Published in Nature on August 12, 1982
Transcriptional induction of two genes in human cells by beta interferon. Proc Natl Acad Sci U S A (1984) 4.84
A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma. Proc Natl Acad Sci U S A (1985) 3.80
Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proc Natl Acad Sci U S A (1985) 3.76
Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. Proc Natl Acad Sci U S A (1986) 3.22
yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family. Proc Natl Acad Sci U S A (1986) 3.19
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul (1991) 2.88
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells. Mol Cell Biol (1983) 2.70
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc Natl Acad Sci U S A (1982) 2.40
Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes. J Clin Invest (1987) 2.36
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. Mol Cell Biol (1988) 2.31
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1984) 2.28
Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis. Proc Natl Acad Sci U S A (1984) 2.23
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts. J Cell Biol (1984) 2.12
Cell surface expression of v-fms-coded glycoproteins is required for transformation. Mol Cell Biol (1984) 2.09
A protein kinase from Xenopus eggs specific for ribosomal protein S6. Proc Natl Acad Sci U S A (1985) 2.03
Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity. J Virol (1984) 1.93
pp60c-src in the developing cerebellum. Mol Cell Biol (1985) 1.90
Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3. EMBO J (1988) 1.86
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1. EMBO J (1989) 1.81
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proc Natl Acad Sci U S A (1992) 1.79
Covalently bound myristate in a lymphoma tyrosine protein kinase. Proc Natl Acad Sci U S A (1984) 1.76
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity. J Clin Invest (1986) 1.67
Role of insulin-induced reactive oxygen species in the insulin signaling pathway. Antioxid Redox Signal (2005) 1.60
Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues. Proc Natl Acad Sci U S A (1987) 1.53
Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase. Proc Natl Acad Sci U S A (1983) 1.49
Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta. Proc Natl Acad Sci U S A (1984) 1.49
Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines. EMBO J (1987) 1.45
Mouse NIH 3T3 cells expressing human colony-stimulating factor 1 (CSF-1) receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor. Proc Natl Acad Sci U S A (1989) 1.39
Tyrosyl protein kinases in normal rat liver: identification and partial characterization. Proc Natl Acad Sci U S A (1983) 1.35
p60c-src is complexed with a cellular protein in subcellular compartments involved in exocytosis. J Cell Biol (1988) 1.33
Protein kinase activity of the insulin receptor. Biochem J (1986) 1.31
Early changes in inositol lipids and their metabolites induced by platelet-derived growth factor in quiescent Swiss mouse 3T3 cells. Biochem J (1985) 1.29
Protein stabilization explains the gag requirement for transformation of lymphoid cells by Abelson murine leukemia virus. J Virol (1985) 1.29
Heparin-binding growth factor 1 stimulates tyrosine phosphorylation in NIH 3T3 cells. Mol Cell Biol (1989) 1.29
Phosphorylation of ribosomal protein S6 on serine after microinjection of the Abelson murine leukemia virus tyrosine-specific protein kinase into Xenopus oocytes. Proc Natl Acad Sci U S A (1985) 1.23
Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts. Biochem J (1986) 1.23
Receptor tyrosine kinases: legacy of the first two decades. Cold Spring Harb Perspect Biol (2014) 1.23
HLA-A2 and HLA-B7 antigens are phosphorylated in vitro by rous sarcoma virus kinase (pp60v-src) at a tyrosine residue encoded in a highly conserved exon of the intracellular domain. Proc Natl Acad Sci U S A (1983) 1.20
Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest (1988) 1.18
Antibodies of predetermined specificity detect two retroviral oncogene products and inhibit their kinase activities. Proc Natl Acad Sci U S A (1983) 1.17
Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells. Biochem J (1988) 1.17
Identification, purification, and characterization of phosphotyrosine-specific protein phosphatases from cultured chicken embryo fibroblasts. Mol Cell Biol (1984) 1.16
Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide. Proc Natl Acad Sci U S A (1987) 1.15
Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase. Biochem J (1985) 1.15
Epidermal growth factor mimics insulin effects in rat hepatocytes. Biochem J (1986) 1.14
Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments. Biochem J (1987) 1.10
