Published in Nucleic Acids Res on December 11, 1984
Identification of more than 500 RFLPs by screening random genomic clones. Am J Hum Genet (1988) 3.01
The X chromosome shows less genetic variation at restriction sites than the autosomes. Am J Hum Genet (1986) 2.22
A systematic approach for detecting high-frequency restriction fragment length polymorphisms using large genomic probes. Am J Hum Genet (1985) 2.12
Genomic analysis I: inheritance units and genetic selection in the rapid discovery of locus linked DNA markers. Nucleic Acids Res (1986) 1.04
Immunoglobulin variable-region-like domains of diverse sequence within the major histocompatibility complex of the chicken. Proc Natl Acad Sci U S A (1991) 0.96
Polymorphism and linkage of the alpha A-crystallin gene in t-haplotypes of the mouse. Genetics (1987) 0.88
A combinatorial approach to the restriction of a mouse genome. BMC Res Notes (2013) 0.84
The relative efficiency of restriction enzymes: an update. Am J Hum Genet (1988) 0.83
Linkage disequilibrium study of RFLPs detected at the human muscle nicotinic acetylcholine receptor subunit genes. Am J Hum Genet (1989) 0.81
Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation. Proc Natl Acad Sci U S A (1978) 16.54
DNA sequence variants in the G gamma-, A gamma-, delta- and beta-globin genes of man. Cell (1979) 15.74
Linkage relationship of a cloned DNA sequence on the short arm of the X chromosome to Duchenne muscular dystrophy. Nature (1982) 11.57
Mitochondrial DNA sequences of primates: tempo and mode of evolution. J Mol Evol (1982) 11.47
Enzymatic synthesis of deoxyribonucleic acid. VIII. Frequencies of nearest neighbor base sequences in deoxyribonucleic acid. J Biol Chem (1961) 9.99
DNA methylation and the frequency of CpG in animal DNA. Nucleic Acids Res (1980) 9.34
Human mitochondrial DNA variation and evolution: analysis of nucleotide sequences from seven individuals. Genetics (1983) 9.22
Restriction sites containing CpG show a higher frequency of polymorphism in human DNA. Cell (1984) 8.14
Enzymatic synthesis of deoxyribonucleic acid. XI. Further studies on nearest neighbor base sequences in deoxyribonucleic acids. J Biol Chem (1962) 7.80
A strategy to reveal high-frequency RFLPs along the human X chromosome. Am J Hum Genet (1984) 7.73
Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster. Proc Natl Acad Sci U S A (1982) 5.85
Some rules in the ordering of nucleotides in the DNA. Nucleic Acids Res (1980) 4.56
Restriction endonuclease mapping of the human gamma globin gene loci. Nucleic Acids Res (1979) 4.55
Intraspecific nucleotide sequence variability surrounding the origin of replication in human mitochondrial DNA. Gene (1983) 4.47
Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature (1982) 4.30
Doublet frequency analysis of fractionated vertebrate nuclear DNA. J Mol Biol (1976) 3.48
Highly variable regions of DNA flank the human alpha globin genes. Nucleic Acids Res (1981) 2.83
A three-allele restriction-fragment-length polymorphism at the hypoxanthine phosphoribosyltransferase locus in man. Proc Natl Acad Sci U S A (1983) 2.73
A model for restriction fragment length distributions. Am J Hum Genet (1983) 2.71
Report of the Committee on Human Gene Mapping by Recombinant DNA Techniques. Cytogenet Cell Genet (1984) 2.70
Isolation of a polymorphic DNA segment unique to human chromosome 7 by molecular cloning of hybrid cell DNA. Mol Gen Genet (1983) 2.43
An approach to evolutionary relationships of mammalian DNA viruses through analysis of the pattern of nearest neighbor base sequences. Cold Spring Harb Symp Quant Biol (1966) 2.20
The 3' untranslated regions of the duplicated human alpha-globin genes are unexpectedly divergent. Cell (1980) 2.08
The insulin gene is located on the short arm of chromosome 11 in humans. Diabetes (1981) 2.00
Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites. Proc Natl Acad Sci U S A (1982) 1.98
