Published in J Biol Chem on January 10, 1984
Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication. Proc Natl Acad Sci U S A (1986) 5.59
Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol Rev (1992) 5.15
Dynamic fatty acylation of p21N-ras. EMBO J (1987) 2.99
Expression and immunological properties of the five subunits of pertussis toxin. Infect Immun (1987) 2.59
Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes. Proc Natl Acad Sci U S A (1987) 2.53
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A (1984) 2.12
GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.09
Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A (1986) 2.03
Promoter of the pertussis toxin operon and production of pertussis toxin. J Bacteriol (1987) 1.98
Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proc Natl Acad Sci U S A (1986) 1.98
Stimulation of phospholipase A2 activity in bovine rod outer segments by the beta gamma subunits of transducin and its inhibition by the alpha subunit. Proc Natl Acad Sci U S A (1987) 1.94
Subunit S1 of pertussis toxin: mapping of the regions essential for ADP-ribosyltransferase activity. Proc Natl Acad Sci U S A (1988) 1.61
Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells. Proc Natl Acad Sci U S A (1985) 1.59
Guanine nucleotide binding protein involvement in early steps of phytochrome-regulated gene expression. Proc Natl Acad Sci U S A (1993) 1.56
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. J Exp Med (1985) 1.54
Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts. EMBO J (1986) 1.40
Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems. Proc Natl Acad Sci U S A (1986) 1.35
Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes. Biochem J (1985) 1.35
Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C. Proc Natl Acad Sci U S A (1986) 1.28
Pertussis toxin inhibition of chemotaxis and the ADP-ribosylation of a membrane protein in a human-mouse hybrid cell line. Proc Natl Acad Sci U S A (1985) 1.24
cDNA-derived amino acid sequence of the gamma subunit of GTPase from bovine rod outer segments. Proc Natl Acad Sci U S A (1985) 1.21
Transducin-alpha C-terminal mutations prevent activation by rhodopsin: a new assay using recombinant proteins expressed in cultured cells. EMBO J (1995) 1.18
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. Proc Natl Acad Sci U S A (1984) 1.16
Maintenance of biological activity of pertussis toxin radioiodinated while bound to fetuin-agarose. Infect Immun (1987) 1.14
Molecular model of the G protein alpha subunit based on the crystal structure of the HRAS protein. Proc Natl Acad Sci U S A (1989) 1.14
Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h. Proc Natl Acad Sci U S A (1986) 1.05
G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate. Biochem J (1986) 1.05
The nature and origin of spontaneous noise in G protein-gated ion channels. J Gen Physiol (1991) 1.04
Intestinal brush border membranes contain regulatory subunits of adenylyl cyclase. Proc Natl Acad Sci U S A (1987) 1.03
Cholera toxin inhibits chemotaxis by a cAMP-independent mechanism. Proc Natl Acad Sci U S A (1985) 1.01
2-Azido-[32P]NAD+, a photoactivatable probe for G-protein structure: evidence for holotransducin oligomers in which the ADP-ribosylated carboxyl terminus of alpha interacts with both alpha and gamma subunits. Proc Natl Acad Sci U S A (1990) 1.00
Regulation of glucose carrier activity by AlCl3 and phospholipase C in fat-cells. Biochem J (1988) 0.95
Drosophila stimulatory G protein alpha subunit activates mammalian adenylyl cyclase but interacts poorly with mammalian receptors: implications for receptor-G protein interaction. Proc Natl Acad Sci U S A (1991) 0.92
Pasteurella multocida toxin as a tool for studying Gq signal transduction. Rev Physiol Biochem Pharmacol (2004) 0.88
Analysis of the receptor binding domain of Gpa1p, the G(alpha) subunit involved in the yeast pheromone response pathway. Mol Cell Biol (1997) 0.85
Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. Biochem J (1988) 0.85
