Restriction and modification enzymes and their recognition sequences.

Nomenclature for incompletely specified bases in nucleic acid sequences: recommendations 1984. Nucleic Acids Res (1985) 9.17

A type II restriction endonuclease with an eight nucleotide specificity from Streptomyces fimbriatus. Nucleic Acids Res (1984) 2.64

Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II). Proc Natl Acad Sci U S A (1985) 2.54

Site-specific cleavage of DNA at 8- and 10-base-pair sequences. Proc Natl Acad Sci U S A (1984) 2.48

Structure of the Saccharomyces cerevisiae HO gene and analysis of its upstream regulatory region. Mol Cell Biol (1986) 2.36

DNA adenine methylation of GATC sequences appeared recently in the Escherichia coli lineage. J Bacteriol (1984) 2.05

Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA X Fe(II). Proc Natl Acad Sci U S A (1983) 1.92

Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1984) 1.75

Transposon Tn5 specifies streptomycin resistance in Rhizobium spp. J Bacteriol (1984) 1.55

A second type II restriction endonuclease from Thermus aquaticus with an unusual sequence specificity. Nucleic Acids Res (1984) 1.38

Sequence and cloning of bacteriophage T4 gene 63 encoding RNA ligase and tail fibre attachment activities. EMBO J (1984) 1.27

Methylated DNA in Borrelia species. J Bacteriol (1990) 1.25

Eight new restriction endonucleases fröm Herpetosiphon giganteus--divergent evolution in a family of enzymes. Nucleic Acids Res (1984) 1.22

Nomenclature for incompletely specified bases in nucleic acid sequences. Recommendations 1984. Nomenclature Committee of the International Union of Biochemistry (NC-IUB). Proc Natl Acad Sci U S A (1986) 1.04

Type III 5-methylcytosine modification of DNA in Neisseria gonorrhoeae. J Bacteriol (1985) 1.02

Structure and physical map of Rhodopseudomonas sphaeroides bacteriophage RS1 DNA. J Virol (1985) 0.90

Nomenclature Committee of the International Union of Biochemistry (NC-IUB). Nomenclature for incompletely specified bases in nucleic acid sequences. Recommendations 1984. Biochem J (1985) 0.85

Complete genome sequence and methylome analysis of bacillus strain x1. Genome Announc (2015) 0.84

Introduction of restriction enzyme sites in protein-coding DNA sequences by site-specific mutagenesis not affecting the amino acid sequence: a computer program. Nucleic Acids Res (1984) 0.84

A new restriction endonuclease from Acetobacter pasteurianus. Nucleic Acids Res (1983) 0.82

Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose--ethidium bromide electrophoresis. Biochemistry (1973) 43.61

A specific endonuclease from Arthrobacter luteus. J Mol Biol (1976) 25.89

DNA nucleotide sequence restricted by the RI endonuclease. Proc Natl Acad Sci U S A (1972) 15.71

A restriction enzyme from Hemophilus influenzae. II. J Mol Biol (1970) 11.54

Isolation of a sequence-specific endonuclease (BamI) from Bacillus amyloliquefaciens H. J Mol Biol (1975) 7.42

A restriction enzyme Tha I from the thermophilic mycoplasma Thermoplasma acidophilum. Nucleic Acids Res (1978) 4.25

A deoxyribonuclease of Diplococcus pneumoniae specific for methylated DNA. J Biol Chem (1975) 3.90

Digestion of deoxyribonucleic acids from bacteriophage T7, lambda, and phi 80h with site-specific nucleases from Hemophilus influenzae strain Rc and strain Rd. Biochemistry (1974) 3.60

Sequence specificity of the P1 modification methylase (M.Eco P1) and the DNA methylase (M.Eco dam) controlled by the Escherichia coli dam gene. J Mol Biol (1978) 3.41

A specific endonuclease from Haemophilus haemolyticus. J Mol Biol (1976) 2.92

Recognition sequence of specific endonuclease BamH.I from Bacillus amyloliquefaciens H. Nature (1977) 2.59

A computer assisted method for the determination of restriction enzyme recognifion sites. Nucleic Acids Res (1978) 2.32

Restriction and modification in B. subtilis. Nucleotide sequence recognised by restriction endonuclease R. Bsu R from strain R. Mol Gen Genet (1975) 2.20

Two restriction-like enzymes from Xanthomonas malvacearum. J Mol Biol (1977) 2.11

