Published in Cell on October 01, 1980
A catalogue of splice junction sequences. Nucleic Acids Res (1982) 39.41
Computer methods to locate signals in nucleic acid sequences. Nucleic Acids Res (1984) 21.53
HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J (1990) 9.34
Evidence for higher rates of nucleotide substitution in rodents than in man. Proc Natl Acad Sci U S A (1985) 8.18
Detection of sickle cell beta S-globin allele by hybridization with synthetic oligonucleotides. Proc Natl Acad Sci U S A (1983) 7.52
The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' termini. Nucleic Acids Res (1985) 7.18
Intron splicing: a conserved internal signal in introns of animal pre-mRNAs. Proc Natl Acad Sci U S A (1984) 4.71
Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proc Natl Acad Sci U S A (1982) 4.69
An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly. EMBO J (1987) 4.52
Purification of genomic sequences from bacteriophage libraries by recombination and selection in vivo. Nucleic Acids Res (1983) 4.32
Human fetal to adult hemoglobin switching: changes in chromatin structure of the beta-globin gene locus. Proc Natl Acad Sci U S A (1983) 4.05
Oligonucleotide directed mutagenesis of the human beta-globin gene: a general method for producing specific point mutations in cloned DNA. Nucleic Acids Res (1981) 3.87
A cellular transcription factor E4F1 interacts with an E1a-inducible enhancer and mediates constitutive enhancer function in vitro. EMBO J (1987) 3.45
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. J Virol (1993) 3.37
Sequence requirements for the transcription of the rabbit beta-globin gene in vivo: the -80 region. Nucleic Acids Res (1982) 3.11
Biochemical activities of T-antigen proteins encoded by simian virus 40 A gene deletion mutants. Mol Cell Biol (1983) 3.06
Multiple interactions between the splicing substrate and small nuclear ribonucleoproteins in spliceosomes. Mol Cell Biol (1987) 3.00
Highly conserved sequences in the 3' untranslated region of mRNAs coding for homologous proteins in distantly related species. Nucleic Acids Res (1985) 2.83
Structure and expression of a cloned beta o thalassaemic globin gene. Nucleic Acids Res (1981) 2.71
A measure of the similarity of sets of sequences not requiring sequence alignment. Proc Natl Acad Sci U S A (1986) 2.68
Direct identification of sickle cell anemia by blot hybridization. Proc Natl Acad Sci U S A (1981) 2.68
Cloning and complete nucleotide sequence of human 5'-alpha-globin gene. Proc Natl Acad Sci U S A (1980) 2.62
Base substitution in an intervening sequence of a beta+-thalassemic human globin gene. Proc Natl Acad Sci U S A (1981) 2.58
High-level expression of sperm whale myoglobin in Escherichia coli. Proc Natl Acad Sci U S A (1987) 2.47
Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity. J Virol (1994) 2.45
Isolation and characterization of cDNA clones for human skeletal muscle alpha actin. Nucleic Acids Res (1983) 2.45
Extraordinarily high evolutionary rate of pseudogenes: evidence for the presence of selective pressure against changes between synonymous codons. Proc Natl Acad Sci U S A (1981) 2.42
Genes for the tumor necrosis factors alpha and beta are linked to the human major histocompatibility complex. Proc Natl Acad Sci U S A (1986) 2.42
Activation of related transforming genes in mouse and human mammary carcinomas. Proc Natl Acad Sci U S A (1981) 2.41
The DNA sequence of the 5' flanking region of the human beta-globin gene: evolutionary conservation and polymorphic differences. Nucleic Acids Res (1982) 2.36
Inducible transcription of five globin genes in K562 human leukemia cells. Proc Natl Acad Sci U S A (1983) 2.35
Nuclear pre-mRNA processing in plants: distinct modes of 3'-splice-site selection in plants and animals. Mol Cell Biol (1988) 2.32
The 5' flanking region of human epsilon-globin gene. Nucleic Acids Res (1980) 2.30
beta zero thalassemia in Sardinia is caused by a nonsense mutation. J Clin Invest (1981) 2.30