Pleiotropic Effects of Bitter Taste Receptors on [Ca2+]i Mobilization, Hyperpolarization, and Relaxation of Human Airway Smooth Muscle Cells. PLoS One (2015) 0.85
Selective inactivation of guanine-nucleotide-binding regulatory protein (G-protein) alpha and betagamma subunits by urea. Biochem J (2001) 0.83
Side chain specificity of ADP-ribosylation by a sirtuin. FEBS J (2009) 0.83
Light-dependent GTP-binding proteins in squid photoreceptors. Biochem J (1990) 0.82
Effects of Bordetella pertussis toxin on catecholamine inhibition of insulin release from intact and electrically permeabilized rat islets. Biochem J (1989) 0.81
Identification of the probable site of choleragen-catalyzed ADP-ribosylation in a Go alpha-like protein based on cDNA sequence. Proc Natl Acad Sci U S A (1986) 0.81
Incorporation of analogues of GTP and GDP into rod photoreceptors isolated from the tiger salamander. J Physiol (1988) 0.80
Comparative analysis of cone and rod transducins using chimeric Gα subunits. Biochemistry (2012) 0.80
Microsomal and cytosolic fractions of guinea pig hepatocytes contain 100-kilodalton GTP-binding proteins reactive with antisera against alpha subunits of stimulatory and inhibitory heterotrimeric GTP-binding proteins. Proc Natl Acad Sci U S A (1990) 0.79
Dominant negative mutants of transducin-alpha that block activated receptor. Biochemistry (2006) 0.78
Effects of phospholipids and ADP-ribosylation on GTP hydrolysis by Escherichia coli-synthesized Ha-ras-encoded p21. Proc Natl Acad Sci U S A (1985) 0.77
Pertussis toxin substrate is a guanosine 5'-[beta-thio]diphosphate-, N-ethylmaleimide-, Mg2+- and temperature-sensitive GTP-binding protein. Biochem J (1985) 0.77
A novel 100 kDa protein, localized to receptor-enriched endosomes, is immunologically related to the signal-transducing guanine-nucleotide-binding proteins Gt and Gi. Biochem J (1990) 0.77
Signaling states of rhodopsin in rod disk membranes lacking transducin βγ-complex. Invest Ophthalmol Vis Sci (2012) 0.76
Inhibition of the GTPase activity of transducin by an NAD+:arginine ADP-ribosyltransferase from turkey erythrocytes. Biochem J (1987) 0.75
Role of the N-terminal region in covalent modification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: comparison of phosphorylation and ADP-ribosylation. Biochem J (1995) 0.75
Light-directed, spatially addressable parallel chemical synthesis. Science (1991) 15.09
Energy transfer: a spectroscopic ruler. Proc Natl Acad Sci U S A (1967) 11.78
Fluorescence energy transfer as a spectroscopic ruler. Annu Rev Biochem (1978) 11.41
An evolutionary trace method defines binding surfaces common to protein families. J Mol Biol (1996) 9.31
The interaction of a naphthalene dye with apomyoglobin and apohemoglobin. A fluorescent probe of non-polar binding sites. J Mol Biol (1965) 7.87
Nature and rates of adverse reactions associated with DTP and DT immunizations in infants and children. Pediatrics (1981) 7.58
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science (2000) 6.93
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate. Science (1992) 6.72
Cyclic GMP cascade of vision. Annu Rev Neurosci (1986) 6.06
G proteins: a family of signal transducers. Annu Rev Cell Biol (1986) 5.38
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours. Nature (1989) 5.03
Statistical distributions of nucleosomes: nonrandom locations by a stochastic mechanism. Nucleic Acids Res (1988) 4.92
Flow of information in the light-triggered cyclic nucleotide cascade of vision. Proc Natl Acad Sci U S A (1981) 4.87
Two G protein oncogenes in human endocrine tumors. Science (1990) 4.46
Modulation of inflammation and immunity by cyclic AMP. Science (1974) 4.31
Surface density determination in membranes by fluorescence energy transfer. Biochemistry (1978) 4.13
Fluorescence spectroscopy of proteins. Science (1968) 3.96
Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha. Nature (1993) 3.57
Extracytoplasmic adenylate cyclase of Bordetella pertussis. Proc Natl Acad Sci U S A (1976) 3.57
The role of cyclic 3',5' adenosine monophosphate in the specific cytolytic activity of lymphocytes. J Immunol (1972) 3.51
Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol (1999) 3.45
Fluorescence studies of nucleotides and polynucleotides. I. Formycin, 2-aminopurine riboside, 2,6-diaminopurine riboside, and their derivatives. J Biol Chem (1969) 3.39
Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions. Nature (1988) 3.37
Molecular mechanics of calcium-myristoyl switches. Nature (1997) 3.36
Pertussis toxin. Affinity purification of a new ADP-ribosyltransferase. J Biol Chem (1983) 3.31
The dimeric nature of the gramicidin A transmembrane channel: conductance and fluorescence energy transfer studies of hybrid channels. J Mol Biol (1977) 3.27
Recoverin: a calcium sensitive activator of retinal rod guanylate cyclase. Science (1991) 3.27
Calmodulin trapping by calcium-calmodulin-dependent protein kinase. Science (1992) 3.26
Activation of the cloned muscarinic potassium channel by G protein beta gamma subunits. Nature (1994) 3.21
Highly cooperative opening of calcium channels by inositol 1,4,5-trisphosphate. Science (1988) 3.07
Calcium spiking. Annu Rev Biophys Biophys Chem (1991) 3.06
Subnanosecond motions of tryptophan residues in proteins. Proc Natl Acad Sci U S A (1979) 3.06
A spin-labeled hapten. Proc Natl Acad Sci U S A (1965) 3.02
Molecular model for receptor-stimulated calcium spiking. Proc Natl Acad Sci U S A (1988) 3.00
Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments. Proc Natl Acad Sci U S A (1980) 3.00
Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals. Neuron (1994) 3.00
Segmental flexibility in an antibody molecule. J Mol Biol (1970) 2.92
Separation and purification of the hemagglutinins from Bordetella pertussis. Infect Immun (1983) 2.85
Role of antibody to leukocytosis-promoting factor hemagglutinin and to filamentous hemagglutinin in immunity to pertussis. Infect Immun (1981) 2.77
Cyanobacterial phycobilisomes. Characterization of the phycobilisomes of Synechococcus sp. 6301. J Biol Chem (1978) 2.73
Fluorescent phycobiliprotein conjugates for analyses of cells and molecules. J Cell Biol (1982) 2.73
Pharmacologic control of allergic histamine release in vitro: evidence for an inhibitory role of 3',5'-adenosine monophosphate in human leukocytes. J Immunol (1972) 2.70
Retinal has a highly dipolar vertically excited singlet state: implications for vision. Proc Natl Acad Sci U S A (1976) 2.68
Hormonal stimulation of adenylyl cyclase through Gi-protein beta gamma subunits. Nature (1992) 2.62
Dynamics of a chemoattractant receptor in living neutrophils during chemotaxis. Mol Biol Cell (1999) 2.61
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol (2000) 2.59
Single-molecule fluorescence detection: autocorrelation criterion and experimental realization with phycoerythrin. Proc Natl Acad Sci U S A (1989) 2.55
Rhodopsin activation blocked by metal-ion-binding sites linking transmembrane helices C and F. Nature (1996) 2.55
Identification of a 69-kilodalton nonfimbrial protein as an agglutinogen of Bordetella pertussis. Infect Immun (1988) 2.55
Gating kinetics of the cyclic-GMP-activated channel of retinal rods: flash photolysis and voltage-jump studies. Proc Natl Acad Sci U S A (1988) 2.53
Gramicidin A crystals contain two cation binding sites per channel. Nature (1979) 2.53
Histamine augments leukocyte adenosine 3',5'-monophosphate and blocks antigenic histamine release. Science (1971) 2.47
Sequestration of the membrane-targeting myristoyl group of recoverin in the calcium-free state. Nature (1995) 2.43
Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies. EMBO J (1988) 2.40
Lipid modifications of trimeric G proteins. J Biol Chem (1995) 2.39
Rapid GDP release from Gs alpha in patients with gain and loss of endocrine function. Nature (1994) 2.36
Cyclic 3',5'-adenosine monophosphate in the human lukocyte: synthesis, degradation, andeffects n neutrophil candidacidal activity. J Clin Invest (1971) 2.35
Structural elements of G alpha subunits that interact with G beta gamma, receptors, and effectors. Cell (1993) 2.34
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
Aerosol infection of mice with Bordetella pertussis. Infect Immun (1980) 2.31
