.75
Cathepsin B1. A lysosomal enzyme that degrades native collagen. Biochem J (1974) 2.65
Cathepsin D. Characteristics of immunoinhibition and the confirmation of a role in cartilage breakdown. Biochem J (1971) 2.60
MEROPS: the peptidase database. Nucleic Acids Res (1999) 2.60
Cyclosporin A for the treatment of graft-versus-host disease in man. Lancet (1979) 2.48
An asparaginyl endopeptidase processes a microbial antigen for class II MHC presentation. Nature (1998) 2.44
Cystatin, a protein inhibitor of cysteine proteinases. Improved purification from egg white, characterization, and detection in chicken serum. Biochem J (1983) 2.42
The macromolecular properties of blood-group substances. Sedimentation-velocity and viscosity measurements. Biochem J (1967) 2.40
On the estimation of the shape of macromolecules from sedimentation and viscosity measurements. Biochim Biophys Acta (1965) 2.30
Pectic polysaccharides of growing plant tissues. Biochem J (1967) 2.24
Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone-marrow transplantation. Lancet (1981) 2.22
Fluorimetric assays for cathepsin B and cathepsin H with methylcoumarylamide substrates. Biochem J (1980) 2.20
Neutral proteinases of human spleen. Purification and criteria for homogeneity of elastase and cathepsin G. Biochem J (1976) 2.17
Human liver cathepsin L. Biochem J (1985) 2.16
Lysosomal acid proteinase of rabbit liver. Biochem J (1967) 2.12
The interaction of alpha2-macroglobulin with proteinases. Binding and inhibition of mammalian collagenases and other metal proteinases. Biochem J (1974) 2.11
Diagnostic utility of flow cytometric immunophenotyping in myelodysplastic syndrome. Blood (2001) 2.11
The inhibition of tissue acid proteinases by pepstatin. Biochem J (1972) 2.06
Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J Biol Chem (1986) 2.03
CA074 methyl ester: a proinhibitor for intracellular cathepsin B. Arch Biochem Biophys (1992) 2.03
The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3. FEBS Lett (2000) 2.03
Hepatitis-associated aplastic anemia. N Engl J Med (1997) 1.98
Families of cysteine peptidases. Methods Enzymol (1994) 1.98
Hypertension and convulsions in children receiving cyclosporin A. Lancet (1982) 1.89
Human cathepsin H. Biochem J (1980) 1.88
An improved color reagent for use in Barrett's assay of Cathepsin B. Anal Biochem (1976) 1.87
Action of rat liver cathepsin L on collagen and other substrates. Biochem J (1982) 1.73
Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin. Biochem J (1986) 1.71
Inhibition of cysteine proteinases and dipeptidyl peptidase I by egg-white cystatin. Biochem J (1984) 1.69
MEROPS: the peptidase database. Nucleic Acids Res (2000) 1.69
Human cathepsin G. Catalytic and immunological properties. Biochem J (1976) 1.65
The many forms and functions of cellular proteinases. Fed Proc (1980) 1.64
Haematological and biochemical monitoring of Ebola infection in rhesus monkeys: implications for patient management. Lancet (1983) 1.64
Cloning, isolation, and characterization of mammalian legumain, an asparaginyl endopeptidase. J Biol Chem (1997) 1.63
Chicken alpha2-proteinase inhibitor: a serum protein homologous with ovoinhibitor of egg white. Biochim Biophys Acta (1974) 1.63
Possible lysosomal activation of pancreatic zymogens. Activation of both human trypsinogens by cathepsin B and spontaneous acid. Activation of human trypsinogen 1. Biol Chem Hoppe Seyler (1988) 1.63
The degradation of cartilage proteoglycans by tissue proteinases. Proteoglycan structure and its susceptibility to proteolysis. Biochem J (1977) 1.63
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. Blood (1997) 1.63
Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. J Biol Chem (1987) 1.61
Human lysosomal elastase. Catalytic and immunological properties. Biochem J (1976) 1.59
The degradation of articular collagen by neutrophil proteinases. Biochim Biophys Acta (1977) 1.59
