Published in Nature on October 02, 1980
Sodium and calcium channels in bovine chromaffin cells. J Physiol (1982) 12.64
Studies of calcium channels in rat clonal pituitary cells with patch electrode voltage clamp. J Physiol (1982) 4.81
A voltage-gated potassium channel in human T lymphocytes. J Physiol (1985) 4.16
Voltage-dependent inactivation of inward-rectifying single-channel currents in the guinea-pig heart cell membrane. J Physiol (1984) 4.08
Effect of N-bromoacetamide on single sodium channel currents in excised membrane patches. J Gen Physiol (1982) 3.65
Membrane patches and whole-cell membranes: a comparison of electrical properties in rat clonal pituitary (GH3) cells. J Physiol (1984) 3.17
Statistical analysis of single sodium channels. Effects of N-bromoacetamide. Biophys J (1984) 3.01
A low voltage-activated calcium conductance in embryonic chick sensory neurons. Biophys J (1984) 2.97
Single channel currents from excised patches of muscle membrane. Proc Natl Acad Sci U S A (1980) 2.77
Blocking kinetics of the anomalous potassium rectifier of tunicate egg studied by single channel recording. J Physiol (1982) 2.74
Relationship between membrane excitability and single channel open-close kinetics. Biophys J (1983) 2.59
Sodium channels in cultured cardiac cells. J Physiol (1983) 2.41
Single calcium-dependent potassium channels in clonal anterior pituitary cells. Biophys J (1982) 2.26
Lateral distribution of sodium and potassium channels in frog skeletal muscle: measurements with a patch-clamp technique. J Physiol (1983) 2.18
Probing the chemistry of thioredoxin catalysis with force. Nature (2007) 2.17
Patch and whole cell calcium currents recorded simultaneously in snail neurons. J Gen Physiol (1984) 2.17
Two modes of gating during late Na+ channel currents in frog sartorius muscle. J Gen Physiol (1986) 2.04
Modification of single Na+ channels by batrachotoxin. Proc Natl Acad Sci U S A (1982) 1.98
Development of a delayed outward-rectifying K+ conductance in cultured mouse peritoneal macrophages. Proc Natl Acad Sci U S A (1984) 1.86
Sodium currents and sodium-current fluctuations in rat myelinated nerve fibres. J Physiol (1982) 1.83
Pflügers Archiv and the advent of modern electrophysiology. From the first action potential to patch clamp. Pflugers Arch (2003) 1.82
A molecular description of nerve terminal function. Annu Rev Biochem (1983) 1.82
Single voltage-dependent chloride-selective channels of large conductance in cultured rat muscle. Biophys J (1983) 1.78
The sodium current underlying action potentials in guinea pig hippocampal CA1 neurons. J Gen Physiol (1988) 1.71
Single K+ channel currents of anomalous rectification in cultured rat myotubes. Proc Natl Acad Sci U S A (1981) 1.64
Adenosine-5'-triphosphate-sensitive single potassium channel in the atrioventricular node cell of the rabbit heart. J Physiol (1984) 1.61
Gating kinetics of batrachotoxin-modified sodium channels in neuroblastoma cells determined from single-channel measurements. Biophys J (1984) 1.58
Sheep cardiac sarcoplasmic reticulum calcium-release channels: modification of conductance and gating by temperature. J Physiol (1991) 1.58
Patch-clamp studies of slow potential-sensitive potassium channels in longitudinal smooth muscle cells of rabbit jejunum. J Physiol (1983) 1.56
An olfactory neuron responds stochastically to temperature and modulates Caenorhabditis elegans thermotactic behavior. Proc Natl Acad Sci U S A (2008) 1.55
The effect of tetramethylammonium on single sodium channel currents. Biophys J (1981) 1.48
Mitogen induction of ion channels in murine T lymphocytes. J Gen Physiol (1987) 1.47
Voltage clamp of rat and human skeletal muscle: measurements with an improved loose-patch technique. J Physiol (1984) 1.46
Kinetic analysis of single sodium channels from canine cardiac Purkinje cells. J Gen Physiol (1990) 1.44
Voltage-gated Ca2+ channel in mouse myeloma cells. Proc Natl Acad Sci U S A (1983) 1.40
Macroscopic and unitary properties of physiological ion flux through T-type Ca2+ channels in guinea-pig heart cells. J Physiol (1992) 1.40
Functional reconstitution of the purified sodium channel protein from rat sarcolemma. Proc Natl Acad Sci U S A (1982) 1.33
The effects of sodium replacement on the responses of toad rods. J Physiol (1982) 1.32