Relationship between the total size of exons and introns in protein-coding genes of higher eukaryotes. Proc Natl Acad Sci U S A (1982) 2.25
Evidence for multiple origins of the beta E-globin gene in Southeast Asia. Proc Natl Acad Sci U S A (1982) 2.24
Genetic analysis of human immunodeficiency virus type 1 integrase and the U3 att site: unusual phenotype of mutants in the zinc finger-like domain. J Virol (1995) 2.22
Unusual evolutionary conservation and frequent DNA segment exchange in class I genes of the major histocompatibility complex. Proc Natl Acad Sci U S A (1983) 2.21
In vitro amplification of hepatitis B virus sequences from liver tumour DNA and from paraffin wax embedded tissues using the polymerase chain reaction. J Clin Pathol (1989) 2.17
Human immunodeficiency virus type 1 T-cell tropism is determined by events prior to provirus formation. J Virol (1990) 2.11
Asymmetrical distribution of CpG in an 'average' mammalian gene. Nucleic Acids Res (1982) 2.04
Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age. Nucleic Acids Res (2003) 2.02
Direct detection of the common Mediterranean beta-thalassemia gene with synthetic DNA probes. An alternative approach for prenatal diagnosis. J Clin Invest (1983) 1.95
T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice. EMBO J (1989) 1.94
A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia. Proc Natl Acad Sci U S A (1981) 1.93
Pattern recognition in nucleic acid sequences. II. An efficient method for finding locally stable secondary structures. Nucleic Acids Res (1982) 1.81
An intron nucleotide sequence variant in a cloned beta +-thalassaemia globin gene. Nucleic Acids Res (1981) 1.80
The half-life of c-myc mRNA in growing and serum-stimulated cells: influence of the coding and 3' untranslated regions and role of ribosome translocation. Mol Cell Biol (1994) 1.76
Localization of pre-messenger RNA at discrete nuclear sites. Proc Natl Acad Sci U S A (1991) 1.74
Accurate in vitro splicing of human beta-globin RNA. Nucleic Acids Res (1982) 1.73
In vivo pathogenesis of a human immunodeficiency virus type 1 reporter virus. J Virol (1998) 1.73
Crosslinking of hnRNP proteins to pre-mRNA requires U1 and U2 snRNPs. Nucleic Acids Res (1990) 1.68
The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6. J Exp Med (1996) 1.65
Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein. Mol Cell Biol (1989) 1.62
Mechanism for cryptic splice site activation during pre-mRNA splicing. Proc Natl Acad Sci U S A (1990) 1.60
The 5' splice site: phylogenetic evolution and variable geometry of association with U1RNA. Nucleic Acids Res (1989) 1.60
Site-specific excision from RNA by RNase H and mixed-phosphate-backbone oligodeoxynucleotides. Proc Natl Acad Sci U S A (1990) 1.50
Human globin psi B2 is not a globin-related sequence. Nucleic Acids Res (1982) 1.48
Nucleotide sequence-directed mapping of the nucleosomes. Nucleic Acids Res (1983) 1.47
Sequence specific generation of a DNA panhandle permits PCR amplification of unknown flanking DNA. Nucleic Acids Res (1992) 1.46
Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc Natl Acad Sci U S A (1992) 1.43
Structural analysis of the 5' flanking region of the beta-globin gene in African sickle cell anemia patients: further evidence for three origins of the sickle cell mutation in Africa. Proc Natl Acad Sci U S A (1988) 1.43
Specific and independent recognition of U3 and U5 att sites by human immunodeficiency virus type 1 integrase in vivo. J Virol (1998) 1.42
Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA. Mol Cell Biol (1988) 1.39
New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo. J Clin Invest (1988) 1.36
Neural network detects errors in the assignment of mRNA splice sites. Nucleic Acids Res (1990) 1.35
Abnormal splice in a mutant human beta-globin gene not at the site of a mutation. Proc Natl Acad Sci U S A (1983) 1.34
Removal of inhibitor(s) of the polymerase chain reaction from formalin fixed, paraffin wax embedded tissues. J Clin Pathol (1991) 1.33
