Published in J Pharmacol Exp Ther on November 01, 1981
The effects of dopexamine on the cardiovascular system of the dog. Br J Pharmacol (1985) 1.22
B-HT 958 lowers blood pressure and heart rate in the rat through stimulation of dopamine receptors. Br J Pharmacol (1986) 0.79
Proceedings of the British Pharmacological Society. Abstracts. Br J Pharmacol (1984) 0.75
A new population-enrichment strategy to improve efficiency of placebo-controlled clinical trials of antidepressant drugs. Clin Pharmacol Ther (2010) 2.74
PHARM--an interactive graphic program for individual and population pharmacokinetic parameter estimation. Comput Biol Med (1984) 2.09
IGPHARM: interactive graphic package for pharmacokinetic analysis. Comput Biomed Res (1978) 1.71
The potassium channel opener cromakalim (BRL 34915) activates ATP-dependent K+ channels in isolated cardiac myocytes. Biochem Biophys Res Commun (1988) 1.65
Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline. Br J Clin Pharmacol (1975) 1.63
A two-step iterative algorithm for estimation in nonlinear mixed-effect models with an evaluation in population pharmacokinetics. J Biopharm Stat (1995) 1.54
Joint modeling of efficacy, dropout, and tolerability in flexible-dose trials: a case study in depression. Clin Pharmacol Ther (2012) 1.41
Role of the central autonomic nervous system in the hypotension and bradycardia induced by (-)-delta 9-trans-tetrahydrocannabinol. J Pharm Pharmacol (1974) 1.40
Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. Clin Pharmacokinet (1976) 1.25
Differential effects of prazosin on the pre- and postsynaptic alpha-adrenoceptors in the rat and dog [proceedings]. Br J Pharmacol (1977) 1.15
Effects of prazosin and phentolamine on cardiac presynaptic alpha-adrenoceptors in the cat, dog and rat. Clin Exp Hypertens (1978) 1.15
Influence of age on mianserin pharmacokinetics. Psychopharmacology (Berl) (1982) 1.13
Studies on the mechanism of the vasodilator effects of prazosin in dogs and rabbits. Eur J Pharmacol (1978) 1.13
Cardiovascular effects of prazosin in dogs. Clin Sci Mol Med Suppl (1976) 1.09
Potassium channel openers act through an activation of ATP-sensitive K+ channels in guinea-pig cardiac myocytes. Pflugers Arch (1989) 1.07
Preliminary studies on SL 75212, a new potent cardioselective beta-adrenoceptor antagonist [proceedings]. Br J Pharmacol (1979) 1.06
The pharmacology of prazosin, a novel antihypertensive agent. Life Sci (1980) 1.03
Cardiovascular characterization of DA-1 and DA-2 dopamine receptor agonists in anesthetized rats. Clin Exp Hypertens A (1987) 1.01
Urethane inhibits cardiovascular responses mediated by the stimulation of alpha-2 adrenoceptors in the rat. J Pharmacol Exp Ther (1982) 1.00
Pharmacological evidence for a role of ATP-dependent potassium channels in myocardial stunning. Circulation (1992) 0.99
The new K+ channel opener Aprikalim (RP 52891) reduces experimental infarct size in dogs in the absence of hemodynamic changes. J Pharmacol Exp Ther (1991) 0.98
Adaptive-optimal design in PET occupancy studies. Clin Pharmacol Ther (2010) 0.96
K+ channel openers and 'natural' cardioprotection. Trends Pharmacol Sci (1992) 0.95
Peripheral dopamine receptors, potential targets for a new class of antihypertensive agents. Part I: Subclassification and functional description. Life Sci (1982) 0.95
"Calcium antagonists": a class of drugs with a bright future. Part II. Determination of basic pharmacological properties. Life Sci (1984) 0.95
Steady-state pharmacokinetics of ciprofloxacin in plasma from patients with nosocomial pneumonia: penetration of the bronchial mucosa. Antimicrob Agents Chemother (1991) 0.93
Vasodilator activity of endothelin-1 and endothelin-3: rapid development of cross-tachyphylaxis and dependence on the rate of endothelin administration. J Pharmacol Exp Ther (1990) 0.93
Cellular pharmacology of potassium channel openers in vascular smooth muscle. Cardiovasc Res (1994) 0.93
Hemodynamic and pharmacological evaluation of the vasodilator and vasoconstrictor effects of endothelin-1 in rats. J Pharmacol Exp Ther (1990) 0.93
The effects of prazosin on the clonidine induced hypotension and bradycardia in rats and sedation in chicks [proceedings]. Br J Pharmacol (1978) 0.92