Molecular genetics of human serum albumin: restriction enzyme fragment length polymorphisms and analbuminemia. Proc Natl Acad Sci U S A (1983) 1.89
Human immune interferon gene is located on chromosome 12. J Exp Med (1983) 1.64
Chromosome 13 restriction fragment length polymorphisms. Hum Genet (1984) 1.30
Structure and variation of human ribosomal DNA: the external transcribed spacer and adjacent regions. Am J Hum Genet (1982) 1.19
A new DNA polymorphism in the beta-globin gene cluster can be used for antenatal diagnosis of beta-thalassaemia. Br J Haematol (1983) 1.05
A new polymorphism in the human beta-globin gene useful in antenatal diagnosis. J Clin Invest (1981) 1.02
Multiple, independent restriction site polymorphisms in human DNA detected with a cDNA probe to argininosuccinate synthetase (AS). Am J Hum Genet (1984) 0.91
Optimal use of restriction enzymes in the analysis of human DNA polymorphism. Hum Genet (1983) 0.88
A common mutant EcoRI restriction endonuclease site in the 5' flanking portion of the human alpha-globin gene. Proc Natl Acad Sci U S A (1981) 0.88
Strategies for detecting and characterizing restriction fragment length polymorphisms (RFLP's). Birth Defects Orig Artic Ser (1982) 0.78
Positional cloning of the Werner's syndrome gene. Science (1996) 10.98
A familial Alzheimer's disease locus on chromosome 1. Science (1995) 3.14
Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14. Science (1992) 3.14
MCMC segregation and linkage analysis. Genet Epidemiol (1997) 3.11
Genome screens using linkage disequilibrium tests: optimal marker characteristics and feasibility. Am J Hum Genet (1998) 2.86
A deductive method of haplotype analysis in pedigrees. Am J Hum Genet (1987) 2.31
Techniques for estimating genetic admixture and applications to the problem of the origin of the Icelanders and the Ashkenazi Jews. Hum Genet (1984) 2.26
The number of trait loci in late-onset Alzheimer disease. Am J Hum Genet (2000) 2.24
Bias in multipoint linkage analysis arising from map misspecification. Genet Epidemiol (2000) 2.21
Meta-analysis of 32 genome-wide linkage studies of schizophrenia. Mol Psychiatry (2008) 2.07
Linkage between quantitative trait and marker loci: methods using all relative pairs. Genet Epidemiol (1993) 2.00
Alzheimer's disease, apolipoprotein E4, and gender. JAMA (1994) 1.86
Multipoint oligogenic analysis of age-at-onset data with applications to Alzheimer disease pedigrees. Am J Hum Genet (1999) 1.72
A keratin 14 mutational hot spot for epidermolysis bullosa simplex, Dowling-Meara: implications for diagnosis. J Invest Dermatol (1993) 1.64
Linkage and mutational analysis of familial Alzheimer disease kindreds for the APP gene region. Am J Hum Genet (1992) 1.63
Interactions of apolipoprotein E genotype, total cholesterol level, age, and sex in prediction of Alzheimer's disease: a case-control study. Neurology (1995) 1.55
Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women. Am J Hum Genet (1996) 1.54
Evidence for multiple loci from a genome scan of autism kindreds. Mol Psychiatry (2006) 1.52
Mutations in the consensus helicase domains of the Werner syndrome gene. Werner's Syndrome Collaborative Group. Am J Hum Genet (1997) 1.52
Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science (1988) 1.44
Design and sample-size considerations in the detection of linkage disequilibrium with a disease locus. Am J Hum Genet (1994) 1.33
Toward localization of the Werner syndrome gene by linkage disequilibrium and ancestral haplotyping: lessons learned from analysis of 35 chromosome 8p11.1-21.1 markers. Am J Hum Genet (1996) 1.31
Linkage analysis of familial Alzheimer disease, using chromosome 21 markers. Am J Hum Genet (1991) 1.26
The apolipoprotein E/CI/CII gene cluster and late-onset Alzheimer disease. Am J Hum Genet (1994) 1.23
Restriction analysis of the structural alpha-L-fucosidase gene and its linkage to fucosidosis. Am J Hum Genet (1988) 1.14
