Published in Eur J Immunol on May 01, 1975
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Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain. J Exp Med (1979) 2.12
Distinct H-2-linked Ir genes control both antibody and T cell responses to different determinants on the same antigen, myoglobin. Proc Natl Acad Sci U S A (1979) 2.06
T-lymphocyte-enriched murine peritoneal exudate cells. IV. Genetic control of cross-stimulation at the T-cell level. J Exp Med (1977) 1.40
Determinants of antigenic molecules responsible for genetically controlled regulation of immune responses. Proc Natl Acad Sci U S A (1976) 1.30
Hock immunization: a humane alternative to mouse footpad injections. J Immunol Methods (2007) 1.23
Key antigenic determinants in regulation of the immune response. Proc Natl Acad Sci U S A (1977) 1.02
Enhanced antigen immunogenicity induced by bispecific antibodies. J Exp Med (1990) 0.94
Limiting dilution comparison of the repertoires of high and low responder MHC-restricted T cells. J Exp Med (1988) 0.93
Production of antigen-specific suppressive T cell factor by radiation leukemia virus-transformed suppressor T cells. Proc Natl Acad Sci U S A (1981) 0.86
Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells. J Immunol (2014) 0.86
Idiotypic analysis of antibodies to hen egg-white lysozyme (HEL). II. Distribution and frequency of occurrence of idiotypes shared by A/J anti-HEL antibody. Immunology (1981) 0.80
Positive selection of major histocompatibility complex-restricted suppressor T cells bearing the predominant idiotype in the immune response to lysozyme. Proc Natl Acad Sci U S A (1981) 0.78
Enhancing effects of oral adjuvants on anti-HBs responses induced by hepatitis B vaccine. Clin Exp Immunol (1988) 0.78
Differential major histocompatibility complex-related activation of idiotypic suppressor T cells. Suppressor T cells cross-reactive to two distantly related lysozymes are not induced by one of them. J Exp Med (1980) 0.75
Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature (1992) 5.47
Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature (1993) 5.47
Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47
Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol Today (1993) 3.62
Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol (1989) 2.22
The X-Y-Z scheme of immunocyte maturation. 3. Early IgM memory and the nature of the memory cell. J Immunol (1967) 2.16
Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain. J Exp Med (1979) 2.12
Different functional specificity repertoires for suppressor and helper T cells. Immunol Rev (1978) 1.91
The asynchronous development of immunological memory in helper (T) and precursor (B) cell lines. Eur J Immunol (1971) 1.91
The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J Exp Med (1993) 1.80
Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein. J Exp Med (1989) 1.65
Epitope specificity of the T cell proliferative response to lysozyme: proliferative T cells react predominantly to different determinants from those recognized by B cells. Eur J Immunol (1980) 1.62
Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW F1 murine SLE model. J Immunol (1987) 1.60
Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity. J Immunol (1993) 1.57
Induction of anti-self-immunity to cure cancer. Cell (1995) 1.54
T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes. J Exp Med (1991) 1.47
Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. Nature (1986) 1.47
Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J Exp Med (1992) 1.46
Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis. J Exp Med (1997) 1.45
T cell determinants from autoantibodies to DNA can upregulate autoimmunity in murine systemic lupus erythematosus. J Exp Med (1995) 1.44
The fine specificity of regulatory T cells. IV. Idiotypic complementarity and antigen-bridging interactions in the anti-lysozyme response. Eur J Immunol (1979) 1.42
Neonatal peptide exposure can prime T cells and, upon subsequent immunization, induce their immune deviation: implications for antibody vs. T cell-mediated autoimmunity. J Exp Med (1996) 1.40
Lysozyme-induced T-suppressor cells and antibodies have a predominant idiotype. Nature (1979) 1.40
A limited region within hen egg-white lysozyme serves as the focus for a diversity of T cell clones. J Immunol (1984) 1.31
Immunological focusing by th mouse major histocompatibility complex: mouse strains confronted with distantly related lysozymes confine their attention to very few epitopes. Eur J Immunol (1982) 1.29
The X-Y-Z scheme of immunocyte maturation. IV. The exhaustion of memory cells. J Exp Med (1968) 1.27
Sharing of an idiotypic marker by monoclonal antibodies specific for distinct regions of hen lysozyme. Nature (1980) 1.25
Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides. J Exp Med (1990) 1.23
The complexity of structures involved in T-cell activation. Annu Rev Immunol (1983) 1.22