Two new restriction endonucleases from Proteus vulgaris. Nucleic Acids Res (1981) 1.84

DNA methylases of Hemophilus influenzae Rd. II. Partial recognition site base sequences. J Mol Biol (1973) 1.72

DNA recognition and cleavage by the EcoP15 restriction endonuclease. J Mol Biol (1979) 1.67

A second site-specific restriction endonuclease from Staphylococcus aureus. Nucleic Acids Res (1978) 1.56

The nucleotide sequence recognized by the BstEII restriction endonuclease. Gene (1980) 1.43

Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1982) 1.42

DNA sequence restricted by restriction endonuclease AP from Haemophilus aphirophilus. Nat New Biol (1973) 1.39

Recognition sequence of restriction endonuclease KpnI from Klebsiella pneumoniae. Nucleic Acids Res (1978) 1.38

Isolation and properties of a thermostable restriction endonuclease (ENDO R-Bst1503). J Bacteriol (1977) 1.37

Occurrence of a class II restriction endonuclease in Staphylococcus aureus. J Bacteriol (1977) 1.35

RsaI: a new sequence-specific endonuclease activity from Rhodopseudomonas sphaeroides. J Bacteriol (1980) 1.34

A new sequence-specific endonuclease (Bsp) from Bacillus sphaericus. Gene (1977) 1.27

The nucleotide sequences recognized by endonucleases AvaI and AvaII from Anabaena variabilis. Biochem J (1980) 1.24

pMG7-mediated restriction of Pseudomonas aeruginosa phage DNAs is determined by a class II restriction endonuclease. Plasmid (1979) 1.16

A new site-specific endonuclease from Streptomyces lavendulae (SlaI). Gene (1979) 1.08

AhaIII: a restriction endonuclease with a recognition sequence containing only A:T basepairs. FEBS Lett (1982) 1.05

A thermostable, sequence-specific restriction endonuclease from Bacillus stearothermophilus: BstPI. Nucleic Acids Res (1979) 1.00

A new sequence-specific endonuclease from a thermophilic cyanobacterium, Mastigocladus laminosus. FEBS Lett (1980) 0.99

Characterization of a site-specific restriction endonuclease from Streptomyces aureofaciens. J Bacteriol (1981) 0.90

Specific restriction endonucleases from Haemophilus influenzae JC9. Acta Microbiol Pol (1980) 0.87

A rapid procedure for purifying a restriction endonuclease from Thermus thermophilus (Tth I). FEBS Lett (1980) 0.86

The sequence of the human genome. Science (2001) 101.55

A specific endonuclease from Arthrobacter luteus. J Mol Biol (1976) 25.89

Computer programs for the assembly of DNA sequences. Nucleic Acids Res (1979) 13.36

Restriction endonucleases. CRC Crit Rev Biochem (1976) 13.22

An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA. Cell (1977) 9.44

Steps toward computer analysis of nucleotide sequences. Science (1980) 8.73

HhaI methyltransferase flips its target base out of the DNA helix. Cell (1994) 8.72

Predictive motifs derived from cytosine methyltransferases. Nucleic Acids Res (1989) 7.63

A second specific endonuclease from Haemophilus aegyptius. J Mol Biol (1975) 6.36

Nucleotide sequences from the adenovirus-2 genome. J Biol Chem (1982) 5.76

Environmental exposure to lead and children's intelligence at the age of seven years. The Port Pirie Cohort Study. N Engl J Med (1992) 5.49

Homing endonucleases: keeping the house in order. Nucleic Acids Res (1997) 5.03

Port Pirie Cohort Study: environmental exposure to lead and children's abilities at the age of four years. N Engl J Med (1988) 4.50

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine. Cell (1993) 3.96

Agarose slab-gel electrophoresis equipment. Anal Biochem (1975) 3.88

Cleavage maps of DNA from adenovirus types 2 and 5 by restriction endonucleases EcoRI and HpaI. Cold Spring Harb Symp Quant Biol (1975) 3.87

Nucleotide sequence analysis of the leader segments in a cloned copy of adenovirus 2 fiber mRNA. Cell (1979) 3.78

Two sequence-specific endonucleases from Moraxella bovis. J Mol Biol (1977) 3.65

The DNA (cytosine-5) methyltransferases. Nucleic Acids Res (1994) 3.58

Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1985) 3.53

Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J Biol Chem (1999) 3.40

One predominant 5'-undecanucleotide in adenovirus 2 late messenger RNAs. Cell (1977) 3.30