A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency. Mol Psychiatry (2005) 1.12
Chromosome 17 and hereditary dementia: linkage studies in three non-Alzheimer families and kindreds with late-onset FAD. Neurology (1997) 1.10
Homozygosity mapping of the Werner syndrome locus (WRN). Genomics (1994) 1.09
Influence of apolipoprotein E genotype on the transmission of Alzheimer disease in a community-based sample. Am J Hum Genet (1996) 1.09
Evaluation of locus heterogeneity and EXT1 mutations in 34 families with hereditary multiple exostoses. Hum Mutat (1998) 1.07
A missense mutation in the desmin rod domain is associated with autosomal dominant distal myopathy, and exerts a dominant negative effect on filament formation. Hum Mol Genet (1999) 1.07
Familial aggregation of dyslexia phenotypes. Behav Genet (2000) 1.06
Evidence for locus heterogeneity in human autosomal dominant split hand/split foot malformation. Am J Hum Genet (1994) 1.02
Homozygosity mapping and Werner's syndrome. Lancet (1992) 1.02
Chromosome 14 and late-onset familial Alzheimer disease (FAD). Am J Hum Genet (1993) 0.98
Monte Carlo analysis on a large pedigree. Genet Epidemiol (1993) 0.93
Pedigree analysis package vs. MIXD: fitting the mixed model on a large pedigree. Genet Epidemiol (1996) 0.92
Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease. Ann Neurol (1992) 0.91
Monte Carlo Markov chain methods for genome screening. Genet Epidemiol (1999) 0.91
Segregation and linkage analysis of a quantitative versus a qualitative trait in large pedigrees. Genet Epidemiol (1997) 0.89
Pedigree analysis package (PAP) vs. MORGAN: model selection and hypothesis testing on a large pedigree. Genet Epidemiol (1998) 0.89
Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. Am J Hum Genet (1999) 0.89
The importance of connections: joining components of the Hutterite pedigree. Genet Epidemiol (2001) 0.86
Characteristics of familial Alzheimer's disease in nine kindreds of Volga German ancestry. Prog Clin Biol Res (1989) 0.85
Alzheimer's disease. Dominant susceptibility genes. Nature (1990) 0.85
Introduction: linkage analyses in the Hutterites. Genet Epidemiol (2001) 0.85
Alzheimer's disease and the family effect. Nat Genet (1994) 0.84
Analysis of quantitative risk factors for a common oligogenic disease. Genet Epidemiol (1995) 0.83
Identification of rare variants from exome sequence in a large pedigree with autism. Hum Hered (2013) 0.82
Beta APP mRNA transcription is increased in cultured fibroblasts from the familial Alzheimer's disease-1 family. Brain Res Mol Brain Res (1995) 0.82
Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease. Ann Neurol (1995) 0.80
Assignment of SOD3 to human chromosome band 4p15.3-->p15.1 with somatic cell and radiation hybrid mapping, linkage mapping, and fluorescent in-situ hybridization. Cytogenet Genome Res (2003) 0.79
Narrowing the position of the Werner syndrome locus by homozygosity analysis-extension of homozygosity analysis. Genomics (1996) 0.79
Evidence for etiologic heterogeneity in Alzheimer's disease. Neurobiol Aging (1989) 0.78
Linkage of hereditary distal myopathy with desmin accumulation to 2q. Hum Hered (2000) 0.77
The genetics of Alzheimer's disease. Biomed Pharmacother (1989) 0.77
Autosomal dominant cyclic hematopoiesis: exclusion of linkage to the major hematopoietic regulatory gene cluster on chromosome 5. Hum Genet (1994) 0.76
Little evidence of reduced survival to adulthood of apoE epsilon4 homozygotes in Down's syndrome. Neuroreport (1997) 0.76
The c-fos gene and early-onset familial Alzheimer's disease. Neurosci Lett (1993) 0.76
The use of nonmetric variation in estimating human population admixture: a test case with Brazilian blacks, whites, and mulattos. Am J Phys Anthropol (1986) 0.75
Semiparametric estimation of major gene effects for age of onset. Genet Epidemiol (1998) 0.75