Time-course analysis of the cardiovascular effects of clonidine resulting from the activation of cardiac pre- and vascular postsynaptic alpha-adrenoceptors in the pithed rat [proceedings]. Br J Pharmacol (1978) 0.92
Nicorandil attenuates myocardial dysfunction associated with transient ischemia by opening ATP-dependent potassium channels. J Cardiovasc Pharmacol (1992) 0.91
Studies on the bradycardia induced by (-)- -trans-tetrahydrocannabinol in anesthetized dogs. Eur J Pharmacol (1973) 0.91
Comparative analysis of beta-1 adrenoceptor agonist and antagonist potency and selectivity of cicloprolol, xamoterol and pindolol. J Pharmacol Exp Ther (1987) 0.90
Systemic and regional hemodynamic characterization of alpha-1 and alpha-2 adrenoceptor agonists in pithed rats. J Pharmacol Exp Ther (1987) 0.89
"Calcium antagonists": a class of drugs with a bright future. Part I. Cellular calcium homeostasis and calcium as a coupling messenger. Life Sci (1983) 0.89
Effects of mianserin, desipramine and maprotiline on blood pressure responses evoked by acetylcholine, histamine and 5-hydroxytryptamine in rats. Br J Pharmacol (1981) 0.89
Pharmacokinetics and pharmacodynamics of vecuronium (ORG NC 45) in patients with cirrhosis. Anesthesiology (1985) 0.89
Studies on the rebound hypertension after clonidine withdrawal in conscious hypertensive cats, rats, and dogs [proceedings]. Br J Pharmacol (1977) 0.89
High affinity specific binding sites for tritiated platelet-activating factor in canine platelet membranes: counterparts of platelet-activating factor receptors mediating platelet aggregation. Mol Pharmacol (1988) 0.89
Recent developments in noradrenergic neurotransmission and its relevance to the mechanism of action of certain antihypertensive agents. Hypertension (1980) 0.88
Rat juxtaglomerular cells are endowed with DA-1 dopamine receptors mediating renin release. J Cardiovasc Pharmacol (1988) 0.88
Frequency-independent blockade of cardiac Na+ channels by riluzole: comparison with established anticonvulsants and class I anti-arrhythmics. Fundam Clin Pharmacol (2000) 0.88
Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin. J Pharmacol Exp Ther (1991) 0.88
Diltiazem protects the isolated rabbit heart from the mechanical and ultrastructural damage produced by transient hypoxia, low-flow ischemia and exposure to Ca++-free medium. J Pharmacol Exp Ther (1983) 0.87
A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia. Eur J Clin Pharmacol (1981) 0.87
The contribution of guanylate cyclase stimulation and K+ channel opening to nicorandil-induced vasorelaxation depends on the conduit vessel and on the nature of the spasmogen. J Pharmacol Exp Ther (1994) 0.87
Sulpiride pharmacokinetics in humans after intramuscular administration at three dose levels. J Pharm Sci (1984) 0.87
RP 55778, a PAF receptor antagonist, prevents and reverses LPS-induced hemoconcentration and TNF release. J Lipid Mediat (1992) 0.87
Hemodynamic and myocardial effects of (-)-delta9-trans-tetrahydrocannabinol in anesthetized dogs. Eur J Pharmacol (1973) 0.87
Endothelin--a new family of endothelium-derived peptides with widespread biological properties. Life Sci (1989) 0.87
Vascular beta-adrenoceptor stimulating properties of phenylephrine. Eur J Pharmacol (1977) 0.86
Cardiovascular and biological effects of K+ channel openers, a class of drugs with vasorelaxant and cardioprotective properties. Life Sci (1990) 0.86
Bayesian estimate of vinorelbine pharmacokinetic parameters in elderly patients with advanced metastatic cancer. Clin Cancer Res (2000) 0.85
Pharmacokinetics of propranolol in normal healthy volunteers. J Pharmacokinet Biopharm (1977) 0.85
Influence of depolarization on vasorelaxant potency and efficacy of Ca2+ entry blockers, K+ channel openers, nitrate derivatives, salbutamol and papaverine in rat aortic rings. Naunyn Schmiedebergs Arch Pharmacol (1998) 0.85
Endotracheal and aerosol administrations of ceftazidime in patients with nosocomial pneumonia: pharmacokinetics and absolute bioavailability. Antimicrob Agents Chemother (1992) 0.85
Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man. Br J Clin Pharmacol (1980) 0.84
RP 58866 and its active enantiomer RP 62719 (terikalant): blockers of the inward rectifier K+ current acting as pure class III antiarrhythmic agents. J Cardiovasc Pharmacol (1992) 0.84
