Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes.

PubWeight™: 5.47‹?› | Rank: Top 1%

🔗 View Article (PMID 7694152)

Published in Nature on November 04, 1993

Authors

D L Kaufman1, M Clare-Salzler, J Tian, T Forsthuber, G S Ting, P Robinson, M A Atkinson, E E Sercarz, A J Tobin, P V Lehmann

Author Affiliations

1: Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles 90024.

Articles citing this

(truncated to the top 100)

B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice. J Exp Med (1996) 3.35

Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. J Exp Med (1995) 3.18

Physiological beta cell death triggers priming of self-reactive T cells by dendritic cells in a type-1 diabetes model. J Exp Med (2003) 2.94

Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev (1999) 2.69

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis. J Exp Med (1995) 2.62

Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci U S A (1996) 2.53

Critical role of macrophages in the marginal zone in the suppression of immune responses to apoptotic cell-associated antigens. J Clin Invest (2007) 2.34

Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes (2009) 2.31

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med (1995) 2.29

Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest (1994) 2.28

Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med (2008) 2.28

Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol (2007) 2.28

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis. J Exp Med (1995) 2.25

Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc Natl Acad Sci U S A (1996) 2.21

Antiviral immune responses: triggers of or triggered by autoimmunity? Nat Rev Immunol (2009) 2.16

Viruses, cytokines, antigens, and autoimmunity. Proc Natl Acad Sci U S A (1996) 2.14

T cell priming versus T cell tolerance induced by synthetic peptides. J Exp Med (1995) 2.07

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med (1996) 2.06

Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05

Newborn humans manifest autoantibodies to defined self molecules detected by antigen microarray informatics. J Clin Invest (2007) 2.00

Immunotherapy of type 1 diabetes: where are we and where should we be going? Immunity (2010) 1.98

Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangement. Proc Natl Acad Sci U S A (1998) 1.82

Functional immunomics: microarray analysis of IgG autoantibody repertoires predicts the future response of mice to induced diabetes. Proc Natl Acad Sci U S A (2004) 1.69

Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes (2008) 1.69

A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. Proc Natl Acad Sci U S A (1996) 1.68

Pancreatic expression of interleukin-4 abrogates insulitis and autoimmune diabetes in nonobese diabetic (NOD) mice. J Exp Med (1996) 1.67

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med (1995) 1.67

Germ line deletion of the CD1 locus exacerbates diabetes in the NOD mouse. Proc Natl Acad Sci U S A (2001) 1.62

Prevalent CD8(+) T cell response against one peptide/MHC complex in autoimmune diabetes. Proc Natl Acad Sci U S A (1999) 1.61

A two-step, two-signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci U S A (1999) 1.58

Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol (2010) 1.58

Clinical implications of the stress response. J Clin Invest (1995) 1.51

Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes. J Exp Med (1996) 1.50

Restricted islet-cell reactive T cell repertoire of early pancreatic islet infiltrates in NOD mice. Proc Natl Acad Sci U S A (2002) 1.49

Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes. J Exp Med (1994) 1.49

Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J Clin Invest (1996) 1.49

Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A). Proc Natl Acad Sci U S A (1995) 1.49

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease. J Exp Med (1996) 1.49

Vaccination against type 1 diabetes. J Intern Med (2011) 1.46

Diversification of T cell responses to carboxy-terminal determinants within the 65-kD heat-shock protein is involved in regulation of autoimmune arthritis. J Exp Med (1997) 1.45

The activation and inactivation of mature CD4 T cells: a case for peripheral self-nonself discrimination. Scand J Immunol (2014) 1.41

Local expression of transgene encoded TNF alpha in islets prevents autoimmune diabetes in nonobese diabetic (NOD) mice by preventing the development of auto-reactive islet-specific T cells. J Exp Med (1996) 1.39

Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies? Nat Rev Endocrinol (2010) 1.39

The outer surface proteins of Lyme disease borrelia spirochetes stimulate T cells to secrete interferon-gamma (IFN-gamma): diagnostic and pathogenic implications. Clin Exp Immunol (1995) 1.39

Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase. J Exp Med (2003) 1.39

In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J Clin Invest (1995) 1.36

Oral tolerance. Proc Natl Acad Sci U S A (1994) 1.35

Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice. Proc Natl Acad Sci U S A (1997) 1.34

GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice. J Clin Invest (1998) 1.32

Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia. Blood (2008) 1.31

Analysis of structure and function relationships of an autoantigenic peptide of insulin bound to H-2K(d) that stimulates CD8 T cells in insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (2002) 1.31

CD4(+) T cells from glutamic acid decarboxylase (GAD)65-specific T cell receptor transgenic mice are not diabetogenic and can delay diabetes transfer. J Exp Med (2002) 1.31

Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol Med (1995) 1.28

Potent inhibitory effects of transplantable rat glucagonomas and insulinomas on the respective endogenous islet cells are associated with pancreatic apoptosis. J Clin Invest (1995) 1.26

Dual T cell receptor alpha chain T cells in autoimmunity. J Exp Med (1995) 1.26

Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23. J Clin Invest (2002) 1.26

A recombinant antibody with the antigen-specific, major histocompatibility complex-restricted specificity of T cells. Proc Natl Acad Sci U S A (1996) 1.24

Epitope-specific tolerance induction with an engineered immunoglobulin. Proc Natl Acad Sci U S A (1996) 1.24

Endogenous presentation of self myelin epitopes by CNS-resident APCs in Theiler's virus-infected mice. J Clin Invest (1999) 1.23

Antigen targets of type 1 diabetes autoimmunity. Cold Spring Harb Perspect Med (2012) 1.18

In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes. J Exp Med (2000) 1.17

Cytokines and cytokine profiles in human autoimmune diseases and animal models of autoimmunity. Mediators Inflamm (2009) 1.17

Heat-shock proteins can promote as well as regulate autoimmunity. Autoimmun Rev (2008) 1.17

The role of immunomodulation therapy in autoimmune diabetes. J Diabetes Sci Technol (2009) 1.15

Transfer of hematopoietic stem cells encoding autoantigen prevents autoimmune diabetes. J Clin Invest (2003) 1.14

Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Clin Invest (1997) 1.14

Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris. J Clin Invest (1997) 1.13

Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus. BMC Immunol (2003) 1.13

The role of MHC class II molecules in susceptibility to type I diabetes: identification of peptide epitopes and characterization of the T cell repertoire. Proc Natl Acad Sci U S A (1999) 1.13

Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice. J Clin Invest (1996) 1.11

The pancreas in human type 1 diabetes. Semin Immunopathol (2010) 1.11

Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. J Immunol (2009) 1.10

A peptide-binding motif for I-A(g7), the class II major histocompatibility complex (MHC) molecule of NOD and Biozzi AB/H mice. J Exp Med (1997) 1.09

Induction of oral tolerance to prevent diabetes with transgenic plants requires glutamic acid decarboxylase (GAD) and IL-4. Proc Natl Acad Sci U S A (2004) 1.08

pH-dependent peptide binding properties of the type I diabetes-associated I-Ag7 molecule: rapid release of CLIP at an endosomal pH. J Exp Med (1999) 1.08

Antigen-specific immunotherapy: is it a real possibility to combat T-cell-mediated autoimmunity? Proc Natl Acad Sci U S A (1994) 1.08

Central nervous system destruction mediated by glutamic acid decarboxylase-specific CD4+ T cells. J Immunol (2010) 1.07

Amino acid residues 24-31 but not palmitoylation of cysteines 30 and 45 are required for membrane anchoring of glutamic acid decarboxylase, GAD65. J Cell Biol (1994) 1.07

Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. J Clin Invest (1998) 1.07

Diversity and plasticity of self recognition during the development of multiple sclerosis. J Clin Invest (1997) 1.07

Progress in immune-based therapies for type 1 diabetes. Clin Exp Immunol (2013) 1.06

Immune tolerance to autoantibody-derived peptides delays development of autoimmunity in murine lupus. J Clin Invest (1995) 1.06

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes (2008) 1.06

Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigens. J Exp Med (1997) 1.04

99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: triggering of autoimmune diseases by infections. Clin Exp Immunol (2010) 1.03

Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient. J Clin Invest (1996) 1.03

Male gonadal environment paradoxically promotes dacryoadenitis in nonobese diabetic mice. J Clin Invest (1998) 1.02

Breaking self-tolerance in nonobese diabetic mice. J Exp Med (1996) 1.02

Prevention of insulin-dependent diabetes mellitus in nonobese diabetic mice by immunogenic but not by tolerated peptides. J Exp Med (1995) 1.02

Transgenic expression of decoy receptor 3 protects islets from spontaneous and chemical-induced autoimmune destruction in nonobese diabetic mice. J Exp Med (2004) 1.02

Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma. Diabetologia (2010) 1.02

T-cell autoantigens in the non-obese diabetic mouse model of autoimmune diabetes. Immunology (2010) 1.01

Virus infection, antiviral immunity, and autoimmunity. Immunol Rev (2013) 1.00

IL-10 is necessary and sufficient for autoimmune diabetes in conjunction with NOD MHC homozygosity. J Exp Med (1996) 1.00

Widespread expression of an autoantigen-GAD65 transgene does not tolerize non-obese diabetic mice and can exacerbate disease. Proc Natl Acad Sci U S A (1998) 1.00

In vivo priming of T cells against cryptic determinants by dendritic cells exposed to interleukin 6 and native antigen. Proc Natl Acad Sci U S A (1998) 0.99

