Published in Nucleic Acids Res on June 11, 1979
Construction of a genetic linkage map in man using restriction fragment length polymorphisms. Am J Hum Genet (1980) 75.25
Nonuniform recombination within the human beta-globin gene cluster. Am J Hum Genet (1984) 7.97
Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer. Proc Natl Acad Sci U S A (1981) 6.03
Nonrandom association of polymorphic restriction sites in the beta-globin gene cluster. Proc Natl Acad Sci U S A (1982) 5.85
RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes. Proc Natl Acad Sci U S A (1979) 3.78
Transcriptional control of the murine albumin/alpha-fetoprotein locus during development. Proc Natl Acad Sci U S A (1982) 3.37
Structural analysis of interspersed repetitive polymerase III transcription units in human DNA. Nucleic Acids Res (1981) 2.77
Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells. Proc Natl Acad Sci U S A (1984) 2.70
Direct identification of sickle cell anemia by blot hybridization. Proc Natl Acad Sci U S A (1981) 2.68
Base substitution in an intervening sequence of a beta+-thalassemic human globin gene. Proc Natl Acad Sci U S A (1981) 2.58
Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man. Proc Natl Acad Sci U S A (1983) 2.56
The 5' flanking region of human epsilon-globin gene. Nucleic Acids Res (1980) 2.30
Evidence for multiple origins of the beta E-globin gene in Southeast Asia. Proc Natl Acad Sci U S A (1982) 2.24
Cloning and characterization of DNA sequences surrounding the human gamma-, delta-, and beta-globin genes. Proc Natl Acad Sci U S A (1980) 2.04
Molecular characterization of seven beta-thalassemia mutations in Asian Indians. EMBO J (1984) 2.04
Origin of the beta S-globin gene in blacks: the contribution of recurrent mutation or gene conversion or both. Proc Natl Acad Sci U S A (1984) 2.00
Embryonic-fetal erythroid characteristics of a human leukemic cell line. Proc Natl Acad Sci U S A (1980) 1.90
G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene. Proc Natl Acad Sci U S A (1984) 1.84
beta-Thalassemia in American Blacks: novel mutations in the "TATA" box and an acceptor splice site. Proc Natl Acad Sci U S A (1984) 1.81
Prenatal diagnosis of sickle cell anemia by restriction and endonuclease analysis: HindIII polymorphisms in gamma-globin genes extend test applicability. Proc Natl Acad Sci U S A (1980) 1.71
alpha-Fetoprotein and albumin genes are in tandem in the mouse genome. Proc Natl Acad Sci U S A (1981) 1.67
Selective in vitro transcription of one of the two Alu family repeats present in the 5' flanking region of the human epsilon-globin gene. Nucleic Acids Res (1981) 1.41
Identification of a recent recombination event within the human beta-globin gene cluster. Proc Natl Acad Sci U S A (1984) 1.30
Use of restriction endonucleases for mapping the allele for beta s-globin. Proc Natl Acad Sci U S A (1982) 1.26
"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA. Proc Natl Acad Sci U S A (1983) 1.25
The thalassemias: molecular mechanisms of human genetic disease. Am J Hum Genet (1983) 1.21
Optimizing selection of restriction enzymes in the search for DNA variants. Nucleic Acids Res (1984) 1.20
A gene controlling fetal hemoglobin expression in adults is not linked to the non-alpha globin cluster. EMBO J (1983) 1.16
Cloning and direct examination of a structurally abnormal human beta 0-thalassemia globin gene. Proc Natl Acad Sci U S A (1980) 1.11
A novel rearrangement of the human beta-like globin gene cluster. Nucleic Acids Res (1981) 1.09
Deletion of the A gamma-globin gene in G gamma-delta beta-thalassemia. J Clin Invest (1979) 1.05
Molecular comparison of delta beta-thalassemia and hereditary persistence of fetal hemoglobin DNAs: evidence of a regulatory area? Proc Natl Acad Sci U S A (1982) 1.02
Beta-globin haplotype analysis suggests that a major source of Malagasy ancestry is derived from Bantu-speaking Negroids. Am J Hum Genet (1996) 0.99
Isolation and characterization of cloned human fetal globin genes. Nucleic Acids Res (1979) 0.98
Molecular and cytogenetic characterization of a de novo t(5p;21q) in a patient previously diagnosed as monosomy 21. Am J Hum Genet (1988) 0.87
Evidence supporting a single origin of the beta(C)-globin gene in blacks. Am J Hum Genet (1985) 0.86
The beta-globin gene in Sardinian delta beta 0-thalassemia carries a C----T nonsense mutation at codon 39. EMBO J (1984) 0.84