The T cell repertoire to a multideterminant antigen. Clonal heterogeneity of the T cell response, variation between syngeneic individuals, and in vitro selection of T cell specificities. J Immunol (1990) 1.17
Recognition of multiple peptide cores by a single T cell receptor. J Exp Med (1995) 1.17
Induction and reversal of immune paralysis in vitro. J Exp Med (1970) 1.16
Repertoires of T cells directed against a large protein antigen, beta-galactosidase. I. Helper cells have a more restricted specificity repertoire than proliferative cells. J Immunol (1982) 1.13
Distribution of plaque-forming cells in the mouse for a protein antigen. Evidence for highly active parathymic lymph nodes following intraperitoneal injection of hen lysozyme. Immunology (1976) 1.13
The dominant self and the cryptic self: shaping the autoreactive T-cell repertoire. Immunol Today (1991) 1.12
Antigen binding to cells: determination by enzymic fluorogenic group hydrolysis. Science (1968) 1.12
Ia molecule-associated selectivity in T cell recognition of a 23-amino-acid peptide of lysozyme. J Exp Med (1986) 1.11
Presence of antigen-binding cells for five diverse antigens at the onset of lymphoid development: lack of evidence for somatic diversification during ontogeny. J Immunol (1974) 1.09
Specific binding of antigen to lymphocytes. Evidence for lack of unispecificity in antigen-binding cells. Am J Pathol (1971) 1.09
Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus. J Clin Invest (1995) 1.06
Antigen binding and the immune response. II. The large number of antigen-binding cells in primed animals. Proc Soc Exp Biol Med (1970) 1.06
Limited T cell response to donor MHC peptides during allograft rejection. Implications for selective immune therapy in transplantation. J Immunol (1994) 1.05
Regulatory and effector CD4 T cells in nonobese diabetic mice recognize overlapping determinants on glutamic acid decarboxylase and use distinct V beta genes. J Immunol (2001) 1.05
The choice between two distinct T cell determinants within a 23-amino acid region of lysozyme depends on their structural context. J Immunol (1986) 1.04
The fine specificity of regulatory T cells. I. Hen egg-white lysozyme-induced suppressor T cells in a genetically nonresponder mouse strain do not recognize a closely related immunogenic lysozyme. J Immunol (1979) 1.04
Modulation of the immunogenicity of antigenic determinants by their flanking residues. Immunol Today (1998) 1.03
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Hindrance of binding to class II major histocompatibility complex molecules by a single amino acid residue contiguous to a determinant leads to crypticity of the determinant as well as lack of response to the protein antigen. Proc Natl Acad Sci U S A (1995) 1.02
Immunodominant protein epitopes. I. Induction of suppression to hen egg white lysozyme is obliterated by removal of the first three N-terminal amino acids. Eur J Immunol (1984) 1.02
Ir gene defects may reflect a regulatory imbalance. I. Helper T cell activity revealed in a strain whose lack of response is controlled by suppression. J Immunol (1979) 1.01
Recall of specific suppression: co-dominance of suppression after primary or secondary antigen stimulation. J Immunol (1977) 1.00
The expressed T cell repertoire is hierarchical: the precise focus of lysozyme-specific T cell clones is dependent upon the structure of the immunogen. J Mol Cell Immunol (1984) 0.99
Proteins in human tears. I. Immunoelectrophoretic patterns. Arch Ophthalmol (1969) 0.99
The molecular context of determinants within the priming antigen establishes a hierarchy of T cell induction: T cell specificities induced by peptides of beta-galactosidase vs. the whole antigen. Eur J Immunol (1989) 0.98
MHC class I-restricted determinants on the glutamic acid decarboxylase 65 molecule induce spontaneous CTL activity. J Immunol (2001) 0.97
Dominant determinants in hen eggwhite lysozyme correspond to the cryptic determinants within its self-homologue, mouse lysozyme: implications in shaping of the T cell repertoire and autoimmunity. J Exp Med (1993) 0.97
Modulation of help and suppression in a hapten-carrier system. J Immunol (1976) 0.97
Human tear lysozyme. 3. Preliminary study on lysozyme levels in subjects with smog eye irritation. Am J Ophthalmol (1968) 0.96
In a small multideterminant peptide, each determinant is recognized by a different V beta gene segment. J Exp Med (1992) 0.95
The X-Y-Z scheme of immunocyte maturation. II. The effect of antigen on spontaneous escape from immune paralysis. J Immunol (1967) 0.94
Eating responses of obese and nonobese humans during dinner meals. Psychosom Med (1975) 0.94
Amino acid residues distinct from the determinant region can profoundly affect activation of T cell clones by related antigens. J Immunol (1986) 0.94
Preferential pairing of T-B specificities in the same antigen: the concept of directional help. Vaccine (1988) 0.93