A guanine nucleotide-sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae. J Biol Chem (1983) 2.31
Kinetics of calcium channel opening by inositol 1,4,5-trisphosphate. Biochemistry (1990) 2.30
Activation and depalmitoylation of Gs alpha. Cell (1994) 2.29
Phase-shift markers in Bordetella: alterations in envelope proteins. J Infect Dis (1981) 2.23
Correlation between segmental flexibility and effector function of antibodies. Nature (1984) 2.22
Filamentous hemagglutinin has a major role in mediating adherence of Bordetella pertussis to human WiDr cells. Infect Immun (1986) 2.18
Transient calcium release induced by successive increments of inositol 1,4,5-trisphosphate. Proc Natl Acad Sci U S A (1990) 2.18
Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin. J Biol Chem (1984) 2.17
Purification and characterization of the gamma regulatory subunit of the cyclic GMP phosphodiesterase from retinal rod outer segments. J Biol Chem (1982) 2.16
Effects of cholera enterotoxin on adenosine 3',5'-monophosphate and neutrophil function. Comparison with other compounds which stimulate leukocyte adenyl cyclase. J Clin Invest (1973) 2.16
Rapid-flow resonance Raman spectroscopy of photolabile molecules: rhodopsin and isorhodopsin. Proc Natl Acad Sci U S A (1976) 2.14
Genetic evidence that cholera toxin substrates are regulatory components of adenylate cyclase. J Biol Chem (1978) 2.12
Separate GTP binding and GTPase activating domains of a G alpha subunit. Science (1993) 2.08
Interaction of hydrolysis-resistant analogs of cyclic GMP with the phosphodiesterase and light-sensitive channel of retinal rod outer segments. Proc Natl Acad Sci U S A (1985) 2.04
Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains. Proc Natl Acad Sci U S A (1986) 2.03
Adenyl cyclase in human leukocytes: evidence for activation by separate beta adrenergic and prostaglandin receptors. J Pharmacol Exp Ther (1971) 2.02
Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. J Biol Chem (1993) 2.02
Helical channels in crystals of gramicidin A and of a cesium--gramicidin A complex: an x-ray diffraction study. J Mol Biol (1978) 2.01
Receptors induce chemotaxis by releasing the betagamma subunit of Gi, not by activating Gq or Gs. Proc Natl Acad Sci U S A (1997) 1.99
cAMP and beta gamma subunits of heterotrimeric G proteins stimulate the mitogen-activated protein kinase pathway in COS-7 cells. J Biol Chem (1994) 1.98
Calcium-myristoyl protein switch. Proc Natl Acad Sci U S A (1992) 1.98
Hemolytic plaque formation by leukocytes in vitro. Control by vasoactive hormones. J Clin Invest (1974) 1.98
Protective activities of the filamentous hemagglutinin and the lymphocytosis-promoting factor of Bordetella pertussis in mice. J Infect Dis (1984) 1.96
Mutations in the GTP-binding site of GS alpha alter stimulation of adenylyl cyclase. J Biol Chem (1989) 1.95
Effects of cholera toxin on in vitro models of immediate and delayed hypersensitivity. Further evidence for the role of cyclic adenosine 3',5'-monophosphate. J Clin Invest (1973) 1.94
Sensitivity and specificity of clinical case definitions for pertussis. Am J Public Health (1988) 1.93
Comparison of type 2 and type 6 fimbriae of Bordetella pertussis by using agglutinating monoclonal antibodies. Infect Immun (1988) 1.92
Activation of the alpha subunit of Gs in intact cells alters its abundance, rate of degradation, and membrane avidity. J Cell Biol (1992) 1.88
Lectin-like binding of pertussis toxin to a 165-kilodalton Chinese hamster ovary cell glycoprotein. J Biol Chem (1988) 1.88
Mutant alpha subunits of Gi2 inhibit cyclic AMP accumulation. Nature (1991) 1.87
Fluorescent probes of biological membranes. Proc Natl Acad Sci U S A (1970) 1.87
Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart. J Clin Invest (1988) 1.85
ADP-ribosylation of membrane components by pertussis and cholera toxin. Methods Enzymol (1985) 1.84
Intracellular localization of the dermonecrotic toxin of Bordetella pertussis. Infect Immun (1979) 1.83
Fluorescence energy transfer in the rapid-diffusion limit. Proc Natl Acad Sci U S A (1978) 1.83