Restriction endonuclease mapping of gamma-delta-beta-globin region in G gamma (beta)+ HPFH and a Chinese A gamma HPFH variant. Am J Hum Genet (1983) 0.79
DNA methylation in hereditary persistence of fetal hemoglobin (HPFH-2). Nucleic Acids Res (1987) 0.77
Thalassemic hemoglobinopathies. Am J Pathol (1983) 0.76
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels. J Mol Biol (1977) 33.84
A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res (1976) 24.00
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88
A physical map of the DNA regions flanking the rabbit beta-globin gene. Cell (1977) 12.96
Changes in restricted human cellular DNA fragments containing globin gene sequences in thalassemias and related disorders. Proc Natl Acad Sci U S A (1978) 6.46
Insertion of synthetic copies of human globin genes into bacterial plasmids. Nucleic Acids Res (1978) 5.99
Analysis of the beta-delta-globin gene loci in normal and Hb Lepore DNA: direct determination of gene linkage and intergene distance. Cell (1978) 5.30
Organization of human delta--and beta-globin genes in cellular DNA and the presence of intragenic inserts. Cell (1978) 4.18
Organization, transcription, and regulation in the animal genome. Q Rev Biol (1973) 3.95
Chromosomal localization of human beta globin gene on human chromosome 11 in somatic cell hybrids. Proc Natl Acad Sci U S A (1978) 2.65
Deletion of the beta-globin structure gene in hereditary persistence of foetal haemoglobin. Nature (1975) 2.45
A very large repeating unit of mouse DNA containing the 18S, 28S and 5.8S rRNA genes. Cell (1977) 2.42
Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing. Science (1978) 2.25
Absence of messenger RNA and gene DNA for beta-globin chains in hereditary persistence of fetal hemoglobin. Cell (1976) 2.10
Structure of the human fetal globin gene locus. Nature (1979) 2.02
Globin gene deletion in HPFH, delta (o) beta (o) thalassaemia and Hb Lepore disease. Nature (1979) 1.88
Isolation and partial sequence of recombinant plasmids containing human alpha-, beta- and gamma-globin cDNA fragments. Nature (1978) 1.83
A direct estimate of the number of human gamma-globin genes. Cell (1976) 1.22
Sequence of the 3'-noncoding and adjacent coding regions of human gamma-globin mRNA. Nucleic Acids Res (1978) 1.14
The nucleotide sequence of the 5' untranslated region of human gamma-globin mRNA. Nucleic Acids Res (1978) 1.06
Quantitation of human gamma globin genes and gamma globin mRNA with purified gamma globin complementary DNA. J Clin Invest (1976) 0.97
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Ubiquitous, interspersed repeated sequences in mammalian genomes. Proc Natl Acad Sci U S A (1980) 9.48
A radioimmunoassay using a monoclonal antibody to monitor the course of epithelial ovarian cancer. N Engl J Med (1983) 8.82
The "beta-like-globin" gene domain in human erythroid cells. Proc Natl Acad Sci U S A (1985) 8.35
Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest (1981) 6.89
Epstein-Barr virus receptor of human B lymphocytes is the C3d receptor CR2. Proc Natl Acad Sci U S A (1984) 6.62
Insertion of synthetic copies of human globin genes into bacterial plasmids. Nucleic Acids Res (1978) 5.99
Short interspersed repetitive DNA elements in eucaryotes: transposable DNA elements generated by reverse transcription of RNA pol III transcripts? Cell (1981) 4.37
Application of endonuclease mapping to the analysis and prenatal diagnosis of thalassemias caused by globin-gene deletion. N Engl J Med (1978) 4.34
Two functionally distinct subpopulations of human T cells that collaborate in the generation of cytotoxic cells responsible for cell-mediated lympholysis. J Immunol (1978) 4.33
A monoclonal antibody to human acute lymphoblastic leukaemia antigen. Nature (1980) 3.90
RNA polymerase III transcriptional units are interspersed among human non-alpha-globin genes. Proc Natl Acad Sci U S A (1979) 3.78
Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA. J Biol Chem (1977) 3.55
Nucleotide sequence of KB cell 5S RNA. Science (1967) 3.40
Complete nucleotide sequence of the human delta-globin gene. Cell (1980) 3.34
RNA of low molecular weight in KB cells infected with adenovirus type 2. J Mol Biol (1966) 3.09
Ganglioside GD2 specific monoclonal antibody 3F8: a phase I study in patients with neuroblastoma and malignant melanoma. J Clin Oncol (1987) 2.81
