Published in Nature on March 10, 1983
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation. Mol Cell Biol (1984) 6.40
Myristylation is required for intracellular transport but not for assembly of D-type retrovirus capsids. J Virol (1987) 5.68
Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog. J Virol (1985) 3.47
Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src. Mol Cell Biol (1985) 3.39
Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein. Mol Cell Biol (1984) 2.98
Fine structural mapping of a critical NH2-terminal region of p60src. Proc Natl Acad Sci U S A (1985) 2.53
Intramembrane translocation and posttranslational palmitoylation of the chloroplast 32-kDa herbicide-binding protein. Proc Natl Acad Sci U S A (1987) 2.50
Processing of p60v-src to its myristylated membrane-bound form. Mol Cell Biol (1985) 2.41
Isolation and characterization of fra-2, an additional member of the fos gene family. Proc Natl Acad Sci U S A (1990) 2.40
Site-directed mutagenesis of the SH2- and SH3-coding domains of c-src produces varied phenotypes, including oncogenic activation of p60c-src. Mol Cell Biol (1990) 2.39
Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src molecules. J Cell Biol (1985) 2.32
Two classes of fatty acid acylated proteins exist in eukaryotic cells. EMBO J (1985) 2.28
Subcellular localization of glycoproteins encoded by the viral oncogene v-fms. J Virol (1984) 2.21
Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation. Proc Natl Acad Sci U S A (1987) 2.20
Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 2.16
Cell surface expression of v-fms-coded glycoproteins is required for transformation. Mol Cell Biol (1984) 2.09
Covalently bound myristate in a lymphoma tyrosine protein kinase. Proc Natl Acad Sci U S A (1984) 1.76
Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum. Proc Natl Acad Sci U S A (1991) 1.62
Studies on the attachment of myristic and palmitic acid to cell proteins in human squamous carcinoma cell lines: evidence for two pathways. EMBO J (1985) 1.52
Rat c-raf oncogene activation by a rearrangement that produces a fused protein. Mol Cell Biol (1987) 1.42
Acylation of viral and eukaryotic proteins. Biochem J (1989) 1.38
Size-variant pp60src proteins of recovered avian sarcoma viruses interact with adhesion plaques as peripheral membrane proteins: effects on cell transformation. Mol Cell Biol (1984) 1.34
The transfer of myristic and other fatty acids on lipid and viral protein acceptors in cultured cells infected with Semliki Forest and influenza virus. EMBO J (1984) 1.14
Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells. Mol Cell Biol (1985) 1.11
Regulation of cellular morphology by the Rous sarcoma virus src gene: analysis of fusiform mutants. Mol Cell Biol (1985) 1.06
NH2-terminal sequences of two src proteins that cause aberrant transformation. Proc Natl Acad Sci U S A (1987) 1.05
Membrane interactions of simian virus 40 large T-antigen: influence of protein sequences and fatty acid acylation. Mol Cell Biol (1984) 1.00
N-myristoylation of p60src. Identification of a myristoyl-CoA:glycylpeptide N-myristoyltransferase in rat tissues. Biochem J (1988) 0.99
Cellular localization of the transforming protein of wild-type and temperature-sensitive Fujinami sarcoma virus. J Virol (1984) 0.98
Identification of acyl donors and acceptor proteins for fatty acid acylation in BHK cells infected with Semliki Forest virus. EMBO J (1984) 0.97
Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus. J Virol (1986) 0.97
Reduced synthesis of pp60src and expression of the transformation-related phenotype in interferon-treated Rous sarcoma virus-transformed rat cells. Mol Cell Biol (1983) 0.96
Development and analysis of a transformation-defective mutant of Harvey murine sarcoma tk virus and its gene product. J Virol (1985) 0.90
Dynamic nature of the association of large tumor antigen and p53 cellular protein with the surfaces of simian virus 40-transformed cells. J Virol (1984) 0.86
In vivo acylation of Dictyostelium actin with palmitic acid. EMBO J (1985) 0.85
Differential inhibition of cellular and viral pp60src kinase by P1,P4-di(adenosine-5')tetraphosphate. Mol Cell Biol (1983) 0.84
Studies on the cellular location, physical properties and endogenously attached lipids of acylated proteins in human squamous-carcinoma cell lines. Biochem J (1987) 0.81
Immunological responsiveness against tumors induced by avian sarcoma virus: reduced expression of pp60src kinase activity in regressing tumors. J Virol (1985) 0.75
Suppression of Rous sarcoma virus-induced tumor formation by preinfection with viruses encoding src protein with novel N termini. J Virol (1989) 0.75
The effects of reciprocal changes in temperature on the transformed state of cells infected with a rous sarcoma virus mutant. Virology (1971) 7.83
Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus. Cell (1983) 7.37
A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation. Mol Cell Biol (1984) 6.40
A novel viral oncogene with structural similarity to phospholipase C. Nature (1988) 5.84
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New mutations in the S cistron of bacteriophage lambda affecting host cell lysis. Virology (1969) 4.78
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Cell transformation by the viral src oncogene. Annu Rev Cell Biol (1987) 4.18
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An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Nature (1985) 4.06
Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein. Science (1985) 3.97
Characterization of protein kinase activity associated with the transforming gene product of Fujinami sarcoma virus. Cell (1980) 3.82
Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 3.73
Evidence that the src gene product of Rous sarcoma virus is membrane associated. Virology (1980) 3.71
Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts. Proc Natl Acad Sci U S A (1984) 3.70
Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. Science (1990) 3.67
Cellular information in the genome of recovered avian sarcoma virus directs the synthesis of transforming protein. Proc Natl Acad Sci U S A (1979) 3.66
Proteins of helper-dependent RSV. Virology (1971) 3.62
Transformation by Rous sarcoma virus induces a novel gene with homology to a mitogenic platelet protein. Cell (1987) 3.50
