Published in Nucleic Acids Res on January 10, 1981
Analysis of Mycoplasma hyorhinis genome by use of restriction endonucleases and by electron microscopy. J Bacteriol (1982) 1.48
A simple and rapid electrophoresis method to detect sequence variation in PCR-amplified DNA fragments. Nucleic Acids Res (1995) 1.09
Gel electrophoresis of partially denatured DNA. Retardation effect: its analysis and application. Nucleic Acids Res (1982) 1.05
Detection of a single base exchange in PCR-amplified DNA fragments using agarose gel electrophoresis containing bisbenzimide-PEG. Nucleic Acids Res (1997) 0.79
In vivo HIV-1 hypermutation and viral loads among antiretroviral-naive Brazilian patients. AIDS Res Hum Retroviruses (2014) 0.75
Analysis of restriction fragments of T7 DNA and determination of molecular weights by electrophoresis in neutral and alkaline gels. J Mol Biol (1977) 33.84
The nucleotide sequence of bacteriophage phiX174. J Mol Biol (1978) 13.55
Length-independent separation of DNA restriction fragments in two-dimensional gel electrophoresis. Cell (1979) 8.26
Measurement of protein-binding phenomena by gel filtration. Biochim Biophys Acta (1962) 7.39
A simple method for identifying the palindromic sequences recognized by restriction endonucleases: the nucleotide sequence of the AvaII site. Gene (1978) 1.91
Interactions of heteroaromatic compounds with nucleic acids. 2. Influence of substituents on the base and sequence specificity of intercalating ligands. Eur J Biochem (1975) 1.36
Fractionation of DNA on hydroxyapatite with a base-specific complexing agent. Proc Natl Acad Sci U S A (1974) 1.03
Isolation of mouse satellite deoxyribonucleic acid by composite polyacrylamide gel electrophoresis. Biochemistry (1971) 0.98
Antibiotic induced electrophoretic mobility shifts of DNA restriction fragments. Nucleic Acids Res (1979) 0.92
A two-dimensional electrophoretic procedure for the separation of DNA restriction fragments. J Mol Biol (1977) 0.87
[Base specific affinity chromatography of nucleic acids]. Naturwissenschaften (1977) 0.85
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97
High gradient magnetic cell separation with MACS. Cytometry (1990) 6.69
Functional MRI evidence for adult motor cortex plasticity during motor skill learning. Nature (1995) 5.75
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A (1995) 5.06
Conditional gene targeting. J Clin Invest (1996) 4.60
The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex. Proc Natl Acad Sci U S A (1998) 4.34
IMGT, the international ImMunoGeneTics database. Nucleic Acids Res (1999) 3.77
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress. Cell (1999) 3.76
Most peripheral B cells in mice are ligand selected. J Exp Med (1991) 3.50
Evaluation of knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc (1993) 3.48
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43
Studies of the binding of actinomycin and related compounds to DNA. J Mol Biol (1968) 3.35
A multifunctional gene (tetR) controls Tn10-encoded tetracycline resistance. J Bacteriol (1982) 3.19
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature (1996) 3.11
A critical role of lambda 5 protein in B cell development. Cell (1992) 3.09
Heterogeneous Hadean hafnium: evidence of continental crust at 4.4 to 4.5 ga. Science (2005) 2.92
A role for CD5 in TCR-mediated signal transduction and thymocyte selection. Science (1995) 2.84
T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med (1996) 2.79
IMGT, the international ImMunoGeneTics database. Nucleic Acids Res (1997) 2.43
IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma. J Immunol (1994) 2.39
Intrapericardial fibrinolysis: a useful treatment in the management of purulent pericarditis. Intensive Care Med (1997) 2.30
The p53-dependent effects of macrophage migration inhibitory factor revealed by gene targeting. Proc Natl Acad Sci U S A (2003) 2.29
Salt stress leads to differential expression of two isogenes of phosphoenolpyruvate carboxylase during Crassulacean acid metabolism induction in the common ice plant. Plant Cell (1989) 2.27
Site-directed mutagenesis in DNA: generation of point mutations in cloned beta globin complementary dna at the positions corresponding to amino acids 121 to 123. J Mol Biol (1978) 2.17
Indicators of lifetime endogenous estrogen exposure and risk of venous thromboembolism. J Thromb Haemost (2006) 2.17