A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. J Exp Med (2009) 0.99

Biosensors for immune cell analysis-A perspective. Biomicrofluidics (2012) 0.99

Immune recognition and rejection of allogeneic skin grafts. Immunotherapy (2011) 0.97

Detection of glutamic acid decarboxylase-activated T cells with I-Ag7 tetramers. Proc Natl Acad Sci U S A (2000) 0.97

Articles by these authors

Collaborative management to achieve treatment guidelines. Impact on depression in primary care. JAMA (1995) 11.90

A multifaceted intervention to improve treatment of depression in primary care. Arch Gen Psychiatry (1996) 7.80

Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate early kidney disease. Kidney Int (2006) 7.02

A randomized, double-blind trial comparing combinations of nevirapine, didanosine, and zidovudine for HIV-infected patients: the INCAS Trial. Italy, The Netherlands, Canada and Australia Study. JAMA (1998) 7.00

Comparison of first-line antiretroviral therapy with regimens including nevirapine, efavirenz, or both drugs, plus stavudine and lamivudine: a randomised open-label trial, the 2NN Study. Lancet (2004) 6.27

Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. The NIAID Mycoses Study Group and the AIDS Clinical Trials Group. N Engl J Med (1992) 5.84

Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature (1992) 5.47

Evolution of organic aerosols in the atmosphere. Science (2009) 4.82

Restricted use of T cell receptor V genes in murine autoimmune encephalomyelitis raises possibilities for antibody therapy. Cell (1988) 4.47

Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E. Proc Natl Acad Sci U S A (1995) 4.31

Induction of TH1 and TH2 immunity in neonatal mice. Science (1996) 4.25

Dominance and crypticity of T cell antigenic determinants. Annu Rev Immunol (1993) 4.23

Extreme Th1 bias of invariant Valpha24JalphaQ T cells in type 1 diabetes. Nature (1998) 4.10

CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J Exp Med (1997) 4.06

Two genes encode distinct glutamate decarboxylases. Neuron (1991) 3.68

Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science (1998) 3.68

A controlled trial of fluconazole or amphotericin B to prevent relapse of cryptococcal meningitis in patients with the acquired immunodeficiency syndrome. The NIAID AIDS Clinical Trials Group and Mycoses Study Group. N Engl J Med (1992) 3.65

Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol Today (1993) 3.62

Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev (1999) 3.51

The role of the primary care physician in patients' adherence to antidepressant therapy. Med Care (1995) 3.29

Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat Genet (1997) 2.98

Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med (1999) 2.92

The CD28-related molecule ICOS is required for effective T cell-dependent immune responses. Immunity (2000) 2.70

Molecular biology of GABAA receptors. FASEB J (1990) 2.66

Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions. J Neurochem (1991) 2.66

Human (HLA-A and HLA-B) and murine (H-2K and H-2D) histocompatibility antigens are cell surface receptors for Semliki Forest virus. Proc Natl Acad Sci U S A (1978) 2.41

Modulating autoimmune responses to GAD inhibits disease progression and prolongs islet graft survival in diabetes-prone mice. Nat Med (1996) 2.35

Comparative localization of two forms of glutamic acid decarboxylase and their mRNAs in rat brain supports the concept of functional differences between the forms. J Neurosci (1994) 2.24

Why peptides? Their possible role in the evolution of MHC-restricted T-cell recognition. Immunol Today (1989) 2.23

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype. Cell Immunol (1989) 2.22

Outcomes of "inadequate" antidepressant treatment. J Gen Intern Med (1995) 2.19

The X-Y-Z scheme of immunocyte maturation. 3. Early IgM memory and the nature of the memory cell. J Immunol (1967) 2.16

Fine specificity of regulatory T cells. II. Suppressor and helper T cells are induced by different regions of hen egg-white lysozyme in a genetically nonresponder mouse strain. J Exp Med (1979) 2.12

Efficient high-frequency body coil for high-field MRI. Magn Reson Med (2004) 2.07

A placebo-controlled trial of maintenance therapy with fluconazole after treatment of cryptococcal meningitis in the acquired immunodeficiency syndrome. California Collaborative Treatment Group. N Engl J Med (1991) 2.06

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. J Exp Med (1996) 2.06

ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer. Am J Hum Genet (1998) 2.06

Dimorphic histopathology of long-standing childhood-onset diabetes. Diabetologia (2010) 2.04

Carbonic anhydrase from parsley leaves. J Biol Chem (1970) 2.03

CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. J Exp Med (2000) 2.02

Osteoarthritis of the thumb carpometacarpal joint: correlation of ultrasound appearances to disability and treatment response. Clin Radiol (2012) 2.00

Two human glutamate decarboxylases, 65-kDa GAD and 67-kDa GAD, are each encoded by a single gene. Proc Natl Acad Sci U S A (1992) 1.93