Two systems in vitro that show insulin-stimulated serine kinase activity towards the insulin receptor. Biochem J (1988) 1.10
pp60c-src is expressed in human fetal and adult brain. Am J Pathol (1985) 1.06
Identification of the human pim-1 gene product as a 33-kilodalton cytoplasmic protein with tyrosine kinase activity. Mol Cell Biol (1988) 1.05
Two different protein kinase activities are associated with the insulin receptor. Biochem J (1983) 1.04
The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor. Proc Natl Acad Sci U S A (1985) 1.03
Identification of the tyrosine protein kinase from LSTRA cells by use of site-specific antibodies. Proc Natl Acad Sci U S A (1984) 1.01
Catecholamines are mitogenic in 3T3 and bovine aortic endothelial cells. J Clin Invest (1984) 1.01
Evidence that a novel serine kinase catalyses phosphorylation of the insulin receptor in an insulin-dependent and tyrosine kinase-dependent manner. Biochem J (1988) 1.01
Two types of receptor for insulin-like growth factors in mammalian brain. EMBO J (1985) 0.99
Insulin-receptor phosphotyrosyl-protein phosphatases. Biochem J (1988) 0.98
Phorbol esters potentiate tyrosine phosphorylation of epidermal growth factor receptors in A431 membranes by a calcium-independent mechanism. Proc Natl Acad Sci U S A (1984) 0.98
Dephosphorylation of insulin-receptor autophosphorylation sites by particulate and soluble phosphotyrosyl-protein phosphatases. Biochem J (1990) 0.97
Epidermal growth factor counteracts the glycogenic effect of insulin in parenchymal hepatocyte cultures. Biochem J (1987) 0.96
Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction. Metabolism (2009) 0.95
Identification of phosphorylated 422(aP2) protein as pp15, the 15-kilodalton target of the insulin receptor tyrosine kinase in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (1988) 0.93
Embryonal carcinoma-derived growth factor activates protein kinase C in vivo and in vitro. EMBO J (1987) 0.92
Phosphorylation differences among proteins of bloodstream developmental stages of Trypanosoma brucei brucei. Biochem J (1991) 0.92
Transmembrane signaling of interleukin 2 receptor. Conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules. J Exp Med (1987) 0.91
Colony-stimulating factor 1-mediated regulation of a chimeric c-fms/v-fms receptor containing the v-fms-encoded tyrosine kinase domain. Proc Natl Acad Sci U S A (1988) 0.91
Insulin resistance, selfish brain, and selfish immune system: an evolutionarily positively selected program used in chronic inflammatory diseases. Arthritis Res Ther (2014) 0.91
Phosphorylation of human growth hormone by the epidermal growth factor-stimulated tyrosine kinase. Proc Natl Acad Sci U S A (1983) 0.90
Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes. J Clin Invest (1987) 0.90
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Res (2014) 0.90
Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line. J Cell Biol (1984) 0.89
Calcium-dependence of insulin receptor phosphorylation. Biochem J (1983) 0.89
Progesterone receptor subunits are high-affinity substrates for phosphorylation by epidermal growth factor receptor. Proc Natl Acad Sci U S A (1984) 0.88
Appropriate glycosylation of the fms gene product is a prerequisite for its transforming potency. EMBO J (1986) 0.87
Antibodies to two defined regions of the transforming protein pp60src interact specifically with the epidermal growth factor receptor kinase system. Proc Natl Acad Sci U S A (1984) 0.86
Landmarks in insulin research. Front Endocrinol (Lausanne) (2011) 0.86
Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing. J Clin Invest (1983) 0.85
Differential sensitivity of the insulin-receptor kinase to thiol and oxidizing agents in the absence and presence of insulin. Biochem J (1987) 0.84
Partial purification and characterization of a pp60v-src-related tyrosine kinase from bovine brain. Proc Natl Acad Sci U S A (1985) 0.83
Identification of the alpha beta monomer of the adipocyte insulin receptor by insulin binding and autophosphorylation. Proc Natl Acad Sci U S A (1984) 0.82
Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK. Am J Physiol Cell Physiol (2011) 0.81
An insulin-sensitive cytosolic protein kinase accounts for the regulation of ATP citrate-lyase phosphorylation. Biochem J (1990) 0.80
Trifluoperazine inhibits insulin action on glucose metabolism in fat cells without affecting inhibition of lipolysis. Proc Natl Acad Sci U S A (1984) 0.80
Disulphide reduction alters the immunoreactivity and increases the affinity of insulin-like growth-factor-I receptors in human placenta. Biochem J (1986) 0.79
Novel link between inflammation, endothelial dysfunction, and muscle insulin resistance. Diabetes (2013) 0.78
