Published in Science on January 08, 1982
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol (1994) 5.13
Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proc Natl Acad Sci U S A (1994) 4.08
Phosphorylation activates the insulin receptor tyrosine protein kinase. Proc Natl Acad Sci U S A (1983) 3.94
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest (1994) 3.16
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99
Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest (1995) 2.66
The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease. Philos Trans R Soc Lond B Biol Sci (1998) 2.53
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity. Mol Cell Biol (1986) 2.52
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc Natl Acad Sci U S A (1982) 2.40
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest (1992) 2.31
Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C. Proc Natl Acad Sci U S A (1983) 2.30
Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev (2012) 2.22
The insulin receptor and the molecular mechanism of insulin action. J Clin Invest (1988) 2.17
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc Natl Acad Sci U S A (1984) 2.09
Differential signaling by insulin receptor substrate 1 (IRS-1) and IRS-2 in IRS-1-deficient cells. Mol Cell Biol (1997) 2.02
Monoclonal antibody to the type I insulin-like growth factor (IGF-I) receptor blocks IGF-I receptor-mediated DNA synthesis: clarification of the mitogenic mechanisms of IGF-I and insulin in human skin fibroblasts. Proc Natl Acad Sci U S A (1986) 1.94
Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase. Proc Natl Acad Sci U S A (1984) 1.82
A molecular description of nerve terminal function. Annu Rev Biochem (1983) 1.82
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proc Natl Acad Sci U S A (1992) 1.79
Tyrosine phosphorylated proteins in different tissues during chick embryo development. J Cell Biol (1988) 1.76
Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects. J Clin Invest (1987) 1.76
Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor. Proc Natl Acad Sci U S A (1983) 1.74
Nerve growth factor induces protein-tyrosine phosphorylation. Proc Natl Acad Sci U S A (1988) 1.73
The structure of the human c-fes/fps proto-oncogene. EMBO J (1985) 1.70
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity. J Clin Invest (1986) 1.67
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Invest (2000) 1.67
Insulin-activated tyrosine phosphorylation of a 15-kilodalton protein in intact 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (1987) 1.65
Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc Natl Acad Sci U S A (1988) 1.64
A 20-kDa protein associated with the murine T-cell antigen receptor is phosphorylated in response to activation by antigen or concanavalin A. Proc Natl Acad Sci U S A (1985) 1.62
Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest (1995) 1.61
Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest (1993) 1.61
A molecular mechanism for sensory adaptation based on ligand-induced receptor modification. Proc Natl Acad Sci U S A (1986) 1.56
Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase. Proc Natl Acad Sci U S A (1983) 1.49
Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta. Proc Natl Acad Sci U S A (1984) 1.49
Activation of a ribosomal protein S6 protein kinase in Xenopus oocytes by insulin and insulin-receptor kinase. EMBO J (1986) 1.41
Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus. J Clin Invest (1993) 1.36
Insulin receptor substrate 1 is required for insulin-mediated mitogenic signal transduction. Proc Natl Acad Sci U S A (1994) 1.33
Insulin exerts actions through a distinct species of guanine nucleotide regulatory protein: inhibition of adenylate cyclase. Biochem J (1983) 1.32
Protein kinase activity of the insulin receptor. Biochem J (1986) 1.31
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. Proc Natl Acad Sci U S A (1993) 1.30
Insulin receptor down-regulation is linked to an insulin-induced postreceptor defect in the glucose transport system in rat adipocytes. J Clin Invest (1985) 1.29
Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C. Proc Natl Acad Sci U S A (1986) 1.28
A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes. EMBO J (1989) 1.24
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts. Mol Cell Biol (1984) 1.24
Phosphorylation at a tyrosine residue of lipomodulin in mitogen-stimulated murine thymocytes. Proc Natl Acad Sci U S A (1984) 1.23
Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proc Natl Acad Sci U S A (1987) 1.22
Insulin and growth factors stimulate the phosphorylation of a Mr-22000 protein in 3T3-L1 adipocytes. Biochem J (1983) 1.20
Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A (1987) 1.17
The Croonian Lecture 1998. Identification of a protein kinase cascade of major importance in insulin signal transduction. Philos Trans R Soc Lond B Biol Sci (1999) 1.17
Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells. Biochem J (1988) 1.17
Calmodulin-stimulated phosphorylation of 17 beta-estradiol receptor on tyrosine. Proc Natl Acad Sci U S A (1984) 1.16
Glucocorticoid regulation of insulin receptor and substrate IRS-1 tyrosine phosphorylation in rat skeletal muscle in vivo. J Clin Invest (1993) 1.15
Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase. Biochem J (1985) 1.15
The ligand specificities of the insulin receptor and the insulin-like growth factor I receptor reside in different regions of a common binding site. Proc Natl Acad Sci U S A (1991) 1.14
Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation. Proc Natl Acad Sci U S A (1992) 1.13
Receptor-mediated endocytosis. J Clin Invest (1986) 1.11
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes. Proc Natl Acad Sci U S A (1993) 1.11
An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity. Proc Natl Acad Sci U S A (1985) 1.11
Diabetes-induced functional and structural changes in insulin receptors from rat skeletal muscle. J Clin Invest (1986) 1.09
pp60c-src is expressed in human fetal and adult brain. Am J Pathol (1985) 1.06
Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Mol Cell Biol (1993) 1.06
Class I histocompatibility antigens and insulin receptors: evidence for interactions. Proc Natl Acad Sci U S A (1986) 1.05
Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells. Proc Natl Acad Sci U S A (1987) 1.04
Regulation of the transcript for a lysosomal protein: evidence for a gene program modified by platelet-derived growth factor. Mol Cell Biol (1985) 1.04
The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor. Proc Natl Acad Sci U S A (1985) 1.03
Insulin receptor substrate 3 (IRS-3) and IRS-4 impair IRS-1- and IRS-2-mediated signaling. Mol Cell Biol (2001) 1.00