Analysis of the B-cell progenitor compartment at the level of single cells. Curr Biol (1994) 2.15
Diagnostic accuracy of magnetic resonance imaging for an acute pulmonary embolism: results of the 'IRM-EP' study. J Thromb Haemost (2012) 2.15
Pulmonary embolectomy by catheter device in massive pulmonary embolism. Chest (1991) 2.09
Production of a monoclonal antibody against an epitope on HeLa cells that is the functional poliovirus binding site. J Gen Virol (1985) 2.08
The isolation of DNA from agarose gels by electrophoretic elution onto malachite green-polyacrylamide columns. Gene (1978) 2.05
Immunoglobulin heavy and light chain genes rearrange independently at early stages of B cell development. Cell (1993) 1.95
Bypass of lethality with mosaic mice generated by Cre-loxP-mediated recombination. Curr Biol (1996) 1.94
Interactions of heteroaromatic compounds with nucleic acids. A - T-specific non-intercalating DNA ligands. Eur J Biochem (1975) 1.93
Trend of hip fracture incidence in Germany 1995-2004: a population-based study. Osteoporos Int (2007) 1.90
Cre-loxP-mediated gene replacement: a mouse strain producing humanized antibodies. Curr Biol (1994) 1.83
Interactions of heteroaromatic compounds with nucleic acids. 1. The influence of heteroatoms and polarizability on the base specificity of intercalating ligands. Eur J Biochem (1975) 1.83
Clinical and molecular analysis of five inv dup(15) patients. Eur J Hum Genet (1993) 1.82
Biosynthesis of the first component of complement by human and guinea pig peritoneal macrophages: evidence for an independent production of the C1 subunits. J Immunol (1978) 1.79
Class switch recombination is IgG1 specific on active and inactive IgH loci of IgG1-secreting B-cell blasts. Proc Natl Acad Sci U S A (1986) 1.76
Synthesis, transport and localization of a nuclear coded 22-kd heat-shock protein in the chloroplast membranes of peas and Chlamydomonas reinhardi. EMBO J (1985) 1.73
Laparoscopic liver resection compared with conventional partial hepatectomy--a prospective analysis. Hepatogastroenterology (1999) 1.70
The effect of treating herpes zoster with oral acyclovir in preventing postherpetic neuralgia. A meta-analysis. Arch Intern Med (1997) 1.68
Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses. J Exp Med (1995) 1.68
Analysis of cytokine mRNA levels in interleukin-4-transgenic mice by quantitative polymerase chain reaction. Eur J Immunol (1992) 1.67
Tumor suppression after tumor cell-targeted tumor necrosis factor alpha gene transfer. J Exp Med (1991) 1.66
A rapidly light-induced chloroplast protein with a high turnover coded for by pea nuclear DNA. Eur J Biochem (1984) 1.65
Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects. J Exp Med (1998) 1.65
Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response. J Exp Med (2001) 1.62
Consensus statement on the diagnosis, treatment and follow-up of patients with primary adrenal insufficiency. J Intern Med (2013) 1.57
Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4. Eur J Immunol (1994) 1.57
Monoclonal anti-CD4 in arthritis. Lancet (1987) 1.55
Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells. J Exp Med (1994) 1.54
IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic disease. J Immunol (1998) 1.54
Hemodynamic effects of fluid loading in acute massive pulmonary embolism. Crit Care Med (1999) 1.51
Transient hypogammaglobulinemia of infancy: Five new cases, review of the literature and redefinition. Acta Paediatr Scand (1989) 1.51
Techniques and results of laparoscopic antireflux surgery in Germany. Surg Endosc (2005) 1.49
Molecular mechanisms determining the strength of receptor-mediated intermembrane adhesion. Biophys J (1995) 1.49
Liposomal amphotericin-B (AmBisome) for treatment of disseminated fungal infections in two infants of very low birth weight. Pediatrics (1992) 1.48
[Present experiences with isoelastic prostheses of the upper extremities]. Z Orthop Ihre Grenzgeb (1975) 1.48
Validation of a fully automatic photoplethysmographic device for toe blood pressure measurement. Eur J Vasc Endovasc Surg (2010) 1.46
Role of STAT3 and PI 3-kinase/Akt in mediating the survival actions of cytokines on sensory neurons. Mol Cell Neurosci (2001) 1.45
The impact of respiratory syncytial virus infection: a prospective study in hospitalized infants younger than 2 years. Infection (2002) 1.45
Expression of different survivin variants in gastric carcinomas: first clues to a role of survivin-2B in tumour progression. Br J Cancer (2002) 1.45