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin. Science (1988) 2.74
Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells. Proc Natl Acad Sci U S A (1984) 2.70
Molecular evolution of human and rabbit beta-globin mRNAs. Proc Natl Acad Sci U S A (1977) 2.70
Selective dissociation of histones from calf thymus nucleoprotein. J Mol Biol (1967) 2.65
Base substitution in an intervening sequence of a beta+-thalassemic human globin gene. Proc Natl Acad Sci U S A (1981) 2.58
Different 3' end points of deletions causing delta beta-thalassemia and hereditary persistence of fetal hemoglobin: implications for the control of gamma-globin gene expression in man. Proc Natl Acad Sci U S A (1983) 2.56
Abnormally spliced messenger RNA in erythroid cells from patients with beta+ thalassemia and monkey cells expressing a cloned beta+-thalassemic gene. Cell (1982) 2.52
The molecular basis of alpha-thalassemias: frequent occurrence of dysfunctional alpha loci among non-Asians with Hb H disease. Cell (1979) 2.41
Quantitative deficiency of chain-specific globin messenger ribonucleic acids in the thalassemia syndromes. Proc Natl Acad Sci U S A (1973) 2.40
Detection, isolation, and functional characterization of two human T-cell subclasses bearing unique differentiation antigens. J Exp Med (1977) 2.34
A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin. Nature (1985) 2.33
A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A (1991) 2.27
A gene in the HLA class I region contributes to susceptibility to IDDM in the Finnish population. Childhood Diabetes in Finland (DiMe) Study Group. Diabetologia (1994) 2.25
Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon. Blood (1984) 2.20
Reverse transcription and direct amplification of cellular RNA transcripts by Taq polymerase. Gene (1990) 2.18
Absence of messenger RNA and gene DNA for beta-globin chains in hereditary persistence of fetal hemoglobin. Cell (1976) 2.10
Nucleotide sequence of the coding portion of human alpha globin messenger RNA. J Biol Chem (1980) 2.07
Genomic representation of the Hind II 1.9 kb repeated DNA. Nucleic Acids Res (1982) 2.02
Nucleotide sequence of 3' untranslated portion of human alpha globin mRNA. Nucleic Acids Res (1977) 1.92
Embryonic-fetal erythroid characteristics of a human leukemic cell line. Proc Natl Acad Sci U S A (1980) 1.90
Defect in messenger RNA for human hemoglobin synthesis in beta thalassemia. J Clin Invest (1971) 1.89
Ankyrin binds to the 15th repetitive unit of erythroid and nonerythroid beta-spectrin. J Cell Biol (1991) 1.85
G gamma beta+ hereditary persistence of fetal hemoglobin: cosmid cloning and identification of a specific mutation 5' to the G gamma gene. Proc Natl Acad Sci U S A (1984) 1.84
A gene deletion ending at the midpoint of a repetitive DNA sequence in one form of hereditary persistence of fetal haemoglobin. Nature (1982) 1.77
Variability in the amount of beta-globin mRNA in beta0 thalassemia. Cell (1978) 1.70
Growth characteristics of virus-transformed cells. Maximum population density, inhibition by normal cells, serum requirement, growth in soft agar, and xenogeneic transplantability. J Exp Med (1970) 1.63
Transcription of the HS2 enhancer toward a cis-linked gene is independent of the orientation, position, and distance of the enhancer relative to the gene. Mol Cell Biol (1997) 1.62
Partial sequence analysis of mouse satellite DNA evidence for short range periodicities. J Mol Biol (1975) 1.61
Full-length sequence of the cDNA for human erythroid beta-spectrin. J Biol Chem (1990) 1.59
Absence of messenger RNA for beta globin chain in beta(0) thalassaemia. Nature (1974) 1.55
Images in clinical medicine. Cutaneous anthrax infection. N Engl J Med (2001) 1.52
The nucleotide sequence of ribosomal 5 S ribonucleic acid from KB cells. J Biol Chem (1969) 1.48
Identification, physical map location and sequence of the denV gene from bacteriophage T4. Nucleic Acids Res (1984) 1.46
Cloning of a portion of the chromosomal gene for human erythrocyte alpha-spectrin by using a synthetic gene fragment. Proc Natl Acad Sci U S A (1986) 1.45
Linkage of dominant hereditary spherocytosis to the gene for the erythrocyte membrane-skeleton protein ankyrin. N Engl J Med (1990) 1.45
Heterogeneity in the molecular basis of hereditary persistence of fetal haemoglobin. Nature (1980) 1.42
Gene mapping by fluorescent in situ hybridization. Cell Biol Int Rep (1977) 1.42