Local mutagenesis of Rous sarcoma virus: the major sites of tyrosine and serine phosphorylation of pp60src are dispensable for transformation. Cell (1983) 3.46
A cell-associated factor essential for formation of an infectious form of Rous sarcoma virus. Proc Natl Acad Sci U S A (1970) 3.43
Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src. Mol Cell Biol (1985) 3.39
Recombination between viral and cellular sequences generates transforming sarcoma virus. Proc Natl Acad Sci U S A (1978) 3.38
Isolation of defective mutant of avian sarcoma virus. Proc Natl Acad Sci U S A (1973) 3.38
DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src. J Virol (1982) 3.35
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Th17 cytokines interleukin (IL)-17 and IL-22 modulate distinct inflammatory and keratinocyte-response pathways. Br J Dermatol (2008) 3.19
Evidence for a transcriptional activation function of BRCA1 C-terminal region. Proc Natl Acad Sci U S A (1996) 3.18
Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein. Cell (1981) 3.12
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Identification of a palmitic acid-modified form of human Sonic hedgehog. J Biol Chem (1998) 2.95
Analysis of a functional change in membrane in the process of cell transformation by Rous sarcoma virus; alteration in the characteristics of sugar transport. Virology (1970) 2.94
Determining factor in the capacity of Rous sarcoma virus to induce tumors in mammals. Proc Natl Acad Sci U S A (1966) 2.86
Detection of avian tumor virus RNA in uninfected chicken embryo cells. J Virol (1973) 2.85
Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein. Mol Cell Biol (1986) 2.84
Association of the polyomavirus middle-T antigen with c-yes protein. Nature (1987) 2.78
Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. J Biol Chem (1996) 2.77
Activation of the transforming potential of p60c-src by a single amino acid change. Proc Natl Acad Sci U S A (1986) 2.70
Cellular sequences related to three new onc genes of avian sarcoma virus (fps, yes, and ros) and their expression in normal and transformed cells. J Virol (1982) 2.69
c-Abl kinase regulates the protein binding activity of c-Crk. EMBO J (1994) 2.68
Characterization of the transforming gene of Fujinami sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.68
TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell (1999) 2.64
A type of chick embryo cell that fails to support formation of infectious RSV. Virology (1970) 2.63
CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris. J Clin Invest (1999) 2.58
Fine structural mapping of a critical NH2-terminal region of p60src. Proc Natl Acad Sci U S A (1985) 2.53
BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci U S A (1998) 2.50
Homology exists among the transforming sequences of avian and feline sarcoma viruses. Proc Natl Acad Sci U S A (1980) 2.50
Association of the v-crk oncogene product with phosphotyrosine-containing proteins and protein kinase activity. Proc Natl Acad Sci U S A (1990) 2.48
Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. Mol Cell Biol (1993) 2.47
DNA sequence of the viral and cellular src gene of chickens. II. Comparison of the src genes of two strains of avian sarcoma virus and of the cellular homolog. J Virol (1982) 2.46
Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies. Mol Cell Biol (1988) 2.44
Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length. J Virol (1977) 2.43
Microinjection analysis of envelope-glycoprotein messenger activities of avian leukosis viral RNAs. Proc Natl Acad Sci U S A (1977) 2.42
Processing of p60v-src to its myristylated membrane-bound form. Mol Cell Biol (1985) 2.41
Changes in microfilament organization and surface topogrophy upon transformation of chick embryo fibroblasts with Rous sarcoma virus. Proc Natl Acad Sci U S A (1976) 2.38
RNA of replication-defective strains of Rous sarcoma virus. Proc Natl Acad Sci U S A (1975) 2.37
Existence and expression of tumor virus genes in chick embryo cells. Virology (1972) 2.36
Synethesis and integration of viral DNA in chicken cells at different time after infection with various multiplicities of avian oncornavirus. J Virol (1976) 2.34
Phosphatidylinositol kinase activity associates with viral p60src protein. Mol Cell Biol (1989) 2.33
N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene. Mol Cell Biol (1985) 2.32
Increased protease levels in transformed cells: a casein overlay assay for the detection of plasminogen activator production. Cell (1974) 2.31
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. Mol Cell Biol (1988) 2.31
Genetic variation in the RNA transcripts of endogenous virus genes in uninfected chicken cells. J Virol (1977) 2.28
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A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO J (1997) 2.22
Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation. Proc Natl Acad Sci U S A (1987) 2.20
Noninfectious RSV deficient in DNA polymerase. Virology (1971) 2.18
Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity. J Virol (1982) 2.14
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Changes in amino-terminal sequences of pp60src lead to decreased membrane association and decreased in vivo tumorigenicity. Cell (1982) 2.13
In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinases. J Biol Chem (1983) 2.10
Response of psoriasis to a lymphocyte-selective toxin (DAB389IL-2) suggests a primary immune, but not keratinocyte, pathogenic basis. Nat Med (1995) 2.09
Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor. Cancer Res (2000) 2.02
Penetration and intracellular release of the genomes of avian RNA tumor viruses. Virology (1972) 2.02
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Further studies on RSV production form transformed cells. Virology (1968) 1.97
The product of the cellular crk gene consists primarily of SH2 and SH3 regions. Cell Growth Differ (1992) 1.94
Subcellular localization of pp60src in RSV-transformed cells. Curr Top Microbiol Immunol (1983) 1.93
Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins. Mol Cell Biol (1991) 1.92
Differences in intracellular location of pp60src in rat and chicken cells transformed by Rous sarcoma virus. Proc Natl Acad Sci U S A (1980) 1.91