Methylated DNA-binding protein from human placenta recognizes specific methylated sites on several prokaryotic DNAs. Nucleic Acids Res (1986) 1.31
Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene. Nucleic Acids Res (1982) 1.31
Detection of hepatitis B virus DNA in serum by polymerase chain reaction amplification and microtiter sandwich hybridization. J Clin Microbiol (1990) 1.30
CRD-BP shields c-myc and MDR-1 RNA from endonucleolytic attack by a mammalian endoribonuclease. Nucleic Acids Res (2007) 1.29
Effect of in vitro DNA methylation on beta-globin gene expression. Proc Natl Acad Sci U S A (1988) 1.29
"Silent" nucleotide substitution in a beta+-thalassemia globin gene activates splice site in coding sequence RNA. Proc Natl Acad Sci U S A (1983) 1.25
Synthesis of predominantly unspliced cytoplasmic RNAs by chimeric herpes simplex virus type 1 thymidine kinase-human beta-globin genes. Mol Cell Biol (1985) 1.24
In vivo pathogenic properties of two clonal human immunodeficiency virus type 1 isolates. J Virol (1995) 1.24
Regulation of asparagine synthetase gene expression by amino acid starvation. Mol Cell Biol (1991) 1.22
The thalassemias: molecular mechanisms of human genetic disease. Am J Hum Genet (1983) 1.21
Expression of human beta-globin genes in transgenic mice: effects of a flanking metallothionein-human growth hormone fusion gene. Mol Cell Biol (1985) 1.18
Short donor site sequences inserted within the intron of beta-globin pre-mRNA serve for splicing in vitro. Mol Cell Biol (1988) 1.17
The diagonal-traverse homology search algorithm for locating similarities between two sequences. Nucleic Acids Res (1984) 1.16
Rate constancy of globin gene evolution in placental mammals. Proc Natl Acad Sci U S A (1988) 1.16
In monkey COS cells only the TATA box and the cap site region are required for faithful and efficient initiation of the fibroin gene transcription. Nucleic Acids Res (1984) 1.15
Two cloned beta thalassemia genes are associated with amber mutations at codon 39. Nucleic Acids Res (1981) 1.14
2',5'-Bis-O-(tert-butyldimethylsilyl)-3'-spiro-5''-(4''-amino-1'',2''- oxathiole-2'',2'-dioxide)pyrimidine (TSAO) nucleoside analogues: highlyselective inhibitors of human immunodeficiency virus type 1 that are targeted at the viral reverse transcriptase. Proc Natl Acad Sci U S A (1992) 1.14
Early molecular replication of human immunodeficiency virus type 1 in cultured-blood-derived T helper dendritic cells. J Clin Invest (1993) 1.13
A 62,000 molecular weight spliceosome protein crosslinks to the intron polypyrimidine tract. Nucleic Acids Res (1990) 1.10
Beta-thalassemia resulting from a single nucleotide substitution in an acceptor splice site. Nucleic Acids Res (1985) 1.09
Nucleotide sequences of immunoglobulin epsilon genes of chimpanzee and orangutan: DNA molecular clock and hominoid evolution. Proc Natl Acad Sci U S A (1987) 1.08
Comparative nucleotide sequence analysis of two types of larval beta-globin mRNAs of Xenopus laevis. Nucleic Acids Res (1985) 1.07
An extensive search for RFLP in the human glucose-6-phosphate dehydrogenase locus has revealed a silent mutation in the coding sequence. Am J Hum Genet (1988) 1.07
Synthesis of 8-(2-4 dinitrophenyl 2-6 aminohexyl) amino-adenosine 5' triphosphate: biological properties and potential uses. Nucleic Acids Res (1982) 1.06
Lack of an initiator element is responsible for multiple transcriptional initiation sites of the TATA-less mouse thymidylate synthase promoter. Mol Cell Biol (1993) 1.05
Stimulation of Na+/H+ antiport is an early event in hypertrophy of renal proximal tubular cells. Proc Natl Acad Sci U S A (1985) 1.03
T-cell activation influences initial DNA synthesis of simian immunodeficiency virus in resting T lymphocytes from macaques. J Virol (1993) 1.03
A new polymorphism in the human beta-globin gene useful in antenatal diagnosis. J Clin Invest (1981) 1.02
A directly repeated sequence in the beta-globin promoter regulates transcription in murine erythroleukemia cells. Mol Cell Biol (1990) 1.01