Circadian rhythm of 5-fluorouracil population pharmacokinetics in patients with metastatic colorectal cancer. Cancer Chemother Pharmacol (1999) 0.84
Increase in plasma renin activity evoked by fenoldopam in dogs is directly mediated by dopamine1 receptor stimulation. J Cardiovasc Pharmacol (1989) 0.84
Functional and biochemical evidence for the lack of cardiac presynaptic alpha-2 adrenoceptor stimulant properties of cirazoline (LD 3098), a potent alpha-1 adrenoceptor agonist in dogs and rats. J Pharmacol Exp Ther (1982) 0.84
Regional distribution and pharmacological characterization of [125I]endothelin-1 binding sites in human fetal placental vessels. Placenta (1991) 0.84
Inhibition of platelet adhesion to fibrin(ogen) in flowing whole blood by Arg-Gly-Asp and fibrinogen gamma-chain carboxy terminal peptides. Thromb Haemost (1992) 0.84
Effects of Ca2+ antagonists and K+-channel activators on K+-induced contractions in the rat aorta. J Auton Pharmacol (1989) 0.84
Differential inhibition of vascular smooth muscle responses to alpha 1- and alpha 2-adrenoceptor agonists by diltiazem and verapamil. Circ Res (1983) 0.84
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers. Br J Clin Pharmacol (1980) 0.83
Glibenclamide-induced blockade of ischemic preconditioning is time dependent in intact rat heart. Am J Physiol (1997) 0.83
Effects of clonidine, prazosin and phentolamine on heart rate and coronary sinus catecholamine concentration during cardioaccelerator nerve stimulation in spinal dogs. Br J Pharmacol (1979) 0.83
Effects of the K+ channel activators, RP 52891, cromakalim and diazoxide, on the plasma insulin level, plasma renin activity and blood pressure in rats. J Pharmacol Exp Ther (1991) 0.82
Certain observations on interrelationships between respiratory and cardiovascular effects of (-)- 9 -trans-tetrahydrocannabinol. Res Commun Chem Pathol Pharmacol (1972) 0.82
SK&F 87516, a close analog of fenoldopam, is a partial agonist at dopamine-1 and alpha-2 receptors and produces stimulation of 5-hydroxytryptamine-2 receptors in the cardiovascular system of the rat. J Pharmacol Exp Ther (1991) 0.82
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocker SL 75212 in healthy volunteers [proceedings]. Br J Clin Pharmacol (1979) 0.82
Activation of cardiac KATP channels: an endogenous protective mechanism during repetitive ischemia. Am J Physiol (1993) 0.82
The blood pressure lowering effects of intravenous versus intracerebroventricular prazosin in anaesthetised cats. Eur J Pharmacol (1978) 0.82
A Kinetic Model for Simultaneous Fit of Clozapine and Norclozapine Concentrations in Chronic Schizophrenic Patients during Long-Term Treatment. Clin Drug Investig (1998) 0.82
Characterization of NK1 and NK2 tachykinin receptors in guinea-pig and rat bronchopulmonary and vascular systems. Br J Pharmacol (1994) 0.81
Influence of pentobarbital anesthesia on the effects of certain autonomic blocking agents on heart rate. Eur J Pharmacol (1973) 0.81
Comparison of single-dose pharmacokinetics of imipramine and maprotiline in the elderly. Psychopharmacology (Berl) (1980) 0.81
Role of the sympathetic nervous system in blood pressure maintenance and in the antihypertensive effects of calcium antagonists in spontaneously hypertensive rats. Hypertension (1988) 0.81
Comparison of mianserin with desipramine, maprotiline and phentolamine on cardiac presynaptic and vascular postsynaptic alpha-adrenoceptors and noradrenaline reuptake in pithed normotensive rats. Br J Pharmacol (1980) 0.81
PAF binding sites. Characterization by [3H]52770 RP, a pyrrolo[1,2-c]thiazole derivative, in rabbit platelets. Biochem Pharmacol (1987) 0.81
Model-based approach and signal detection theory to evaluate the performance of recruitment centers in clinical trials with antidepressant drugs. Clin Pharmacol Ther (2008) 0.81
Population pharmacokinetics of mycophenolic acid in kidney transplant pediatric and adolescent patients. Ther Drug Monit (2005) 0.81
[3H]52770 RP, a platelet-activating factor receptor antagonist, and tritiated platelet-activating factor label a common specific binding site in human polymorphonuclear leukocytes. J Pharmacol Exp Ther (1988) 0.81
Contractile responses to calcium chloride in rat aortic rings bathed in K+-free solution are resistant to organic calcium antagonists. Br J Pharmacol (1989) 0.81