The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem Res (1991) 1.93

Different functional specificity repertoires for suppressor and helper T cells. Immunol Rev (1978) 1.91

The asynchronous development of immunological memory in helper (T) and precursor (B) cell lines. Eur J Immunol (1971) 1.91

Early infant diets and insulin-dependent diabetes. Lancet (1996) 1.86

ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat Immunol (2001) 1.85

Suppression of plasma viral load below 20 copies/ml is required to achieve a long-term response to therapy. AIDS (1998) 1.81

Ultrasound for initial evaluation and triage of clinically suspicious soft-tissue masses. Clin Radiol (2009) 1.80

The involvement of T cell receptor peptide-specific regulatory CD4+ T cells in recovery from antigen-induced autoimmune disease. J Exp Med (1993) 1.80

Incremental cholesterol reduction with ezetimibe/simvastatin, atorvastatin and rosuvastatin in UK General Practice (IN-PRACTICE): randomised controlled trial of achievement of Joint British Societies (JBS-2) cholesterol targets. Int J Clin Pract (2010) 1.78

Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein. J Neurosci (1987) 1.78

Localization of the heparin-binding site on complement factor H. J Biol Chem (1991) 1.77

Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet (1992) 1.73

Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin. Biochim Biophys Acta (1989) 1.73

Apoptosis in sepsis: a new target for therapeutic exploration. FASEB J (2001) 1.73

Iliopsoas abscess--a review and update on the literature. Int J Surg (2012) 1.70

To retract or not to retract. Br Dent J (1990) 1.70

Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J Exp Med (1998) 1.70

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus. J Clin Invest (1992) 1.67

Synergistic activation of dynamin GTPase by Grb2 and phosphoinositides. J Biol Chem (1998) 1.67

Adjuvant-guided type-1 and type-2 immunity: infectious/noninfectious dichotomy defines the class of response. J Immunol (1999) 1.66

In vivo competition between self peptides and foreign antigens in T-cell activation. Nature (1988) 1.66

Nasal packing after routine nasal surgery--is it justified? J Laryngol Otol (1993) 1.66

Pharmacokinetics of lamivudine in human immunodeficiency virus-infected patients with renal dysfunction. Antimicrob Agents Chemother (1996) 1.65

Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein. J Exp Med (1989) 1.65

Do affluent societies have the only options for the best therapy? Leukemia (2007) 1.63

Smoking, the environment and meningococcal disease: a case control study. Epidemiol Infect (1994) 1.62

Epitope specificity of the T cell proliferative response to lysozyme: proliferative T cells react predominantly to different determinants from those recognized by B cells. Eur J Immunol (1980) 1.62

Factors affecting the incidence of deep wound infection after hip fracture surgery. J Bone Joint Surg Br (2012) 1.61

Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity. J Immunol (2000) 1.61

Brain glutamate decarboxylase cloned in lambda gt-11: fusion protein produces gamma-aminobutyric acid. Science (1986) 1.60

Mechanisms of T and B cell collaboration in the in vitro production of anti-DNA antibodies in the NZB/NZW F1 murine SLE model. J Immunol (1987) 1.60

Ouabain interaction with cardiac Na+/K+-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca2+ concentrations. J Biol Chem (2000) 1.60

Degenerate recognition of a dissimilar antigenic peptide by myelin basic protein-reactive T cells. Implications for thymic education and autoimmunity. J Immunol (1993) 1.57

Taenia solium cysticercosis: host-parasite interactions and the immune response. Chem Immunol (1997) 1.57

Combined acetaminophen and ibuprofen for pain relief after oral surgery in adults: a randomized controlled trial. Br J Anaesth (2010) 1.56

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J Clin Invest (1995) 1.55

Induction of anti-self-immunity to cure cancer. Cell (1995) 1.54

Therapeutic impact of percutaneous spinal biopsy in spinal infection. Postgrad Med J (2004) 1.54

Saccharomyces cerevisiae synthesizes proteins related to the p21 gene product of ras genes found in mammals. Mol Cell Biol (1984) 1.53

A novel alpha subunit in rat brain GABAA receptors. Neuron (1989) 1.51

Interaction of an immunodominant epitope with Ia molecules in T-cell activation. Proc Natl Acad Sci U S A (1988) 1.51

Neonatal T-cell tolerance to minimal immunogenic peptides is caused by clonal inactivation. Nature (1986) 1.47

T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes. J Exp Med (1991) 1.47

Combination therapy an ACE inhibitor and an angiotensin receptor blocker for IgA nephropathy: a meta-analysis. Int J Clin Pract (2012) 1.47

Distribution of developmentally regulated hemoglobins in embryonic erythroid populations. Dev Biol (1979) 1.47

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection. J Exp Med (1992) 1.46

Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets. Diabetes (2000) 1.46