K channel subconductance levels result from heteromeric pore conformations. J Gen Physiol (2005) 1.29
Single-channel properties of the reconstituted voltage-regulated Na channel isolated from the electroplax of Electrophorus electricus. Proc Natl Acad Sci U S A (1984) 1.27
A quantitative description of the sodium current in the rat sympathetic neurone. J Physiol (1986) 1.25
Cardiac optogenetics. Am J Physiol Heart Circ Physiol (2013) 1.24
Single sodium channels from the squid giant axon. Biophys J (1987) 1.18
Extracting dwell time sequences from processive molecular motor data. Biophys J (2006) 1.16
Channel currents during spontaneous action potentials in embryonic chick heart cells. The action potential patch clamp. Biophys J (1984) 1.15
The influence of transverse tubular delays on the kinetics of charge movement in mammalian skeletal muscle. J Gen Physiol (1985) 1.14
Ca2+-activated K+ channels in human red cells. Comparison of single-channel currents with ion fluxes. Biophys J (1984) 1.13
Modes of glutamate receptor gating. J Physiol (2011) 1.10
Synthesis of sodium channels in the cell bodies of squid giant axons. Proc Natl Acad Sci U S A (1987) 1.09
Transients of perforin pore formation observed by fluorescence microscopic single channel recording. EMBO J (1990) 1.04
Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices. Glia (2013) 1.02
Sodium currents in Schwann cells from myelinated and non-myelinated nerves of neonatal and adult rabbits. J Physiol (1990) 1.02
The Ca2+-dependent slow K+ conductance in cultured rat muscle cells: characterization with apamin. EMBO J (1982) 1.01
Single channel currents induced by complement in antibody-coated cell membranes. Proc Natl Acad Sci U S A (1981) 0.99
Kinetic diversity of Na+ channel bursts in frog skeletal muscle. J Gen Physiol (1989) 0.97
The Hodgkin-Huxley heritage: from channels to circuits. J Neurosci (2012) 0.97
The distribution of sodium and potassium channels in single demyelinated axons of the frog. J Physiol (1987) 0.97
Sodium and potassium currents involved in action potential propagation in normal bovine lactotrophs. J Physiol (1987) 0.95
Time-dependent molecular memory in single voltage-gated sodium channel. J Membr Biol (2007) 0.95
Reconstitution of highly purified saxitoxin-sensitive Na+-channels into planar lipid bilayers. EMBO J (1984) 0.94
Novel suppression of an L-type calcium channel in neurones of murine dorsal root ganglia by 2,3-butanedione monoxime. J Physiol (1992) 0.93
Modal behavior of the mu 1 Na+ channel and effects of coexpression of the beta 1-subunit. Biophys J (1996) 0.92
Ca channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells. Biophys J (1993) 0.92
Characterization of voltage-gated sodium channels in ovine gonadotrophs: relationship to hormone secretion. J Physiol (1988) 0.90
Analysis of sodium current fluctuations in the cut-open squid giant axon. J Gen Physiol (1984) 0.89
Voltage-gated and chemically gated ionic channels in the cultured cochlear ganglion neurone of the chick. J Physiol (1990) 0.88
Sensitivity of membranes to their environment. Role of stochastic processes. Biophys J (1984) 0.88
Specific modulation of sodium channels in mammalian nerve by monoclonal antibodies. Proc Natl Acad Sci U S A (1986) 0.88
Currents recorded through small areas of squid axon membrane with an internal virtual ground voltage clamp. Biophys J (1981) 0.85
Rapid sodium channel conductance changes during voltage clamp steps in squid giant axons. Biophys J (1984) 0.83
Probability fluxes and transition paths in a Markovian model describing complex subunit cooperativity in HCN2 channels. PLoS Comput Biol (2012) 0.82
KATP Channels in the Cardiovascular System. Physiol Rev (2016) 0.82
Reduced Na(+) and higher K(+) channel expression and function contribute to right ventricular origin of arrhythmias in Scn5a+/- mice. Open Biol (2012) 0.81
Incorporation of ion channels from bovine rod outer segments into planar lipid bilayers. Biophys J (1984) 0.80
From Galvani to patch clamp: the development of electrophysiology. Pflugers Arch (2006) 0.79
Voltage gating by molecular subunits of Na+ and K+ ion channels: higher-dimensional cubic kinetics, rate constants, and temperature. J Neurophysiol (2015) 0.79
Agonists binding nicotinic receptors elicit specific channel-opening patterns at αγ and αδ sites. J Physiol (2014) 0.78