Contributions of obesity, gender, hunger, food preference, and body size to bite size, bite speed, and rate of eating. Appetite (1984) 0.93
Multiple H-2 and non-H-2 genes controlling the antilysozyme response: alternative gene constellations can lead to responsiveness. Eur J Immunol (1980) 0.92
T cell determinant structure of myelin basic protein in B10.PL, SJL/J, and their F1S. J Immunol (1994) 0.92
The self-directed T cell repertoire: its creation and activation. Rev Immunogenet (2000) 0.91
Recognition of prostate-specific antigenic peptide determinants by human CD4 and CD8 T cells. Clin Exp Immunol (1998) 0.91
Unresponsiveness to a self-peptide of mouse lysozyme owing to hindrance of T cell receptor-major histocompatibility complex/peptide interaction caused by flanking epitopic residues. J Exp Med (1996) 0.90
Human tear lysozyme. I. Purification, physicochemical, and immunochemical characterization. J Lab Clin Med (1967) 0.90
Molecular characterization of the T cell repertoire using immunoscope analysis and its possible implementation in clinical practice. Curr Mol Med (2001) 0.90
Role of flanking variable sequences in antigenicity of consensus regions of HIV gp120 for recognition by specific human T helper clones. Eur J Immunol (1993) 0.90
Cutting edge: introduction of an endopeptidase cleavage motif into a determinant flanking region of hen egg lysozyme results in enhanced T cell determinant display. J Immunol (2000) 0.90
Epitope-specific and idiotype-specific cellular interactions in a model protein antigen system. Springer Semin Immunopathol (1980) 0.89
Subjugation of dominant immunogenic determinants within a chimeric peptide. Eur J Immunol (1992) 0.89
The expressed lysozyme-specific B cell repertoire. I. Heterogeneity in the monoclonal anti-hen egg white lysozyme specificity repertoire, and its difference from the in situ repertoire. Eur J Immunol (1984) 0.89
Idiotypic repertoire of anti-hen eggwhite lysozyme antibodies probed with hybridomas. Selection after immunization of an IdX marker common to antibodies of distinct epitope specificity. J Exp Med (1981) 0.88
Early simultaneous appearance of antigen binding cells in the foetal sheep. Nature (1974) 0.88
Ir-gene control of T cell proliferative responses: two distinct expressions of the genetically nonresponsive state. Eur J Immunol (1980) 0.87
Structural basis for immune recognition of lysozymes. I. Effect of cyanogen bromide on hen egg-white lysozyme. Biochemistry (1969) 0.87
Immunodominance is independent of structural constraints: each region within hen eggwhite lysozyme is potentially available upon processing of native antigen. J Immunol (1997) 0.87
Vaccination of the Leishmania major susceptible BALB/c mouse. I. The precise selection of peptide determinant influences CD4+ T cell subset expression. Int Immunol (1994) 0.87
Environmental modulation of autoimmune arthritis involves the spontaneous microbial induction of T cell responses to regulatory determinants within heat shock protein 65. J Immunol (2001) 0.87
Amputation of a suppressor determinant on lysozyme reveals underlying T-cell reactivity to other determinants. Nature (1979) 0.87
Induction of tolerance to one determinant on a synthetic peptide does not affect the response to a second linked determinant. Implications for the mechanism of neonatal tolerance induction. J Exp Med (1986) 0.86
Selective reversal of H-2-linked genetic unresponsiveness to lysozymes. II. Alteration in the T helper/T suppressor balance, owing to gene(s) linked to Ir-2, leads to responsiveness in BALB.B. Eur J Immunol (1986) 0.86
Heterogeneity of the T cell response to immunodominant determinants within hen eggwhite lysozyme of individual syngeneic hybrid F1 mice: implications for autoimmunity and infection. J Immunol (1998) 0.86
Repertoires of T cells directed against a large protein antigen, beta-galactosidase. II. Only certain T helper or T suppressor cells are relevant in particular regulatory interactions. J Exp Med (1985) 0.85
Self-reactive T cells and degeneracy of T cell recognition: evolving concepts-from sequence homology to shape mimicry and TCR flexibility. J Autoimmun (2001) 0.85
Characterization of responding cells in oxidative mitogen stimulation. III. Presence of I-A- and I-J, E, C-subregion gene products on the surface of required cells. Immunogenetics (1980) 0.84
T cells with multiple fine specificities are used by non-obese diabetic (NOD) mice in the response to GAD(524-543). J Autoimmun (1996) 0.84
A predominant idiotype on anti-hen egg white lysozyme antibodies from diverse mouses strains. J Immunol (1980) 0.84
The T cell repertoire against cryptic self determinants and its involvement in autoimmunity and cancer. Clin Immunol Immunopathol (1994) 0.84
Oligodendrocyte-specific protein peptides induce experimental autoimmune encephalomyelitis in SJL/J mice. J Immunol (1999) 0.83
The X-Y-Z scheme of immunocyte maturation. V. Paralysis of memory cells. J Exp Med (1968) 0.83
Antigen processing differences among APC. Hum Immunol (1997) 0.83