Baboon endogenous virus genome: molecular cloning and structural characterization of nondefective viral genomes from DNA of a baboon cell strain. Proc Natl Acad Sci U S A (1981) 1.00
Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res (1984) 86.56
Nucleotide sequence of the rightward operator of phage lambda. Proc Natl Acad Sci U S A (1975) 56.75
The isolation of structural genes from libraries of eucaryotic DNA. Cell (1978) 37.13
The isolation and characterization of linked delta- and beta-globin genes from a cloned library of human DNA. Cell (1978) 22.88
Chain length determination of small double- and single-stranded DNA molecules by polyacrylamide gel electrophoresis. Biochemistry (1975) 22.00
Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucleic Acids Res (1979) 21.96
The structure and evolution of the human beta-globin gene family. Cell (1980) 21.24
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Identification of two distinct regulatory regions adjacent to the human beta-interferon gene. Cell (1983) 17.60
Regulation of inducible and tissue-specific gene expression. Science (1987) 15.04
Amplification and characterization of a beta-globin gene synthesized in vitro. Cell (1976) 14.99
Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries. Proc Natl Acad Sci U S A (1985) 13.19
Normal and mutant human beta-globin pre-mRNAs are faithfully and efficiently spliced in vitro. Cell (1984) 12.30
The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B. Cell (1994) 11.62
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
Nonviral retroposons: genes, pseudogenes, and transposable elements generated by the reverse flow of genetic information. Annu Rev Biochem (1986) 11.03
Detection and localization of single base changes by denaturing gradient gel electrophoresis. Methods Enzymol (1987) 10.90
Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell (1993) 10.36
The evolution of genes: the chicken preproinsulin gene. Cell (1980) 10.25
A bacterial clone synthesizing proinsulin. Proc Natl Acad Sci U S A (1978) 10.23
Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system. Cell (1981) 9.81
Human beta-globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell (1983) 9.77
Human lipoprotein lipase complementary DNA sequence. Science (1987) 9.50
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro. Cell (1984) 9.13
The chromosomal arrangement of human alpha-like globin genes: sequence homology and alpha-globin gene deletions. Cell (1980) 9.13
Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature (1990) 8.79
Transcriptional activation: a complex puzzle with few easy pieces. Cell (1994) 8.63
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing. Nature (1987) 8.28
Role of insulin-like growth factors in embryonic and postnatal growth. Cell (1993) 8.22
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07
Molecular cloning and characterization of the human beta-like globin gene cluster. Cell (1980) 7.77
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev (1995) 7.36
NF-kappa B: a lesson in family values. Cell (1995) 7.33
Transcriptional activation of cloned human beta-globin genes by viral immediate-early gene products. Cell (1983) 7.22
Virus induction of human IFN beta gene expression requires the assembly of an enhanceosome. Cell (1995) 7.17
Parental imprinting of the mouse insulin-like growth factor II gene. Cell (1991) 7.11
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo. Mol Cell (1998) 7.01
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
Structure of the lambda operators. Nature (1973) 6.66
End labeling of enzymatically decapped mRNA. Nucleic Acids Res (1977) 6.58
Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Nucleic Acids Res (1985) 6.52
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48
A role for exon sequences and splice-site proximity in splice-site selection. Cell (1986) 6.41