AdoMet-dependent methylation, DNA methyltransferases and base flipping. Nucleic Acids Res (2001) 3.16

Cold machine perfusion versus static cold storage of kidneys donated after cardiac death: a UK multicenter randomized controlled trial. Am J Transplant (2010) 2.97

A specific endonuclease from Haemophilus haemolyticus. J Mol Biol (1976) 2.92

The nucleotide sequences at the termini of adenovirus-2 DNA. J Mol Biol (1979) 2.68

Recognition sequence of specific endonuclease BamH.I from Bacillus amyloliquefaciens H. Nature (1977) 2.59

Nucleotide sequence of the BsuRI restriction-modification system. Nucleic Acids Res (1985) 2.59

Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1980) 2.56

Functional analysis of putative restriction-modification system genes in the Helicobacter pylori J99 genome. Nucleic Acids Res (2000) 2.48

A semi-automated method for the reading of nucleic acid sequencing gels. Nucleic Acids Res (1982) 2.44

Nobel laureates' letter to President Bush. Washington Post (2001) 2.43

Different functional domains of the adenovirus E1A gene are involved in regulation of host cell cycle products. Mol Cell Biol (1987) 2.38

A computer assisted method for the determination of restriction enzyme recognifion sites. Nucleic Acids Res (1978) 2.32

Acetaminophen elimination kinetics in neonates, children, and adults. Clin Pharmacol Ther (1976) 2.24

PubMed Central: The GenBank of the published literature. Proc Natl Acad Sci U S A (2001) 2.20

A specific endonuclease from Bacillus caldolyticus. Nucleic Acids Res (1978) 2.18

Lytic and transforming functions of individual products of the adenovirus E1A gene. J Virol (1986) 2.14

Two restriction-like enzymes from Xanthomonas malvacearum. J Mol Biol (1977) 2.11

Restriction and modification enzymes and their recognition sequences. Gene (1978) 2.02

Oxygen toxicity in neonatal and adult animals of various species. J Appl Physiol Respir Environ Exerc Physiol (1978) 2.00

Modification profiles of bacterial genomes. Nucleic Acids Res (1982) 1.99

Identification of type II restriction and modification systems in Helicobacter pylori reveals their substantial diversity among strains. Proc Natl Acad Sci U S A (2000) 1.98

Production of anti-Mycoplasma (PPLO) antibodies in rabbits. Proc Soc Exp Biol Med (1967) 1.97

The sequence specificity domain of cytosine-C5 methylases. Nucleic Acids Res (1991) 1.94

M.HhaI binds tightly to substrates containing mismatches at the target base. Nucleic Acids Res (1995) 1.91

A new specific endonuclease from Xanthomonas badrii. J Mol Biol (1977) 1.91

Computer programs for handling nucleic acid sequences. Nucleic Acids Res (1984) 1.88

Comparative genomics of the restriction-modification systems in Helicobacter pylori. Proc Natl Acad Sci U S A (2001) 1.87

Two new restriction endonucleases from Proteus vulgaris. Nucleic Acids Res (1981) 1.84

Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1984) 1.75

Sequence specificity of the human mRNA N6-adenosine methylase in vitro. Nucleic Acids Res (1990) 1.73

A new restriction endonuclease from Streptomyces albus G. J Mol Biol (1978) 1.70

Characterization of the major mRNAs from adenovirus 2 early region 4 by cDNA cloning and sequencing. Nucleic Acids Res (1984) 1.69

Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaL methyltransferase-DNA-AdoHcy complexes. J Mol Biol (1996) 1.68

Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1981) 1.67

dna, single stranded/*metab. Virology (1976) 1.66

Restriction enzymes and their isoschizomers. Nucleic Acids Res (1987) 1.65

Cloning and characterization of the dcm locus of Escherichia coli K-12. J Bacteriol (1986) 1.65

Computer programs for nucleic acid sequence manipulation. Nucleic Acids Res (1982) 1.60

Needle-stick injuries in primary care in Wales. J Public Health (Oxf) (2007) 1.58

Characterization and sequence analysis of a recombination site in the hybrid virus Ad2+ND. J Mol Biol (1978) 1.50