Antibodies to insulin receptor tyrosine kinase stimulate its activity towards exogenous substrates without inducing receptor autophosphorylation. Biochem J (1989) 0.78
Mathematical modeling of the insulin signal transduction pathway for prediction of insulin sensitivity from expression data. Mol Genet Metab (2014) 0.78
Evidence that insulin and guanosine triphosphate regulate dephosphorylation of the beta-subunit of the insulin receptor in sarcolemma membranes isolated from skeletal muscle. Biochem J (1986) 0.77
Protein kinase activity associated with the purified rat hepatic glucocorticoid receptor. Proc Natl Acad Sci U S A (1985) 0.76
Decreased insulin binding to mononuclear leucocytes and erythrocytes from dogs after S-nitroso-N-acetypenicillamine administration. BMC Biochem (2002) 0.76
Comparative sequence-structure analysis of Aves insulin. Bioinformation (2015) 0.75
Evidence that a 90-kDa phosphoprotein, an associated kinase, and a specific phosphatase are involved in the regulation of Cloudman melanoma cell proliferation by insulin. Proc Natl Acad Sci U S A (1985) 0.75
Studying the structure of the intracellular moiety of the insulin receptor with a kinase-splitting membranal proteinase. EMBO J (1989) 0.75
Insulin signalling and the regulation of glucose and lipid metabolism. Nature (2001) 16.41
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature (2001) 11.72
Role of brain insulin receptor in control of body weight and reproduction. Science (2000) 8.14
A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell (1998) 8.10
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell (2000) 7.26
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell (1999) 6.53
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature (1994) 6.50
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study. Lancet (1992) 6.28
The insulin signaling system. J Biol Chem (1994) 5.25
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol (1994) 5.13
Monitoring the expression pattern of 1300 Arabidopsis genes under drought and cold stresses by using a full-length cDNA microarray. Plant Cell (2001) 5.11
The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med (1976) 5.09
Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor. Science (1982) 5.01
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med (1990) 4.87
Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol (1987) 4.27
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest (2000) 3.79
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (1985) 3.57
Membrane receptors for hormones and neurotransmitters. J Cell Biol (1976) 3.54
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med (2000) 3.53
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Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet (2001) 3.50
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr Biol (1994) 3.44
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology (2001) 3.40
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest (1999) 3.36
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15
beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass. Nat Genet (2002) 3.12
Quantitative aspects of the insulin-receptor interaction in liver plasma membranes. J Biol Chem (1974) 3.04
PI 3-kinase: structural and functional analysis of intersubunit interactions. EMBO J (1994) 3.02
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
Bidirectional modulation of insulin action by amino acids. J Clin Invest (1998) 2.92
A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem (1988) 2.90
Insulin action and the insulin signaling network. Endocr Rev (1995) 2.89
Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance. J Biol Chem (1973) 2.80
Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle. J Clin Invest (2000) 2.75
Regulation of eIF-4E BP1 phosphorylation by mTOR. J Biol Chem (1997) 2.73
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology (1997) 2.67
Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol (1998) 2.59
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
Rad: a member of the Ras family overexpressed in muscle of type II diabetic humans. Science (1993) 2.57
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
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125I-insulin binding to cultured human lymphocytes. Initial localization and fate of hormone determined by quantitative electron microscopic autoradiography. J Clin Invest (1978) 2.47
A role for phosphoinositide 3-kinase in bacterial invasion. Science (1996) 2.46
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The riddle of tumour hypoglycaemia revisited. Clin Endocrinol Metab (1980) 1.91
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The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J (1992) 1.85
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