Fine structure genetic analysis of a beta-globin promoter. Science (1986) 6.36
Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Science (1985) 6.35
Ordered recruitment of chromatin modifying and general transcription factors to the IFN-beta promoter. Cell (2000) 6.32
Sequence of a repressor-binding site in the DNA of bacteriophage lamda. Nature (1974) 6.22
Disruption of imprinting caused by deletion of the H19 gene region in mice. Nature (1995) 6.18
Insertion of synthetic copies of human globin genes into bacterial plasmids. Nucleic Acids Res (1978) 5.99
Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99
Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell (1996) 5.91
The high mobility group protein HMG I(Y) is required for NF-kappa B-dependent virus induction of the human IFN-beta gene. Cell (1992) 5.85
The human beta-interferon gene enhancer is under negative control. Cell (1986) 5.61
Transcriptional regulation of endothelial cell adhesion molecules: NF-kappa B and cytokine-inducible enhancers. FASEB J (1995) 5.59
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting. Nature (1990) 5.47
Characterization of the human factor VIII gene. Nature (1984) 5.37
Enzymatic in vitro synthesis of globin genes. Cell (1976) 5.31
Intron sequences involved in lariat formation during pre-mRNA splicing. Cell (1985) 5.30
Multiple repressor binding at the operators in bacteriophage lambda. Proc Natl Acad Sci U S A (1973) 5.15
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell (1993) 4.82
NF-kappaB signaling pathways in mammalian and insect innate immunity. Genes Dev (2001) 4.70
Bovine papillomavirus vector that propagates as a plasmid in both mouse and bacterial cells. Proc Natl Acad Sci U S A (1982) 4.69
Human beta-interferon gene expression is regulated by an inducible enhancer element. Cell (1985) 4.68
The molecular genetics of human hemoglobins. Annu Rev Genet (1980) 4.67
Structure and in vitro transcription of human globin genes. Science (1980) 4.65
cDNA sequence of human apolipoprotein(a) is homologous to plasminogen. Nature (1987) 4.54
The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature (1981) 4.50
cis and trans activation of globin gene transcription in transient assays. Proc Natl Acad Sci U S A (1983) 4.41
Associations between distinct pre-mRNA splicing components and the cell nucleus. EMBO J (1991) 4.38
Activation of the human beta-interferon gene requires an interferon-inducible factor. Mol Cell Biol (1986) 4.38
Expression of active human factor VIII from recombinant DNA clones. Nature (1984) 4.36
Recognition sequences of repressor and polymerase in the operators of bacteriophage lambda. Cell (1975) 4.28
A striking organization of a large family of human neural cadherin-like cell adhesion genes. Cell (1999) 4.25
Tuberculosis as a manifestation of the acquired immunodeficiency syndrome (AIDS). JAMA (1986) 4.25
Control elements in the DNA of bacteriophage lambda. Cold Spring Harb Symp Quant Biol (1974) 4.23
A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Cell (1982) 4.22
Characterisation of deletions which affect the expression of fetal globin genes in man. Nature (1979) 4.18
Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination. Proc Natl Acad Sci U S A (1995) 4.16
The structure of a human alpha-globin pseudogene and its relationship to alpha-globin gene duplication. Cell (1980) 4.15
The structure of the human zeta-globin gene and a closely linked, nearly identical pseudogene. Cell (1982) 4.13
Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell (1993) 4.01
General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5' and 3' splice site selection. Proc Natl Acad Sci U S A (1992) 3.97
A general method for saturation mutagenesis of cloned DNA fragments. Science (1985) 3.94
Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway. Cell (1997) 3.91
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev (1997) 3.83
Full length and discrete partial reverse transcripts of globin and chorion mRNAs. Cell (1975) 3.83