Effects of drugs on acetylcholine-activated ionic channels of internally perfused chick myoballs. J Physiol (1983) 0.78
Voltage clamp methods for the study of membrane currents and SR Ca(2+) release in adult skeletal muscle fibres. Prog Biophys Mol Biol (2012) 0.78
Stochastic and deterministic dynamics of intrinsically irregular firing in cortical inhibitory interneurons. Elife (2016) 0.77
Finding Channels. J Biol Chem (2015) 0.76
Nobel lecture. Ion channels for communication between and within cells. EMBO J (1992) 0.76
Domain and interdomain energetics underlying gating in Shaker-type Kv channels. Biophys J (2014) 0.75
Patch-clamp fluorometry-based channel counting to determine HCN channel conductance. J Gen Physiol (2016) 0.75
Inverted battery design as ion generator for interfacing with biosystems. Nat Commun (2017) 0.75
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch (1981) 134.60
Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature (1976) 13.78
Sodium and calcium channels in bovine chromaffin cells. J Physiol (1982) 12.64
A patch-clamp study of bovine chromaffin cells and of their sensitivity to acetylcholine. J Physiol (1982) 10.42
Local anaesthetics transiently block currents through single acetylcholine-receptor channels. J Physiol (1978) 10.05
The variance of sodium current fluctuations at the node of Ranvier. J Physiol (1980) 9.29
Discrete changes of cell membrane capacitance observed under conditions of enhanced secretion in bovine adrenal chromaffin cells. Proc Natl Acad Sci U S A (1982) 8.20
Correction for liquid junction potentials in patch clamp experiments. Methods Enzymol (1992) 8.06
Conductance fluctuations and ionic pores in membranes. Annu Rev Biophys Bioeng (1977) 7.60
Rates of diffusional exchange between small cells and a measuring patch pipette. Pflugers Arch (1988) 7.30
Single acetylcholine-activated channels show burst-kinetics in presence of desensitizing concentrations of agonist. Nature (1980) 6.83
Inward current channels activated by intracellular Ca in cultured cardiac cells. Nature (1981) 6.62
The size of gating charge in wild-type and mutant Shaker potassium channels. Science (1992) 6.42
Voltage dependence of K channels in guard-cell protoplasts. Proc Natl Acad Sci U S A (1987) 6.40
Capacitance measurements reveal stepwise fusion events in degranulating mast cells. Nature (1985) 5.41
Delay in vesicle fusion revealed by electrochemical monitoring of single secretory events in adrenal chromaffin cells. Nature (1992) 5.23
Two fast transient current components during voltage clamp on snail neurons. J Gen Physiol (1971) 5.15
Primary structure and functional expression of a mammalian skeletal muscle sodium channel. Neuron (1989) 5.13
Patch-clamp techniques for time-resolved capacitance measurements in single cells. Pflugers Arch (1988) 4.88
Calcium dependence of the rate of exocytosis in a synaptic terminal. Nature (1994) 4.77
Mobile and immobile calcium buffers in bovine adrenal chromaffin cells. J Physiol (1993) 4.61
Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J Gen Physiol (1998) 4.56
Single channel recordings of K+ currents in squid axons. Nature (1980) 4.48
Intracellular calcium dependence of transmitter release rates at a fast central synapse. Nature (2000) 4.46
The extracellular patch clamp: a method for resolving currents through individual open channels in biological membranes. Pflugers Arch (1978) 4.42
The Ca signal from fura-2 loaded mast cells depends strongly on the method of dye-loading. FEBS Lett (1985) 3.95
The charge carried by single-channel currents of rat cultured muscle cells in the presence of local anaesthetics. J Physiol (1983) 3.76
Potassium channels in cultured bovine adrenal chromaffin cells. J Physiol (1985) 3.60
Regulation of calcium influx by second messengers in rat mast cells. Nature (1988) 3.60
Multiple kinetic components of exocytosis distinguished by neurotoxin sensitivity. Nat Neurosci (1998) 3.37
Calcium requirements for secretion in bovine chromaffin cells. J Physiol (1992) 3.34
Highly nonlinear photodamage in two-photon fluorescence microscopy. Biophys J (2001) 3.34
Linearized buffered Ca2+ diffusion in microdomains and its implications for calculation of [Ca2+] at the mouth of a calcium channel. J Neurosci (1997) 3.28