Point mutation in the beta-spectrin gene associated with alpha I/74 hereditary elliptocytosis. Implications for the mechanism of spectrin dimer self-association. J Clin Invest (1990) 1.41
Identification of human genomic clones coding the major histocompatibility antigens HLA-a2 and HLA-B7 by DNA-mediated gene transfer. Proc Natl Acad Sci U S A (1982) 1.39
New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo. J Clin Invest (1988) 1.36
Structural and functional analysis of a growth-regulated gene, the human calcyclin. J Biol Chem (1987) 1.36
Malignant potential of a cell line isolated from the peripheral blood in infectious mononucleosis. Cancer (1971) 1.36
Sequences of human repetitive DNA, non-alpha-globin genes, and major histocompatibility locus genes. Cold Spring Harb Symp Quant Biol (1983) 1.33
Randomized, multicenter, open-label study of pegfilgrastim compared with daily filgrastim after chemotherapy for lymphoma. J Clin Oncol (2003) 1.32
Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis. Nat Genet (1996) 1.32
A low molecular weight ribonucleic acid synthesized by Escherichia coli in the presence of chloramphenicol: characterization and relation to normally synthesized 5 s ribonucleic acid. J Mol Biol (1971) 1.31
Oligonucleotides produced by digestion of KB cell ribosomal 5 S ribonucleic acid with specific nucleases. J Biol Chem (1968) 1.30
An olfactory receptor gene is located in the extended human beta-globin gene cluster and is expressed in erythroid cells. Genomics (1999) 1.28
A long terminal repeat of the human endogenous retrovirus ERV-9 is located in the 5' boundary area of the human beta-globin locus control region. Genomics (1998) 1.28
An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene. J Biol Chem (1998) 1.27
Amino acid sequences in the alpha 1 domain and not glycosylation are important in HLA-A2/beta 2-microglobulin association and cell surface expression. Mol Cell Biol (1987) 1.26
Molecular genetics of human hemoglobin synthesis. Ann Intern Med (1979) 1.26
Nucleotide sequences of human globin messenger RNA. Proc Natl Acad Sci U S A (1974) 1.26
Randomized trial of peribulbar triamcinolone acetonide with and without focal photocoagulation for mild diabetic macular edema: a pilot study. Ophthalmology (2007) 1.25
Human globin messenger RNA: importance of cloning for structural analysis. Science (1977) 1.25
Sequence and evolution of mouse satellite DNA. J Mol Biol (1978) 1.24
Molecular organization of the class I genes of human major histocompatibility complex. Immunol Rev (1985) 1.24
Delta beta thalassemia and hereditary persistence of fetal hemoglobin. Hematol Oncol Clin North Am (1991) 1.23
Beta II-spectrin (fodrin) and beta I epsilon 2-spectrin (muscle) contain NH2- and COOH-terminal membrane association domains (MAD1 and MAD2). J Biol Chem (1994) 1.23
Nucleotide sequences of human globin messenger RNA. Ann N Y Acad Sci (1974) 1.22
The thalassemias: molecular mechanisms of human genetic disease. Am J Hum Genet (1983) 1.21
Erythroid and nonerythroid spectrins. Blood (1993) 1.21
Beta spectrin in human skeletal muscle. Tissue-specific differential processing of 3' beta spectrin pre-mRNA generates a beta spectrin isoform with a unique carboxyl terminus. J Biol Chem (1990) 1.20
Serial transplantation of Burkitt's tumor (EB3) cells in newborn Syrian hamsters and its facilitation by antilymphocyte serum. Cancer Res (1970) 1.18
Gamma-beta thalassemia: a cause of hemolytic disease of the newborn. N Engl J Med (1972) 1.16
Use of globin cDNA as a hybridization probe for globin mRNA. Ann N Y Acad Sci (1974) 1.16
Structure and polymorphism of class I MHC antigen mRNA. Immunogenetics (1985) 1.14
The gene for the human erythropoietin receptor: analysis of the coding sequence and assignment to chromosome 19p. Blood (1990) 1.12
Molecular characterization of serologic recognition sites in the human HLA-A2 molecule. J Immunol (1988) 1.12
Developmental regulation of human gamma- and beta-globin genes in the absence of the locus control region. Blood (1994) 1.12
Recognition of HLA-A2 and -B7 antigens by cloned cytotoxic T lymphocytes after gene transfer into human and monkey, but not mouse, cells. Proc Natl Acad Sci U S A (1984) 1.11
The question of stemlines in human acute leukemia. Comparison of cells isolated in vitro and in vivo from a patient with acute lymphoblastic leukemia. Exp Cell Res (1970) 1.11