IMGT, the International ImMunoGeneTics database. Nucleic Acids Res (1998) 1.45
Evidence base in guideline generation in diabetes. Diabetologia (2013) 1.43
[Minimally invasive interventions in solitary liver cysts]. Chirurg (1992) 1.43
Plasmodium chabaudi chabaudi: differential susceptibility of gene-targeted mice deficient in IL-10 to an erythrocytic-stage infection. Exp Parasitol (1996) 1.42
2008 SOR guidelines for the prevention and treatment of thrombosis associated with central venous catheters in patients with cancer: report from the working group. Ann Oncol (2009) 1.41
["A life threatening event" in infants. Results of polysomnography and examination of a group of 122 infants]. Monatsschr Kinderheilkd (1992) 1.40
Microheterogeneity of alpha 1-antitrypsin in relation to the concentration of its complex with immunoglobulin A in the sera of patients with rheumatoid arthritis. Clin Exp Rheumatol (1996) 1.40
[In vitro and in vivo studies of isolation, transplantation and function of Langerhans islets in the swine]. Langenbecks Arch Chir (1990) 1.40
Fighting the spread of AmpC-hyperproducing Enterobacteriaceae: beneficial effect of replacing ceftriaxone with cefotaxime. J Antimicrob Chemother (2013) 1.40
Familial clustering of infantile cirrhosis in Northern Germany: A clue to the etiology of idiopathic copper toxicosis. J Pediatr (1999) 1.39
[The influence of depression on the effect of Tropisetron in the therapy of fibromyalgia]. Z Rheumatol (2003) 1.38
[Neonatal diabetes mellitus: treatment with sulfonylurea in a preterm born infant]. Klin Padiatr (2009) 1.38
Hemodynamic effects of bolus vs 2-h infusion of alteplase in acute massive pulmonary embolism. A randomized controlled multicenter trial. Chest (1994) 1.38
Time dependent effects on contractile properties, fibre population, myosin light chains and enzymes of energy metabolism in intermittently and continuously stimulated fast twitch muscles of the rabbit. Pflugers Arch (1976) 1.37
Mice reconstituted with DNA polymerase beta-deficient fetal liver cells are able to mount a T cell-dependent immune response and mutate their Ig genes normally. Proc Natl Acad Sci U S A (2000) 1.36
Interactions of heteroaromatic compounds with nucleic acids. 2. Influence of substituents on the base and sequence specificity of intercalating ligands. Eur J Biochem (1975) 1.36
c-fos expression interferes with thymus development in transgenic mice. Cell (1988) 1.35
Early B-cell development in the mouse: insights from mutations introduced by gene targeting. Immunol Rev (1994) 1.35
A non-intercalating proflavine derivative. Eur J Biochem (1973) 1.34
Base specific fractionation of double stranded DNA: affinity chromatography on a novel type of adsorbant. Nucleic Acids Res (1978) 1.34
Regulation of in vitro capillary tube formation by anti-integrin antibodies. J Cell Biol (1993) 1.34
An accessory gene, lipB, required for the production of active Pseudomonas glumae lipase. Mol Microbiol (1993) 1.33
Improperly placed anterior cruciate ligament grafts: correlation between radiological parameters and clinical results. Knee Surg Sports Traumatol Arthrosc (2000) 1.32
Nuclear transformation of Volvox carteri. Proc Natl Acad Sci U S A (1994) 1.31
IUPAC collaborative trial study of a method to detect genetically modified soy beans and maize in dried powder. J AOAC Int (1999) 1.30
Laparoscopic creation of a loop colostomy. J Laparoendosc Surg (1991) 1.29
Chronic colitis in IL-10-/- mice: insufficient counter regulation of a Th1 response. Int Rev Immunol (2000) 1.28
Lymphocyte populations and immune responses in CD5-deficient mice. Eur J Immunol (1994) 1.25
Porous hydroxyapatite and tricalcium phosphate cylinders with two different pore size ranges implanted in the cancellous bone of rabbits. A comparative histomorphometric and histologic study of bony ingrowth and implant substitution. Clin Orthop Relat Res (1988) 1.24
Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J Immunol (1997) 1.23
Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. J Immunol (1998) 1.23
Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development. Immunity (1996) 1.22
Outbreaks of monophasic Salmonella enterica serovar 4,[5],12:i:- in Luxembourg, 2006. Euro Surveill (2007) 1.22
L-selectin and beta7 integrin synergistically mediate lymphocyte migration to mesenteric lymph nodes. Eur J Immunol (1998) 1.22