Voltage-dependence of drug-induced conductance in frog neuromuscular junction. Proc Natl Acad Sci U S A (1975) 3.18
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Kinetics of the secretory response in bovine chromaffin cells following flash photolysis of caged Ca2+. Biophys J (1994) 3.14
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Released fraction and total size of a pool of immediately available transmitter quanta at a calyx synapse. Neuron (1999) 3.04
Calmodulin mediates rapid recruitment of fast-releasing synaptic vesicles at a calyx-type synapse. Neuron (2001) 2.90
Patch clamp techniques for studying ionic channels in excitable membranes. Annu Rev Physiol (1984) 2.86
How does the W434F mutation block current in Shaker potassium channels? J Gen Physiol (1997) 2.81
Munc18-1 promotes large dense-core vesicle docking. Neuron (2001) 2.71
Ionic selectivity, saturation, and block in gramicidin A channels. II. Saturation behavior of single channel conductances and evidence for the existence of multiple binding sites in the channel. J Membr Biol (1978) 2.71
Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron (1993) 2.69
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron (1998) 2.68
Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. J Physiol (1995) 2.67
Sodium channels in nerve apparently have two conductance states. Nature (1977) 2.62
Noise analysis of drug induced voltage clamp currents in denervated frog muscle fibres. J Physiol (1976) 2.62
Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules. Neuron (1996) 2.59
Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions. J Gen Physiol (1998) 2.49
Inhibition of SNARE complex assembly differentially affects kinetic components of exocytosis. Cell (1999) 2.49
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Modeling buffered Ca2+ diffusion near the membrane: implications for secretion in neuroendocrine cells. Biophys J (1997) 2.48
Rapid changes of potassium concentration at the outer surface of exposed single neurons during membrane current flow. J Gen Physiol (1973) 2.46
Impaired slow inactivation in mutant sodium channels. Biophys J (1996) 2.45
Calcium dependence of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse. Neuron (2001) 2.43
Rat brain serotonin receptors in Xenopus oocytes are coupled by intracellular calcium to endogenous channels. Proc Natl Acad Sci U S A (1987) 2.41
Covariance of nonstationary sodium current fluctuations at the node of Ranvier. Biophys J (1981) 2.39
A Ca-dependent early step in the release of catecholamines from adrenal chromaffin cells. Science (1993) 2.29
Single channel activity associated with the calcium dependent outward current in Helix pomatia. Pflugers Arch (1981) 2.29
Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. J Gen Physiol (1999) 2.27
Substance P reduces acetylcholine-induced currents in isolated bovine chromaffin cells. J Physiol (1984) 2.09
The conductance of sodium channels under conditions of reduced current at the node of Ranvier. J Physiol (1980) 2.07
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Mechanisms underlying phasic and sustained secretion in chromaffin cells from mouse adrenal slices. Neuron (1999) 2.01
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Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells. EMBO J (2000) 1.98
Yet another approach to the dwell-time omission problem of single-channel analysis. Biophys J (1990) 1.97
Multiple gating modes and the effect of modulating factors on the microI sodium channel. Neuron (1991) 1.95
Fast calcium transients in rat peritoneal mast cells are not sufficient to trigger exocytosis. EMBO J (1986) 1.94
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Multiple forms of endocytosis in bovine adrenal chromaffin cells. J Cell Biol (1997) 1.85
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Electrostatics and the gating pore of Shaker potassium channels. J Gen Physiol (2001) 1.72
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Optimizing imaging parameters for the separation of multiple labels in a fluorescence image. J Microsc (2004) 1.62
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Interpreting power spectra from nonstationary membrane current fluctuations. Biophys J (1981) 1.58
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