A new specific endonuclease present in Xanthomonas holcicola, Xanthomonas papavericola and Brevibacterium luteum. J Mol Biol (1978) 1.48

Sequences from the beginning of the fiber messenger RNA of adenovirus-2. J Mol Biol (1979) 1.46

A specific endonuclease from Brevibacterium albidum. J Mol Biol (1977) 1.43

How M.MspI and M.HpaII decide which base to methylate. Nucleic Acids Res (1992) 1.43

Restriction and modification enzymes and their recognition sequences. Nucleic Acids Res (1982) 1.42

Cloning and characterization of the genes encoding the MspI restriction modification system. Nucleic Acids Res (1989) 1.41

DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase. Nucleic Acids Res (1997) 1.40

Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex. Biochemistry (1992) 1.40

Melano-macrophage centres and their role in fish pathology. J Fish Dis (2003) 1.40

A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase. J Mol Biol (1996) 1.40

Neuropsychiatric correlates of theta bursts in patients with closed head injury. Brain Inj (1992) 1.39

Recognition sequence of restriction endonuclease KpnI from Klebsiella pneumoniae. Nucleic Acids Res (1978) 1.38

Class of promotor sites for Escherichia coli DNA-dependent RNA polymerase. Nature (1974) 1.36

Structures of two glycyl-tRNAs from Staphylococcus epidermidis. Nat New Biol (1972) 1.35

Primary sequence of the EcoRII endonuclease and properties of its fusions with beta-galactosidase. J Biol Chem (1990) 1.35

Baculovirus-mediated expression and characterization of the full-length murine DNA methyltransferase. Nucleic Acids Res (1997) 1.35

Port Pirie Cohort study: childhood blood lead and neuropsychological development at age two years. J Epidemiol Community Health (1988) 1.35

Sequence-specific DNA binding by the MspI DNA methyltransferase. Nucleic Acids Res (1992) 1.34

Survey and mapping of restriction endonuclease cleavage sites in bacteriophage T7 DNA. J Mol Biol (1979) 1.31

Novel species of tRNA. Nature (1971) 1.30

A community outbreak of food-borne small round-structured virus gastroenteritis caused by a contaminated water supply. Epidemiol Infect (1999) 1.30

Structure of a binary complex of HhaI methyltransferase with S-adenosyl-L-methionine formed in the presence of a short non-specific DNA oligonucleotide. J Mol Biol (1999) 1.30

Finding errors in DNA sequences. Proc Natl Acad Sci U S A (1992) 1.30

Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines. Do aldehydic by-products of lipid peroxidation contribute to oxidative stress? Biochem J (1990) 1.30

Recombinant human DNA (cytosine-5) methyltransferase. II. Steady-state kinetics reveal allosteric activation by methylated dna. J Biol Chem (1999) 1.27

Mapping of the HhaI and HinfI cleavage sites on simian virus 40 DNA. J Mol Biol (1977) 1.27

Staphylococcal transfer ribonucleic acids. II. Sequence analysis of isoaccepting glycine transfer ribonucleic acids IA and IB from Staphylococcus epidermidis Texas 26. J Biol Chem (1974) 1.27

Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nat Struct Biol (1998) 1.27

Extent of terminal repetition in adenovirus 2 DNA. Cold Spring Harb Symp Quant Biol (1975) 1.26

The length of the terminal repetition in adenovirus-2 DNA. Proc Natl Acad Sci U S A (1974) 1.25

Cloning and characterization of the HpaII methylase gene. Nucleic Acids Res (1990) 1.21

The DNA binding affinity of HhaI methylase is increased by a single amino acid substitution in the catalytic center. Nucleic Acids Res (1993) 1.21

Structure of the inverted terminal repetition of adenovirus type 2 DNA. J Virol (1977) 1.20

DNA sequences from the adenovirus 2 genome. J Biol Chem (1984) 1.17

Use of hemoperfusion for treatment of theophylline intoxication. Am J Med (1983) 1.16

Spontaneously productive C-type retrovirus infection of fish cell lines. J Gen Virol (1991) 1.15

Recombinant human DNA (cytosine-5) methyltransferase. III. Allosteric control, reaction order, and influence of plasmid topology and triplet repeat length on methylation of the fragile X CGG.CCG sequence. J Biol Chem (2001) 1.14

Effect of phenobarbital on the excretion of an exogenous bilirubin load. Biochem Pharmacol (1967) 1.14