Loss of reciprocal modulations of growth and liver function of hepatoma cells in culture by contact with cells or cell membranes. Proc Natl Acad Sci U S A (1984) 1.00
Dual regulation of glycogen metabolism by insulin and insulin-like growth factors in human hepatoma cells (HEP-G2). Analysis with an anti-receptor monoclonal antibody. J Clin Invest (1984) 1.00
Another version of the human insulin receptor kinase domain: expression, purification, and characterization. Proc Natl Acad Sci U S A (1989) 0.99
Regulation of mTOR by amino acids and resistance exercise in skeletal muscle. Eur J Appl Physiol (2005) 0.98
Vanadate normalizes hyperglycemia in two mouse models of non-insulin-dependent diabetes mellitus. J Clin Invest (1991) 0.98
Association of insulin receptor substrate 1 (IRS-1) y895 with Grb-2 mediates the insulin signaling involved in IRS-1-deficient brown adipocyte mitogenesis. Mol Cell Biol (2001) 0.97
Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction. Metabolism (2009) 0.95
Intestinal crypt stem cells possess high levels of cytoskeletal-associated phosphotyrosine-containing proteins and tyrosine kinase activity relative to differentiated enterocytes. J Cell Biol (1989) 0.95
Insulin and rabbit anti-insulin receptor antibodies stimulate additively the intrinsic receptor kinase activity. EMBO J (1987) 0.95
Metabolic regulation by protein tyrosine phosphatases. J Biomed Res (2014) 0.95
Protein kinase C is not required for insulin stimulation of hexose uptake in muscle cells in culture. Biochem J (1987) 0.95
Insulin activates the plasma-membrane and dense-vesicle cyclic AMP phosphodiesterase in hepatocytes by distinct routes. Biochem J (1983) 0.94
The insulin-like effect of sodium vanadate on adipocyte glucose transport is mediated at a post-insulin-receptor level. Biochem J (1986) 0.94
Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns. Arch Med Sci (2015) 0.93
Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization. J Clin Invest (1988) 0.93
Transmembrane signaling of interleukin 2 receptor. Conformation and function of human interleukin 2 receptor (p55)/insulin receptor chimeric molecules. J Exp Med (1987) 0.91
Concanavalin A-induced receptor aggregation stimulates the tyrosine kinase activity of the insulin receptor in intact cells. Biochem J (1990) 0.91
Structural analysis of normal and mutant insulin receptors in fibroblasts cultured from families with leprechaunism. Am J Hum Genet (1987) 0.91
Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes. J Clin Invest (1987) 0.90
Tyrosine-specific phosphorylation of calmodulin by the insulin receptor kinase purified from human placenta. Biochem J (1989) 0.90
Differential sensitivity of two functions of the insulin receptor to the associated proteolysis: kinase action and hormone binding. Proc Natl Acad Sci U S A (1986) 0.90
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Res (2014) 0.90
Hepatic protein phosphotyrosine phosphatase. Dephosphorylation of insulin and epidermal growth factor receptors in normal and alloxan diabetic rats. J Clin Invest (1990) 0.89
Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line. J Cell Biol (1984) 0.89
Calcium-dependence of insulin receptor phosphorylation. Biochem J (1983) 0.89
An Mr 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta. Biochem J (1987) 0.89
Hepatic steatosis in type 1 diabetes. Rev Diabet Stud (2012) 0.87
Identification of pp120, an endogenous substrate for the hepatocyte insulin receptor tyrosine kinase, as an integral membrane glycoprotein of the bile canalicular domain. Proc Natl Acad Sci U S A (1988) 0.86
Insulin signaling. West J Med (1997) 0.86
Insulin receptors in isolated human adipocytes. Characterization by photoaffinity labeling and evidence for internalization and cellular processing. J Clin Invest (1983) 0.85
Differential sensitivity of the insulin-receptor kinase to thiol and oxidizing agents in the absence and presence of insulin. Biochem J (1987) 0.84
Insulin signalling and the regulation of glucose and lipid metabolism. Nature (2001) 16.41
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature (2001) 11.72
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A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol Cell (1998) 8.10
Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol Cell (2000) 7.26
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. Cell (1999) 6.53
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature (1994) 6.50
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The insulin signaling system. J Biol Chem (1994) 5.25
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol (1994) 5.13
Monitoring the expression pattern of 1300 Arabidopsis genes under drought and cold stresses by using a full-length cDNA microarray. Plant Cell (2001) 5.11
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Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med (1990) 4.87
Magnitude and determinants of coronary artery disease in juvenile-onset, insulin-dependent diabetes mellitus. Am J Cardiol (1987) 4.27
Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system. Nature (1982) 3.90
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest (2000) 3.79
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (1985) 3.57
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Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat Genet (2001) 3.50
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling. Curr Biol (1994) 3.44
Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology (2001) 3.40
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest (1999) 3.36
Direct demonstration that receptor crosslinking or aggregation is important in insulin action. Proc Natl Acad Sci U S A (1978) 3.15
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Antibodies that impair insulin receptor binding in an unusual diabetic syndrome with severe insulin resistance. Science (1975) 2.97
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A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor. J Biol Chem (1988) 2.90
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Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport. Mol Cell Biol (1998) 2.59
Insulin stimulation of phosphorylation of the beta subunit of the insulin receptor. Formation of both phosphoserine and phosphotyrosine. J Biol Chem (1982) 2.58
Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression. Nat Genet (1999) 2.57
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Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
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A role for phosphoinositide 3-kinase in bacterial invasion. Science (1996) 2.46
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