Lysosomes. Essays Biochem (1976) 1.58
The place of human gamma-trace (cystatin C) amongst the cysteine proteinase inhibitors. Biochem Biophys Res Commun (1984) 1.56
Alpha 2-macroglobulin. Methods Enzymol (1981) 1.55
Human plasma kallikrein. A rapid purification method with high yield. Biochem J (1981) 1.53
Inhibition of mammalian legumain by some cystatins is due to a novel second reactive site. J Biol Chem (1999) 1.52
Degradation of fructose-1,6-bisphosphate aldolase by cathepsin B. Biochem J (1980) 1.52
Lysis and killing of bacteria by lysosomal proteinases. Infect Immun (1976) 1.50
Calpain inhibition by peptide epoxides. Biochem J (1985) 1.49
Elastinolytic activity of human cathepsin L. Biochem J (1986) 1.48
The possible role of neutrophil proteinases in damage to articular cartilage. Agents Actions (1978) 1.48
Specific inhibition of cartilage breakdown. Nature (1969) 1.47
The effects of proteolytic enzymes on the mechanical properties of adult human articular cartilage. Biochim Biophys Acta (1976) 1.47
Engraftment kinetics after nonmyeloablative allogeneic peripheral blood stem cell transplantation: full donor T-cell chimerism precedes alloimmune responses. Blood (1999) 1.47
Massive immune haemolysis after allogeneic peripheral blood stem cell transplantation with minor ABO incompatibility. Br J Haematol (2001) 1.46
Purification of cathepsin B by a new form of affinity chromatography. Biochem J (1986) 1.45
Chymopapain. Chromatographic purification and immunological characterization. Biochem J (1984) 1.45
Delayed donor red cell chimerism and pure red cell aplasia following major ABO-incompatible nonmyeloablative hematopoietic stem cell transplantation. Blood (2001) 1.44
The specificity of cathepsin B. Hydrolysis of glucagon at the C-terminus by a peptidyldipeptidase mechanism. Biochem J (1978) 1.44
Acute myeloid leukaemia relapsing following interleukin-2 treatment expresses the alpha chain of the interleukin-2 receptor. Br J Haematol (1991) 1.42
Covalent binding of proteinases in their reaction with alpha 2-macroglobulin. Biochem J (1980) 1.41
Cellular and cytokine-mediated effects of CD4-positive lymphocyte lines generated in vitro against chronic myelogenous leukemia. Exp Hematol (1995) 1.40
A new family of serine-type peptidases related to prolyl oligopeptidase. Biochem J (1991) 1.40
Inhibition by alpha-macroglobulin and other serum proteins. Biochem J (1973) 1.40
Human cathepsin B. Application of the substrate N-benzyloxycarbonyl-L-arginyl-L-arginine 2-naphthylamide to a study of the inhibition by leupeptin. Biochem J (1980) 1.38
The degradation of human glomerular basement membrane with purified lysosomal proteinases: evidence for the pathogenic role of the polymorphonuclear leucocyte in glomerulonephritis. Clin Sci Mol Med (1978) 1.38
Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease. Bone Marrow Transplant (2004) 1.37
Cyclosporin A as prophylaxis against graft-versus-host disease in 36 patients. Br Med J (Clin Res Ed) (1982) 1.35
Further characterization of the covalent linking reaction of alpha 2-macroglobulin. Biochem J (1981) 1.35
Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant. J Biol Chem (1994) 1.34
Evolution of proteins of the cystatin superfamily. J Mol Evol (1990) 1.34
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. FEBS Lett (1998) 1.33
Human low-Mr kininogen contains three copies of a cystatin sequence that are divergent in structure and in inhibitory activity for cysteine proteinases. Biochem J (1986) 1.32
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum (1993) 1.30
Proteoglycan-degrading enzymes. A radiochemical assay method and the detection of a new enzyme cathepsin F. Biochem J (1977) 1.30
Cystatin-like cysteine proteinase inhibitors from human liver. Biochem J (1984) 1.30
Immunoinhibition of intracellular protein digestion in macrophages. J Exp Med (1973) 1.29
Cathepsin G. Methods Enzymol (1981) 1.29